Seminar "Pathogenic and regulatory antibodies: placenta and the impact of glycosylation"
It is a great pleasure to invite you to a CIR-seminar initiated by Dr. Jan Terje Andersen which is a Work Package coordinator at CIR. Refreshments will be served from 13:45. All welcome!
14.00-15.00: "Regulated IgG Fc-glycosylation in humans and it's significance".
Dr. Gestur Vidarsson, Department of Experimental Immunohematology , Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam , The Netherlands.
15:00-15:20: "Fighting FNAIT – murine models and antibody prophylaxis".
Dr. Maria Therese Ahlen, Division of Diagnostic Services, Department of Laboratory Medicine, University Hospital of North Norway, Tromsø, Norway. Immunology Research Group, Department of Medical Biology, University of Tromsø - The Arctic University of Norway, Tromsø, Norway.
15:20-15:40: "How is transport of IgG and albumin regulated in the human placenta?". Dr. Kine Marita Knudsen Sand, Centre for Immune Regulation and Department of Immunology, University of Oslo and Oslo University Hospital, Norway.
Abstract, Dr. Gestur Vidarsson:
Abstract: IgG antibodies are crucial for protection against invading pathogens, and have a highly conserved glycan at position 297 within their Fc-tail required for their function. Recent advances in antibody-mediated immunotherapy against cancer have taught us that removal of core fucose from this glycan generates antibodies with higher potency. This is caused by a stronger binding to IgG-Fc-receptor IIIa (FcγRIIIa) on myeloid effectors and natural killer (NK) cells. Afucosylated mouse antibodies have also enhanced activity and binding to the orthologue mouse FcγRIV, suggesting this type of responses have evolved in mammals for stronger effector functions. However, in humans afucosylated antibodies are rare, with only 6% of total IgG bearing this glycan signature. Here, I will show that although afucosylated antibodies are uncommon, they do occur in most individuals against some infectious agents. Furthermore, I will show that afucosylated antibody responses can be inappropriately triggered by paternal antigens in pregnancy, causing morbidity and mortality. Finally, I will show what these changes mean, which we have answered by multilevel geoengineering of human IgG, quering the significance of these changes through binding to and activity of Fc-receptors and complement.