Ludvig M. Sollid heads a group that studies coeliac disease to understand the interplay between genetic and environmental factors in chronic inflammatory disorders.
Ludvig M. Sollid
About the group
Our group is striving to understand what happens when the body's defense from disease, the immune system, directly or indirectly causes harm to the body.
Coeliac disease, rheumatoid arthritis, type 1 (insulin-dependent) diabetes, and multiple sclerosis are examples of autoimmune disorders of a chronic inflammatory nature. We are concentrating on coeliac disease as a model to understand the molecular mechanisms leading to chronic inflammatory disease.
Research in the group has lead to a better understanding of the molecular basis of coeliac disease, but has also revealed general principles of immune regulation that are applicable to other immune-mediated disorders.
Translational research on coeliac disease on our group is organized within the KG Jebsen Centre for Coeliac Disease Research (J CoDiRC).
The Sollid group is part of the Department of Immunology at UiO and OUS and is located at OUS-Rikshospitalet.
As part of CIR the group runs projects focusing on:
- B cells and the auto-antibody response of coeliac disease.
- How certain variants of HLA molecules predispose to disease development.
- Characterisation of how T cells recognise gluten protein, the dietary antigen precipitating coeliac disease.
- How transglutaminase (TG) 2 mediated post-translational protein modification increases antigenicity.
Read more about coeliac disease.
- Spencer J, Sollid LM. The human intestinal B-cell response. Mucosal Immunol. 2016 Jul 27. doi: 10.1038/mi.2016.59
- Dahal-Koirala S, Risnes LF, Christophersen A, Sarna VK, Lundin KE, Sollid LM, Qiao SW. TCR sequencing of single cells reactive to DQ2.5-glia-α2 and DQ2.5-glia-ω2 reveals clonal expansion and epitope-specific V-gene usage. Mucosal Immunol. 2016 May;9(3):587-96.
- Stamnaes J, Iversen R, du Pré MF, Chen X, Sollid LM. Enhanced B-Cell receptor recognition of the autoantigen transglutaminase 2 by efficient catalytic self-multimerization. PLoS One. 2015 Aug 5;10(8):e0134922.
- Snir O, Mesin L, Gidoni M, Lundin KE, Yaari G, Sollid LM. Analysis of celiac disease autoreactive gut plasma cells and their corresponding memory compartment in peripheral blood using high-throughput sequencing. J Immunol. 2015 Jun 15;194(12):5703-12.
- Sollid LM and Jabri B. Triggers and drivers of autoimmunity: lessons from coeliac disease. Nat Rev Immunol. 2013 Apr;13(4):294-302.