Hua Hu

Associate Professor - Division of Physiology
Image of Hua Hu
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Visiting address Section of Physiology Department of Molecular Medisin University of Oslo
Postal address Postboks 1103 Blindern 0317 OSLO

Research Interest

Synaptic communication in healthy and diseased brains

Hua Hu's Group Website

Research Description

My group studies how neurons in the mammalian brain communicate with each other at synapses. We use advanced electrophysiological, imaging and computer modeling techniques to analyze synaptic signaling mechanisms in presynaptic axons and postsynaptic dendrites.

Current Projects

Functional analysis of cortical interneuron axons. Inhibitory interneurons play a key role in several higher microcircuit functions, such as feedforward and feedback inhibition, high-frequency network oscillations, and temporal encoding of information in the brain. Many of these functions are critically dependent on the rapid and temporally precise release of GABA from inhibitory axon terminals. We study synaptic computation mechanisms in these interneuron axon terminals that are highly specialized in fast signaling.

Dendritic computation in the medial entorhinal cortex. Combining electrophysiological recording, 2-photon glutamate uncaging, and molecular manipulation of dendritic ion channels, we aim to understand how grid cells in the medial entorhinal cortex process synaptic input during spatial navigation.

Publications

Selected publications
1. Hu H, Gan J, Jonas P (2014) Fast-spiking, parvalbumin+ GABAergic interneurons: from cellular design to microcircuit function. Science 345: 1255263.            
2. Hu H and Jonas P (2014) A supercritical density of Na+ channels ensures fast signaling in GABAergic interneuron axons. Nature Neuroscience 17: 686-693.         
3. Kim S, Guzman SJ, Hu H, Jonas P (2012) Active dendrites support efficient initiation of dendritic spikes in hippocampal CA3 pyramidal neurons. Nature Neuroscience 15: 600-606.           
4. Hu H, Martina M and Jonas P (2010) Dendritic mechanisms underlying rapid synaptic activation of fast-spiking hippocampal interneurons. Science 327: 52-58.     
5. Vervaeke K, Hu H, Graham LJ and Storm JF (2006) Contrasting effects of the persistent Na+ current on neuronal excitability and spike timing. Neuron 49: 257-270. 
6. Peters HC, Hu H, Pongs O, Storm JF, and Isbrandt D (2005) Conditional transgenic suppression of M-channels in mouse brain reveals functions in neuronal excitability, resonance, and behavior. Nature Neuroscience 8: 51-60.

  • Hu, Hua & Vervaeke, Koen Gerard Alois (2017). Synaptic integration in cortical inhibitory neuron dendrites.. Neuroscience.  ISSN 0306-4522. . doi: 10.1016/j.neuroscience.2017.06.065.
  • Hu, Hua; Gan, Jian & Jonas, Peter (2014). Interneurons. Fast-spiking, parvalbumin⁺ GABAergic interneurons: from cellular design to microcircuit function. Science.  ISSN 0036-8075.  345, s 1255263 . doi: doi: 10.1126/science.1255263
  • Hu, Hua & Jonas, Peter (2014). A supercritical density of Na+ channels ensures fast signaling in GABAergic interneuron axons.. Nature Neuroscience.  ISSN 1097-6256.  17, s 686- 693 . doi: 10.1038/nn.3678
  • Kim, Sooyun; Guzman, Segundo J; Hu, Hua & Jonas, Peter (2012). Active dendrites support efficient initiation of dendritic spikes in hippocampal CA3 pyramidal neurons.. Nature Neuroscience.  ISSN 1097-6256.  15, s 600- 606 . doi: 10.1038/nn.3060
  • Hu, Hua; Martina, Marco & Jonas, Peter (2010). Dendritic Mechanisms Underlying Rapid Synaptic Activation of Fast-Spiking Hippocampal Interneurons. Science.  ISSN 0036-8075.  327(5961), s 52- 58 . doi: 10.1126/science.1177876
  • Nörenberg, A; Hu, Hua; Vida, Imre; Bartos, Marlene & Jonas, Peter (2010). Distinct nonuniform cable properties optimize rapid and efficient activation of fast-spiking GABAergic interneurons. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  107(2), s 894- 899 . doi: 10.1073/pnas.0910716107
  • Hu, Hua; Vervaeke, Koen; Graham, Lyle & Storm, Johan Frederik (2009). Complementary Theta Resonance Filtering by Two Spatially Segregated Mechanisms in CA1 Hippocampal Pyramidal Neurons. Journal of Neuroscience.  ISSN 0270-6474.  29(46), s 14472- 14483 . doi: 10.1523/JNEUROSCI.0187-09.2009
  • Storm, Johan Frederik; Vervaeke, Koen Gerard Alois & Hu, Hua (2009). Functions of the Persistent Na+ Current in Cortical Neurons Revealed by Dynamic Clamp, In Alain Destexhe & Thierry Bal (ed.),  Dynamic-clamp: From Principles To Applications.  Springer.  ISBN 978-0-387-89278-8.  Kapittel 8.  s 165 - 199
  • Storm, Johan Frederik; Vervaeke, Koen Gerard Alois; Hu, Hua & Graham, LJ (2009). Functions of the persistent Na+ current in cortical neurons revealed by dynamic clamp, In Alain Destexhe & Thierry Bal (ed.),  Dynamic-clamp: From Principles To Applications.  Springer.  ISBN 978-0-387-89278-8.  1.  s 1 - 33
  • Gu, Ning; Hu, Hua; Vervaeke, Koen Gerard Alois & Storm, Johan Frederik (2008). SK (K(Ca)2) Channels Do Not Control Somatic Excitability in CA1 Pyramidal Neurons But Can Be Activated by Dendritic Excitatory Synapses and Regulate Their Impact. Journal of Neurophysiology.  ISSN 0022-3077.  100(5), s 2589- 2604 . doi: 10.1152/jn.90433.2008
  • Hu, Hua; Vervaeke, Koen Gerard Alois & Storm, Johan Frederik (2007). M-channels (Kv7/KCNQ channels) that regulate synaptic integration, excitability, and spike pattern of CA1 pyramidal cells are located in the perisomatic region. Journal of Neuroscience.  ISSN 0270-6474.  27, s 1853- 1867 . doi: 10.1523/JNEUROSCI.4463-06.2007
  • Lancaster, B; Hu, Hua; Gibb, B & Storm, Johan Frederik (2006). Kinetics of ion channel modulation by cAMP in rat hippocampal neurones. Journal of Physiology.  ISSN 0022-3751.  576, s 403- 416
  • Vervaeke, Koen Gerard Alois; Gu, Ning; Agdestein, Christine; Hu, Hua & Storm, Johan Frederik (2006). Kv7/KCNQ/M-channels in rat glutamatergic hippocampal axons and their role in regulation of excitability and transmitter release. Journal of Physiology.  ISSN 0022-3751.  576, s 235- 256
  • Vervaeke, Koen Gerard Alois; Hu, Hua; Graham, LJ & Storm, Johan Fredrik (2006). Contrasting effects of the persistent Na+ current on neuronal excitability and spike timing. Neuron.  ISSN 0896-6273.  49, s 257- 270
  • Gu, Ning; Vervaeke, Koen Gerard Alois; Hu, Hua & Storm, Johan Frederik (2005). Kv7/KCNQ/M and HCN/h, but not K(Ca)2/SK channels, contribute to the somatic medium after-hyperpolarization and excitability control in CA1 hippocampal pyramidal cells. Journal of Physiology.  ISSN 0022-3751.  566, s 689- 715
  • Peters, Christian; Hu, Hua; Pongs, Olaf; Storm, Johan Frederik & Isbrandt, Dirk (2005). Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior. Nature Neuroscience.  ISSN 1097-6256.  8(1), s 51- 60 . doi: 10.1038/nn1375
  • Sausbier, M; Hu, Hua; Arntz, C; Feil, S; Kamm, S; Adelsberger, H; Sausbier, U; Sailer, CA; Feil, R; Hofmann, F; Korth, M; Shipston, MJ; Knaus, HG; Wolfer, DP; Pedroarena, CM; Storm, Johan Frederik & Ruth, P (2004). Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  101(25), s 9474- 9478
  • Hu, Hua; Vervaeke, Koen Gerard Alois & Storm, Johan Fredrik (2002). Two forms of electrical resonance at theta frequencies, generated by M-current, h-current and persistent Na+ current in rat hippocampal pyramidal cells. Journal of Physiology.  ISSN 0022-3751.  545(3), s 783- 805
  • Sailer, Claudia A.; Hu, Hua; Kaufmann, Walter; Trieb, Maria; Schwarzer, Christoph; Storm, Johan Fredrik & Knaus, Hans Gunther (2002). Regional differences in distribution and functional expression of small-conductance Ca2+ activated K+ channels in rat brain. Journal of Neuroscience.  ISSN 0270-6474.  s 9698- 9707
  • Hu, Hua; Shao, Li-Rong; Chavoshy, Sorush; Gu, Ning; Trieb, Maria; Behrens, Ralf; Laake, Petter; Pongs, Olaf; Knaus, Hans Gunther; Ottersen, Ole Petter & Storm, Johan Fredrik (2001). Presynaptic Ca2+-Activated K+ Channels in Glutamatergic Hippocampal Terminals and Their Role in Spike Repolarization and Regulation of Transmitter Release. Journal of Neuroscience.  ISSN 0270-6474.  21, s 1- 13
  • Lancaster, B.; Hu, Hua; Ramakers, G. M. J. & Storm, Johan Fredrik (2001). Interaction between synaptic excitation and slow afterhyperpolarization current in rat hippocampal pyramidal cells. Journal of Physiology.  ISSN 0022-3751.  536,3, s 809- 823

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  • Storm, Johan Frederik; Vervaeke, Koen Gerard Alois; Hu, Hua & Graham, LJ (2009). Dynamic clamp. Springer.  ISBN 978-0-387-89278-8.  429 s.

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  • Hu, Hua & Jonas, Peter (2016). Energy efficient action potential signaling in GABAergic inhibitory axons.
  • Jonas, Peter & Hu, Hua (2016). Energy-efficient action potential signaling in inhibitory interneuron axons.
  • Hu, Hua; Vervaeke, Koen Gerard Alois & Storm, Johan Frederik (2007). Theta resonance regulates frequency-dependence of postsynaptic responses and signal transfer along the apical dendrites of hippocampal pyramidal cells.
  • Storm, Johan; Hu, Hua; Vervaeke, Koen Gerard Alois & Gu, Ning (2005). Threshold currents in hippocampal neurons.
  • Hu, Hua & Storm, Johan Frederik (2005). Functions of Ca2+ -activated and KCNQ/M-type potassium channels in the brain.
  • Storm, Johan Frederik; Vervaeke, Koen Gerard Alois; Gu, Ning & Hu, Hua (2005). NMDA receptor - activated postsynaptic SK ( KCa2 ) K+ channels can regulate postsynaptic excitatory responses but do not underlie somatic spike afterhyperpolarizations or adaptation in rat CA1 pyramidal neurons.
  • Vervaeke, Koen Gerard Alois; Hu, Hua; Graham, LJ & Storm, Johan Frederik (2005). Persistent sodium current modulates temporal precision of action potential discharge in CA1 pyramidal cells.
  • Gu, Ning; Hu, Hua; Ruth, Peter & Storm, Johan Fredrik (2004). Pre- and postsynaptic functions of BK-type potassium channels in hippocampal CA1 pyramidal cells studied by knockout of the gene encoding the pore-forming channel subunit in mice.
  • Gu, Ning; Hu, Hua; Vervaeke, Koen Gerard Alois & Storm, Johan Frederik (2004). M- and H-channels, but not SK channels, generate the medium afterhyperpolarisation (mAHP) following single spikes and spike bursts in CA1 pyramidal cells.
  • Vervaeke, Koen Gerard Alois; Hu, Hua; Graham, Lyle & Storm, Johan Frederik (2004). The persistent sodium current enhances afterhyperpolarisations and reduces f/I gain in pyramidal neurons.
  • Vervaeke, Koen Gerard Alois; Hu, Hua & Storm, Johan Frederik (2004). An "inhibitory" action of voltage-dependent persistent sodium channels: amplification of the medium and slow afterhyperpolarisations in CA1 hippocampal pyramidal neurons.
  • Gu, Ning; Hu, Hua; Sausbier, M; Arntz, C; Ruth, P & Storm, Johan Frederik (2004). Pre - and postsynaptic functions of BK - type potassium channels in hippocampal CA1 pyramidal cells studied by knockout of the gene encoding the pore - forming channel subunit in mice.
  • Hu, Hua; Gu, Ning & Storm, Johan Frederik (2004). Apamin - sensitive SK potassium channels underlie medium - duration afterhyperpolarizations ( mAHP ) in rat subicular pyramidal neurons but not in CA1 pyramidal neurons.
  • Ruth, P; Hu, Hua; Sausbier, M; Arntz, C; Feil, S; Kamm, S; Adelsberger, H; Sausbier, U; Sailer, CA; Feil, R.; Hofmann, F; Korth, M; Shipston, MJ; Knaus, HG; Wolfer, DP; Pedroarena, CM & Storm, Johan Frederik (2004). Cerebellar ataxia and Purkinje cell dysfunction caused by CA - activated K - channel deficiency.
  • Gu, Ning; Hu, Hua; Vervaeke, Koen Gerard Alois & Storm, Johan Fredrik (2003). M- AND H-CHANNELS, BUT NOT SK CHANNELS, GENERATE THE MEDIUM AFTERHYPERPOLARIZATION (mAHP) FOLLOWING SPIKE BURSTS IN HIPPOCAMPAL PYRAMIDAL CELLS.
  • Storm, Johan Frederik & Hu, Hua (2003). Theta - resonance generated by H - and M - channels in hippocampal Str.oriens interneurons.
  • Storm, Johan Frederik & Hu, Hua (2003). Transient BK channel current in hippocampal CA1 pyramidal neurons.
  • Storm, Johan Fredrik; Vervaeke, Koen Gerard Alois & Hu, Hua (2002). M- and H-current contribute to subthreshold electrical resonance at theta frequencies in rat CA1 hippocampal pyramidal neurons.

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Published Apr. 13, 2011 2:40 PM - Last modified Mar. 10, 2017 1:49 PM

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