Jan E. Brinchmann

Image of Jan E. Brinchmann
Norwegian version of this page
Phone +47-22840489
Room 2244
Username
Visiting address Sognsvannsveien 9 Domus Medica 0372 OSLO
Postal address Postboks 1112 Blindern 0317 OSLO

Academic interests

  • Stem cell biology
  • Tissue engineering
  • Cell therapy

Courses taught

PBL

Background

Education:

  • 1991: PhD in HIV immunology and virology, University of Oslo
  • 1987: Specialist in internal medicine
  • 1976: MD, Royal College of Surgeons in Ireland

Work:

  • 2009 - Group leader, Norwegian Center for Stem Cell Research, Rikshospitalet and University of Oslo
  • 2005 - Section head, Cell therapy, Institute of Immunology, Rikshospitalet University Hospital, Oslo
  • 1998 - 2005 Medical director, Cell Processing Laboratory, Rikshospitalet University Hospital, Oslo, Norway
  • 1995 - 2005 Senior scientist, Institute of Immunology, Rikshospitalet
  • 1992 - 1995 Post doc. scientist, Institute of Immunology, Rikshospitalet
  • 1986 - 1991 Doctoral fellow, Institute of Immunology, Rikshospitalet
  • 1985 - 1986 Physician, Department of Medicine, Akershus University Hospital, Norway
  • 1982 - 1985 Registrar, Department of Medicine, Woden Valley Hospital and Royal Canberra Hospital, Canberra, Australia
  • 1979 - 1982 Resident medical officer, Department of Infectious Diseases, Ullevål Hospital, Oslo, Norway

Awards

  • 1990: Domagk-Bayer Prize for best paper within infectious diseases: NOK 10.000
  • 1991: Medinnova Prize for excellent research concepts, NOK 100.000

Collaboration

  • Norwegian Center for Stem Cell Research, Jan E. Brinchmann group
  • Department of Immunology, Oslo University Hospital Rikshospitalet
  • Professor Lars Engebretsen, Department of Orthopedics, OUS Ullevål sykehus
  • Dr. Svend Aakhus, Department of Cardiology, OUS Rikshospitalet
  • Professor Philippe Collas, Department of Biochemistry, Institute of Basic Madical Sciences, UoO
  • Dr. Leonardo Meza-Zepeda, Microarray Core Facility, OUS Radiumhospitalet
  • Dr. Tarjei Mikkelsen, Broad Institute, Massachusetts Institute of Technology and Harvard Stem Cell Institute
Tags: Stem cells, Muscolo-Skeletal system, Heart vascular and lungs

Publications

  • Behnan, Jinan; Stangeland, Biljana; Hosainey, Sayied Abdol Mohieb; Joel, Mrinal; Olsen, Thale Kristin; Micci, Francesca; Glover, Joel; Isakson, Pauline & Brinchmann, Jan E. (2017). Differential propagation of stroma and cancer stem cells dictates tumorigenesis and multipotency. Oncogene.  ISSN 0950-9232.  36(4), s 570- 584 . doi: 10.1038/onc.2016.230
  • Karlsen, Tommy Aleksander; De Souza, Gustavo Antonio; Ødegård, Bjørn; Engebretsen, Lars & Brinchmann, Jan E. (2016). microRNA-140 Inhibits Inflammation and Stimulates Chondrogenesis in a Model of Interleukin 1beta-induced Osteoarthritis.. Molecular Therapy - Nucleic Acids.  ISSN 2162-2531.  5, s e373 . doi: 10.1038/mtna.2016.64
  • Aae, Tommy Frøseth; Randsborg, Per-Henrik; Breen, Anne Berg; Visnes, Håvard; Vindfeld, Søren; Sivertsen, Einar; Løken, Sverre Bertrand; Brinchmann, Jan E.; Hanvold, Heidi Andreassen & Årøen, Asbjørn (2016). Norwegian Cartilage Project - a study protocol for a double-blinded randomized controlled trail comparing arthroscopic microfracture with debridement in focal cartilage defects in the knee. BMC Musculoskeletal Disorders.  ISSN 1471-2474.  17:292 . doi: 10.1186/s12891-016-1156-y
  • Behnan, Jinan; Stangeland, Biljana; Langella, Tiziana; Finocchiaro, Gaetano; Murrell, Wayne & Brinchmann, Jan E. (2016). Ultrasonic Surgical Aspirate is a Reliable Source for Culturing Glioblastoma Stem Cells. Scientific Reports.  ISSN 2045-2322.  6 . doi: 10.1038/srep32788 Full text in Research Archive
  • Costantini, Marco; Idaszek, Joanna; Szoke, Krisztina; Jaroszewicz, Jakub; Dentini, Mariella; Barbetta, Andrea; Brinchmann, Jan E. & Swieszkowski, Wojciech (2016). 3D bioprinting of BM-MSCs-loaded ECM biomimetic hydrogels for in vitro neocartilage formation. Biofabrication.  ISSN 1758-5082.  8(3) . doi: 10.1088/1758-5090/8/3/035002
  • Foldager, Casper B.; Bendtsen, Michael; Berg, Lise C.; Brinchmann, Jan E.; Brittberg, Mats; Bunger, Cody; Canseco, Jose; Chen, Li; Christensen, Bjørn; Colombier, Pauline; Deleuran, Bent W.; Edwards, James; Elmengaard, Brian; Farr, Jack; Gatenholm, Birgitta; Gomoll, Andreas H.; Hui, James H.; Jakobsen, Rune Bruhn; Jørgensen, Natasja L.; Kassem, Moustapha; Koch, Thomas; Kold, Søren; Krogsgaard, Michael R.; Lauridsen, Henrik; Le, Dang; Le Visage, Catherine; Lind, Martin; Nygaard, Jens V.; Olesen, Morten L.; Pedersen, Michael; Rathcke, Martin; Richardson, James B.; Roberts, Sally; Rölfing, Jan H.D.; Sakai, Daisuke; Toh, Wei Seong; Urban, Jill & Spector, Myron (2016). Aarhus Regenerative Orthopaedics Symposium (AROS): Regeneration in the ageing population. Acta Orthopaedica.  ISSN 1745-3674.  87, s 1- 5 . doi: 10.1080/17453674.2017.1297918
  • Randsborg, Per-Henrik; Brinchmann, Jan E.; Løken, Sverre Bertrand; Hanvold, Heidi Andreassen; Aae, Tommy Frøseth & Årøen, Asbjørn (2016). Focal cartilage defects in the knee -a randomized controlled trial comparing autologous chondrocyte implantation with arthroscopic debridement. BMC Musculoskeletal Disorders.  ISSN 1471-2474.  17(1) . doi: 10.1186/s12891-016-0969-z
  • Szoke, Krisztina; Reinisch, Andreas; Østrup, Esben; Reinholt, Finn P. & Brinchmann, Jan E. (2016). Autologous cell sources in therapeutic vasculogenesis: In vitro and in vivo comparison of endothelial colony-forming cells from peripheral blood and endothelial cells isolated from adipose tissue . Cytotherapy.  ISSN 1465-3249.  18(2), s 242- 252 . doi: 10.1016/j.jcyt.2015.10.009
  • Hart, Melanie L.; Izeta, Ander; Herrera-Imbroda, Bernardo; Amend, Bastian & Brinchmann, Jan E. (2015). Cell therapy for stress urinary incontinence. Tissue engineering. Part B, Reviews.  ISSN 1937-3368.  21(4), s 365- 376 . doi: 10.1089/ten.teb.2014.0627
  • Klein, Gerd; Hart, Melanie L.; Brinchmann, Jan E.; Rolauffs, Bernd; Stenzl, Arnulf; Sievert, Karl-Dietrich & Aicher, Wilhelm K. (2015). Mesenchymal stromal cells for sphincter regeneration. Advanced Drug Delivery Reviews.  ISSN 0169-409X.  82, s 123- 136 . doi: 10.1016/j.addr.2014.10.026
  • Lilledahl, Magnus Borstad; Magnus Østgård, Olderøy; Finnøy, Andreas; Olstad, Kristin & Brinchmann, Jan E. (2015). Second harmonic generation imaging in tissue engineering and cartilage pathologies. Progress in Biomedical Optics and Imaging.  ISSN 1605-7422.  9329 . doi: 10.1117/12.2081583
  • Pullisaar, Helen; Verket, Anders; Szoke, Krisztina; Tiainen, Hanna; Haugen, Håvard Jostein; Brinchmann, Jan E.; Reseland, Janne Elin & Østrup, Esben (2015). Alginate hydrogel enriched with enamel matrix derivative to target osteogenic cell differentiation in TiO2 scaffolds. Journal of Tissue Engineering.  ISSN 2041-7314.  6 . doi: 10.1177/2041731415575870 Full text in Research Archive
  • Herlofsen, Sarah; Høiby, Torill; Cacchiarelli, Davide; Zhang, Xiaolan; Mikkelsen, Tarjei S. & Brinchmann, Jan E. (2014). Brief report: Importance of SOX8 for in vitro chondrogenic differentiation of human mesenchymal stromal cells. Stem Cells.  ISSN 1066-5099.  32(6), s 1629- 1635 . doi: 10.1002/stem.1642
  • Jakobsen, Rune Bruhn; Østrup, Esben; Xiaolan, Zhang; Mikkelsen, Tarjei S. & Brinchmann, Jan E. (2014). Analysis of the effects of five factors relevant to in vitro chondrogenesis of human mesenchymal stem cells using factorial design and high throughput mRNA-profiling. PLoS ONE.  ISSN 1932-6203.  9(5) . doi: 10.1371/journal.pone.0096615
  • Karlsen, Tommy Aleksander; Jakobsen, Rune Bruhn; Mikkelsen, Tarjei S. & Brinchmann, Jan E. (2014). microRNA-140 Targets RALA and Regulates Chondrogenic Differentiation of Human Mesenchymal Stem Cells by Translational Enhancement of SOX9 and ACAN. Stem Cells and Development.  ISSN 1547-3287.  23(3), s 290- 304 . doi: 10.1089/scd.2013.0209
  • Magnus Østgård, Olderøy; Lilledahl, Magnus Borstad; Beckwith, Marianne; Melvik, Jan Egil; Reinholt, Finn P.; Sikorski, Pawel & Brinchmann, Jan E. (2014). Biochemical and Structural Characterization of Neocartilage Formed by Mesenchymal Stem Cells in Alginate Hydrogels. PLoS ONE.  ISSN 1932-6203.  9(3), s e91662 . doi: 10.1371/journal.pone.0091662 Full text in Research Archive
  • Pullisaar, Helen; Reseland, Janne Elin; Haugen, Håvard Jostein; Brinchmann, Jan E. & Østrup, Esben (2014). Simvastatin coating of TiO2 scaffold induces osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  447(1), s 139- 144 . doi: 10.1016/j.bbrc.2014.03.133
  • Fernandes, Amilton Moreira; Herlofsen, Sarah; Karlsen, Tommy Aleksander; Kuchler, Axel Matthias; Fløisand, Yngvar & Brinchmann, Jan E. (2013). Similar Properties of Chondrocytes from Osteoarthritis Joints and Mesenchymal Stem Cells from Healthy Donors for Tissue Engineering of Articular Cartilage. PLoS ONE.  ISSN 1932-6203.  8(5) . doi: 10.1371/journal.pone.0062994
  • Herlofsen, Sarah; Bryne, Jan Christian; Høiby, Torill; Wang, Li; Issner, Robbyn; Zhang, XL; Coyne, Michael J; Boyle, P; Gu, Hongcang; Meza-Zepeda, Leonardo Andrés; Collas, Philippe; Mikkelsen, Tarjei S. & Brinchmann, Jan E. (2013). Genome-wide map of quantified epigenetic changes during in vitro chondrogenic differentiation of primary human mesenchymal stem cells. BMC Genomics.  ISSN 1471-2164.  14 . doi: 10.1186/1471-2164-14-105
  • Karlsen, Tommy Aleksander & Brinchmann, Jan E. (2013). Liposome Delivery of MicroRNA-145 to Mesenchymal Stem Cells Leads to Immunological Off-target Effects Mediated by RIG-I. Molecular Therapy.  ISSN 1525-0016.  21(6), s 1169- 1181 . doi: 10.1038/mt.2013.55
  • Rohban, Rokhsareh; Reinisch, Andreas; Etchart, Nathalie; Schallmoser, Katharina; Hofmann, Nicole A.; Szoke, Krisztina; Brinchmann, Jan E.; Rad, Ehsan Bonyadi; Rohde, Eva & Strunk, Dirk (2013). Identification of an Effective Early Signaling Signature during Neo-Vasculogenesis In Vivo by Ex Vivo Proteomic Profiling. PLoS ONE.  ISSN 1932-6203.  8(6) . doi: 10.1371/journal.pone.0066909
  • Vik-Mo, Einar O.; Nyakas, Marta Sølvi; Mikkelsen, Birthe Viftrup; Moe, Morten Carsten; Due-Tønnessen, Paulina; Suso, Else Marit Inderberg; Sæbøe-Larssen, Stein; Sandberg, Cecilie; Brinchmann, Jan E.; Helseth, Eirik; Rasmussen, Anne Marie; Lothe, Knut; Aamdal, Steinar; Gaudernack, Gustav; Kvalheim, Gunnar & Langmoen, Iver Arne (2013). Therapeutic vaccination against autologous cancer stem cells with mRNA-transfected dendritic cells in patients with glioblastoma. Cancer Immunology and Immunotherapy.  ISSN 0340-7004.  62(9), s 1499- 1509 . doi: 10.1007/s00262-013-1453-3
  • Beitnes, Jan Otto; Øie, Erik; Shahdafar, Aboulghassem; Karlsen, Tommy Aleksander; Müller, Regine; Aakhus, Svend; Reinholt, Finn P. & Brinchmann, Jan E. (2012). Intramyocardial Injections of Human Mesenchymal Stem Cells Following Acute Myocardial Infarction Modulate Scar Formation and Improve Left Ventricular Function. Cell Transplantation.  ISSN 0963-6897.  21(8), s 1697- 1709 . doi: 10.3727/096368911X627462
  • Szoke, Krisztina; Beckstrøm, Karen Johanne & Brinchmann, Jan E. (2012). Ectopic expression of CDX4 in human mesenchymal stem cells does not affect HOX gene expression or induce hematopoietic reprogramming. Stem Cell Research.  ISSN 1873-5061.  9(2), s 135- 142 . doi: 10.1016/j.scr.2012.05.006
  • Szoke, Krisztina; Beckstrøm, Karen Johanne & Brinchmann, Jan E. (2012). Human adipose tissue as a source of cells with angiogenic potential. Cell Transplantation.  ISSN 0963-6897.  21(1), s 235- 250 . doi: 10.3727/096368911X580518
  • Szoke, Krisztina & Brinchmann, Jan E. (2012). Concise review: therapeutic potential of adipose tissue-derived angiogenic cells. Stem Cells Translational Medicine.  ISSN 2157-6564.  1(9), s 658- 667 . doi: 10.5966/sctm.2012-0069
  • Beitnes, Jan Otto; Lunde, Ketil; Brinchmann, Jan E. & Aakhus, Svend (2011). Stem cells for cardiac repair in acute myocardial infarction. Expert Review of Cardiovascular Therapy.  ISSN 1477-9072.  9(8), s 1015- 1025
  • Duggal, Shivali & Brinchmann, Jan E. (2011). Importance of Serum Source for the In Vitro Replicative Senescence of Human Bone Marrow Derived Mesenchymal Stem Cells. Journal of Cellular Physiology.  ISSN 0021-9541.  226(11), s 2908- 2915 . doi: 10.1002/jcp.22637
  • Gordeladze, Jan Oxholm; Reseland, Janne Elin; Karlsen, Tommy Aleksander; Jakobsen, Rune Bruhn; Engebretsen, Lars; Lyngstadaas, Ståle Petter; Jorgensen, Christian; Yssel, Hans & Brinchmann, Jan E. (2011). Bone and Cartilage from Stem Cells: Growth Optimalization and Stabilization of Cell Phenotypes, In Daniel Eberli (ed.),  Bone and Cartilage from Stem Cells: Growth Optimalization and Stabilization of Cell Phenotypes.  INTECH.  ISBN 978-953-307-663-8.  2.  s 23 - 56
  • Herlofsen, Sarah; Kuechler, Axel Matthias; Melvik, Jan Egil & Brinchmann, Jan E. (2011). Chondrogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells in Self-Gelling Alginate Discs Reveals Novel Chondrogenic Signature Gene Clusters. Tissue engineering.  ISSN 1076-3279.  17(7-8), s 1003- 1013 . doi: 10.1089/ten.tea.2010.0499
  • Karlsen, Tommy Aleksander; Mirtaheri, Peyman; Shahdafar, Aboulghassem; Fløisand, Yngvar & Brinchmann, Jan E. (2011). Effect of Three-Dimensional Culture and Incubator Gas Concentration on Phenotype and Differentiation Capability of Human Mesenchymal Stem Cells. Journal of Cellular Biochemistry.  ISSN 0730-2312.  112(2), s 684- 693 . doi: 10.1002/jcb.22978
  • Karlsen, Tommy Aleksander; Shahdafar, Aboulghassem & Brinchmann, Jan E. (2011). Human Primary Articular Chondrocytes, Chondroblasts-Like Cells, and Dedifferentiated Chondrocytes: Differences in Gene, MicroRNA, and Protein Expression and Phenotype. Tissue Engineering. Parts A, B and C.  ISSN 2152-4947.  17(2), s 219- 227 . doi: 10.1089/ten.tec.2010.0200
  • Jakobsen, Rune Bruhn; Shahdafar, Aboulghassem; Reinholt, Finn P. & Brinchmann, Jan E. (2010). Chondrogenesis in a hyaluronic acid scaffold: comparison between chondrocytes and MSC from bone marrow and adipose tissue. Knee Surgery, Sports Traumatology, Arthroscopy.  ISSN 0942-2056.  18(10), s 1407- 1416 . doi: 10.1007/s00167-009-1017-4
  • Beitnes, Jan Otto; Halvorsen, Bente; Hopp, Einar; Lunde, Ketil; Solheim, Svein; Arnesen, Harald; Brinchmann, Jan E.; Forfang, Kolbjørn & Aakhus, Svend (2009). Long-term results after intracoronary injection of autologous mononuclear bone marrow cells in acute myocardial infarction: the ASTAMI randomised, controlled study. Heart.  ISSN 1355-6037.  95(24), s 1983- 1989 . doi: 10.1136/hrt.2009.178913
  • Duggal, Shivali; Frønsdal, Katrine; Szoke, Krisztina; Shahdafar, Aboulghassem; Melvik, Jan Egil & Brinchmann, Jan E. (2009). Phenotype and Gene Expression of Human Mesenchymal Stem Cells in Alginate Scaffolds. Tissue engineering.  ISSN 1076-3279.  15(7), s 1763- 1773 . doi: 10.1089/ten.tea.2008.0306
  • Hildrestrand, Gunn Annette; Duggal, Shivali; Bjørås, Magnar; Luna, Luisa & Brinchmann, Jan E. (2009). Modulation of DNA glycosylase activities in mesenchymal stem cells. Experimental Cell Research.  ISSN 0014-4827.  315(15), s 2558- 2567 . doi: 10.1016/j.yexcr.2009.05.017
  • Brinchmann, Jan E. (2008). Expanding autologous multipotent mesenchymal bone marrow stromal cells. Journal of the Neurological Sciences.  ISSN 0022-510X.  265 . doi: 10.1016/j.jns.2007.05.006
  • Dahl, John Arne; Duggal, Shivali; Coulston, N; Millar, D; Melki, J; Shahdafar, Aboulghassem; Brinchmann, Jan E. & Collas, Philippe (2008). Genetic and epigenetic instability of human bone marrow mesenchymal stem cells expanded in autologous serum or fetal bovine serum. International Journal of Developmental Biology.  ISSN 0214-6282.  52(8), s 1033- 1042 . doi: 10.1387/ijdb.082663jd
  • Løken, Sverre Bertrand; Jakobsen, Rune Bruhn; Årøen, Asbjørn; Heir, Stig; Shahdafar, Aboulghassem; Brinchmann, Jan E.; Engebretsen, Lars & Reinholt, Finn P. (2008). Bone marrow mesenchymal stem cells in a hyaluronan scaffold for treatment of an osteochondral defect in a rabbit model. Knee Surgery, Sports Traumatology, Arthroscopy.  ISSN 0942-2056.  16, s 896- 903 . doi: 10.1007/s00167-008-0566-2
  • Shahdafar, Aboulghassem; Løken, Sverre Bertrand; Dahl, John Arne; Tunheim, Siv Haugen; Collas, Philippe; Reinholt, Finn P.; Engebretsen, Lars & Brinchmann, Jan E. (2008). Persistence of Collagen Type II Synthesis and Secretion in Rapidly Proliferating Human Articular Chondrocytes In Vitro. Tissue engineering.  ISSN 1076-3279.  14(12), s 1999- 2007 . doi: 10.1089/ten.tea.2007.0344
  • Wester, T; Jorgensen, JJ; Stranden, E; Sandbaek, G; Tjonnfjord, G; Bay, D; Kolleros, D; Kroese, AJ & Brinchmann, Jan E. (2008). Treatment with autologous bone marrow mononuclear cells in patients with critical lower limb ischaemia. A pilot study. Scandinavian Journal of Surgery.  ISSN 1457-4969.  97
  • Wester, T; Jørgensen, Jørgen J.; Stranden, Einar; Tønnfjord, Geir E.; Bay, Dag; Sandbæk, Gunnar; Kollerøs, Dagfinn; Kroese, Andries Jan & Brinchmann, Jan E. (2008). Treatment with autologous mononuclear cells in patients with critical lower limb ischemia. A pilot study. Scandinavian Journal of Surgery.  ISSN 1457-4969.  97, s 56- 62
  • Wester, Torjus; Jørgensen, Jørgen J.; Stranden, Einar; Sandbæk, Gunnar; Tjønnfjord, G; Bay, Dag; Kollerøs, Dagfinn; Kroese, Andries Jan & Brinchmann, Jan E. (2008). Treatment with autologous mononuclear cells in patients with critical lower limb ischaemia. A pilot study. Scandinavian Journal of Surgery.  ISSN 1457-4969.  97, s 56- 62
  • Boquest, Andrew Craig; Shahdafar, Aboulghassem; Brinchmann, Jan E. & Collas, Philippe (2006). Isolation of stromal stem cells from human adipose tissue. Methods in Molecular Biology.  ISSN 1064-3745.  (325), s 35- 46
  • Kvale, Espen Østhagen; Dalgaard, Jakob; Lund-Johansen, Fridtjof; Rollag, Halvor; Farkas, Lorant; Midtvedt, Karsten; Jahnsen, Frode Lars; Brinchmann, Jan E. & Olweus, Johanna (2006). CD11c+ dendritic cells and plasmacytoid DCs are activated by human cytomegalovirus and retain efficient T cell–stimulatory capability upon infection. Blood.  ISSN 0006-4971.  107(5), s 2022- 2029 . doi: 10.1182/blood-2005-05-2016
  • Lunde, Ketil; Solheim, S; Aakhus, Svend; Arnesen, Harald; Abdelnoor, M; Egeland, T; Endresen, Knut; Ilebekk, Arnfinn; Mangschau, A.; Fjeld, J G; Smith, Hans-Jørgen; Taraldsrud, Eli; Grøgaard, Haakon Kiil; Bjørnerheim, Reidar; Brekke, M.; Muller, C; Hopp, Einar; Ragnarsson, Asgrimur; Brinchmann, Jan E. & Forfang, Kolbjørn (2006). Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction. New England Journal of Medicine.  ISSN 0028-4793.  355(12), s 1199- 1209
  • Boquest, Andrew Craig; Shahdafar, A; Frønsdal, Katrine; Sigurjonsson, Olaur E.; Tunheim, S.H.; Collas, Philippe & Brinchmann, Jan E. (2005). Isolation and transcription profiling of purified uncultured human stromal stem cells: alteration of gene expression after in vitro cell culture. Molecular Biology of the Cell.  ISSN 1059-1524.  16, s 1131- 1141
  • Dalgaard, Jakob; Beckstrøm, Karen Johanne; Jahnsen, Frode Lars & Brinchmann, Jan E. (2005). Differential capability for phagocytosis of apoptotic and necrotic leukaemia cells by human peripheral blood dendritic cell subsets. Journal of Leukocyte Biology.  ISSN 0741-5400.  77, s 689- 698
  • Shahdafar, Aboulghassem; Frønsdal, Katrine; Haug, Terje; Reinholt, Finn P. & Brinchmann, Jan E. (2005). In vitro expansion of human mesenchymal stem cells: choice of serum is a determinant of cell proliferation, differentiation, gene expression and trascriptome stability. Stem Cells.  ISSN 1066-5099.  23, s 1357- 1366
  • Hedfors, Ida Aagård & Brinchmann, Jan E. (2004). Polyclonal T-cell activation protocol stimulates preferential expansion of EBV-specific T-cell clones in vitro. Cancer Immunology and Immunotherapy.  ISSN 0340-7004.  58(5), s 522- 532

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  • Karlsen, Tommy Aleksander; Jakobsen, Rune Bruhn & Brinchmann, Jan E. (2017). Early molecular events during in vitro chondrogenesisi, In Kerry Atkinson (ed.),  The biology and therapeutic Application of mesenchymal cells.  Wiley-Blackwell.  ISBN 978-1-118-90751-1.  Chapter 14.  s 167 - 190
  • Jakobsen, Rune Bruhn; Shahdafar, Aboulghassem; Reinholt, Finn P. & Brinchmann, Jan E. (2014). Erratum to Chondrogenesis in a hyaluronic acid scaffold: Comparison between chondrocytes and MSC from bone marrow and adipose tissue (Knee Surg Sports Traumatol Arthrosc, (2010), 18, (1407-1416), 10.1007/s00167-009-1017-4). Knee Surgery, Sports Traumatology, Arthroscopy.  ISSN 0942-2056.  22(7), s 1711- 1714 . doi: 10.1007/s00167-014-2938-0
  • Pullisaar, Helen; Verket, Anders; Szoke, Krisztina; Tiainen, Hanna; Haugen, Håvard Jostein; Brinchmann, Jan E.; Reseland, Janne Elin & Østrup, Esben (2014). Extracellular matrix coated ceramic scaffold enhance osteoblast differentiation.
  • Fernandes, Amilton; Brinchmann, Jan E. & Engebretsen, Lars (2013). Tissue engineering of hyaline cartilage. A comparison between articular chondrocytes and mesenchymal stem cells.
  • Olderøy, Magnus Østgård; Beckwith, Marianne; Rrinholt, F P; Lilledahl, Magnus Borstad; Sikorski, Pawel & Brinchmann, Jan E. (2013). Identification of functional structures in tissue engineered cartilage: from nm to macro scale . European Cells and Materials.  ISSN 1473-2262.  26, s 23- 23
  • Østrup, Esben; Tiainen, Hanna; Reseland, Janne Elin; Melvik, Jan Egil; Lyngstadaas, Ståle Petter & Brinchmann, Jan E. (2012). Improving conditions for MSC growth on porous TiO2 scaffolds. Journal of Tissue Engineering and Regenerative Medicine.  ISSN 1932-6254.  6, s 234- 234
  • Beitnes, Jan Otto; Øie, Erik; Shahdafar, Aboulghassem; Karlsen, Tommy Aleksander; Aakhus, Svend & Brinchmann, Jan E. (2010). Mesenchymal stem cells from skeletal muscle and adipose tissue improve LV function after myocardial infarction, but do not differentiate into cardiomyocytes. European Heart Journal.  ISSN 0195-668X.  31, s 397- 397
  • Duggal, Shivali & Brinchmann, Jan E. (2010). Human mesenchymal stem cells: Culture conditions, genomic and epigenetic stability and senescence.
  • Beitnes, JO; Hopp, Einar; Lunde, Ketil; Smith, Hans-Jørgen; Solheim, Svein; Arnesen, Harald; Forfang, Kolbjørn; Brinchmann, Jan E. & Aakhus, Svend (2008). Long-term follow-up of left ventricular function after acute myocardial infarction treated with intracoronary injection of autologous bone marrow cells. The ASTAMI Study.
  • Hedfors, Ida Aagård & Brinchmann, Jan E. (2007). Activation and gene transduction of human T cells .
  • Shahdafar, Aboulghassem & Brinchmann, Jan E. (2007). Human somatic cells in regenerative medicine : in vitro characterization of mesenchymal stem cells and chondrocytes.
  • Wester, Torjus; Stranden, Einar; Jørgensen, Jørgen J.; Kroese, Andries Jan; Kazmi, SS; Sandbæk, Gunnar; Bay, Dag; Kollerøs, Dagfinn; Tjønnfjord, G & Brinchmann, Jan E. (2005). Autologe stamceller i behandlingen av pasienter med kritisk iskemi – en pilotstudie.

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Published Apr. 13, 2011 2:40 PM - Last modified Apr. 9, 2014 9:44 AM