Danielsen group - Genomic Instability
The Danielsen group is developing high throughput methods for detection and characterisation of large-scale genomic instability (chromatin structure and ploidy), based on high-resolution digital microscopy and advanced image analysis. They are studying archival material at the time of diagnosis from patients with proper clinical follow-up and known prognosis, in large series of colorectal, breast, prostate and gynaecological cancers. In parallel, karyotyping, CGH and FISH are used to search for specific genomic changes in the same tumours, and attempts are made to establish the relationship between specific genomic changes and chromatin structure.
The Danielsen group. Foto: Terje Heiestad and Erling Sæthre Hansen.
Our main aim is to complete the methodology and system that detects and classifies large scale genomic instability in tumours by analysing nuclei in routine histological biopsies, and to use this to analyse the large series of common cancers and define more precise prognostic markers for these cancer types.
Detection and classification of genomic instability may be a key disease biomarker for cancer, and knowledge of the biochemical mechanisms behind it is likely to identify the next set of key therapeutic targets.
This group is also part of the Institute for Cancer Genetics and Informatics at Oslo University Hospital, established in 2004 with the aim of being at the forefront of medical informatics, both nationally and internationally. The institute is organized around three main units; Interphase Genetics, Cancer Cytogenetics and Applied Informatics.
See the Institute for Cancer Genetics and Informatics website for further information about our work.