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Bakke group

Oddmund Bakke heads a research group that employs advanced imaging technology to study intracellular events, such as antigen presentation, with implications for immune responses.

 

Oddmund Bakke

About the group

Our group studies the endocytic pathway and how peptide loading of the MHC class II complexes (MHC II) is regulated.

A special focus for the group is to elucidate the contribution of the invariant chain (Ii) to the biogenesis of an antigen-presenting cell (APC) specific endocytic pathway.

The Bakke group runs a national imaging facility, NorMIC-Oslo, at the University of Oslo. This core facility is used by CIR and other research groups for a wide variety of projects involving advanced live cell imaging.

The Bakke group is part of the Department of Molecular Biosciences and is located at Blindern campus.

Projects

We study the process of antigen uptake, processing and presentation - instrumental events in the initiation and propagation of adaptive immune responses. The endocytic pathway common to all cells is uniquely adapted by specific immune cells.

We have contributed to the current understanding of cell biological processes in the endocytic pathway in general and our current goal is to use this foundation to elucidate the unique adaptations to this system in APCs. This will provide the basis to better understand vaccination regimes and protocols for immune therapy of cancer, autoimmune-, and infectious diseases.

The projects can be divided into four sub themes:

  1. Sorting and trafficking of immune molecules in model cell lines and APCs
  2. Regulation of vesicular transport
  3. Endosomal fusion and fision events
  4. Regulation of receptor signaling by endosomal sorting and kinetics in the endosomal pathway

Read more about the Bakke group at the Department of Molecular Biosciences.

Read more about cell biology and advanced imaging technology.

Selected publications

 

  • Borg M, Bakke O, Progida CA. A novel interaction between Rab7b and actomyosin reveals a dual role in intracellular transport and cell migration. 2014 J. Cell Sci (in press).
  • Wälchli S, Kumari S, Fallang LE, Sand KM, Yang W, Landsverk OJ, Bakke O, Olweus J, Gregers TF. Invariant chain as a vehicle to load antigenic peptides on human MHC class I for cytotoxic T-cell activation. 2014, Eur J Immunol. 44:774-84.
  • Berg-Larsen A, Landsverk OJB, Progida C, Gregers TF, Bakke O. Differential regulation of Rab GTPase expression in monocyte-derived dendritic cells upon lipopolysaccharide activation: A correlation to maturation dependent functional properties. PLoS One. 2013 Sep 5;8(9):e73538. doi: 10.1371/journal.
  • Progida C, Nielsen M, Koster G, Bucci C, Bakke O. Dynamics of Rab7b-dependent transport of sorting receptors. Traffic. 2012, 13, 1273-85.
  • Skjeldal FM, Strunze S, Bergeland T, Walseng E, Gregers TF, Bakke O. The fusion of early endosomes induces molecular-motor-driven tubule formation and fission. Journal of cell science. 2012. 125:1910-1919.
  • Neefjes J, Jongsma ML, Paul P, Bakke O. Towards a systems understanding of MHC class I and MHC class II antigen presentation. Nat Rev Immunol. 2011 Nov 11;11(12):823-36. Review.
  • Landsverk OJ, Bakke O, Gregers TF. MHC II and the endocytic pathway: regulation by invariant chain. Scand J Immunol. 2009 Sep;70(3):184-93. Review.
Published Jan 26, 2012 05:33 PM - Last modified Sep 18, 2014 02:12 PM

Contact

  • Department of Molecular Biosciences, University of Oslo, PO box 1041, Blindern, Oslo 0316, Norway.

 

Group leader