Leiv Otto Watne

Image of Leiv Otto Watne
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Phone +47-23016137
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Visiting address Sognsvannsveien 9 Domus Medica 0372 OSLO
Postal address Postboks 1105 Blindern 0317 OSLO

Watne is a resident in geriatrics at Oslo University Hospital (50% position) and a post doctoral fellow at the Institute of Basic Medical Sciences, University of Oslo (50% position). His main research interest is delirium (“acute confusion”), a common and serious complication in elderly patients. He is focusing on delirium pathophysiology and the impact of delirium on cognitive trajectories.

Background:

2014: PhD. “Delirium in hip fracture patients: consequenses, prevention strategies and pathophysiological mechanisms”. University of Oslo.

2005:  Cand. med., University of Oslo

 

Tags: Delirium, Dementia, Orthogeriatrics, Geriatrics

Publications

  • Ernst, Gernot Walter; Watne, Leiv Otto; Frihagen, Frede Jon; Wyller, Torgeir Bruun; Dominik, Andreas & Rostrup, Morten (2017). Decreases in heart rate variability are associated with postoperative complications in hip fracture patients. PLoS ONE.  ISSN 1932-6203.  12:e0180423(7), s 1- 14 . doi: 10.1371/journal.pone.0180423
  • Fjell, Anders Martin; Idland, Ane-Victoria; Sala Llonch, Roser; Watne, Leiv Otto; Borza, Tom; Brækhus, Anne; Lona, Tarjei; Zetterberg, Henrik; Blennow, Kaj; Wyller, Torgeir Bruun & Walhovd, Kristine B (2017). Neuroinflammation and Tau Interact with Amyloid in Predicting Sleep Problems in Aging Independently of Atrophy. Cerebral Cortex.  ISSN 1047-3211.  s 1- 11 . doi: 10.1093/cercor/bhx157
  • Guren, Ellen; Figved, Wender; Frihagen, Frede Jon; Watne, Leiv Otto & WESTBERG, MARIANNE (2017). Prosthetic joint infection?a devastating complication of hemiarthroplasty for hip fracture. Acta Orthopaedica.  ISSN 1745-3674.  88(4), s 383- 389 . doi: 10.1080/17453674.2017.1301009
  • Idland, Ane-Victoria; Roser, Sala-Llonch; Borza, Tom; Watne, Leiv Otto; Wyller, Torgeir Bruun; Brækhus, Anne; Zetterberg, Henrik; Blennow, Kaj; Walhovd, Kristine B & Fjell, Anders Martin (2017). CSF neurofilament light levels predict hippocampal atrophy in cognitively healthy older adults. Neurobiology of Aging.  ISSN 0197-4580.  49, s 138- 144 . doi: 10.1016/j.neurobiolaging.2016.09.012
  • Idland, Ane-Victoria; Wyller, Torgeir Bruun; Støen, Randi; Dahl, Gry Torsæter; Frihagen, Frede Jon; Brækhus, Anne; Hassel, Bjørnar & Watne, Leiv Otto (2017). Cerebrospinal Fluid Phosphate in Delirium after Hip Fracture. Dementia and geriatric cognitive disorders extra.  ISSN 1664-5464.  7, s 309- 317 . doi: 10.1159/000478723
  • Neerland, Bjørn Erik; Krogseth, Maria; Juliebø, Vibeke; Ranhoff, Anette Hylen; Engedal, Knut; Frihagen, Frede Jon; Ræder, Johan; Wyller, Torgeir Bruun & Watne, Leiv Otto (2017). Perioperative hemodynamics and risk for delirium and new onset dementia in hip fracture patients; A prospective follow-up study. PLoS ONE.  ISSN 1932-6203. . doi: 10.1371/journal.pone.0180641
  • Sala Llonch, Roser; Idland, Ane-Victoria; Borza, Tom; Watne, Leiv Otto; Wyller, Torgeir Bruun; Brækhus, Anne; Zetterberg, Henrik; Blennow, Kaj; Walhovd, Kristine B & Fjell, Anders Martin (2017). Inflammation, Amyloid, and Atrophy in The Aging Brain: Relationships with Longitudinal Changes in Cognition . Journal of Alzheimer's Disease.  ISSN 1387-2877.  58(3), s 829- 840 . doi: 10.3233/JAD-161146
  • Torbergsen, Anne Cathrine; Watne, Leiv Otto; Wyller, Torgeir Bruun; Frihagen, Frede Jon; Strømsøe, Knut; Bøhmer, Thomas & Mowe, Morten (2017). Micronutrients and the risk of hip fracture: Case–control study. Clinical Nutrition.  ISSN 0261-5614.  36(2), s 438- 443 . doi: 10.1016/j.clnu.2015.12.014
  • Hall, Roanna J.; Watne, Leiv Otto; Idland, Ane-Victoria; Ræder, Johan; Frihagen, Frede Jon; MacLullich, Alasdair M.J.; Staff, Anne Cathrine; Wyller, Torgeir Bruun & Fekkes, Durk (2016). Cerebrospinal fluid levels of neopterin are elevated in delirium after hip fracture. Journal of Neuroinflammation.  ISSN 1742-2094.  13:170 . doi: 10.1186/s12974-016-0636-1
  • Hov, Karen Roksund; Berg, Jens Petter; Frihagen, Frede Jon; Ræder, Johan; Hall, Roanna J.; Wyller, Torgeir Bruun & Watne, Leiv Otto (2016). Blood-cerebrospinal fluid barrier integrity in delirium determined by Q-Albumin. Dementia and Geriatric Cognitive Disorders.  ISSN 1420-8008.  41(3-4), s 192- 198 . doi: 10.1159/000443789
  • Idland, Ane-Victoria; Wyller, Torgeir Bruun; Støen, Randi; Eri, Lars Magne; Frihagen, Frede Jon; Ræder, Johan; Chaudhry, Farrukh Abbas; Hansson, Oskar; Zetterberg, Henrik; Blennow, Kaj; Bogdanovic, Nenad; Brækhus, Anne & Watne, Leiv Otto (2016). Preclinical amyloid-β and axonal degeneration pathology in delirium. Journal of Alzheimer's Disease.  ISSN 1387-2877.  55(1), s 371- 379 . doi: 10.3233/JAD-160461
  • Krogseth, Maria; Watne, Leiv Otto; Juliebø, Vibeke; Skovlund, Eva; Engedal, Knut; Frihagen, Frede Jon & Wyller, Torgeir Bruun (2016). Delirium is a risk factor for further cognitive decline in cognitively impaired hip fracture patients. Archives of gerontology and geriatrics (Print).  ISSN 0167-4943.  64, s 38- 44 . doi: 10.1016/j.archger.2015.12.004
  • Neerland, Bjørn Erik; Hall, Roanna J.; Seljeflot, Ingebjørg; Frihagen, Frede Jon; MacLullich, Alasdair M.J.; Ræder, Johan; Wyller, Torgeir Bruun & Watne, Leiv Otto (2016). Associations between delirium and preoperative cerebrospinal fluid C-reactive protein, interleukin-6, and interleukin-6 receptor in individuals with acute hip fracture. Journal of The American Geriatrics Society.  ISSN 0002-8614.  64(7), s 1456- 1463 . doi: 10.1111/jgs.14238
  • Watne, Leiv Otto; Idland, Ane-Victoria; Fekkes, Durk; Ræder, Johan; Frihagen, Frede Jon; Ranhoff, Anette Hylen; Chaudhry, Farrukh Abbas; Engedal, Knut; Wyller, Torgeir Bruun & Hassel, Bjørnar (2016). Increased CSF levels of aromatic amino acids in hip fracture patients with delirium suggests higher monoaminergic activity. BMC Geriatrics.  ISSN 1471-2318.  16(149) . doi: 10.1186/s12877-016-0324-0 Full text in Research Archive
  • O'Sullivan, Roisin; Meagher, David; Leonard, Maeve; Watne, Leiv Otto; Hall, Roanna J.; MacLullich, Alasdair M.J.; Trzepacz, Paula & Adamis, Dimitrios (2015). A comparison of the revised Delirium Rating Scale (DRS-R98) and the Memorial Delirium Assessment Scale (MDAS) in a palliative care cohort with DSM-IV delirium. Palliative & Supportive Care.  ISSN 1478-9515.  13(4), s 937- 944 . doi: 10.1017/S1478951514000613
  • Skrede, Kjersti; Wyller, Torgeir Bruun; Watne, Leiv Otto; Seljeflot, Ingebjørg & Juliebø, Vibeke (2015). Is there a role for monocyte chemoattractant protein-1 in delirium? Novel observations in elderly hip fracture patients. BMC Research Notes.  ISSN 1756-0500.  8(1) . doi: 10.1186/s13104-015-1129-5
  • Torbergsen, Anne Cathrine; Watne, Leiv Otto; Frihagen, Frede Jon; Wyller, Torgeir Bruun; Brugård, Anniken & Mowe, Morten (2015). Vitamin deficiency as a risk factor for delirium . European Geriatric Medicine.  ISSN 1878-7649.  6(4), s 314- 318 . doi: 10.1016/j.eurger.2014.09.002
  • Torbergsen, Anne Cathrine; Watne, Leiv Otto; Wyller, Torgeir Bruun; Frihagen, Frede Jon; Strømsøe, Knut; Bøhmer, Thomas & Mowe, Morten (2015). Vitamin K1 and 25(OH)D are independently and synergistically associated with a risk for hip fracture in an elderly population: A case control study. Clinical Nutrition.  ISSN 0261-5614.  34(1), s 101- 106 . doi: 10.1016/j.clnu.2014.01.016
  • Watne, Leiv Otto; Hall, Roanna J.; Molden, Espen; Ræder, Johan; Frihagen, Frede Jon; MacLullich, Alasdair M.J.; Juliebø, Vibeke; Nyman, Anna Armika Tussilago; Meagher, David & Wyller, Torgeir Bruun (2014). Anticholinergic activity in cerebrospinal fluid and serum in individuals with hip fracture with and without delirium. Journal of The American Geriatrics Society.  ISSN 0002-8614.  62(1), s 94- 102 . doi: 10.1111/jgs.12612
  • Watne, Leiv Otto; Torbergsen, Anne Cathrine; Conroy, Simon; Engedal, Knut; Frihagen, Frede; Hjorthaug, Geir Aasmund; Juliebø, Vibeke; Ræder, Johan; Saltvedt, Ingvild; Skovlund, Eva & Wyller, Torgeir Bruun (2014). The effect of a pre- and postoperative orthogeriatric service on cognitive function in patients with hip fracture: Randomized controlled trial (Oslo Orthogeriatric Trial). BMC Medicine.  ISSN 1741-7015.  12(1) . doi: 10.1186/1741-7015-12-63 Full text in Research Archive
  • Neerland, Bjørn Erik; Watne, Leiv Otto & Wyller, Torgeir Bruun (2013). Delirium hos eldre pasienter . Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  133(15), s 1596- 1600 . doi: 10.4045/tidsskr.12.1327
  • Juliebø, Vibeke; Krogseth, Maria; Neerland, Bjørn Erik; Watne, Leiv Otto & Wyller, Torgeir Bruun (2012). Delirium - a common condition associated with negative outcome in the elderly : . Norsk Epidemiologi.  ISSN 0803-2491.  22(2), s 253- 260
  • Wyller, Torgeir Bruun; Watne, Leiv Otto; Torbergsen, Anne Cathrine; Engedal, Knut Arne; Frihagen, Frede Jon; Juliebø, Vibeke; Saltvedt, Ingvild; Skovlund, Eva; Ræder, Johan & Conroy, Simon (2012). The effect of a pre- and post-operative orthogeriatric service on cognitive function in patients with hip fracture. The protocol of the Oslo Orthogeriatrics Trial. BMC Geriatrics.  ISSN 1471-2318.  12(36) . doi: 10.1186/1471-2318-12-36

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  • Myrstad, Marius; Neerland, Bjørn Erik; Hagberg, Guri & Watne, Leiv Otto (2017). Vurdering av mental status hos akutt syke gamle. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  137(12) . doi: 10.4045/tidsskr.17.0480
  • Berg, Geir Vegard; Watne, Leiv Otto & Gjevjon, Edith L Roth (2016). Ny screening gir sikrere diagnose - Bruk av screeninginstrumentet 4AT kan forbedre diagnostiseringen av akutt delirium. . Tidsskriftet sykepleien.  ISSN 0806-7511.  104(3), s 52- 53 . doi: 10.4220/Sykepleiens.2016.56686
  • Wyller, Torgeir Bruun & Watne, Leiv Otto (2016). Re: En kvinne i 70-årene med rask forverring av kognitiv funksjon. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  136(16), s 1325- 1325 . doi: 10.4045/tidsskr.16.0686
  • Johnsen, Lars Gunnar; Watne, Leiv Otto; Frihagen, Frede Jon; Helbostad, Jorunn L.; Prestmo, Anders; Saltvedt, Ingvild; Sletvold, Olav & Wyller, Torgeir Bruun (2015). Hvorfor ortogeriatri?. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  135(6), s 523- 524 . doi: 10.4045/tidsskr.15.0188
  • Neerland, Bjørn Erik; Ahmed, Marc; Watne, Leiv Otto; Roksund Hov, Karen & Wyller, Torgeir Bruun (2014). Ny bevissthetsskala ved delirium. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  134(2), s 150- 150 . doi: 10.4045/tidsskr.13.1603
  • Watne, Leiv Otto; Wyller, Torgeir Bruun; Hall, Roanna J. & MacLullich, Alasdair M.J. (2014). Response to Paul regal. Journal of The American Geriatrics Society.  ISSN 0002-8614.  62(7), s 1415 . doi: 10.1111/jgs.12875
  • Johannessen, Aud & Watne, Leiv Otto (2013). Fjernundervisning i geriatri og alderspsykiatri. Bruk av IT for å utvikle kunnskaper og erfaringer. Tidsskriftet Demens & Alderspsykiatri.  ISSN 1890-4130.  16(4), s 12
  • Watne, Leiv Otto (2013). Assessment of biomarkers in cerebrospinal fluid (CSF) from hip fracture patients with and without delirium. Congress presentation, Anestesiologisk høstmøte, Lillestrøm 24.oktober 2013.
  • Watne, Leiv Otto (2013). Delirium og demens, Demensdagene, Oslo Kongressenter 03.12.13.
  • Watne, Leiv Otto (2013). Effect of a New Dedicated Pre- and Post-operative Orthogeriatric Service on Cognitive Function in Patients with Hip Fractures. ADS meeting, Indianapolis, USA. 04.06.13.
  • Watne, Leiv Otto (2013). Inflammasjon og delirium. Congress presentation, Den femte norske kongressen i geriatri.
  • Watne, Leiv Otto (2013). Ortogeriatri i Norge og i verden. Congress presentation. Høstmøte i norsk ortopedisk forening. Oslo 23. Oktober 2013.
  • Watne, Leiv Otto (2013). The Oslo Orthogeriatric Trial, Congress presentation, Ortopedisk høstmøte, Oslo 24.oktober 2013.
  • Watne, Leiv Otto (2013). The Oslo Orthogeriatric Trial. Congress presentation, Den femte norske kontressen i geriatri, Oslo.
  • Johannessen, Aud & Watne, Leiv Otto (2012). Fjernundervisning i geriatri og alderpsykiatri- Bruk av IT for å utveksle kunnskaper og erfaringer. Demens : tidsskrift om demenssykdommer.  ISSN 0809-3520.  16(4), s 12- 12
  • Watne, Leiv Otto (2012). Assessment of Anticholinergic Acitivity and Inflammatory Biomarkers in CSF for Hip Fracture Patients With and Without Delirium. ADS meeting, Indianapolis, USA. 03.06.13.
  • Watne, Leiv Otto (2012). Loss of integrity of the blood-brain barrier, assessed with Q-albumin, is not associated with delirium in hip fracture patients. Watne LO, Ræder J, Frihagen F, Wyller T et al. Congress Presentation, American Delirium Society, Indianapolis June 2012.
  • Watne, Leiv Otto (2012). No difference in anticholinergic activity in CSF and serum between hip fracture patients with and without delirium. Congress presentation, , Copenhagen June 2012.
  • Watne, Leiv Otto (2012). RCT on orthogeriatric care for hip fracture patients. Congress presentation, Nordic Congress of Gerontology, Copenhagen June 2012.
  • Watne, Leiv Otto (2011). C-reactive protein is elevated in CSF in delirium in hip fracture patients without pre-fracture cognitive impairment Watne LO, Hall RJ, Ræder J, Frihagen F, Wyller T et al. Congress Presentation, American Delirium Society, Indianapolis June 2011.
  • Watne, Leiv Otto (2011). No difference in anticholinergic activity in CSF and serum between hip fracture patients with and without delirium. Watne LO, Hall RJ, Ræder J, Frihagen F, Wyller T et al. Congress Presentation, American Delirium Society, Indianapolis June 2011.
  • Watne, Leiv Otto (2010). Can better treatment and prophylaxis of delirium in the early phase of a hip fracture improve long-term cognitive outcome? Ongoing randomised, controlled trial. Watne LO, Frihagen F, Wyller T et al. Congress Presentation, European Delirium Association, Amsterdam 2010.
  • Watne, Leiv Otto (2009). Ortogeriatri - Ullevålmodellen. Congress presentation, Den tredje norske kongressen i geriatri, Oslo, 21.april 2009.
  • Watne, Leiv Otto (2008). Engasjement for det uvanlege intervjuet: Per Holck. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  118(8), s 950- 951

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Published May 27, 2016 9:09 AM - Last modified May 27, 2016 1:05 PM