Sandvig group - Intracellular transport
Our group is interested in the mechanisms of endocytosis, intracellular transport and secretion.
The Sandvig group.
About the group
Sandvig has been studying endocytosis and intracellular transport of protein toxins from bacteria and plants. These toxins include the bacterial toxins Shiga toxin and diphtheria toxin, as well as plant toxins such as ricin. The interactions of the toxins with cells are studied to learn more about endocytic mechanisms and intracellular transport in general, to investigate protein translocation across membranes, and to study toxins in particular with respect to their use in diagnosis and therapy of cancer. Increased knowledge about toxins and their interactions with cells is also of interest in connection with infectious diseases, and of interest to learn more about cell signalling and apoptosis.
There are several project leaders in the group (subgroups), and these are involved in investigations of release and characterization of exosomes, in vitro and in vivo studies of nanoparticles, as well as intracellular transport in general.
Sandvig is heading a project to build national competence in the field of biodegradable nanoparticles for cancer diagnosis and therapy. The project received a grant of 30.4 million NOK from The Research Council of Norway. It started September 2013 and lasts for 5 years. The project involves many national and international groups from basic research, university hospitals, research institutes and pharmaceutical industry.