Helga Refsum

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Phone +47-22851357
Room 2195
Username
Visiting address Sognsvannsveien 9 Domus Medica 0372 OSLO
Postal address Postboks 1046 Blindern 0317 OSLO
Other affiliations Department of Nutrition

Publications

  • Kumar, Tivendra; Taneja, Sunita; Sachdev, Harshpal S; Refsum, Helga; Yajnik, Chittaranjan S.; Bhandari, Nita & Strand, Tor A (2017). Supplementation of vitamin B12 or folic acid on hemoglobin concentration in children 6-36 months of age: A randomized placebo controlled trial.. Clinical Nutrition.  ISSN 0261-5614.  36(4), s 986- 991 . doi: 10.1016/j.clnu.2016.07.002
  • Olsen, Thomas; Vinknes, Kathrine; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Tell, Grethe S.; Blomhoff, Rune; Drevon, Christian A; Ueland, Per Magne; Midttun, Øivind; Refsum, Helga & Nygård, Ottar (2017). Cardiovascular disease risk associated with serum apolipoprotein B is modified by serum vitamin A. Atherosclerosis.  ISSN 0021-9150.  (265), s 325- 330 . doi: 10.1016/j.atherosclerosis.2017.07.020
  • Parr, Christine Louise; Magnus, Maria Christine; Karlstad, Øystein; Haugen, Alice Margaretha; Refsum, Helga; Ueland, Per Magne; Mccann, Adrian; Nafstad, Per; Håberg, Siri Eldevik; Nystad, Wenche & London, Stephanie J (2017). Maternal folate intake during pregnancy and childhood asthma in a population-based cohort. American Journal of Respiratory and Critical Care Medicine.  ISSN 1073-449X.  195(2), s 221- 228 . doi: 10.1164/rccm.201604-0788OC
  • Cabout, Mieke; Alssema, Marjan; Nijpels, Giel; Stehouwer, Coen D.A.; Zock, Peter L.; Brouwer, Ingeborg A.; Elshorbagy, Amany; Refsum, Helga & Dekker, Jacqueline M. (2016). Circulating linoleic acid and alpha-linolenic acid and glucose metabolism: the Hoorn Study. European Journal of Nutrition.  ISSN 1436-6207.  Published ahead of print . doi: 10.1007/s00394-016-1261-6
  • Elshorbagy, Amany K.; Jernerén, Fredrik; Samocha-Bonet, D.; Refsum, Helga & Heilbronn, L.K. (2016). Serum S-adenosylmethionine, but not methionine, increases in response to overfeeding in humans. Nutrition and Diabetes.  ISSN 2044-4052.  6 . doi: 10.1038/nutd.2015.44
  • Elshorbagy, Amany K; Jernerén, Fredrik; Scudamore, Cheryl L.; McMurray, Fiona; Cater, Heather; Hough, Tertius; Cox, Roger & Refsum, Helga (2016). Exploring the lean phenotype of glutathione-depleted mice: Thiol, amino acid and fatty acid profiles. PLoS ONE.  ISSN 1932-6203.  11(10) . doi: 10.1371/journal.pone.0163214
  • Hooshmand, Babak; Mangialasche, Francesca; Kalpouzos, Grégoria; Solomon, Alina; Kåreholt, Ingemar; Smith, A. David; Refsum, Helga; Wang, Rui; Mühlmann, Marc; Ertl-Wagner, Birgit; Laukka, Erika Jonsson; Bäckman, Lars; Fratiglioni, Laura & Kivipelto, Miia (2016). Association of Vitamin B<sub>12</sub>, folate, and sulfur amino acids with brain magnetic resonance imaging measures in older adults a longitudinal population-based study. JAMA psychiatry.  ISSN 2168-622X.  73(6), s 606- 613 . doi: 10.1001/jamapsychiatry.2016.0274
  • Smith, A. David & Refsum, Helga (2016). Homocysteine, B Vitamins, and Cognitive Impairment. Annual review of nutrition (Print).  ISSN 0199-9885.  36, s 211- 239 . doi: 10.1146/annurev-nutr-071715-050947
  • Zhang, Weihua; Jernerén, Fredrik; Lehne, Benjamin C.; Chen, Ming-Huei; Luben, Robert N.; Johnston, Carole; Elshorbagy, Amany; Eppinga, Ruben N.; Scott, William R.; Adeyeye, Elizabeth; Scott, James; Böger, Rainer H.; Khaw, Kay-Tee; Van Der Harst, Pim; Wareham, Nicholas J.; Vasan, Ramachandran S.; Chambers, John C.; Refsum, Helga & Kooner, Jaspal S. (2016). Genome-wide association reveals that common genetic variation in the kallikrein-kinin system is associated with serum L-arginine levels. Thrombosis and Haemostasis.  ISSN 0340-6245.  116(6), s 1041- 1049 . doi: 10.1160/TH16-02-0151
  • Hanvold, Susanna; Løken, Elin Bjørge; Paus, Sofie Flottorp; de Brisis, Eva Rustad; Bjerkan, Kirsti; Refsum, Helga & Aas, Anne-Marie (2015). Great Health Benefits But No Change in Employment or Psychopharmaceutical Drug Use 2 Years After Roux-en-Y Gastric Bypass. Obesity Surgery.  ISSN 0960-8923.  25(9), s 1672- 1679 . doi: 10.1007/s11695-015-1583-0
  • Jernerén, Fredrik; Elshorbagy, Amany K.; Oulhaj, Abderrahim; Smith, Stephen M.; Refsum, Helga & Smith, A. David (2015). Brain atrophy in cognitively impaired elderly: The importance of long-chain ω-3 fatty acids and B vitamin status in a randomized controlled trial. American Journal of Clinical Nutrition.  ISSN 0002-9165.  102(1), s 215- 221 . doi: 10.3945/ajcn.114.103283
  • Kvestad, Ingrid; Taneja, Sunita; Kumar, Tivendra; Hysing, Mari; Refsum, Helga; Yajnik, Chittaranjan S.; Bhandari, Nita & Strand, Tor (2015). Vitamin B12 and folic acid improve gross motor and problem-solving skills in young North Indian children: A randomized placebo-controlled trial. PLoS ONE.  ISSN 1932-6203.  10(6) . doi: 10.1371/journal.pone.0129915 Full text in Research Archive
  • Oulhaj, Abderrahim; Jernerén, Fredrik; Refsum, Helga; Smith, A. David & de Jager, Celeste A. (2015). Omega-3 fatty acid status enhances the prevention of cognitive decline by B Vitamins in mild cognitive impairment. Journal of Alzheimer's Disease.  ISSN 1387-2877.  50(2), s 547- 557 . doi: 10.3233/JAD-150777
  • Strand, Tor; Taneja, Sunita; Kumar, Tivendra; Manger, Mari Skar; Refsum, Helga; Yajnik, Chittaranjan S. & Bhandari, Nita (2015). Vitamin B-12, folic acid, and growth in 6- to 30-month-old children: A randomized controlled trial. Pediatrics.  ISSN 0031-4005.  135(4), s e918- e926 . doi: 10.1542/peds.2014-1848
  • Doets, EL; Ueland, Per Magne; Tell, Grethe S; Vollset, Stein Emil; Nygård, Ottar; van't Veer, Pieter; de Groot, Lisette C.P.G.M.; Nurk, Eha; Refsum, Helga; Smith, David & Eussen, Simone (2014). Interactions between plasma concentrations of folate and markers of vitamin B12 status with cognitive performance in elderly people not exposed to folic acid fortification: the Hordaland Health Study. British Journal of Nutrition.  ISSN 0007-1145.  111(6), s 1085- 1095 . doi: 10.1017/S000711451300336X
  • Ulak, Manjeswori; Chandyo, Ram Krishna; Adhikari, Ramesh K.; Sharma, Pushpa R.; Sommerfelt, Halvor; Refsum, Helga & Strand, Tor (2014). Cobalamin and folate status in 6 to 35 months old children presenting with acute diarrhea in Bhaktapur, Nepal. PLoS ONE.  ISSN 1932-6203.  9(3:e90097) . doi: 10.1371/journal.pone.0090079 Full text in Research Archive
  • Yajnik, Chittaranjan S; Chandak, Giriraj R; Joglekar, Charudatta V; Katre, Prachi; Bhat, Dattatray S; Singh, Suraj N; Janipalli, Charles S; Refsum, Helga; Krishnaveni, Ghattu; Veena, Sargoor; Osmond, Clive & Fall, Caroline H (2014). Maternal homocysteine in pregnancy and offspring birthweight: Epidemiological associations and Mendelian randomization analysis. International Journal of Epidemiology.  ISSN 0300-5771.  43(5), s 1487- 1497 . doi: 10.1093/ije/dyu132
  • Douaud, Gwenaëlle; Refsum, Helga; de Jager, Celeste; Jacoby, Robin; Nichols, Thomas E; Smith, Stephen M. & Smith, A. David (2013). Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  110(23), s 9523- 9528 . doi: 10.1073/pnas.1301816110
  • Elshorbagy, AK; Nijpels, G; Valdivia-Garcia, Maria; Stehouwer, C.D.A.; Ocké, Marga C; Refsum, Helga & Dekker, J.M. (2013). S-Adenosylmethionine Is Associated with Fat Mass and Trunkal Adiposity in Older Adults. Journal of Nutrition.  ISSN 0022-3166.  143(12), s 1982- 1988 . doi: 10.3945/jn.113.179192
  • Elshorbagy, Amany K.; Valdivia-Garcia, Maria; Mattocks, Dwight A.L.; Plummer, Jason D.; Orentreich, David S.; Orentreich, Norman; Refsum, Helga & Perrone, Carmen E. (2013). Effect of taurine and N-acetylcysteine on methionine restriction-mediated adiposity resistance. Metabolism: Clinical and Experimental.  ISSN 0026-0495.  62(4), s 509- 517 . doi: 10.1016/j.metabol.2012.10.005
  • Haj-Yasein, Nadia Nabil; Dalen, Knut Tomas; Berg, Ole; Bastani, Nasser Ezzatkhah; Refsum, Helga & Nebb, Hilde Irene (2013). Low Cysteine Interferes With PPARγ Activity And Reduces Adipocyte Differentiation. Journal of Inherited Metabolic Disease.  ISSN 0141-8955.  36, s S44 . doi: 10.1007/s10545-013-9631-1
  • Nurk, Eha; Refsum, Helga; Bjelland, Ingvar; Drevon, Christian A; Tell, Grethe S; Ueland, Per Magne; Vollset, Stein Emil; Engedal, Knut Arne; Nygaard, Harald A. & Smith, David A (2013). Plasma free choline, betaine and cognitive performance: the Hordaland Health Study. British Journal of Nutrition.  ISSN 0007-1145.  109(3), s 511- 519 . doi: 10.1017/S0007114512001249 Full text in Research Archive
  • Rajagopalan, Priya; Refsum, Helga; Hua, Xue; Toga, Arthur W.; Jack, Clifford R.; Weiner, Michael W & Thompson, Paul M. (2013). Mapping creatinine- and cystatin C-related white matter brain deficits in the elderly. Neurobiology of Aging.  ISSN 0197-4580.  34(4), s 1221- 1230 . doi: 10.1016/j.neurobiolaging.2012.10.022
  • Reinders, I; Ballegooijen, A J van; Visser, M; Elshorbagy, AK; Refsum, Helga; Henry, R.M.A.; Dekker, J.M.; Nijpels, G; Stehouwer, C.D.A. & Brouwer, I A (2013). Low Cysteine Interferes With PPARγ Activity And Reduces Adipocyte Differentiation. European Journal of Clinical Nutrition.  ISSN 0954-3007. . doi: 10.1038/ejcn.2013.167
  • Reinders, Ilse; van Ballegooijen, Adriana J.; Visser, Marjolein; Elshorbagy, Amany K.; Refsum, Helga; Henry, Ronald M.A.; Dekker, Jacqueline M.; Nijpels, Giel; Stehouwer, Coen D.A. & Brouwer, Ingeborg A. (2013). Associations of serum n-3 and n-6 polyunsaturated fatty acids with echocardiographic measures among older adults: the Hoorn Study. European Journal of Clinical Nutrition.  ISSN 0954-3007.  67(12), s 1277- 1283 . doi: 10.1038/ejcn.2013.167
  • Strand, Bjørn Heine; Langballe, Ellen Melbye; Hjellvik, Vidar; Handal, Marte; Næss, Øyvind; Knudsen, Gun Peggy; Refsum, Helga; Tambs, Kristian; Nafstad, Per; Schirmer, Henrik; Bergem, Astrid Liv Mina; Selmer, Randi; Engedal, Knut Arne; Magnus, Per & Bjertness, Espen (2013). Midlife vascular risk factors and their association with dementia deaths: Results from a Norwegian prospective study followed up for 35 years. Journal of Neurological Sciences.  ISSN 1302-1664.  324(1-2), s 124- 130 . doi: 10.1016/j.jns.2012.10.018
  • Strand, Tor A; Taneja, Sunita; Ueland, Per Magne; Refsum, Helga; Bahl, Rajiv; Schneede, Jørn; Sommerfelt, Halvor & Bhandari, Nita (2013). Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age. American Journal of Clinical Nutrition.  ISSN 0002-9165.  97(2), s 310- 317 . doi: 10.3945/ajcn.111.032268
  • Taneja, Sunita; Strand, Tor A; Kumar, Tivendra; Mahesh, Madhu; Mohan, Sanjana; Manger, Mari Skar; Refsum, Helga; Yajnik, Chittaranjan S. & Bhandari, Nita (2013). Folic acid and vitamin B-12 supplementation and common infections in 6-30-mo-old children in India: a randomized placebo-controlled trial. American Journal of Clinical Nutrition.  ISSN 0002-9165.  98(3), s 731- 737 . doi: 10.3945/ajcn.113.059592
  • Vinknes, Kathrine; Dekker, Jacqueline M.; Drevon, Christian A; Refsum, Helga; Nurk, Eha; Nijpels, Giel; Stehouwer, Coen D.A.; Teerlink, Tom; Tell, Grethe S; Nygård, Ottar; Vollset, Stein Emil; Ueland, Per Magne & Elshorbagy, AK (2013). Plasma sulfur amino acids and stearoyl-CoA desaturase activity in two caucasian populations. Prostaglandins Leukot Essent Fatty Acids 2. Prostaglandins, Leukotrienes and Essential Fatty Acids.  ISSN 0952-3278.  89(5), s 297- 303 . doi: 10.1016/j.plefa.2013.09.007
  • Vinknes, Kathrine; Elshorbagy, Amany K.; Drevon, Christian A; Gjesdal, Clara Gram; Tell, Grethe S; Nygård, Ottar; Vollset, Stein Emil & Refsum, Helga (2013). Evaluation of the body adiposity index in a caucasian population: the Hordaland Health Study. American Journal of Epidemiology.  ISSN 0002-9262.  177(6), s 586- 592 . doi: 10.1093/aje/kws271
  • Vinknes, Kathrine; Elshorbagy, Amany K.; Drevon, Christian A; Nurk, Eha; Tell, Grethe S; Nygård, Ottar; Vollset, Stein Emil & Refsum, Helga (2013). Associations between plasma polyunsaturated fatty acids, plasma stearoyl-CoA desaturase indices and body fat. Obesity.  ISSN 1930-7381.  21(9), s E512- E519 . doi: 10.1002/oby.20457
  • Vinknes, Kathrine; Elshorbagy, Amany K; Nurk, Eha; Drevon, Christian A; Gjesdal, Clara Gram; Tell, Grethe S; Nygård, Ottar; Vollset, Stein Emil & Refsum, Helga (2013). Plasma stearoyl-CoA desaturase indices: Association with lifestyle, diet and body composition. Obesity.  ISSN 1930-7381.  21(3), s E294- E302 . doi: 10.1002/oby.20011
  • Vogiatzoglou, Anna; Smith, David; Nurk, Eha; Drevon, Christian A; Ueland, Per Magne; Vollset, Stein Emil; Nygaard, Harald A.; Engedal, Knut Arne; Tell, Grethe S & Refsum, Helga (2013). Cognitive function in an elderly population: Interaction between vitamin B12 status, depression and apolipoprotein E4. The Hordaland Homocysteine Study. Psychosomatic Medicine.  ISSN 0033-3174.  75(1), s 20- 29 . doi: 10.1097/PSY.0b013e3182761b6c
  • Bonilla, Carolina; Lawlor, Debbie A.; Taylor, Amy E; Gunnell, David; Ben-Shlomo, Yoav; Ness, Andrew R; Timpson, Nicholas J.; St Pourcain, Beate; Ring, Susan M.; Emmett, Pauline M; Smith, A. David; Refsum, Helga; Pennell, Craig E.; Brion, Marie-Jo A.; Smith, George Davey & Lewis, Sarah J. (2012). Vitamin B-12 Status during Pregnancy and Child's IQ at Age 8: A Mendelian Randomization Study in the Avon Longitudinal Study of Parents and Children. PLoS ONE.  ISSN 1932-6203.  7(12) . doi: 10.1371/journal.pone.0051084
  • de Jager, Celeste; Oulhaj, Abderrahim; Jacoby, Robin; Refsum, Helga & Smith, A. David (2012). Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial. International Journal of Geriatric Psychiatry.  ISSN 0885-6230.  27(6), s 592- 600 . doi: 10.1002/gps.2758
  • Elshorbagy, AK; Valdivia-Garcia, Maria; Graham, I. M.; Reis, R Palma; Luis, A Sales; Smith, A.D. & Refsum, Helga (2012). The association of fasting plasma sulfur-containing compounds with BMI, serum lipids and apolipoproteins. NMCD. Nutrition Metabolism and Cardiovascular Diseases.  ISSN 0939-4753.  22(12), s 1031- 1038 . doi: 10.1016/j.numecd.2011.01.008
  • Elshorbagy, Amany K.; Church, Chris; Valdivia-Garcia, Maria; Smith, A. David; Refsum, Helga & Cox, Roger (2012). Dietary cystine level affects metabolic rate and glycaemic control in adult mice. Journal of Nutritional Biochemistry.  ISSN 0955-2863.  23(4), s 332- 340 . doi: 10.1016/j.jnutbio.2010.12.009
  • Elshorbagy, Amany K; Kozich, Viktor; Smith, A. David & Refsum, Helga (2012). Cysteine and obesity: consistency of the evidence across epidemiologic, animal and cellular studies. Current opinion in clinical nutrition and metabolic care.  ISSN 1363-1950.  15(1), s 49- 57 . doi: 10.1097/MCO.0b013e32834d199f
  • Elshorbagy, Amany K; Smith, A. David; Kozich, Viktor & Refsum, Helga (2012). Cysteine and Obesity. Obesity.  ISSN 1930-7381.  20(3), s 473- 481 . doi: 10.1038/oby.2011.93
  • Elshorbagy, Amany K; Valdivia-Garcia, Maria; Refsum, Helga & Butte, Nancy (2012). The Association of Cysteine with Obesity, Inflammatory Cytokines and Insulin Resistance in Hispanic Children and Adolescents. PLoS ONE.  ISSN 1932-6203.  7(9) . doi: 10.1371/journal.pone.0044166 Full text in Research Archive
  • Aasheim, Erlend T; Elshorbagy, Amany K; Diep, Lien My; Søvik, Torgeir Thorson; Mala, Tom; Valdivia-Garcia, Maria; Olbers, Torsten; Bøhmer, Thomas; Birkeland, Kåre I. & Refsum, Helga (2011). Effect of bariatric surgery on sulphur amino acids and glutamate. British Journal of Nutrition.  ISSN 0007-1145.  106(3), s 432- 440 . doi: 10.1017/S0007114511000201 Full text in Research Archive
  • Bleie, Øyvind; Strand, Elin; Ueland, Per Magne; Vollset, Stein Emil; Refsum, Helga; Igland, Jannicke; Nordrehaug, Jan Erik & Nygård, Ottar (2011). Coronary blood flow in patients with stable coronary artery disease treated long term with folic acid and vitamin B12. Coronary Artery Disease.  ISSN 0954-6928.  22(4), s 270- 278 . doi: 10.1097/MCA.0b013e328344fff4
  • Elshorbagy, Amany K; Valdivia-Garcia, Maria; Mattocks, Dwight A.L.; Plummer, Jason D.; Smith, A. David; Drevon, Christian A; Refsum, Helga & Perrone, Carmen E. (2011). Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase. Journal of Lipid Research.  ISSN 0022-2275.  52(1), s 104- 112 . doi: 10.1194/jlr.M010215
  • Hay, Gry; Trygg, Kerstin Ulla; Whitelaw, Andrew; Johnston, Carole & Refsum, Helga (2011). Folate and cobalamin status in relation to diet in healthy 2-y-old children. American Journal of Clinical Nutrition.  ISSN 0002-9165.  93(4), s 727- 735 . doi: 10.3945/ajcn.110.003426
  • Lehmann, Donald J; Refsum, Helga; Warden, Donald R; Medway, Christopher; Wilcock, Gordon K & Smith, David (2011). The vitamin D receptor gene is associated with Alzheimer's disease. Neuroscience Letters.  ISSN 0304-3940.  504(2), s 79- 82 . doi: 10.1016/j.neulet.2011.08.057
  • Manger, Mari Skar; Strand, Tor A; Taneja, Sunita; Refsum, Helga; Ueland, Per Magne; Nygård, Ottar; Schneede, Jørn; Sommerfelt, Halvor & Bhandari, Nita (2011). Cobalamin Status Modifies the Effect of Zinc Supplementation on the Incidence of Prolonged Diarrhea in 6-to 30-Month-Old North Indian Children. Journal of Nutrition.  ISSN 0022-3166.  141(6), s 1108- 1113 . doi: 10.3945/jn.110.127415
  • Manger, Mari Skar; Taneja, Sunita; Strand, Tor A; Ueland, Per Magne; Refsum, Helga; Schneede, Jørn; Nygård, Ottar; Sommerfelt, Halvor & Bhandari, Nita (2011). Poor folate status predicts persistent diarrhea in 6- to 30-month-old north Indian children. Journal of Nutrition.  ISSN 0022-3166.  141(12), s 2226- 2232 . doi: 10.3945/jn.111.144220
  • Vinknes, Kathrine; De Vogel, Stefan; Elshorbagy, Amany K; Nurk, Eha; Drevon, Christian A; Gjesdal, Clara Gram; Tell, Grethe S; Vollset, Stein Emil & Refsum, Helga (2011). Dietary intake of protein is positively associated with percent body fat in middle-aged and older adults. Journal of Nutrition.  ISSN 0022-3166.  141(3), s 440- 446 . doi: 10.3945/jn.110.133710
  • Collin, Simon M.; Metcalfe, Chris; Refsum, Helga; Lewis, Sarah J.; Zuccolo, Luisa; Smith, George Davey; Chen, Lina; Harris, Ross; Davis, Michael I.; Marsden, Gemma; Johnston, Carole; Lane, J. Athene; Ebbing, Marta; Bønaa, Kaare Harald; Nygård, Ottar; Ueland, Per Magne; Grau, Maria V.; Baron, John A.; Donovan, Jenny L.; Neal, David E.; Hamdy, Freddie C.; Smith, A. David & Martin, Richard M. (2010). Circulating folate, vitamin B-12, homocysteine, vitamin B-12 transport proteins, and risk of prostate cancer: a case-control study, systematic review, and meta-analysis. Cancer Epidemiology, Biomarkers and Prevention.  ISSN 1055-9965.  19(6), s 1632- 1642 . doi: 10.1158/1055-9965.EPI-10-0180
  • Collin, Simon M.; Metcalfe, Chris; Refsum, Helga; Lewis, Sarah; Smith, George Davey; Cox, Angela; Davis, M.; Marsden, Gemma; Johnston, Carole; Lane, J. Athene; Donovan, Jenny L.; Neal, David E.; Hamdy, Freddie C.; Smith, AD & Martin, Richard M (2010). Associations of Folate, Vitamin B-12, Homocysteine, and Folate-Pathway Polymorphisms with Prostate-Specific Antigen Velocity in Men with Localized Prostate Cancer. Cancer Epidemiology, Biomarkers and Prevention.  ISSN 1055-9965.  19(11), s 2833- 2838 . doi: 10.1158/1055-9965.EPI-10-0582
  • de Lau, LML; van Meurs, JBJ; Uitterlinden, André G.; Smith, AD; Refsum, Helga; Johnston, C & Breteler, MMB (2010). Genetic variation in homocysteine metabolism, cognition, and white matter lesions. Neurobiology of Aging.  ISSN 0197-4580.  31(11), s 2020- 2022 . doi: 10.1016/j.neurobiolaging.2008.10.004
  • Deshmukh, U.S.; Joglekar, Charudatta V; Lubree, Himangi G; Ramdas, LV; Bhat, Dattatray S; Naik, Sadanand S; Hardikar, P.S.; Raut, D.A.; Konde, T.B.; Wills, A.K.; Jackson, AA; Refsum, Helga; Nanivadekar, A.S.; Fall, Caroline H & Yajnik, Chittaranjan S (2010). Effect of physiological doses of oral vitamin B-12 on plasma homocysteine: a randomized, placebo-controlled, double-blind trial in India. European Journal of Clinical Nutrition.  ISSN 0954-3007.  64(5), s 495- 502 . doi: 10.1038/ejcn.2010.15
  • Ebbing, M; Bønaa, Kaare Harald; Arnesen, E; Ueland, PM; Nordrehaug, Jan Erik; Rasmussen, K; Njølstad, I; Nilsen, DW; Refsum, H; Tverdal, Aage; Vollset, Stein Emil; Schirmer, H; Bleie, Ø; Steigen, Terje; Midttun, Ø; Fredriksen, Å; Pedersen, ER & Nygård, O (2010). Combined analyses and extended follow-up of two randomized controlled homocysteine-lowering B-vitamin trials. Journal of Internal Medicine.  ISSN 0954-6820.  268(4), s 367- 382 . doi: 10.1111/j.1365-2796.2010.02259.x
  • Elshorbagy, Amany K; Valdivia-Garcia, Maria; Refsum, Helga; Smith, A.D.; Mattocks, Dwight A.L. & Perrone, Carmen E. (2010). Sulfur amino acids in methionine-restricted rats: Hyperhomocysteinemia. Nutrition (Burbank, Los Angeles County, Calif.).  ISSN 0899-9007.  26(11-12), s 1201- 1204 . doi: 10.1016/j.nut.2009.09.017
  • Hay, Gry; Clausen, Torun; Whitelaw, Andrew; Trygg, Kerstin Ulla; Johnston, Carole; Henriksen, Tore & Refsum, Helga (2010). Maternal Folate and Cobalamin Status Predicts Vitamin Status in Newborns and 6-Month-Old Infants. Journal of Nutrition.  ISSN 0022-3166.  140(3), s 557- 564 . doi: 10.3945/jn.109.117424
  • Løland, Kjetil Halvorsen; Bleie, Øyvind; Blix, Are Jordahl; Strand, Elin; Ueland, Per Magne; Refsum, Helga; Ebbing, Marta; Nordrehaug, Jan Erik & Nygård, Ottar (2010). Effect of homocysteine-lowering B vitamin treatment on angiographic progression of coronary artery disease: a western Norway B vitamin intervention trial (WENBIT) substudy. American Journal of Cardiology.  ISSN 0002-9149.  105(11), s 1577- 1584 . doi: 10.1016/j.amjcard.2010.01.019
  • Manger, Mari Skar; Strand, Elin; Ebbing, Marta; Seifert, Reinhard; Refsum, Helga; Nordrehaug, Jan Erik; Nilsen, Dennis W.T.; Drevon, Christian A; Tell, Grethe S; Bleie, Øyvind; Vollset, Stein Emil; Pedersen, Eva Kristine Ringdal & Nygård, Ottar (2010). Dietary intake of n-3 long-chain polyunsaturated fatty acids and coronary events in Norwegian patients with coronary artery disease. American Journal of Clinical Nutrition.  ISSN 0002-9165.  92(1), s 244- 251 . doi: 10.3945/ajcn.2010.29175
  • Nurk, Eha; Refsum, Helga; Drevon, Christian A; Tell, Grethe S; Nygaard, Harald; Engedal, Knut Arne & Smith, David A (2010). Cognitive performance among the elderly in relation to the intake of plant foods. The Hordaland Health Study. British Journal of Nutrition.  ISSN 0007-1145.  104(8), s 1190- 1201 . doi: 10.1017/S0007114510001807
  • Oulhaj, Abderrahim; Refsum, Helga; Beaumont, Helen; Williams, Jonathan; King, Elizabeth; Jacoby, Robin & Smith, David (2010). Homocysteine as a predictor of cognitive decline in Alzheimer's disease. International Journal of Geriatric Psychiatry.  ISSN 0885-6230.  25(1), s 82- 90
  • Smith, AD; Smith, Stephen M.; de Jager, Celeste; Whitbread, P; Johnston, Carole; Agacinski, G; Oulhaj, Abderrahim; Bradley, Kevin M.; Jacoby, Robin & Refsum, Helga (2010). Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial. PLoS ONE.  ISSN 1932-6203.  5(9) . doi: 10.1371/journal.pone.0012244
  • Antoniades, C; Shirodaria, C; Leeson, P; Bårholm, Otto Andreas; Van-Assche, T; Cunnington, C; Pillai, R; Ratnatunga, C; Tousoulis, D; Stefanadis, C; Refsum, Helga & Channon, KM (2009). MTHFR 677 C > T Polymorphism Reveals Functional Importance for 5-Methyltetrahydrofolate, Not Homocysteine, in Regulation of Vascular Redox State and Endothelial Function in Human Atherosclerosis. Circulation.  ISSN 0009-7322.  119(18), s 2507- U147 . doi: 10.1161/CIRCULATIONAHA.108.808675
  • Bhat, Dattatray S; Thuse, Nileema V; Lubree, Himangi G; Joglekar, Charudatta V; Naik, Sadanand S; Randas, Lalita V; Johnston, Carole; Refsum, Helga; Fall, Caroline H & Yajnik, Chittaranjan S (2009). Increases in plasma holotranscobalamin can be used to assess vitamin B-12 absorption in individuals with low plasma vitamin B-12. Journal of Nutrition.  ISSN 0022-3166.  139(11), s 2119- 2123 . doi: 10.3945/jn.109.107359
  • de Lau, LML; Smith, AD; Refsum, Helga; Johnston, C & Breteler, MMB (2009). Plasma vitamin B-12 status and cerebral white-matter lesions. Journal of Neurology, Neurosurgery and Psychiatry.  ISSN 0022-3050.  80(2), s 149- 157 . doi: 10.1136/jnnp.2008.149286
  • Ebbing, Marta; Bønaa, Kaare Harald; Nygård, Ottar; Arnesen, Egil; Ueland, Per Magne; Nordrehaug, Jan Erik; Rasmussen, Knut; Njølstad, Inger; Refsum, Helga; Nilsen, Dennis W; Tverdal, Aage; Meyer, Klaus & Vollset, Stein Emil (2009). Cancer incidence and mortality after treatment with folic acid and vitamin B12. Journal of the American Medical Association (JAMA).  ISSN 0098-7484.  302(19), s 2119- 2126 . doi: 10.1001/jama.2009.1622
  • Elshorbagy, AK; Refsum, Helga; Smith, David & Graham, Ian M (2009). The Association of Plasma Cysteine and gamma-Glutamyltransferase With BMI and Obesity. Obesity.  ISSN 1930-7381.  17(7), s 1435- 1440 . doi: 10.1038/oby.2008.671
  • Elshorbagy, Amany K; Gjesdal, Clara Gram; Nurk, Eha; Tell, Grethe Seppola; Ueland, Per M; Nygård, Ottar; Tverdal, Aage; Vollset, Stein Emil; Smith, A David & Refsum, Helga (2009). Cysteine, homocysteine and bone mineral density: A role for body composition?. Bone.  ISSN 8756-3282.  44(5), s 954- 958 . doi: 10.1016/j.bone.2008.12.018
  • Nurk, Eha; Refsum, Helga; Drevon, Christian André; Tell, Grethe S; Nygaard, Harald; Engedal, Knut; Engedal, Knut Arne & Smith, A. David (2009). Intake of flavonoid-rich wine, tea, and chocolate by elderly men and women is associated with better cognitive test performance. Journal of Nutrition.  ISSN 0022-3166.  139(1), s 120- 127 . doi: 10.3945/jn.108.095182
  • Rudberg, Ida; Reubsaet, Jan Leo; Hermann, Monica; Refsum, Helga & Molden, Espen (2009). Identification of a Novel CYP2C19-Mediated Metabolic Pathway of S-Citalopram in Vitro. Drug Metabolism And Disposition.  ISSN 0090-9556.  37(12), s 2340- 2348 . doi: 10.1124/dmd.109.029355
  • Smith, AD & Refsum, Helga (2009). Vitamin B-12 and cognition in the elderly. American Journal of Clinical Nutrition.  ISSN 0002-9165.  89(2), s 707S- 711S . doi: 10.3945/ajcn.2008.26947D
  • Vogiatzoglou, Anna; Oulhaj, Abderrahim; Smith, David; Smith, AD; Nurk, Eha; Drevon, CA; Ueland, Per Magne; Vollset, Stein Emil; Tell, Grethe S & Refsum, Helga (2009). Determinants of plasma methylmalonic acid in a large population: implications for assessment of vitamin B12 status. Clinical Chemistry.  ISSN 0009-9147.  55(12), s 2198- 2206 . doi: 10.1373/clinchem.2009.128678
  • Vogiatzoglou, Anna; Smith, A. David; Nurk, Eha; Berstad, Paula; Drevon, Christian André; Ueland, Per Magne; Vollset, Stein Emil; Tell, Grethe S & Refsum, Helga (2009). Dietary sources of vitamin B-12 and their association with plasma vitamin B-12 concentrations in the general population: the Hordaland Homocysteine Study. American Journal of Clinical Nutrition.  ISSN 0002-9165.  89(4), s 1078- 1087 . doi: 10.3945/ajcn.2008.26598
  • Hermann, Monica; Hendset, M; Fosaas, Kristina; Hjerpset, M & Refsum, Helga (2008). Serum concentrations of venlafaxine and its metabolites O-desmethylvenlafaxine and N-desmethylvenlafaxine in heterozygous carriers of the CYP2D6*3, *4 or *5 allele. European Journal of Clinical Pharmacology.  ISSN 0031-6970.  64(5), s 483- 487 . doi: 10.1007/s00228-007-0453-7
  • Ebbing, Marta; Bleie, Øyvind; Bleie, O; Ueland, Per Magne; Nordrehaug, Jan Erik; Nilsen, Dennis W.T.; Vollset, Stein Emil; Refsum, Helga; Pedersen, Eva Kristine Ringdal; Nygård, Ottar & Nygard, O (2008). Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography - A Randomized controlled trial. Journal of the American Medical Association (JAMA).  ISSN 0098-7484.  300(7), s 795- 804
  • Elshorbagy, Amany K.; Nurk, Eha; Gjesdal, Clara Gram; Tell, Grethe S; Ueland, Per M; Nygård, Ottar; Tverdal, Aage; Vollset, Stein Emil & Refsum, Helga (2008). Homocysteine, cysteine, and body composition in the Hordaland Homocysteine Study: does cysteine link amino acid and lipid metabolism?. American Journal of Clinical Nutrition.  ISSN 0002-9165.  88(3), s 738- 746
  • Hay, Gry; Johnston, Carole; Whitelaw, Andrew; Trygg, Kerstin Ulla & Refsum, Helga (2008). Folate and cobalamin status in relation to breastfeeding and weaning in healthy infants. American Journal of Clinical Nutrition.  ISSN 0002-9165.  88, s 105- 114
  • Tunbridge, EM; Harrison, PJ; Warden, DR; Johnston, C; Refsum, Helga & Smith, AD (2008). Polymorphisms in the catechol-O-methyltransferase (COMT) gene influence plasma total homocysteine levels. American Journal of Medical Genetics.  ISSN 0148-7299.  147B, s 996- 999 . doi: 10.1002/ajmg.b.30700
  • Vogiatzoglou, Anna; Refsum, Helga; Johnston, Carole; Smith, Stephen M.; Bradley, Kevin M.; de Jager, Celeste; Budge, Mark M & Smith, A.D. (2008). Vitamin B-12 status and rate of brain volume loss in community-dwelling elderly. Neurology.  ISSN 0028-3878.  71, s 826- 832
  • Yajnik, CS; Deshpande, SS; Jackson, AA; Refsum, Helga; Rao, S; Fisher, DJ; Bhat, DS; Naik, SS; Coyaji, KJ; Joglekar, CV; Joshi, N; Lubree, HG; Deshpande, VU; Rege, SS & Fall, CHD (2008). Vitamin B-12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study. Diabetologia.  ISSN 0012-186X.  51 . doi: 10.1007/s00125-007-0793-y
  • Berstad, Paula; Konstantinova, Svetlana; Refsum, Helga; Nurk, Eha; Vollset, Stein Emil; Tell, Grethe S; Ueland, Per Magne; Drevon, Christian A & Ursin, Giske (2007). Dietary fat and plasma total homocysteine concentrations in 2 adult age groups: the Hordaland Homocysteine Study. American Journal of Clinical Nutrition.  ISSN 0002-9165.  85(6), s 1598- 1605
  • Bleie, O; Bleie, Øyvind; Semb, Anne Grete; Grundt, Heidi; Nordrehaug, Jan Erik; Vollset, Stein Emil; Ueland, Per Magne; Nilsen, Dennis W.T.; Bakken, Anne M.; Refsum, Helga; Nygard, OK & Nygård, Ottar (2007). Homocysteine-lowering therapy does not affect inflammatory markers of atherosclerosis in patients with stable coronary artery disease. Journal of Internal Medicine.  ISSN 0954-6820.  262(2), s 244- 253 . doi: 10.1111/j.1365-2796.2007.01810.x

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  • Skålhegg, Bjørn Steen & Refsum, Helga (2012). Mat og Medisin. Kapittel 11, B-vitaminer. Cappelen Damm Akademisk.  ISBN 978-82-7634-967-2.  18 s.

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  • Smith, A. David; Refsum, Helga & Jacoby, Robin (2016). Evidence-based prevention and treatment of dementia. Lancet Neurology.  ISSN 1474-4422.  15(10), s 1005- 1006 . doi: 10.1016/S1474-4422(16)30074-6
  • Smith, A. David; Refsum, Helga; Selhub, Jacob & Rosenberg, Irwin H. (2016). Decision on folic acid fortification in Europe must consider both risks and benefits. BMJ-BRITISH MEDICAL JOURNAL.  ISSN 1756-1833.  352:i734, s 1- 2 . doi: 10.1136/bmj.i734
  • Smith, David A; de Jager, Celeste A.; Refsum, Helga & Rosenberg, Irwin H. (2015). Homocysteine lowering, B vitamins, and cognitive aging. American Journal of Clinical Nutrition.  ISSN 0002-9165.  101(2), s 415- 416 . doi: 10.3945/ajcn.114.098467
  • Dalen, Knut Tomas; Haj-Yasein, Nadia Nabil; Berg, Ole; Refsum, Helga & Nebb, Hilde Irene (2014). Cysteine and adipocyte differentiation.
  • Strand, Tor; Taneja, Sunita; Kumar, Tivendra; Manger, Mari Skar; Refsum, Helga; Yajnik, Chittaranjan S & Bhandari, Nita (2014). The Effect of Daily Vitamin B12 and Folic Acid Supplementation on Growth in 6-30 Month Old Children in India: A Randomized Controlled Trial.
  • Smith, A. David & Refsum, Helga (2012). Do we need to reconsider the desirable blood level of vitamin B12?. Journal of Internal Medicine.  ISSN 0954-6820.  271(2), s 179- 182 . doi: 10.1111/j.1365-2796.2011.02485.x
  • Clarke, Robert; Halsey, J; Lewington, S; Lonn, E; Armitage, J.; Manson, JE; Bønaa, KH; Spence, JD; Nygård, Ottar; Jamison, R; Gaziano, JM; Guarino, Peter; Bennett, D; Mir, F; Peto, R.; Collins, Rory; Collaborators:, WENBIT; Ebbing, Marta; Nordrehaug, Jan Erik; Nilsen, Dennis W.T.; Refsum, Helga; Vollset, Stein Emil; Nygård, Ottar & Ueland, Per Magne (2010). Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals.
  • Strand, Tor A; Sharma, PR; Chandyo, RK; Refsum, Helga; Ulak, M; Adhikari, RK & Sommerfelt, Halvor (2009). FOLATE AND VITAMIN B12 STATUS IN YOUNG NEPALESE CHILDREN. Annals of Nutrition and Metabolism.  ISSN 0250-6807.  55, s 488- 489
  • Ebbing, Marta; Bønaa, Kaare Harald; Nordrehaug, Jan Erik; Ueland, Per Magne; Arnesen, Egil; Refsum, Helga; Njølstad, Inger; Nilsen, Dennis W.T.; Rasmussen, Knut & Nygård, Ottar (2009). Combined results and long-term follow-up in NORVIT and WENBIT with 6837 coronary artery disease patients: Homocysteine-lowering B-vitamin treatment does not prevent major cardiovascular events. European Heart Journal 2009: 30 (Abstract Supplement), 184. P 1274.
  • Manger, Mari Skar; Bhan, Maharaj Kishan; Strand, Tor A; Taneja, Sunita; Bahl, Rajiv; Sommerfelt, Halvor; Refsum, Helga; Ueland, Per Magne; Schneede, Jørn & Bhandari, Nita (2009). DOES VITAMIN B12 OR FOLATE STATUS MODIFY THE IMPACT OF ZINC SUPPLEMENTATION ON THE INCIDENCE OF DIARRHEA?. Annals of Nutrition and Metabolism.  ISSN 0250-6807.  55, s 261- 262
  • Strand, Tor A; Sharma, Pushpa R; Chandyo, Ram Krishna; Refsum, Helga; Ulak, Manjeswori; Adhikari, Ramesh K & Sommerfelt, Halvor (2009). Folate and vitamin B12 status in young nepalese children.
  • Strand, Tor A; Sunita, T; Bhandari, Nita; Schneede, Jørn; Refsum, H; Ueland, PM; Bahl, R; Sommerfelt, HM & Bhan, MK (2009). VITAMIN B12, BUT NOT FOLATE STATUS PREDICTS MENTAL DEVELOPMENT SCORES IN NORTH INDIAN TODDLERS. Annals of Nutrition and Metabolism.  ISSN 0250-6807.  55, s 691- 692
  • Strand, Tor A; Taneja, Sunita; Bhandari, Nita; Schneede, Jørn; Refsum, Helga; Ueland, Per Magne; Bahl, Rajiv; Sommerfelt, Halvor & Bhan, Maharaj K (2009). Vitamin B12, but not folate status predicts mental development scores in north indian toddlers.
  • Bleie, Øyvind; Bleie, O; Strand, Elin; Strand, Erik M; Loland, KH; Løland, Kjetil Halvorsen; Ueland, Per Magne; Vollset, Stein Emil; Refsum, Helga; Ebbing, Marta; Nordrehaug, Jan Erik; Nygård, Ottar & Nygard, O (2008). Homocysteine lowering B-vitamin therapy and in-stent restenosis. A WENBIT sub study. Circulation.  ISSN 0009-7322.  118(12), s E472- E473 . doi: 10.1161/CIRCULATIONAHA.108.189875
  • Bleie, Øyvind; Bleie, O; Strand, Elin; Strand, Erik M; Ueland, Per Magne; Vollset, Stein Emil; Refsum, Helga; Igland, Jannicke; Nordrehaug, Jan Erik; Nygård, Ottar & Nygard, O (2008). Homocysteine lowering B-vitamin therapy improves coronary flow in patients with stable coronary artery disease, a WENBIT substudy. Circulation.  ISSN 0009-7322.  118(12), s E487- E487 . doi: 10.1161/CIRCULATIONAHA.108.189875
  • Blix, Are Jordahl; Loland, KH; Løland, Kjetil Halvorsen; Bleie, Øyvind; Bleie, O; Strand, Erik M; Strand, Elin; Ueland, Per Magne; Refsum, Helga; Ebbing, Marta; Nordrehaug, Jan Erik; Nygård, Ottar & Nygard, OK (2008). The ratio of apolipoproteins ApoB/ApoA1 as a predictor of angiographic progression of atherosclerosis in patients with coronary artery disease. Circulation.  ISSN 0009-7322.  118(12), s E345- E346 . doi: 10.1161/CIRCULATIONAHA.108.189874
  • Løland, Kjetil Halvorsen; Blix, Are Jordahl; Bleie, Øyvind; Strand, Elin; Ueland, Per Magne; Refsum, Helga; Ebbing, Marta; Nordrehaug, Jan Erik & Nygård, Ottar (2008). The effect of homocysteine-lowering B-vitamin intervention on angiographic coronary artery disease may be adverse - A WENBIT sub-study. Circulation.  ISSN 0009-7322.  118(12), s E334- E334 . doi: 10.1161/CIRCULATIONAHA.108.189874
  • Refsum, Helga & Smith, AD (2008). Are we ready for mandatory fortification with vitamin B-12?. American Journal of Clinical Nutrition.  ISSN 0002-9165.  88, s 253- 254
  • Smith, AD; Kim, YI & Refsum, Helga (2008). Is folic acid good for everyone?. American Journal of Clinical Nutrition.  ISSN 0002-9165.  87, s 517- 533

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Published Apr. 13, 2011 2:40 PM - Last modified Jan. 29, 2014 12:34 PM