Manuela Zucknick

Associate Professor - Department of Biostatistics
Image of Manuela Zucknick
Norwegian version of this page
Phone +47-22851193
Visiting address Sognsvannsveien 9 Domus Medica 0372 OSLO
Postal address Postboks 1122 Blindern 0317 OSLO

Academic interests

  • Statistical analysis of high-dimensional data
  • Statistical methods for risk prediction modelling and the evaluation of prognostic and predictive markers
  • Regularization (using penalized likelihood and Bayesian methods)
  • Bayesian methods for integrating different sources of genomic data and for incorporating prior biological knowledge in risk prediction models

Applications have been mostly in translational and clinical cancer research, in particular in the development of risk prediction models based on clinicopathological features as well as genomic and epigenomic high-throughput data.


  • Since 2015
    Associate professor, Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo
  • 04/2014 – 09/2014
    Visiting lecturer, Faculty of Statistics, TU Dortmund University, Germany
  • 2008 – 2014
    Postdoc, Division of Biostatistics, German Cancer Research Center, Heidelberg, Germany
    • 2013 – 2014
      Working group «Bayesian statistics for integrative genomics» (team leader)
    • 2008 – 2013
      Working group «Statistics for translational oncology»
  • 2004 – 2008
    PhD Biostatistics, Department of Epidemiology and Public Health, Imperial College London, United Kingdom
  • 2003 – 2004
    MSc Bioinformatics, Centre for Bioinformatics, Imperial College London, United Kingdom
  • 1998 – 2003
    Diplom Statistik, Department of Statistics, University of Dortmund, Germany

Complete CV (pdf)

Tags: biostatistics, epidemiology, integrative genomics, cancer, risk prediction, genetics


  • Ickstadt, Katja; Schäfer, Martin & Zucknick, Manuela (2018). Integrative Bayesian Approaches for Molecular Biology. Annual Review of Statistics and Its Application.  ISSN 2326-8298.  5 . doi:
  • Wolf, Christine; Garding, Angela; Filarsky, Katharina; Bahlo, Jasmin; Robrecht, Sandra; Becker, Natalia; Zucknick, Manuela; Rouhi, Arefeh; Weigel, Anja; Claus, Rainer; Weichenhan, Dieter; Eichhorst, Barbara; Fischer, Kirsten; Hallek, Michael; Kuchenbauer, Florian; Plass, Christoph; Döhner, Hartmut; Stilgenbauer, Stephan; Lichter, Peter & Mertens, Daniel (2018). NFATC1 activation by DNA hypomethylation in chronic lymphocytic leukemia correlates with clinical staging and can be inhibited by ibrutinib. International Journal of Cancer.  ISSN 0020-7136.  142(2), s 322- 333
  • Goeppert, Benjamin; Roessler, Stephanie; Becker, Natalia; Zucknick, Manuela; Vogel, Monika Nadja; Warth, Arne; Pathil‐Warth, Anita; Mehrabi, Arianeb; Schirmacher, Peter; Mollenhauer, Jan & Renner, Marcus (2017). DMBT1 expression in biliary carcinogenesis with correlation of clinicopathological data. Histopathology.  ISSN 0309-0167.  70(7), s 1064- 1071 . doi: 10.1111/his.13175
  • Henriksen, Hege; Ræder, Hanna; Bøhn, Siv Kjølsrud; Paur, Ingvild; Kværner, Ane Sørlie; Billington, S.; Eriksen, Morten Tandberg; Wiedsvang, G.; Erlund, Iris; Færden, Arne Engebreth; Veierød, Marit Bragelien; Zucknick, Manuela; Smeland, Sigbjørn & Blomhoff, Rune (2017). The Norwegian dietary guidelines and colorectal cancer survival (CRC-NORDIET) study: A food-based multicentre randomized controlled trial. BMC Cancer.  ISSN 1471-2407.  17(1) . doi: 10.1186/s12885-017-3072-4
  • Holm, Maia Blomhoff; Bastani, Nasser Ezzatkhah; Holme, Ane Moe; Zucknick, Manuela; Jansson, Thomas; Refsum, Helga; Mørkrid, Lars; Blomhoff, Rune; Henriksen, Tore & Michelsen, Trond Melbye (2017). Uptake and release of amino acids in the fetal-placental unit in human pregnancies. PLoS ONE.  ISSN 1932-6203.  12(10) . doi: 10.1371/journal.pone.0185760 Full text in Research Archive.
  • Majak, Guri Bårdstu; Reisæter, Anna Varberg; Zucknick, Manuela; Lorentzen, Bjørg; Vangen, Siri; Henriksen, Tore & Michelsen, Trond Melbye (2017). Preeclampsia in kidney transplanted women; Outcomes and a simple prognostic risk score system. PLoS ONE.  ISSN 1932-6203.  12:e0173420(3), s 1- 11 . doi: 10.1371/journal.pone.0173420
  • Treppmann, Tabea; Ickstadt, Katja & Zucknick, Manuela (2017). Integration of multiple genomic data sources in a Bayesian Cox model for variable selection and prediction. Computational & Mathematical Methods in Medicine.  ISSN 1748-670X.  2017 . doi: 10.1155/2017/7340565 Full text in Research Archive.
  • Øystese, Kristin Astrid Berland; Casar-Borota, Olivera; Normann, Kjersti Ringvoll; Zucknick, Manuela; Berg, Jens Petter & Bollerslev, Jens (2017). Estrogen Receptor α, a Sex-Dependent Predictor of Aggressiveness in Nonfunctioning Pituitary Adenomas: SSTR and Sex Hormone Receptor Distribution in NFPA. Journal of Clinical Endocrinology and Metabolism.  ISSN 0021-972X.  102(9), s 3581- 3590 . doi: 10.1210/jc.2017-00792
  • Øystese, Kristin Astrid Berland; Zucknick, Manuela; Casar-Borota, Olivera; Ringstad, Geir & Bollerslev, Jens (2017). Early postoperative growth in non-functioning pituitary adenomas; A tool to tailor safe follow-up. Endocrine (Basingstoke).  ISSN 1355-008X.  57(1), s 35- 45 . doi: 10.1007/s12020-017-1314-5
  • Joshi, Sarita; Schjølberg, Aasa Rambæk; Ekstrøm, Per Olaf; De Angelis, Paula; Zucknick, Manuela; Andersen, Solveig Norheim & Clausen, Ole Petter Fraas (2016). Tp53/p53 status in keratoacanthomas. Journal of cutaneous pathology.  ISSN 0303-6987.  43(7), s 571- 578 . doi: 10.1111/cup.12713
  • Kap, Elisabeth J; Seibold, Petra; Scherer, Dominique; Habermann, Nina; Balavarca, Yesilda; Jansen, Lina; Zucknick, Manuela; Becker, Natalia; Hoffmeister, Michael; Ulrich, Alexis; Benner, Axel; Ulrich, Cornelia M; Burwinkel, Barbara; Brenner, Hermann & Chang-Claude, Jenny (2016). SNPs in transporter and metabolizing genes as predictive markers for oxaliplatin treatment in colorectal cancer patients. International Journal of Cancer.  ISSN 0020-7136.  138(12), s 2993- 3001 . doi: 10.1002/ijc.30026
  • Kostareli, Efterpi; Hielscher, Thomas; Zucknick, Manuela; Baboci, Lorena; Wichmann, Gunnar; Holzinger, Dana; Mucke, Oliver; Pawlita, Michael; Del Mistro, Annarosa; Boscolo-Rizzo, Paolo; Da Mosto, Maria Cristina; Tirelli, Giancarlo; Plinkert, Peter; Dietz, Andreas; Plass, Christoph; Weichenhan, Dieter & Hess, Jochen (2016). Gene promoter methylation signature predicts survival of head and neck squamous cell carcinoma patients. Epigenetics.  ISSN 1559-2294.  11(1), s 61- 73 . doi: 10.1080/15592294.2015.1137414
  • Madhavan, Dharanija; Peng, Cike; Wallwiener, Markus; Zucknick, Manuela; Nees, Juliane; Schott, Sarah; Rudolph, Anja; Riethdorf, Sabine; Trumpp, Andreas; Pantel, Klaus; Sohn, Christof; Chang-Claude, Jenny; Schneeweiss, Andreas & Burwinkel, Barbara (2016). Circulating miRNAs with prognostic value in metastatic breast cancer and for early detection of metastasis. Carcinogenesis.  ISSN 0143-3334.  37(5), s 461- 470 . doi: 10.1093/carcin/bgw008
  • Mock, Andreas; Geisenberger, Christoph; Orlik, Christian; Warta, Rolf; Schwager, Christian; Jungk, Christine; Dutruel, Celine; Geiselhart, Lea; Weichenhan, Dieter; Zucknick, Manuela; Nied, Ann-Katrin; Friauf, Sara; Exner, Janina; Capper, David; Hartmann, Christian; Lahrmann, Bernd; Grabe, Niels; Debus, Jurgen; Von Deimling, Andreas; Popanda, Odilia; Plass, Christoph; Unterberg, Andreas; Abdollahi, Amir; Schmezer, Peter & Herold-Mende, Christel (2016). LOC283731 promoter hypermethylation prognosticates survival after radiochemotherapy in IDH1 wild-type glioblastoma patients. International Journal of Cancer.  ISSN 0020-7136.  139(2), s 424- 432 . doi: 10.1002/ijc.30069
  • Chen, Hongda; Zucknick, Manuela; Werner, Simone; Knebel, Phillip & Brenner, Hermann (2015). Head-to-head comparison and evaluation of 92 plasma protein biomarkers for early detection of colorectal cancer in a true screening setting. Clinical Cancer Research.  ISSN 1078-0432.  21(14), s 3318- 3326 . doi: 10.1158/1078-0432.CCR-14-3051
  • Goeppert, Benjamin; Frauenschuh, Lena; Zucknick, Manuela; Roessler, Stephanie; Mehrabi, Arianeb; Hafezi, Mohammadreza; Stenzinger, Albrecht; Warth, Arne; Pathil, Anita; Renner, Marcus; Schirmacher, Peter & Weichert, Wilko (2015). Major histocompatibility complex class I expression impacts on patient survival and type and density of immune cells in biliary tract cancer. British Journal of Cancer.  ISSN 0007-0920.  113(9), s 1343- 1349
  • Yang, Rongxi; Pfütze, Katrin; Zucknick, Manuela; Sutter, Christian; Wappenschmidt, Barbara; Marme, Frederik; Qu, Bin; Cuk, Katarina; Engel, Christoph; Schott, Sarah; Schneeweiss, Andreas; Brenner, Hermann; Claus, Rainer; Plass, Christoph; Bugert, Peter; Hoth, Markus; Sohn, Christof; Schmutzler, Rita; Bartram, Claus R & Burwinkel, Barbara (2015). DNA methylation array analyses identified breast cancer‐associated HYAL2 methylation in peripheral blood. International Journal of Cancer.  ISSN 0020-7136.  136(8), s 1845- 1855
  • Zucknick, Manuela; Saadati, Maral & Benner, Axel (2015). Nonidentical twins: Comparison of frequentist and Bayesian lasso for Cox models. Biometrical Journal.  ISSN 0323-3847.  57(6), s 959- 981 . doi: 10.1002/bimj.201400160

View all works in Cristin

  • Filarsky, Katharina; Garding, Angela; Becker, Natalia; Wolf, Christine; Zucknick, Manuela; Claus, Rainer; Weichenhan, Dieter; Plass, Christoph; Döhner, Hartmut; Stilgenbauer, Stephan; Lichter, Peter & Mertens, Daniel (2016). Krüppel-like factor 4 (KLF4) inactivation in chronic lymphocytic leukemia correlates with promoter DNA-methylation and can be reversed by inhibition of NOTCH signaling. Haematologica.  ISSN 0390-6078.  101(6), s e249- e253 . doi: 10.3324/haematol.2015.138172
  • Hellton, Kristoffer Herland & Zucknick, Manuela (2016). Drug synergy prediction for personalized therapy.
  • Lipka, Daniel B.; Witte, Tania; Wiesenfarth, Manuel; Zucknick, Manuela; Konermann, Carolin; Gu, Lei; Claus, Rainer; Nöllke, Peter; Niemeyer, Charlotte M; Flotho, Christian & Plass, Christoph (2015). Genome-wide DNA methylation profiling reveals two prognostically distinct subgroups of juvenile myelomonocytic leukemia. Experimental Hematology.  ISSN 0301-472X.  43(9), s S47
  • Maierthaler, Melanie; Mennesson, Eric; Cuk, Katarina; Madhavan, Dharanija; Zucknick, Manuela; Fixe, Isabelle; Foucher, Alexandra; Wallwiener, Markus; Schneeweiss, Andreas; Normand, Nadia & Burwinkel, Barbara (2015). Comparison of different highly sensitive miRNA array platforms for the investigation of circulating cell-free microRNAs in blood. Cancer Research.  ISSN 0008-5472.  75(15), s 3973- 3973

View all works in Cristin

Published Jan. 5, 2015 12:33 PM - Last modified Jan. 7, 2015 9:40 AM