Erik Dissen

Image of Erik Dissen
Norwegian version of this page
Phone +47-22851152
Mobile phone +47-91823478
Room 2390
Username
Visiting address Sognsvannsveien 9 Domus Medica 0372 OSLO
Postal address Postboks 1105 Blindern 0317 OSLO

Academic interests

  • Immunology
  • Natural killer cell biology
  • NK cell receptors and recognition of cancer cells and intracellular infection

Courses taught

  • MEDSEM1-4
  • Immunology
  • Anatomy
  • Histology.

Background

Positions

  • 2003-: Professor, Department of Anatomy, IMB, University of Oslo 
  • 1999-2003: Associate professor, Department of Anatomy, IMB, University of Oslo 
  • 1997-99: Postdoc
  • 1996-97: Military service as physician
  • 1994-95: Clinical internship, Molde county hospital/Fræna district
  • 1991-97: PhD fellowship (interrupted as above)

Education

  • 1997: PhD (Dr. med.)
  • 1995: Clinical authorization
  • 1991: MD (Cand. Med.)

Awards

  • H. M. the King´s gold medal for best thesis in medicine 1998
  • Lecturer of the year award 2004, Medical Students Association, University of Oslo

Positions held

  • Chairman, Department of anatomy, Institute of basic medical sciences 2008 – present
  • Vice Chairman 2004 -2008
  • President, Norwegian society for immunology, 2001-2003
  • Head of 2. Semester board, Faculty of medicine, 2004 – present
  • Delegate to the representative assembly of the Norwegian Cancer Society
Tags: Immunology, Life science, NK cells

Publications

  • Golic, Michaela; Haase, Nadine; Herse, Florian; Wehner, Anika; Vercruysse, Lisbeth; Pijnenborg, Robert; Balogh, Andras; Sæther, Per Christian; Dissen, Erik; Luft, Friedrich C.; Przybyl, Lukasz; Park, Joon-Keun; Alnæs-Katjavivi, Patji; Staff, Anne Cathrine; Verlohren, Stefan; Henrich, Wolfgang; Müller, Dominik N. & Dechend, Ralf (2016). Natural killer cell reduction and uteroplacental vasculopathy. Hypertension.  ISSN 0194-911X.  68(4), s 964- 973 . doi: 10.1161/HYPERTENSIONAHA.116.07800
  • Moussa, P; Abrahamsen, Greger; Fodil, N; Gopalakrishnan, Ramakrishna Prabhu; Mancini, M; Dissen, Erik; Sæther, Per Christian; Wiltshire, SA; Boivin, GA; Caignard, G; Spurkland, Anne & Vidal, SM (2015). Reduced MCMV Δm157 viral clearance in the absence of TSAd. Scientific Reports.  ISSN 2045-2322.  5 . doi: 10.1038/srep09219 Full text in Research Archive
  • Pandya, Abhilash D.; Leergaard, Trygve Brauns; Dissen, Erik; Haraldsen, Guttorm & Spurkland, Anne (2014). Expression of the T cell-specific adapter protein in human tissues. Scandinavian Journal of Immunology.  ISSN 0300-9475.  80(3), s 169- 179 . doi: 10.1111/sji.12199
  • Lobato Pascual, Ana; Sæther, Per Christian; Dahle, Maria Krudtaa; Gaustad, Peter; Dissen, Erik; Fossum, Sigbjørn & Daws, Michael Rory (2013). Rat Macrophage C-type Lectin is an Activating Receptor Expressed by Phagocytic Cells. PLoS ONE.  ISSN 1932-6203.  8(2) . doi: 10.1371/journal.pone.0057406
  • Lobato Pascual, Ana; Sæther, Per Christian; Fossum, Sigbjørn; Dissen, Erik & Daws, Michael Rory (2013). Mincle, the receptor for mycobacterial cord factor, forms a functional receptor complex with MCL and FcεRI-γ. European Journal of Immunology.  ISSN 0014-2980.  43(12), s 3167- 3174 . doi: 10.1002/eji.201343752
  • Fossum, Sigbjørn; Sæther, Per Christian; Vaage, John Torgils; Daws, Michael Rory & Dissen, Erik (2011). Paired opposing leukocyte receptors recognizing rapidly evolving ligands are subject to homogenization of their ligand binding domains. Immunogenetics.  ISSN 0093-7711.  63(12), s 809- 820 . doi: 10.1007/s00251-011-0553-5
  • Sæther, Per Christian; Hoelsbrekken, Sigurd Erik; Fossum, Sigbjørn & Dissen, Erik (2011). Rat and Mouse CD94 Associate Directly with the Activating Transmembrane Adaptor Proteins DAP12 and DAP10 and Activate NK Cell Cytotoxicity. Journal of Immunology.  ISSN 0022-1767.  187(12), s 6365- 6373 . doi: 10.4049/jimmunol.1102345
  • Flornes, Line Mari; Nylenna, Øyvind; Sæther, Per Christian; Daws, Michael Rory; Dissen, Erik & Fossum, Sigbjørn (2010). The complete inventory of receptors encoded by the rat natural killer cell gene complex. Immunogenetics.  ISSN 0093-7711.  62(8), s 521- 530 . doi: 10.1007/s00251-010-0455-y
  • Orr, Mark T; Wu, Jun; Fang, Min; Sigal, Luis J.; Spee, Pieter; Egebjerg, Thomas; Dissen, Erik; Fossum, Sigbjørn; Phillips, Joseph H & Lanier, Lewis L. (2010). Development and Function of CD94-Deficient Natural Killer Cells. PLoS ONE.  ISSN 1932-6203.  5(11) . doi: 10.1371/journal.pone.0015184
  • Dissen, Erik; Hoelsbrekken, Sigurd Erik; Sæther, Per Christian & Fossum, Sigbjørn (2008). NK cell receptors in rodents and cattle. Seminars in Immunology.  ISSN 1044-5323.  20(6), s 369- 375
  • Sæther, Per Christian; Westgaard, Ingunn Hagen; Hoelsbrekken, Sigurd Erik; Benjamin, J; Lanier, LL; Fossum, Sigbjørn & Dissen, Erik (2008). KLRE/I1 and KLRE/I2: A novel pair of heterodimeric receptors that inversely regulate NK cell cytotoxicity. Journal of Immunology.  ISSN 0022-1767.  181, s 3177- 3182
  • Lorentzen, JC; Flornes, Line Marie; Eklow, C; Backdahl, L; Ribbhammar, U; Guo, JP; Smolnikova, M; Dissen, Erik; Seddighzadeh, M; Brookes, AJ; Alfredsson, L; Klareskog, L; Padyukov, L & Fossum, Sigbjørn (2007). Association of arthritis with a gene complex encoding C-type lectin-like receptors. Arthritis and Rheumatism.  ISSN 0004-3591.  56, s 2620- 2632 . doi: 10.1002/art.22813
  • Kveberg, Lise; Dai, Kezheng; Dissen, Erik; Ryan, James C.; Rolstad, Bent; Vaage, John Torgils & Naper, Christian (2006). Strain-dependent expression of four structurally related rat Ly49 receptors; correlation with NK gene complex haplotype and NK alloreactivity. Immunogenetics.  ISSN 0093-7711.  58(11), s 905- 916
  • Bryceson, Yenan T.; Torgersen, Knut Martin; Inngjerdingen, Marit; Berg, Siri Fuglem; Hoelsbrekken, Sigurd Erik; Fossum, Sigbjørn & Dissen, Erik (2005). The rat orthologue to the inhibitory receptor gp49B is expressed by neutrophils and monocytes, but not by NK cells or mast cells. European Journal of Immunology.  ISSN 0014-2980.  35(4)
  • Hoelsbrekken, Sigurd Erik; Fossum, Sigbjørn & Dissen, Erik (2005). Molecular cloning of LILRC1 and LILRC2 in the mouse and the rat, two novel immunoglobulin-like receptors encoded by the leukocyte receptor gene complex. Immunogenetics.  ISSN 0093-7711.  57(7), s 479- 486
  • Nylenna, Øyvind; Naper, Christian; Vaage, John Torgils; Woon, P.Y.; Gauguier, D; Dissen, Erik; Ryan, JC & Fossum, Sigbjørn (2005). The genes and gene organization of the Ly49 region of the rat natural killer cell gene complex. European Journal of Immunology.  ISSN 0014-2980.  35
  • Sæther, Per Christian; Westgaard, Ingunn Hagen; Flornes, Line Marie; Hoelsbrekken, Sigurd Erik; Ryan, James C.; Fossum, Sigbjørn & Dissen, Erik (2005). Molecular cloning of KLRI1 and KLRI2, a novel pair of lectin-like natural killer-cell receptors with opposing signalling motifs. Immunogenetics.  ISSN 0093-7711.  56
  • Helgeland, Lars; Dissen, Erik; Dai, Kezheng; Midtvedt, Tore; Brandtzæg, Per & Vaage, John Torgils (2004). Microbial colonization induces oligoclonal expansions of intraepithelial CD8 T cells in the gut . European Journal of Immunology.  ISSN 0014-2980.  34, s 3389- 3400 . doi: 10.1002/eji.200425122
  • Morton, H. Craig; Pleass, RJ; Storset, Anne K; Dissen, Erik; Williams, JL; Brandtzæg, Per & Woof, JM (2004). Cloning and characterization of an immunoglobulin A FC receptor from cattle. Immunology.  ISSN 0019-2805.  111(2), s 204- 211
  • Morton, Hugh Craig; Pleass, Richard J; Storset, Anne K.; Dissen, Erik; Williams, John L; Brandtzæg, Per & Woof, Jenny M. (2004). Cloning and characterization of an immunoglobulin A Fc receptor from cattle. Immunology.  ISSN 0019-2805.  111(2), s 204- 211
  • Storset, Anne K.; Kulberg, S; Berg, I; Boysen, P; Hope, JC & Dissen, Erik (2004). NKp46 defines a subset of bovine leukocytes with natural killer cell characteristics. European Journal of Immunology.  ISSN 0014-2980.  34, s 669- 676
  • Westgaard, Ingunn Hagen; Berg, Siri F.; Vaage, John Torgils; Wang, Lawrence L; Yokoyama, Wayne M.; Dissen, Erik & Fossum, Sigbjørn (2004). Rat NKp46 activates natural killer cell cytotoxicity and is associated with Fc{epsilon}RI{gamma} and CD3{zeta} . Journal of Leukocyte Biology.  ISSN 0741-5400.  76, s 1200- 1206 . doi: 10.1189/jlb.0903428
  • Flornes, Line Marie; Bryceson, Yenan T.; Spurkland, Anne; Lorentzen, JC; Dissen, Erik & Fossum, Sigbjørn (2004). Identification of lectin-like receptors expressed by antigen presenting cells and neutrophils and their mapping to a novel gene complex. Immunogenetics.  ISSN 0093-7711.  56, s 506- 517
  • Nejad, S; Bryceson, Yenan T.; Dissen, Erik; Sundvold-Gjerstad, V; Naper, Christian; Rolstad, Bent; Spurkland, Anne & Vaage, John Torgils (2004). cDNA cloning of a rat orthologue of SH2D2A encoding T-cell-specific adaptor protein (TSAd): expression in T and NK cells . Immunogenetics.  ISSN 0093-7711.  56(5), s 338- 342 . doi: 10.1007/s00251-004-0695-9
  • Storset, Anne K; Kulberg, Siri; Berg, Ingvild; Boysen, Preben; Dissen, Erik & Hope, Jayne (2004). NKp46 defines a subset of bovine leukocytes with natural killer cell characteristics. European Journal of Immunology.  ISSN 0014-2980.  34(3), s 669- 676
  • Hoelsbrekken, Sigurd E.; Nylenna, Øyvind; Sæther, Per Christian; Slettedal, Imer Ö; Ryan, James C.; Fossum, Sigbjørn & Dissen, Erik (2003). Cutting edge: molecular cloning of a killer cell Ig-like receptor in the mouse and rat. Journal of Immunology.  ISSN 0022-1767.  170(5), s 2259- 2263
  • Storset, Anne K.; Slettedal, Imer Ö; Williams, John L; Law, Andy & Dissen, Erik (2003). Natural killer cell receptors in cattle: a bovine killer cell immunoglobulin-like receptor multigene family contains members with divergent signaling motifs. European Journal of Immunology.  ISSN 0014-2980.  33(4), s 980- 990
  • Westgaard, Ingunn Hagen; Dissen, Erik; Torgersen, Knut Martin; Lazetic, Sascha; Lanier, Lewis L.; Phillips, JH & Fossum, Sigbjørn (2003). The lectin-like receptor KLRE1 inhibits natural killer cell cytotoxicity. Journal of Experimental Medicine.  ISSN 0022-1007.  197(11), s 1551- 1561
  • Storset, Anne K.; Slettedal, Imer Ö; Williams, John L.; Law, Andy & Dissen, Erik (2003). Natural killer cell receptors in cattle. A bovine killer cell immunoglobulin-like receptor multigene family contains members with divergent signaling motifs. European Journal of Immunology.  ISSN 0014-2980.  33, s 980- 990
  • Naper, Christian; Hayashi, Shigenari; Løvik, Guro; Kveberg, Lise; Niemi, Eréne C.; Rolstad, Bent; Dissen, Erik; Ryan, James C. & Vaage, John Torgils (2002). Characterization of a novel killer cell lectin-like receptor (KLRH1) expressed by alloreactive rat NK cells. Journal of Immunology.  ISSN 0022-1767.  s 5147- 5154
  • Løvik, Guro; Vaage, John Torgils; Dissen, Erik; Szpirer, Claude; Ryan, James C. & Rolstad, Bent (2000). Characterization and molecular cloning of rat C1qRp, a receptor on NK cells. European Journal of Immunology.  ISSN 0014-2980.  30, s 3355- 3362
  • Berg, Siri Fuglem; Fossum, Sigbjørn & Dissen, Erik (1999). NILR-1, a novel immunoglobulin-like receptor expressed by neutrophilic granulocytes, is encoded by a leukocyte receptor gene complex on rat chromosome 1. European Journal of Immunology.  ISSN 0014-2980.  29, s 2000- 2006
  • Berg, Siri Fuglem; Westgaard, Ingunn Hagen; Fossum, Sigbjørn & Dissen, Erik (1999). A rat gene homologous to human granule membrane protein 17 is expressed by natural killer cells, CD8+ T cells and a mast cell line. Immunogenetics.  ISSN 0093-7711.  29, s 815- 818
  • Berg, Siri Fuglem; Dissen, Erik; Westgaard, Ingunn Hagen & Fossum, Sigbjørn (1998). Molecular characterization of rat NKR-P2, a lectin-like receptor expressed by NK cells and resting T cells. International Immunology.  ISSN 0953-8178.  10, s 379- 385
  • Berg, Siri Fuglem; Dissen, Erik; Westgaard, Ingunn Hagen & Fossum, Sigbjørn (1998). Two genes in the rat homologous to human NKG2. European Journal of Immunology.  ISSN 0014-2980.  28, s 444- 450
  • Westgaard, Ingunn Hagen; Berg, Siri Fuglem; Ørstavik, Sigurd; Fossum, Sigbjørn & Dissen, Erik (1998). Identification of a human member of the Ly-49 multigene family. European Journal of Immunology.  ISSN 0014-2980.  28, s 1839- 1846
  • Dissen, Erik; Berg, Siri Fuglem; Westgaard, Ingunn Hagen & Fossum, Sigbjørn (1997). Molecular characterization of a gene in the rat homologous to human CD94. European Journal of Immunology.  ISSN 0014-2980.  27, s 2080- 2086
  • Dissen, Erik & Fossum, Sigbjørn (1996). Chromosomal localization of the genes encoding rat CD4, CD8 and CD8. Immunogenetics.  ISSN 0093-7711.  44, s 312- 314
  • Dissen, Erik; Ryan, James C.; Seaman, W. E. & Fossum, Sigbjørn (1996). An autosomal dominant locus, Nka, mapping to the Ly-49 region of a rat natural killer (NK) gene complex, controls NK cell lysis of allogeneic lymphocytes. Journal of Experimental Medicine.  ISSN 0022-1007.  183, s 2197- 2207

View all works in Cristin

  • Kristensen, Petter; Levy, Finn; Grahnstedt, Svein G; Martinsen, Aud; Schiel, Anja Elisabeth; Flornes, Line Mari; Daws, Michael Rory; Dissen, Erik & Fossum, Sigbjørn (2011). Oils and Health. Report to the Ministry of Health and Care Services.
  • Dissen, Erik (1997). Recognition of allogeneic lymphocytes by natural killer cells. A molecular genetic study in the rat.

View all works in Cristin

Published Apr. 13, 2011 2:40 PM - Last modified Mar. 29, 2012 3:24 PM