Oddmund Bakke heads a research group that employs advanced imaging technology to study intracellular events, such as antigen presentation, with implications for immune responses.
About the group
Our group studies the endocytic pathway and how peptide loading of the MHC class II complexes (MHC II) is regulated.
A special focus for the group is to elucidate the contribution of the invariant chain (Ii) to the biogenesis of an antigen-presenting cell (APC) specific endocytic pathway.
The Bakke group runs a national imaging facility, NorMIC-Oslo, at the University of Oslo. This core facility is used by CIR and other research groups for a wide variety of projects involving advanced live cell imaging.
The Bakke group is part of the Department of Molecular Biosciences and is located at Blindern campus.
We study the process of antigen uptake, processing and presentation - instrumental events in the initiation and propagation of adaptive immune responses. The endocytic pathway common to all cells is uniquely adapted by specific immune cells.
We have contributed to the current understanding of cell biological processes in the endocytic pathway in general and our current goal is to use this foundation to elucidate the unique adaptations to this system in APCs. This will provide the basis to better understand vaccination regimes and protocols for immune therapy of cancer, autoimmune-, and infectious diseases.
The projects can be divided into four sub themes:
- Sorting and trafficking of immune molecules in model cell lines and APCs
- Regulation of vesicular transport
- Endosomal fusion and fision events
- Regulation of receptor signaling by endosomal sorting and kinetics in the endosomal pathway
Read more about the Bakke group at the Department of Molecular Biosciences.
Read more about cell biology and advanced imaging technology.
- Neefjes J, Jongsma ML, Paul P, Bakke O. Towards a systems understanding of MHC class I and MHC class II antigen presentation. Nat Rev Immunol. 2011 Nov 11;11(12):823-36. Review.
- Walseng E, Furuta K, Bosch B, Weih KA, Matsuki Y, Bakke O, Ishido S, Roche PA. Ubiquitination regulates MHC class II-peptide complex retention and degradation in dendritic cells. Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20465-70.
- Landsverk OJ, Barois N, Gregers TF, Bakke O. Invariant chain increases the half-life of MHC II by delaying endosomal maturation. Immunol Cell Biol. 2011 Jul;89(5):619-29.
- Husebye H, Aune MH, Stenvik J, Samstad E, Skjeldal F, Halaas O, Nilsen NJ, Stenmark H, Latz E, Lien E, Mollnes TE, Bakke O, Espevik T. The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes. Immunity. 2010 Oct 29;33(4):583-96.
- Landsverk OJ, Bakke O, Gregers TF. MHC II and the endocytic pathway: regulation by invariant chain. Scand J Immunol. 2009 Sep;70(3):184-93. Review.
- Bergeland T, Haugen L, Landsverk OJ, Stenmark H, Bakke O. Cell-cycle-dependent binding kinetics for the early endosomal tethering factor EEA1. EMBO Rep. 2008 Feb;9(2):171-8.