Sandip Kanse

Image of Sandip Kanse
Norwegian version of this page
Phone +47-22851464
Room 1256
Username
Visiting address Sognsvannsveien 9 Domus Medica 0372 OSLO
Postal address Postboks 1112 Blindern 0317 OSLO

Academic Interests

  • Proteases in vascular biology
  • Atherosclerosis/stroke/myocardial Infarction
  • Thrombosis/haemostasis
  • Inflammation

Courses taught

  • Medical Biochemistry

Background

Academic background

  • Habilitation, University of Giessen, Germany, 2003
  • PhD, University of London, UK, 1986-1991
  • BSc Biochemistry, University of London, UK 1983-1986

Previous positions held

  • Member of the Excellence Cluster in Cardiopulmonary Sciences (ECCPS), University of Giessen, Germany (2007-2014)
  • Member of the Sonderforschungsbereich SFB-547 University of Giessen, Germany (2006-2009)
  • Faculty Member, University of Giessen, Germany, 1999-2011
  • Postdoctoral Fellow, Max Planck Institute, Bad Nauheim, Germany, 1994-1998
  • Postdoctoral Fellow, Thrombosis Research Institute, London, UK 1992-1993

Collaboration

  • Jan Marcus Daniel, Giessen, Germany
  • Joerg Herold, Magdeburg, Germany
  • Christina Jern, Gothenburg, Sweden
  • Paul Declerck, Leuven, Belgium
  • Ralf Weiskirchen, Aachen, Germany
  • Michael Etscheid, Langen, Germany
  • Markus Huber-Lang, Ulm, Germany
  • Marcus Krueger, Bad Nauheim, Germany
  • Christoph Reichel, Munich Germany
  • Denis Vivien, Caen, France
  • Radislav Sedlacek, Prague, The Czech Republic
  • Per Morten Sandset, Oslo, Norway
  • Geir Åge Løset, Oslo, Norway
  • Jens Preben Morth, Oslo, Norway
Tags: Atherosclerosis, Thrombosis, Coagulation, Fibrinolysis, Proteases, Heart vascular and lungs, Inflammation, Cardiovascular disease, Blood and immunology

Publications

  • Chavakis T, Hussain M, Kanse SM, Peters G, Bretzel RG, Flock JI, Herrmann M and Preissner KT. Staphylococcus aureus extracellular adherence protein serves as anti- inflammatory factor by inhibiting the recruitment of host leukocytes. Nature Medicine. 2002;8:687-93.
  • Deindl E, Ziegelhoffer T, Kanse SM, Fernandez B, Neubauer E, Carmeliet P, Preissner KT and Schaper W. Receptor-independent role of the urokinase-type plasminogen activator during arteriogenesis. FASEB Journal. 2003;17:1174-6.
  • Kannemeier C, Al-Fakhri N, Preissner KT and Kanse SM. Factor VII activating protease (FSAP) inhibits growth factor-mediated cell proliferation and migration of vascular smooth muscle cells. FASEB Journal. 2004;18:728-30.
  • Sedding D, Daniel JM, Muhl L, Hersemeyer K, Brunsch H, Kemkes-Matthes B, Braun-Dullaeus RC, Tillmanns H, Weimer T, Preissner KT and Kanse SM. The G534E polymorphism of the gene encoding the factor VII-activating protease is associated with cardiovascular risk due to increased neointima formation. The Journal of Experimental Medicine. 2006;203:2801-7.
  • Shibamiya A, Muhl L, Tannert-Otto S, Preissner KT and Kanse SM. Nucleic acids potentiate Factor VII-activating protease (FSAP)-mediated cleavage of platelet-derived growth factor-BB and inhibition of vascular smooth muscle cell proliferation. The Biochemical Journal. 2007;404:45-50.
  • Parahuleva MS, Kanse SM, Parviz B, Barth A, Tillmanns H, Bohle RM, Sedding DG and Holschermann H. Factor Seven Activating Protease (FSAP) expression in human monocytes and accumulation in unstable coronary atherosclerotic plaques. Atherosclerosis. 2008;196:164-71.
  • Roderfeld M, Weiskirchen R, Atanasova S, Gressner AM, Preissner KT, Roeb E and Kanse SM. Altered factor VII activating protease expression in murine hepatic fibrosis and its influence on hepatic stellate cells. Liver International. 2009;29:686.
  • Shibamiya A, Hersemeyer K, Schmidt Woll T, Sedding D, Daniel JM, Bauer S, Koyama T, Preissner KT and Kanse SM. A key role for Toll-like receptor-3 in disrupting the hemostasis balance on endothelial cells. Blood. 2009;113:714-22.
  • Wasmuth HE, Tag CG, Van de Leur E, Hellerbrand C, Mueller T, Berg T, Puhl G, Neuhaus P, Samuel D, Trautwein C, Kanse SM and Weiskirchen R. The Marburg I variant (G534E) of the factor VII-activating protease determines liver fibrosis in hepatitis C infection by reduced proteolysis of platelet-derived growth factor BB. Hepatology. 2009;49:775-80.
  • Reichel CA, Uhl B, Lerchenberger M, Puhr-Westerheide D, Rehberg M, Liebl J, Khandoga A, Schmalix W, Zahler S, Deindl E, Lorenzl S, Declerck PJ, Kanse S and Krombach F. Urokinase-type plasminogen activator promotes paracellular transmigration of neutrophils via mac-1, but independently of urokinase-type plasminogen activator receptor. Circulation. 2011;124:1848-59.
  • Hanson E, Kanse SM, Joshi A, Jood K, Nilsson S, Blomstrand C and Jern C. Plasma factor VII-activating protease antigen levels and activity are increased in ischemic stroke. Journal of Thrombosis and Haemostasis. 2012;10:848-56.
  • Kanse SM, Declerck PJ, Ruf W, Broze G and Etscheid M. Factor VII-activating protease promotes the proteolysis and inhibition of tissue factor pathway inhibitor. Arteriosclerosis, Thrombosis, and Vascular Biology. 2012;32:427-33.
  • Kanse SM, Gallenmueller A, Zeerleder S, Stephan F, Rannou O, Denk S, Etscheid M, Lochnit G, Krueger M and Huber-Lang M. Factor VII-activating protease is activated in multiple trauma patients and generates anaphylatoxin C5a. Journal of Immunol. 2012;188:2858-65.
  • Borkham-Kamphorst E, Zimmermann HW, Gassler N, Bissels U, Bosio A, Tacke F, Weiskirchen R and Kanse SM. Factor VII activating protease (FSAP) exerts anti-inflammatory and anti-fibrotic effects in liver fibrosis in mice and men. Journal of Hepatology. 2013;58:104-11.
  • Parahuleva MS, Maj R, Holschermann H, Parviz B, Abdallah Y, Erdogan A, Tillmanns H and Kanse SM. Regulation of monocyte/macrophage function by factor VII activating protease (FSAP). Atherosclerosis. 2013;230:365-72.
  • Roedel EK, Schwarz E and Kanse SM. The Factor VII-activating protease (FSAP) enhances the activity of bone morphogenetic protein-2 (BMP-2). The Journal of Biological Chemistry. 2013;288:11.
  • Espada Serrano, Sandra; Stavik, Benedicte; Holm, Sverre; Sagen, Ellen Lund; Bjerkeli, Vigdis; Skjelland, Mona; Dahl, Tuva Børresdatter; Espevik, Terje; Kanse, Sandip; Sandset, Per Morten; Skretting, Grethe & Halvorsen, Bente (2017). Tissue factor pathway inhibitor attenuates ER stress-induced inflammation in human M2-polarized macrophages. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  491(2), s 442- 448 . doi: 10.1016/j.bbrc.2017.07.070
  • Herold, Joerg; Nowak, Steven; Kostin, Sawa; Daniel, Jan-Marcus; Francke, Alexander; Subramaniam, Saravanan; Braun-Dullaeus, Ruediger C. & Kanse, Sandip (2017). Factor VII activating protease (FSAP) influences vascular remodeling in the mouse hind limb ischemia model. American journal of translational research.  ISSN 1943-8141.  9(6), s 3084- 3095
  • Kara, Emrah; Manna, Dipankar; Løset, Geir Åge; Schneider, E L; Craik, C S & Kanse, Sandip (2017). Analysis of the substrate specificity of Factor VII activating protease (FSAP) and design of specific and sensitive peptide substrates. Thrombosis and Haemostasis.  ISSN 0340-6245. . doi: 10.1160/TH17-02-0081
  • Reiterer-Farhan, Veronika; Figueras‐Puig, Cristina; Le Guerroue,, Francois; Confalonieri, Stefano; Vecchi, Manuela; Jalapothu, Dasaradha; Kanse, Sandip; Deshaies, Raymond J; Di Fiore, Pier Paolo; Behrends, Christian & Farhan, Hesso (2017). The pseudophosphatase STYX targets the F‐box of FBXW7 and inhibits SCFFBXW7 function. EMBO Journal.  ISSN 0261-4189.  36(3), s 260- 273 . doi: 10.15252/embj.201694795
  • Bustamante, Alejandro; Diaz-Fernandez, Belen; Giralt, Dolors; Boned, Sandra; Pagola, Jorge; Molina, Carlos; Garcia-Berrocosco, Teresa; Kanse, Sandip & Montaner, Joan (2016). Factor seven activating protease (FSAP) predicts response to intravenous thrombolysis in acute ischemic stroke. International Journal of Stroke.  ISSN 1747-4930.  11(6), s 646- 655 . doi: 10.1177/1747493016641949
  • Cheng, Yu-Ching; Stanne, Tara M.; Giese, Anne-Katrin; Ho, Weang Kee; Traylor, Matthew; Amouyel, Philippe; Holliday, Elizabeth G.; Malik, Rainer; Xu, Huichun; Kittner, Steven J.; Cole, John W.; O'Connell, Jeffrey R.; Danesh, John; Rasheed, Asif; Zhao, Wei; Engelter, Stefan; Grond-Ginsbach, Caspar; Kamatani, Yoichiro; Lathrop, Mark; Leys, Didier; Thijs, Vincent; Metso, Tiina M.; Tatlisumak, Turgut; Pezzini, Alessandro; Parati, Eugenio A.; Norrving, Bo; Bevan, Steve; Rothwell, Peter M.; Sudlow, Cathie; Slowik, Agnieszka; Lindgren, Arne; Walters, Matthew R.; Jannes, Jim; Shen, Jess; Crosslin, David; Doheny, Kimberly; Laurie, Cathy C.; Kanse, Sandip; Bis, Joshua C.; Fornage, Myriam; Mosley, Thomas H.; Hopewell, Jemma C.; Strauch, Konstantin; Muller-Nurasyid, Martina; Gieger, Christian; Waldenberger, Melanie; Peters, Annette; Meisinger, Christine; Ikram, M. Arfan; Longstreth, William T.E.; Meschia, James F.; Seshadri, Sudha; Sharma, Pankaj; Worrall, Bradford; Jern, Christina; Levi, Christopher; Dichgans, Martin; Boncoraglio, Giorgio B.; Markus, Hugh S.; Debette, Stephanie; Rolfs, Arndt; Saleheen, Danish & Mitchell, Braxton D. (2016). Genome-wide association analysis of young-onset stroke identifies a locus on chromosome 10q25 near HABP2. Stroke.  ISSN 0039-2499.  47(2), s 307- 316 . doi: 10.1161/STROKEAHA.115.011328
  • Chillo, Omary; Kleinert, Eike Christian; Lautz, Thomas; Lasch, Manuel; Pagel, Judith-Irina; Heun, Yvonn; Troidl, Kerstin; Fischer, Silvia; Caballero-Martinez, Amelia; Mauer, Annika; Kurz, Angela; Assmann, Gerald; Rehberg, Markus; Kanse, Sandip; Nieswandt, Bernhard; Walzog, Barbara; Reichel, Christoph A.; Mannell, Hanna; Preissner, Klaus T. & Deindl, E. (2016). Perivascular mast cells govern shear stress-induced arteriogenesis by orchestrating leukocyte function. Cell reports.  ISSN 2211-1247.  16(8), s 2197- 2207 . doi: 10.1016/j.celrep.2016.07.040
  • Cui, Xue-Yan; Tinholt, Mari; Stavik, Benedicte; Dahm, Anders Erik A; Kanse, Sandip; Jin, Yang; Seidl, Sebastian; Sahlberg, Kristine Kleivi; Iversen, Nina; Skretting, Grethe & Sandset, Per Morten (2016). Effect of hypoxia on tissue factor pathway inhibitor expression in breast cancer. Journal of Thrombosis and Haemostasis.  ISSN 1538-7933.  14(2), s 387- 396 . doi: 10.1111/jth.13206
  • Daniel, JM; Reichel, Christoph A.; Schmidt-Woell, T.; Dutzmann, J.; Zuchtriegel, G.; Krombach, Fritz; Herold, J.; Bauersachs, J; Sedding, DG & Kanse, Sandip (2016). Factor VII-activating protease deficiency promotes neointima formation by enhancing leukocyte accumulation.. Journal of Thrombosis and Haemostasis.  ISSN 1538-7933.  14(10), s 2058- 2067 . doi: 10.1111/jth.13417
  • Leiting, Silke; Seidl, Sebastian; Martinez-Palaciàn, Adoraciòn; Muhl, Lars & Kanse, Sandip (2016). Transforming growth factor-β (TGF-β) inhibits the expression of factor VII-activating protease (FSAP) in hepatocytes. Journal of Biological Chemistry.  ISSN 0021-9258.  291(40), s 21020- 21028 . doi: 10.1074/jbc.M116.744631
  • Joshi, Amit; Orset, Cyrille; Engelhardt, Britta; Baumgart-Vogt, Eveline; Gerriets, Tibo; Vivien, Denis & Kanse, Sandip (2015). Deficiency of Factor VII Activating Protease (FSAP) alters the outcome of ischemic stroke in mice. European Journal of Neuroscience.  ISSN 0953-816X. . doi: 10.1111/ejn.12830
  • Reichel, Christoph A.; Hessenauer, Maximilian E.T.; Pflieger, Kerstin; Rehberg, Markus; Kanse, Sandip; Zahler, Stefan; Krombach, Fritz; Berghaus, Alexander & Strieth, Sebastian (2015). Components of the plasminogen activation system promote engraftment of porous polyethylene biomaterial via common and distinct effects. PLoS ONE.  ISSN 1932-6203.  10:e0116883(2) . doi: 10.1371/journal.pone.0116883
  • Subramaniam, Saravanan; Thielmann, Ina; Morowski, Martina; Pragst, Ingo; Sandset, Per Morten; Nieswandt, Bernhard; Etscheid, Michael & Kanse, Sandip (2015). Defective thrombus formation in mice lacking endogenous factor VII activating protease (FSAP). Thrombosis and Haemostasis.  ISSN 0340-6245.  113(4), s 870- 880 . doi: 10.1160/TH14-06-0519
  • Martinez-Palaciàn, Adoraciòn; Kanse, Sandip & Weiskirchen, Ralf (2014). Factor VII activating protease (FSAP): A novel protective factor in liver fibrosis. PROTEOMICS - Clinical Applications.  ISSN 1862-8354.  8(5-6), s 438- 446 . doi: 10.1002/prca.201300078
  • Parahuleva, Mariana S.; Kanse, Sandip; Hölschermann, Hans; Zheleva, Kirila; Zandt, Daniel; Worsch, Michael; Parviz, Behnoush; Güttler, Norbert; Tillmanns, Harald; Böning, Andreas & Erdogan, Ali (2014). Association of circulating factor seven activating protease (FSAP) and of oral Omega-3 fatty acids supplements with clinical outcome in patients with atrial fibrillation: the OMEGA-AF study. Journal of Thrombosis and Thrombolysis.  ISSN 0929-5305.  37(3), s 317- 325 . doi: 10.1007/s11239-013-0921-0
  • Subramaniam, Saravanan & Kanse, Sandip (2014). Ferric Chloride–Induced Arterial Thrombosis in Mice. Current Protocols in Mouse Biology.  ISSN 2161-2617. . doi: 10.1002/9780470942390.mo140140
  • Borkham-Kamphorst, Erawan; Zimmermann, Henning W.; Gassler, Nikolaus; Bissels, Ute; Bosio, Andreas; Tacke, Frank; Wisekirchen, Ralf & Kanse, Sandip (2013). Factor VII activating protease (FSAP) exerts anti-inflammatory and anti-fibrotic effects in liver fibrosis in mice and men. Journal of Hepatology.  ISSN 0168-8278.  58(1), s 104- 111 . doi: 10.1016/j.jhep.2012.09.007
  • Parahuleva, Mariana S; Ball, N; Parviz, Behnoush; Zandt, Daniel; Abdallah, Yaser; Tillmanns, Harald; Hoelschermann, H & Kanse, Sandip (2013). Factor seven activating protease (FSAP) expression in human placenta and its role in trophoblast migration. European Journal of Obstetrics, Gynecology, and Reproductive Biology.  ISSN 0301-2115.  167(1), s 34- 40 . doi: 10.1016/j.ejogrb.2012.10.035
  • Parahuleva, Mariana S.; Maj, Robert; Hölschermann, Hans; Parviz, Behnoush; Abdallah, Yaser; Erdogan, Ali; Tillmanns, Harald & Kanse, Sandip (2013). Regulation of monocyte/macrophage function by factor VII activating protease (FSAP). Atherosclerosis.  ISSN 0021-9150.  230(2), s 365- 372 . doi: 10.1016/j.atherosclerosis.2013.08.007
  • Roedel, Elfie Kathrin; Schwarz, Elisabeth & Kanse, Sandip (2013). The Factor VII-activating Protease (FSAP) Enhances the Activity of Bone Morphogenetic Protein-2 (BMP-2). Journal of Biological Chemistry.  ISSN 0021-9258.  288(10), s 7193- 7203 . doi: 10.1074/jbc.M112.433029
  • Fraineau, Sylvain; Monvoisin, Arnaud; Clarhaut, Jonathan; Talbot, Julie; Simonneau, Claire; Kanthou, Chryso; Kanse, Sandip; Philippe, Michel & Benzakour, Omar (2012). The vitamin K-dependent anti-coagulant factor, protein S, inhibits multiple VEGF-A-induced angiogenesis events in a Mer- and SHP2-dependent manner. Blood.  ISSN 0006-4971.  120(25), s 5073- 5083 . doi: 10.1182/blood-2012-05-429183
  • Huber-Lang, Markus; Denk, Stephanie; Fulda, Simone; Erler, Ellen; Kalbitz, Miriam; Weckbach, Sebastian; Schneider, E Marion; Weiss, Manfred; Kanse, Sandip & Perl, Mario (2012). Cathepsin D is released after severe tissue trauma in vivo and is capable of generating C5a in vitro. Molecular Immunology.  ISSN 0161-5890.  50(1-2), s 60- 65 . doi: http://dx.doi.org/10.1016/j.molimm.2011.12.005
  • Kanse, Sandip; Declerk, Paul J; Ruf, Wolfram; Broze, George & Etscheid, Michael (2012). Factor VII activating protease (FSAP) promotes the proteolysis and inhibition of tissue factor pathway inhibitor. Arteriosclerosis, Thrombosis and Vascular Biology.  ISSN 1079-5642.  32, s 427- 433
  • Kanse, Sandip; Gallenmueller, Andrea; Zeerleder, Sasha; Stephan, Femke; Rannou, Olivier; Denk, Stephanie; Etscheid, Michael; Lochnit, Guenter; Kreuger, Marcus & Huber-Lang, Markus (2012). Factor VII activating protease (FSAP) is massively activated in multiple trauma patients and generates anaphylatoxin C5a. Journal of Immunology.  ISSN 0022-1767.  188(6), s 2858- 2865
  • Parahuleva, Mariana S; Hölschermann, Hans; Zandt, Daniel; Pons-Kühnemann, Jörn; Parviz, Behnoush; Weiskirchen, Ralf; Staubitz, Anne; Tillmanns, Harald; Erdogan, Ali & Kanse, Sandip (2012). Circulating Factor VII Activating Protease (FSAP) Is Associated With Clinical Outcome in Acute Coronary Syndrome. Circulation Journal.  ISSN 1346-9843.  76(11), s 2653- 2661 . doi: 10.1253/circj.CJ-11-1502
  • Parahuleva, Mariana S; Langanke, Eva; Hölschermann, Hans; Parviz, Behnoush; Abdallah, Yaser; Stracke, Siegbert; Tillmanns, Harald & Kanse, Sandip (2012). Nicotine Modulation of Factor VII Activating Protease (FSAP) Expression in Human Monocytes. Journal of atherosclerosis and thrombosis.  ISSN 1340-3478.  19(11), s 962- 969 . doi: 10.5551/jat.9589
  • Reichel, Christoph A.; Kanse, Sandip & Krombach, Fritz (2012). At the Interface of Fibrinolysis and Inflammation: The Role of Urokinase-Type Plasminogen Activator in the Leukocyte Extravasation Cascade. Trends in cardiovascular medicine.  ISSN 1050-1738.  22(7), s 192- 196 . doi: 10.1016/j.tcm.2012.07.019
  • Etscheid, Michael; Muhl, L.; Pons, D.; Jukema, J. Wouter; Konig, H. & Kanse, Sandip (2012). The Marburg I polymorphism of factor VII activating protease is associated with low proteolytic and low pro-coagulant activity. Thrombosis Research.  ISSN 0049-3848.  130(6), s 935- 941 . doi: 10.1016/j.thromres.2012.07.023
  • Hanson, E; Kanse, Sandip; Joshi, A; Jood, K; Nilsson, S; Blomstrand, C & Jern, C (2012). Plasma factor VII-activating protease antigen levels and activity are increased in ischemic stroke. Journal of Thrombosis and Haemostasis.  ISSN 1538-7933.  10(5), s 848- 856 . doi: 10.1111/j.1538-7836.2012.04692.x
  • Kanse, Sandip; Declerck, Paul J.; Ruf, Wolfram; Broze, George & Etscheid, Michael (2012). Factor VII-Activating Protease Promotes the Proteolysis and Inhibition of Tissue Factor Pathway Inhibitor. Arteriosclerosis, Thrombosis and Vascular Biology.  ISSN 1079-5642.  32(2), s 427- U619 . doi: 10.1161/ATVBAHA.111.238394
  • Kanse, Sandip; Gallenmueller, Andrea; Zeerleder, Sacha; Stephan, Femke; Rannou, Olivier; Denk, Stephanie; Etscheid, Michael; Lochnit, Guenter; Krueger, Marcus & Huber-Lang, Markus (2012). Factor VII-Activating Protease Is Activated in Multiple Trauma Patients and Generates Anaphylatoxin C5a. Journal of Immunology.  ISSN 0022-1767.  188(6), s 2858- 2865 . doi: 10.4049/jimmunol.1103029

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  • Kara, Emrah; Manna, Dipankar; Løset, Geir Åge; Schneider, Eric L.; Craik, Charles S. & Kanse, Sandip (2017). Analysis of the Substrate Specificity of Factor VII Activating Protease (FSAP) and Design of a Specific and Sensitive Peptide Substrate. Res Pract Thromb Haemost.  s 560- 560 . doi: 10.1002/rth2.12012
  • Nielsen, Nis Valentin; Manna, Dipankar; J. Preben, Morth; Roedel, Elfie; Etscheid, Michael & Kanse, Sandip (2017). Factor VII Activating Protease (FSAP) and Marburg I (G534E) Polymorphism; How One Amino Acid Determines Function. Res Pract Thromb Haemost.  s 358- 359 . doi: 10.1002/rth2.12012
  • Nielsen, Nis Valentin; Morth, Jens Preben & Kanse, Sandip (2016). Structure function analysis of Factor Seven Activating Protease (FSAP) a protease in vascular biology.
  • Kanse, Sandip (2015). Factor VII activating protease (FSAP):From single nucleotide polymorphisms to mechanisms of action in thrombosis and vascular diseases.
  • Nielsen, Nis Valentin; Morth, Jens Preben & Kanse, Sandip (2015). Expression, Purification and Refolding of Factor Seven Activating Protease(FSAP) for structure function analysis.
  • Nielsen, Nis Valentin; Morth, Jens Preben & Kanse, Sandip (2015). Purification and refolding of Factor Seven Activating Protease (FSAP) a protease in vascular biology.
  • Nielsen, Nis Valentin; Morth, Jens Preben & Kanse, Sandip (2015). Purification and refolding of Factor Seven Activating Protease (FSAP) a protease in vascular biology.

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Published Jan. 12, 2012 2:25 PM - Last modified June 2, 2014 9:03 AM

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