Jan Oxholm Gordeladze

Professor Emeritus - Division of Biochemistry
Image of Jan Oxholm Gordeladze
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Phone +47-22851138
Mobile phone +47-91701076
Room 2260
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Visiting address Sognsvannsveien 9 Domus Medica 0372 OSLO

Academic interests

In terms of teaching, I am particularly interested in the concept of “Scholarly teaching”, as well as computer-based test and evaluation systems. My main academic interests are the development of cell phenotypes and the regulation of cell function and metabolism.

Examples of such phenomena are cell engineering of bone and cartilage through the control of signaling pathways; the communication between cells through microRNA-containing exosomes; and the regulation of satiety and hunger and body weight influenced by hormones, metabolites and genetic predisposition.

Courses taught

I teach carbohydrate metabolism in relation to diabetes and obesity, and calcium metabolism in relation to osteoporosis and osteomalacia (4th semester), the impact of calcium, vitamin-D, and vitamin-K on bone health (ERN 3120), and I give two laboratory courses: Glucose tolerance test (2nd semester), and Liver glycogen contents (4th semester) after periods of fast and feeding. Finally, I have developed three computer-based test systems encompassing endocrinology and signaling systems, and ERN3120.

See:

Background

I have served as a professor of medical biochemistry at The Institute of Basic Medical Science since 1993.

Other relevant academic merits are:

  • Associate professor of Experimental Rheumatology, University of Montpellier (2006-2009)
  • Leader of 4th semester, preclinical medicine, medical studies, IBMS, University of Oslo (2001-2002)
  • Fulbright Scholar at the NIH, Bethesda, Maryland, USA (1990-1991)
  • Senior Research Fellow (Norwegian Research Council, 1985-1988)
  • Medical Director of MSD, Norway (1983-1984)
  • PhD, University of Oslo, Norway (Adenylyl cyclase in germ cells, 1981)
  • Master in Biochemistry, NTNU, Trondheim (1975)

folk.uio.no/jango

Collaboration

I collaborate with professor Andrew Collins (Inst. of Nutritional Research, University of Oslo) developing E-learning systems and computer-based self-assessment modules.

In terms of research on stem cells and differentiation, I collaborate with the following partners:

  • INSERM U844 (professor Jorgensen), Montpellier, France (microRNA and differentiation of chondrocytes from stem cells, understand the senescence of cartilage)
  • DNK (professor Fodstad) (osteosarcomas: microRNAs as markers for cancer growth and drug sensitivity)
  • Department of Materials, UiO (professors Reseland and Lyngstadaas) (impact of biomaterials on microRNAs as signatures for osteoblasts to be used in bone replacement in patients with jaw/tooth defects, cancer and osteoporosis)
  • Norwegian Center for Stem Cell Rersearch (professor Glover), The National Hospital, Oslo, Norway and Institute of Basic Medical Science, University of Oslo, Norway
Tags: Stem cells, Diabetes and hormones, Musculo-skeletal system, Nutritional Science, Osteochondral cells and Immune cells, MicroRNA, Exosomes, Life science, Vitamin K

Publications

  • Stakkestad, Øystein; Lyngstadaas, Ståle Petter; Vondrášek, Jiří; Gordeladze, Jan Oxholm & Reseland, Janne Elin (2017). Ameloblastin peptides modulates the osteogenic capacity of human mesenchymal stem cells. Frontiers in Physiology.  ISSN 1664-042X.  8 . doi: 10.3389/fphys.2017.00058
  • Gordeladze, Jan Oxholm; Stakkestad, Øystein; Haugen, Sigrid; Reseland, Janne Elin; Syversen, Unni; Johnsen, Gaute Floer; Haugen, Håvard Jostein; Lyngstadaas, Ståle Petter; Møller, Mona & Valtieri, Mauro (2014). Regulatory Loops Consisting of Transcription Factors and MicroRNA Species Determining the Mineralizing Characteristics of Cell Phenotypes - Implications for Bone Engineering and Prevention of Soft Tissue Mineralization, In Daniel Eberli (ed.),  Cells and Biomaterials in Regenerative Medicine.  INTECH.  ISBN 978-953-51-1731-5.  Chapter 3.
  • Gordeladze, Jan Oxholm; Reseland, Janne Elin; Karlsen, Tommy Aleksander; Jakobsen, Rune Bruhn; Stunes, Astrid Kamilla; Syversen, Unni; Engebretsen, Lars; Lyngstadaas, Ståle Petter & Jorgensen, Christian (2013). Engineering of Inflammation-Resistant Osteochondral Cells, In Jose A. Andrades (ed.),  Regenerative Medicine and Tissue Engineering.  INTECH.  ISBN 978-953-51-1108-5.  20.
  • Stunes, Astrid Kamilla; Westbroek, Irene; Gordeladze, Jan Oxholm; Gustafsson, Björn; Reseland, Janne Elin & Syversen, Unni (2012). Systemic leptin administration in supraphysiological doses maintains bone mineral density and mechanical strength despite significant weight loss . Endocrinology.  ISSN 0013-7227.  153(5), s 2245- 2253 . doi: 10.1210/en.2011-1848
  • Fritz, V.; Brondello, J.M.; Gordeladze, Jan Oxholm; Reseland, Janne Elin; Bony, C.; Yssel, H.; Noël, D. & Jorgensen, C. (2011). Bone-Metastatic Prostate Carcinoma Favors Mesenchymal Stem Cell Differentiation Toward Osteoblasts and Reduces their Osteoclastogenic Potential. Journal of Cellular Biochemistry.  ISSN 0730-2312.  112(11), s 3234- 3245 . doi: 10.1002/jcb.23258
  • Gordeladze, Jan Oxholm; Reseland, Janne Elin; Karlsen, Tommy Aleksander; Jakobsen, Rune Bruhn; Engebretsen, Lars; Lyngstadaas, Ståle Petter; Jorgensen, Christian; Yssel, Hans & Brinchmann, Jan E. (2011). Bone and Cartilage from Stem Cells: Growth Optimalization and Stabilization of Cell Phenotypes, In Daniel Eberli (ed.),  Bone and Cartilage from Stem Cells: Growth Optimalization and Stabilization of Cell Phenotypes.  INTECH.  ISBN 978-953-307-663-8.  2.  s 23 - 56
  • Gordeladze, Jan Oxholm; Reseland, Janne Elin; Duroux-Richard, Isabelle; Apparailly, F & Jorgensen, C (2010). From stem cells to bone: phenotype acquisition, stabilization, and tissue engineering in animal models. ILAR journal.  ISSN 1084-2020.  51(1), s 42- 61
  • Gordeladze, Jan Oxholm; Djouad, Farida; Brondello, Jean-Marc; Noel, Daniele; Duroux-Richard, Isabelle; Apparailly, Florence & Jorgensen, Christian (2009). Concerted stimuli regulating osteo-chondral differentiation from stem cells: phenotype acquisition regulated by microRNAs. Acta Pharmacologica Sinica.  ISSN 1671-4083.  30(10), s 1369- 1384 . doi: 10.1038/aps.2009.143
  • Vinatier, Claire; Bouffi, Claire; Merceron, Christoffe; Gordeladze, Jan Oxholm; Brondello, Jean-Marc; Jorgensen, Christian; Weiss, Pierre; Guicheux, Jerome & Noel, Daniele (2009). Cartilage Tissue Engineering: Towards a biomaterial-Assisted Mesenchymal Stem Cell Therapy. Current Stem Cell Research & Therapy.  ISSN 1574-888X.  4, s 318- 329
  • Gordeladze, Jan Oxholm; Noel, D; Bony, C; Apparailly, F; Louis-Plence, P & Jorgensen, C (2008). Transient down-regulation of cbfa1/Runx2 by RNA interference in murine C3H10T1/2 mesenchymal strornal cells delays in vitro and in vivo osteogenesis, but does not overtly affect chondrogenesis. Experimental Cell Research.  ISSN 0014-4827.  314 . doi: 10.1016/j.yexcr.2007.12.023
  • Fjeldheim, Åse-Karine; Høvring, Per Ivar; Løseth, Ole-Petter; Johansen, Per Wiik; Glover, Joel; Matre, Vilborg; Olstad, Ole Kristoffer; Reppe, Sjur; Gordeladze, Jan Oxholm; Walaas, Sven Ivar & Gautvik, Kaare M (2005). Thyrotrophin-releasing hormone receptor 1 and prothyrotrophin-releasing hormone mRNA expression in the central nervous system are regulated by suckling in lactating rats. European Journal of Endocrinology.  ISSN 0804-4643.  152, s 791- 803
  • Jorgensen, Christian; Gordeladze, Jan Oxholm & Noel, Daniele (2004). Tissue engineering through autologous mesenchymal stem cells. Current Opinion in Biotechnology.  ISSN 0958-1669.  15, s 406- 410
  • Reseland, Janne Elin & Gordeladze, Jan Oxholm (2003). A unified model for the action of leptin on bone turnover. Journal of Cellular Biochemistry.  ISSN 0730-2312.  88(4), s 706- 712
  • Gordeladze, Jan Oxholm; Drevon, Christian A; Syversen, Unni & Reseland, Janne Elin (2002). Leptin stimulates human osteoblastic cell proliferation, de novo collagen synthesis and mineralisation: impact on differentiation markers, apoptosis and osteoclastic signaling. Journal of Cellular Biochemistry.  ISSN 0730-2312.  85, s 825- 836
  • Reseland, Janne E & Gordeladze, Jan Oxholm (2002). Role of leptin in bone growth: central player or peripheral supporter?. FEBS Letters.  ISSN 0014-5793.  528(40-2), s 1- 3
  • Reseland, Janne Elin; Gordeladze, Jan Oxholm & Drevon, Christian A (2002). Leptin receptor (OB-R) expression in human primary osteoblasts: Reaffirmation. Journal of Bone and Mineral Research.  ISSN 0884-0431.  17, s 1136
  • Gordeladze, Jan Oxholm; Reseland, Janne Elin & Drevon, Christian A (2001). Pharmacological interference with transcriptional control of osteoblasts: A possible role for leptin and fatty acids in maintaining bone strength and body lean mass. Current opinion in pharmacology (Print).  ISSN 1471-4892.  7, s 275- 290
  • Gordeladze, Jan Oxholm; Reseland, Janne Elin; Eide, Liv G.; Bakke, I.; Hjertner, Ø.; Qvigstad, G.; Syversen, Unni & Drevon, Christian A (2001). Leptin and leptin receptors in osteoblastic cells: implications for bone remodelling and growth. Proceedings from Int Soc for Musculoskeletal & neuronal interactions.
  • Johansen, Per Wiik; Lund, Hanne Wessel & Gordeladze, Jan Oxholm (2001). Specific combinations of G-protein sububits discriminate hormonal signalling in rat pituitary (GH(3)) cell in culture. Cellular Signalling.  ISSN 0898-6568.  13(4), s 251- 6
  • Johansen, Per Wiik; Paulssen, Ruth H; Bjøro, Trine; Gautvik, Kaare M & Gordeladze, Jan Oxholm (2001). Distinct guanine nucleotide binding protein alpha-subunit receptor coupling in GH cell lines: effects of bromocriptine and hormones on effector enzyme modulation. Cellular Physiology and Biochemistry.  ISSN 1015-8987.  11(6), s 339- 352
  • Reseland, Janne Elin; Syversen, Unni; Bakke, I.; Qvigstad, G.; Eide, Liv G.; Hjertner, Ø.; Gordeladze, Jan Oxholm & Drevon, Christian A (2001). Leptin is expressed in and secreted from primary cultures of human osteoblasts, and promotes bone mineralization. Journal of Bone and Mineral Research.  ISSN 0884-0431.  16, s 1426- 1433
  • Mamen, Asgeir; Medbø, Jon Ingulf & Gordeladze, Jan Oxholm (2000). EFFECT OF FAT AND L-CARNITINE INGESTION ON BICYCLING PERFORMANCE. Acta Kinesiologiae Universitatis Tartuensis.  ISSN 1406-9822.  8, s 89- 105
  • Gordeladze, Jan Oxholm; Sellevold, O.F.M. & Jynge, Per (1999). Beta-adrenergic signalling and threshhold adrenaline concentration for induction of fibrillation in the perfused heart pretreated with antihypertensive drugs. Journal of Experimental Medicine.  ISSN 0022-1007.  199, s 129- 140
  • Høvik, K. E.; Wu, Pengfei & Gordeladze, Jan Oxholm (1999). The Inhibitory Guanine Nucleotide-Binding Protein Gi2-alpha Induces and Potentiates Adipocyte Differentiation. Lipids.  ISSN 0024-4201.  34(4), s 355- 362
  • Gordeladze, Jan Oxholm; Jynge, Per; Borchgrevink, P. C. & Sellevold, O.F.M. (1998). Enhanced Responsiveness of the myocardial ß-adrenoceptor-adenylate cyclase system in the perfused rat heart (I). Bioscience Reports.  ISSN 0144-8463.  18(5), s 229- 250
  • Gordeladze, Jan Oxholm; Høvik, K. E.; Merendino, J.J.; Hermouet, S.; Gutkind, S. & Accili, D. (1997). Effect of activating and inactivating mutations of Gs- and Gi2-alpha protein subunits on growth and differentiation of 3T3-L1 preadipocytes. Journal of Cellular Biochemistry.  ISSN 0730-2312.  64, s 242- 257
  • Gordeladze, Jan Oxholm; Haugen, T. B.; Paulssen, E. J. & Paulssen, R. H. (1996). Phospholipase C activation in rat pituitary adenoma (GH) cells. Bioscience Reports.  ISSN 0144-8463.  16, s 65- 74
  • Gordeladze, Jan Oxholm; Haugen, Trine B.; Paulssen, Eyvind Jakob & Paulssen, Ruth H (1996). Phospholipase C activation in rat pituitary adenoma (GH) cells.. Bioscience Reports.  ISSN 0144-8463.  16(1), s 65- 74
  • Gordeladze, Jan Oxholm; Lund, H. W.; Jablonski, Greg & Bruland, Øyvind (1996). Diverse expression of G-proteins in human sarcoma cell lines with different osteogenic potential: evidence for the involvement of Gi2 in cell proliferation. Journal of Cellular Biochemistry.  ISSN 0730-2312.  60, s 95- 106
  • Jablonski, Greg; Klem, K. H.; Danielsen, C.C.; Mosekilde, Leif & Gordeladze, Jan Oxholm (1996). Aluminium-induced bone disease in uremic rats: effect of deferoxamine. Bioscience Reports.  ISSN 0144-8463.  16, s 49- 63
  • Jablonski, Greg; Mortensen, Berit Marie; Klem, Knut Henning; Mosekilde, Lis; Danielsen, CC & Gordeladze, Jan Oxholm (1995). Vitamin D analogs and salmon calcitonin partially reverse the development of renal dystrophy in rats. Calcified Tissue International.  ISSN 0171-967X.  57(5), s 385- 391
  • Mortensen, Berit Marie; Lund, Hanne Wessel; Jablonski, Greg; Paulssen, Ruth H & Gordeladze, Jan Oxholm (1995). Direct effects of vitamin D3 analogues on G-protein mediated signalling systems in rat osteosarcoma cells and rat pituitary adenoma cells. Bioscience Reports.  ISSN 0144-8463.  15(3), s 135- 50
  • Berg, Jens Petter; Sandvik, Joe Alexander; Ree, Anne Hansen; Sørnes, G.; Bjøro, Trine; Torjesen, Peter A.; Gordeladze, Jan Oxholm & Haug, Egil (1994). 1,25-Dihydroxyvitamin D3 attenuates adenylyl cyclase activity in rat thyroid cells: reduction of thyrotropin receptor number and increase in guanine nucleotide binding-protein Gi-2alpha. Endocrinology.  ISSN 0013-7227.  135, s 595- 602
  • Gordeladze, Jan Oxholm; Johansen, Per Wiik; Paulssen, Ruth H; Paulssen, Eyvind J & Gautvik, Kaare M (1994). G-proteins: implications for pathophysiology and disease. European Journal of Endocrinology.  ISSN 0804-4643.  131(6), s 557- 574
  • Jablonski, Greg; Danielsen, CC; Mosekilde, Lis & Gordeladze, Jan Oxholm (1994). Surgically induced uremia in rats. II: Osseous PTH-susceptible signaling systems as predictors of bone resorption. Calcified Tissue International.  ISSN 0171-967X.  55(4), s 281- 287
  • Paulssen, Ruth H; Johansen, Per Wiik; Gordeladze, Jan Oxholm; Nymoen, Ole-Martin; Paulssen, Eyvind Jakob & Gautvik, Kaare M (1994). Cell-specific expression and function of adenylyl cyclases in rat pitruitary tumour cell lines. European Journal of Biochemistry.  ISSN 0014-2956.  222(1), s 97- 103
  • Jablonski, Greg; Klem, Knut Henning; Attramadal, Audun; Dahle, E; Rønningen, Helge; Gautvik, Kaare M; Haug, Egil & Gordeladze, Jan Oxholm (1993). Surgically induced uremia in rats. I: Effect on bone strength and metabolism. Bioscience Reports.  ISSN 0144-8463.  13(5), s 275- 287
  • Jablonski, Greg; Nordahl, Knut P; Halse, Johan; Dahl, E; Aksnes, L; Gautvik, Kaare M & Gordeladze, Jan Oxholm (1993). PTH-stimulated adenylate cyclase activity and bone histomorphometry in iliac crest biopsies in the evaluation of uremic patients: a pilot study with the use of artificial intelligence. Mineral and Electrolyte Metabolism.  ISSN 0378-0392.  19(6), s 351- 361
  • Mortensen, Berit Marie; Aarseth, Hans P; Ganss, R.; Haug, Egil; Gautvik, Kaare M & Gordeladze, Jan Oxholm (1993). 24,25-dihydroxy vitamin D3 treatment inhibits parathyroid-stimulated adenylate cyclase in iliac crest biopsies from uremic patients. Bone.  ISSN 8756-3282.  14(2), s 125- 131
  • Mortensen, Berit Marie; Gautvik, Kaare M & Gordeladze, Jan Oxholm (1993). Bone turnover in rats treated with 1,25-dihydroxyvitamin D3, 25-hydroxyvitamin D3 or 24,25 dihydroxyvitamin D3. Bioscience Reports.  ISSN 0144-8463.  13(1), s 27- 39
  • Mortensen, Berit Marie; Gordeladze, Jan Oxholm; Haug, Egil; Schjerven, L. & Gautvik, Kaare M (1993). Relationship between circulating vitamin D3 metabolites and prolactin or growth hormone levels in rat. Pharmacology and Toxicology.  ISSN 0901-9928.  72(3), s 188- 193
  • Mortensen, Berit Marie; Gordeladze, Jan Oxholm; Lyngdal, PT; Aarseth, Hans P & Gautvik, Kaare M (1993). Alterations in serum and urine parameters reflecting bone turnover in uremic patients during treatment with 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3. Mineral and Electrolyte Metabolism.  ISSN 0378-0392.  19(2), s 78- 85
  • Rian, Edith; Jemtland, Rune; Olstad, Ole Kristoffer; Gordeladze, Jan Oxholm & Gautvik, Kaare M (1993). Synthesis of human parathyroid-hormone-related protein (1-141) in Saccharomyces cerevisiae. A correct amino-terminal processing vital for the hormone's biological activity is obtained by an ubiquitin fusion protein approach. European Journal of Biochemistry.  ISSN 0014-2956.  213(1), s 641- 648
  • Friedman, Eitan; Gordeladze, Jan Oxholm; Gejman, Pablo V; Murtagh, JJ Jr; Gertch, DS & Tu, T (1992). Hypertrophic cardiomyopathy: failure to demonstrate mutations in exon 13 of the cardiac beta myosin heavy-chain gene. Basic Research in Cardiology.  ISSN 0300-8428.  87(2), s 106- 112
  • Paulssen, Eyvind Jakob; Paulssen, Ruth H; Gautvik, Kaare M & Gordeladze, Jan Oxholm (1992). "Cross-talk" between phospholipase C and adenylyl cyclase involves regulation of G-protein levels in GH3 rat pituitary cells. Cellular Signalling.  ISSN 0898-6568.  4(6), s 747- 755
  • Paulssen, Eyvind Jakob; Paulssen, Ruth H; Gautvik, Kaare M & Gordeladze, Jan Oxholm (1992). Hypothalamic hormones modulate G protein levels and second messenger responsiveness in GH3 rat pituitary tumour cells. Biochemical Pharmacology.  ISSN 0006-2952.  44(3), s 471- 477
  • Paulssen, Ruth H; Paulssen, Eyvind Jakob; Gautvik, Kaare M & Gordeladze, Jan Oxholm (1992). Modulation of G proteins and second messenger responsiveness by steroid hormones in GH3 rat pituitary tumour cells. Acta Physiologica Scandinavica.  ISSN 0001-6772.  146(2), s 511- 518
  • Paulssen, Ruth H; Paulssen, Eyvind Jakob; Gautvik, Kaare M & Gordeladze, Jan Oxholm (1992). The thyroliberin receptor interacts directly with a stimulatory guanine-nucleotide-binding protein in the activation of adenylyl cyclase in GH3 rat pituitary tumour cells. Evidence obtained by use of antisense RNA inhibition and immunoblocking of the stimulatory guanine-nucleotide-binding protein. European Journal of Biochemistry.  ISSN 0014-2956.  204(1), s 413- 418
  • Parrow, VC; Gordeladze, Jan Oxholm; Paulssen, Eyvind Jakob; Alestrøm, Peter & Gautvik, Kaare M (1991). Signal transduction alterations in GH(1)2C1 rat pituitary tumour cells following treatment with 5-azacytidine. Journal of Molecular Endocrinology.  ISSN 0952-5041.  6(3), s 257- 268
  • Hysing, Jan; Gordeladze, Jan Oxholm; Christensen, G. & Tolleshaug, Helge (1991). Renal uptake and degradation of trapped-label calcitonin. Biochemical Pharmacology.  ISSN 0006-2952.  41(8), s 1119- 1126
  • Paulssen, Eyvind Jakob; Paulssen, Ruth H; Haugen, Trine B.; Gautvik, Kaare M & Gordeladze, Jan Oxholm (1991). Cell specific distribution of guanine nucleotide-binding regulatory proteins in rat pituitary tumour cell lines. Molecular and Cellular Endocrinology.  ISSN 0303-7207.  76(1-3), s 45- 53
  • Paulssen, Eyvind Jakob; Paulssen, Ruth H; Haugen, Trine B.; Gautvik, Kaare M & Gordeladze, Jan Oxholm (1991). Regulation of G protein mRNA levels by thyroliberin, vasoactive intestinal peptide and somatostatin in prolactin-producing rat pituitary adenoma cells. Acta Physiologica Scandinavica.  ISSN 0001-6772.  143(2), s 195- 201
  • Paulssen, Ruth H; Paulssen, Eyvind Jakob; Gordeladze, Jan Oxholm; Hansson, Vidar & Haugen, Trine B. (1991). Cell-specific expression of guanine nucleotide-binding proteins in rat testicular cells. Biology of Reproduction.  ISSN 0006-3363.  45(4), s 566- 571
  • Reppe, Sjur; Gabrielsen, Odd Stokke; Olstad, Ole Kristoffer; Morrison, N; Saether, O; Billingsmo, OR; Gautvik, VT; Gordeladze, Jan Oxholm; Haflan, AK; Voelkel, EF & Gautvik, Kaare M (1991). Characterization of a K26Q site-directed mutant of human parathyroid hormone expressed in yeast. Journal of Biological Chemistry.  ISSN 0021-9258.  266(22), s 14198- 14201
  • Høgset, Anders; Blingsmo, OR; Gautvik, VT; Saether, O; Jacobsen, PB; Gordeladze, Jan Oxholm; Alestrøm, Peter & Gautvik, Kaare M (1990). Expression of human parathyroid hormone in Escherischia coli. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  166(1), s 50- 60
  • Høgset, Anders; Blingsmo, OR; Saether, O; Gautvik, VT; Holmgren, E; Hartmanis, M; Josephson, S; Gabrielsen, Odd Stokke; Gordeladze, Jan Oxholm; Alestrøm, Peter & Gautvik, Kaare M (1990). Expression and characterization of recombinant human parathyroid hormone secreted by Escherischia coli employing the staphylococcal protein A promoter and signal sequence. Journal of Biological Chemistry.  ISSN 0021-9258.  265(13), s 7338- 7344
  • Paulssen, Ruth H; Paulssen, Eyvind Jakob; Alestrøm, Peter; Gordeladze, Jan Oxholm & Gautvik, Kaare M (1990). Specific antisense RNA inhibition of growth hormone production in differentiated rat pituitary tumour cells. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  171(1), s 293- 300
  • Bjøro, Trine; Sand, Olav; Østberg, BC; Gordeladze, Jan Oxholm; Torjesen, Peter A; Gautvik, Kaare M & Haug, Egil (1990). The mechanisms by which vasoactive intestinal peptide (VIP) and thyrotropin releasing hormone (TRH) stimulate prolactin release from pituitary cells. Bioscience Reports.  ISSN 0144-8463.  10(2), s 189- 199
  • Gabrielsen, OS; Reppe, Sjur; Saether, O; Blingsmo, OR; Sletten, K; Gordeladze, Jan Oxholm; Høgset, Anders; Gautvik, VT; Alestrøm, P.; Øyen, TB & Gautvik, Kaare M (1990). Efficient secretion of human parathyroid hormone by Saccharomyces cerevisiae. Gene.  ISSN 0378-1119.  90(2), s 255- 262
  • Gordeladze, Jan Oxholm (1990). The pharmacodynamic action of the cyclic AMP phosphodiesterase inhibitor rolipram on prolactin producing rat pituitary adenoma (GH4C1) cells. Bioscience Reports.  ISSN 0144-8463.  10(4), s 375- 388
  • Gordeladze, Jan Oxholm; Paulssen, Eyvind Jakob & Hracky, Ruth (1990). G-proteins and their involvement in hormonal signal transduction. Scandinavian Journal of Clinical and Laboratory Investigation.  ISSN 0036-5513.  202, s 127- 130
  • Haugen, Trine B.; Paulssen, Eyvind Jakob; Gordeladze, Jan Oxholm & Hansson, Vidar (1990). A unique mRNA species of the alpha subunit of Gs is present in rat haploid germ cells. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  168(1), s 91- 98
  • Klem, HK; Jablonski, Greg; Saether, O; Jarosz, G; Gautvik, Kaare M & Gordeladze, Jan Oxholm (1990). 1,25-dihydroxyvitamin D-3 and 24,25-dihydroxyvitamin D-3 affect parathormone (PTH)-sensitive adenylate cyclase activity and alkaline phosphatase secretion of osteoblastic cells through different mechanisms of action. Biochimica et Biophysica Acta.  ISSN 0006-3002.  1054(3), s 304- 310
  • Mortensen, Berit Marie; Gordeladze, Jan Oxholm; Aksnes, Lage & Gautvik, Kaare M (1990). Long-term administration of vitamin D3 metabolites alters PTH-responsive osteoblastic adenylyl cyclase in rats. Calcified Tissue International.  ISSN 0171-967X.  46(5), s 339- 345
  • Gordeladze, Jan Oxholm; Bjøro, Trine; Torjesen, PA; Østberg, BC; Haug, Egil & Gautvik, Kaare M (1989). Protein kinase C stimulates adenylate cyclase activity in prolactin-secreting adenoma (GH4C1) pituicytes by inactivating the inhbitory GTP-binding protein Gi. European Journal of Biochemistry.  ISSN 0014-2956.  183(2), s 397- 406
  • Rui, Hallgeir; Purvis, Ken & Gordeladze, Jan Oxholm (1989). Sperm adenylyl cyclase in young and middle-aged men. Andrologia.  ISSN 0303-4569.  21(2), s 131- 135
  • Wickstrøm, Egil; Bredesen, JE & Gordeladze, Jan Oxholm (1989). Effects of flunitrazepam and triazolam in man: are they influenced by the time of ingestion?. Pharmacology and Toxicology.  ISSN 0901-9928.  64(5), s 417- 420

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  • Gordeladze, Jan Oxholm; Landin, Maria Augusta Dos S Silva; Johnsen, Gaute Floer; Haugen, Håvard Jostein & Osmundsen, Harald (2017). Vitamin K2 and its Impact on Tooth Epigenetics. INTECH.  ISBN 978-953-51-3020-8.  27 s.
  • Gordeladze, Jan Oxholm (1998). Osteoporose. Universitetsforlaget.  ISBN 82-00-42543-6.  210 s.
  • Gordeladze, Jan Oxholm & Wiik, Johansen P. (1997). G proteins in etiology and treatment of mental disorders. Humana Press Inc.Totowa, NJ..  ISBN 0-89603-490-9.  26 s.

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  • Gordeladze, Jan Oxholm (2014). Epigenetic factors involved in the "mineralizing/demineralizing" capability of cell phenotypes: Histone deacetylaces (HDACs), transcription factors (TFs), microRNAs, and vitamin K2 (MK-7) .
  • Gordeladze, Jan Oxholm & Reseland, Janne Elin (2014). Stem Cells and Scaffold Materials for Osteoblast Engineering: Guidance from microRNA Signatures and Bioinformatics.
  • Gordeladze, Jan Oxholm; Reseland, Janne Elin; Haugen, Håvard Jostein; Haugen, Sigrid; Stakkestad, Øystein; Johnsen, Gaute Floer; Verket, Anders; Valtieri, Mauro & Møller, Mona (2014). Epigenetic factors involved in the "mineralizing/demineralizing" capability of cell phenotypes: Histone deacetylaces (HDACs/Sirts), transcription factors (TFs), microRNAs, and vitamin K2 (MK-7).
  • Gordeladze, Jan Oxholm; Reseland, Janne Elin & Møller, Mona (2014). Vitamin K2 (MK-7) is involved in bone and energy homeostasis: Effects on osteoblast, adipocyte and beta-cell regulatory loops.
  • Gordeladze, Jan Oxholm; Reseland, Janne Elin; Syversen, Unni & Valtieri, Mauro (2014). Key regulatory junctions stabilizing the osteoblast phenotype: Implications for cell and tissue engineering.
  • Gordeladze, Jan Oxholm; Reseland, Janne Elin; Syversen, Unni & Valtieri, Mauro (2014). Regulation of osteoblastogenesis: Concerted action of transcription factors (TFs), microRNAs and histone deacetylases (HDACs).
  • Gordeladze, Jan Oxholm (2013). "The role of microRNA signature(s) in osteoblastic cell engineering“ Scaffold materials for osteoblast engineering; Guidance from microRNA signatures and bioinformatics.
  • Gordeladze, Jan Oxholm (2013). The use of Micro-RNA and Gene-Assisted Manipulation of Mesenchymal Cell (hMSC) Derived Osteoblasts Optimally Propagated and Differentiated in TiO2 Scaffolds.
  • Gordeladze, Jan Oxholm & Reseland, Janne Elin (2013). Scaffold materials for osteoblast engineering: Guidance from microRNA signatures and bioinformatics. European Cells and Materials.  ISSN 1473-2262.
  • Gordeladze, Jan Oxholm; Reseland, Janne Elin & Syversen, Unni (2013). The impact of leptin on stem cell differentiation towards osteoblasts: Assessed by and osteo/chondro microRNA signature .
  • Gordeladze, Jan Oxholm (2012). Engineering of Osteoblasts for Bone Replacement: How to Test for Acquisition and Maintenance of a Proper Phenotype. J Tissue Science & Engineering.  ISSN 2157-7552.  3(3) . doi: 10.4172/2157-7552.1000e114
  • Gordeladze, Jan Oxholm (2012). Engineering of inflammation-resistant cells.
  • Gordeladze, Jan Oxholm (2012). Interaction between T-cells and engineered osteoblasts and chondrocytes: Implications for tissue repair .
  • Gordeladze, Jan Oxholm (2012). MicroRNA and the differentiation of stem cells – focus on the osteochondral phenotypes.
  • Gordeladze, Jan Oxholm (2012). MicroRNAs as determinants of T-helper cells: Th-cell and potential interactions with osteochondral cells.
  • Gordeladze, Jan Oxholm (2012). The use of microRNA assisted and gene-manipulated mesenchymal stem cells (hMSCs) derived from osteoblasts optimally propagated and differentiated in TiO2 scaffolds.
  • Gordeladze, Jan Oxholm & Reseland, Janne Elin (2012). Growth Conditions Facilitating Stem Cell Differentiation towards Osteoblasts: Assessed by an OsteoChondral MicroRNA Signature.
  • Duroux-Richard, Isabelle; Presumey, Jessy; Courties, Gabriel; Gay, Steffen; Gordeladze, Jan Oxholm; Jorgensen, Christian; Kyburtz, Diego & Apparailly, Florence (2011). MicroRNAs as new players in rheumatoid arthritis.
  • Gordeladze, Jan Oxholm (2011). MicroRNA and the differentiation of stem cells – focus on the osteochondral phenotypes.
  • Gordeladze, Jan Oxholm (2011). MicroRNAs as determinants of T-helper cells: Th-cell and potential interactions with osteochondral cells.
  • Mæhlum Wang, Grethe & Gordeladze, Jan Oxholm (2007). Effekten av magnesium og kalsium/D-vitamin tilskudd i 28 dager på kalsiumregulerende hormoner og beinparametre hos kvinner over 70 år. En pilotstudie.
  • Gordeladze, Jan Oxholm & Bony, Claire (2005). Regulation de la differenciation des cellules souches mesenchymateuses: Perspective pour l'ingenierie du cartilage.
  • Gordeladze, Jan Oxholm (2000). Sequential gene expression determines optimal bone cell function. European Journal of Clinical Investigation.  ISSN 0014-2972.  30, s 373- 375
  • Reseland, Janne Elin; Syversen, Unni; Bakke, I.; Qvigstad, G.; Eide, Liv G.; Hjertner, Ø.; Gordeladze, Jan Oxholm & Drevon, Christian A (2000). Leptin expression in human osteoblasts and a possible link between energy and bone metabolism.
  • Gordeladze, Jan Oxholm & Wiik Johansen, Per (1999). Regulation of prolactin and growth hormone secretion and synthesis in cultured rat pituitary adenoma cells (GH cells) with emphasis on dopaminergic mechanisms.
  • Mamen, Asgeir; Medbø, Jon Ingulf & Gordeladze, Jan Oxholm (1999). EFFECTS OF MEDIUM-CHAIN TRIACYLGLYCEROL INGESTION ON SPRINT PERFORMANCE AFTER TWO HOURS CYCLING AT AEROBIC THRESHOLD.
  • Gordeladze, Jan Oxholm & Jablonski, Greg (1995). Renal osteodystropy and aluminum related bone disease.
  • Gordeladze, Jan Oxholm & Mortensen, Berit (1995). The influence of vitamin D3 on bone remodelling: In vitro and in vivo studies of bone turnover in the normal and uraemic conditions.
  • Paussen, Ruth H; Paulssen, Eyvind J & Gordeladze, Jan Oxholm (1992). G protein-Coupled Transmembrane Signalling in Prolactin-Producing Rat Pituitary Tumour Cells.
  • Egil, Haug; Bjøro, Trine; Østberg, Bjørn Christian; Torjesen, P.A.; Penman, E.; Gordeladze, Jan Oxholm; Iversen, Jens Gustav; Gautvik, Kaare M. & Sand, Olav (1988). Multiple mechanisms of somatostatin inhibition of prolactin release from rat pituitary cells. Acta Physiologica Scandinavica.  ISSN 0001-6772.  132, s 20A

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Published Apr. 13, 2011 2:40 PM - Last modified May 31, 2012 12:37 PM