Selected publications

  • Dragich JM, Kuwajima T, Hirose-Ikeda M, Yoon MS, Eenjes E, Bosco JR, Fox LM, Lystad AH, Oo TF, Yarygina O, Mita T, Waguri S, Ichimura Y, Komatsu M, Simonsen A, Burke RE, Mason CA, Yamamoto A. Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain. Elife. 2016 Sep 20;5.

  • Shatz O, Holland P, Elazar Z, Simonsen A. Complex Relations Between Phospholipids, Autophagy, and Neutral Lipids. Trends Biochem Sci. 2016 Nov;41(11):907-923. Review.

  • Lystad AH, Simonsen A. Phosphoinositide-binding proteins in autophagy. FEBS Lett. 2016 Aug;590(15):2454-68. Review.

  • Holland P and Simonsen A.  Actin shapes the autophagosome. Nat Cell Biol. 2015 Sep;17(9):1094-6.

  • Ylä-Anttila P, Mikkonen E, Happonen KE, Holland P, Ueno T, Simonsen A, Eskelinen EL. RAB24 facilitates clearance of autophagic compartments during basal conditions. Autophagy. 2015; 11(10):1833-48.

  • Carlsson SR, Simonsen A. Membrane dynamics in autophagosome biogenesis. J Cell Sci. 2015 15;128(2):193-205.

  • Lystad AH, Simonsen A. Assays to monitor aggrephagy. Methods. 2015;75:112-9. 

  • Holland P, Torgersen ML, Sandvig K, Simonsen A (2014) LYST affects lysosome size and quantity, but not trafficking or degradation through autophagy or endocytosis. Traffic 15: 1390-1405

  • Lystad AH, Ichimura Y, Takagi K, Yang Y, Pankiv S, Kanegae Y, Kageyama S, Suzuki M, Saito I, Mizushima T, Komatsu M, Simonsen A (2014) Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures. EMBO reports
  • Torgersen ML, Simonsen A (2013) Autophagy: friend or foe in the treatment of fusion protein-associated leukemias? Autophagy 9: 2175-2177

  • Isakson P, Lystad AH, Breen K, Koster G, Stenmark H, Simonsen A (2013) TRAF6 mediates ubiquitination of KIF23/MKLP1 and is required for midbody ring degradation by selective autophagy. Autophagy 9: 1955-1964
  • Knaevelsrud H, Carlsson SR, Simonsen A (2013) SNX18 tubulates recycling endosomes for autophagosome biogenesis. Autophagy 9: 1639-1641

  • Torgersen ML, Engedal N, Boe SO, Hokland P, Simonsen A (2013) Targeting autophagy potentiates the apoptotic effect of histone deacetylase inhibitors in t(8;21) AML cells. Blood 122: 2467-2476

  • Knaevelsrud H, Soreng K, Raiborg C, Haberg K, Rasmuson F, Brech A, Liestol K, Rusten TE, Stenmark H, Neufeld TP, Carlsson SR, Simonsen A (2013) Membrane remodeling by the PX-BAR protein SNX18 promotes autophagosome formation. J Cell Biol 202: 331-349

  • Reggiori F, Komatsu M, Finley K, Simonsen A (2012) Autophagy: more than a nonselective pathway. International journal of cell biology 2012: 219625

  • Isakson P, Holland P and Simonsen A. The role of ALFY in selective autophagy. Cell Death Differ. 2012 Jun 1. doi: 10.1038/cdd.2012.66.

  • Reggiori F, Komatsu M, Finley KD and Simonsen A. Autophagy: More than a nonselective pathway. Int J Cell Biol, 2012;2012:219625.

  • Knævelsrud H and Simonsen A. Lipids in autophagy: Constituents, signaling molecules and cargo with relevance to disease. Biochim Biophys Acta. 2012 Aug;1821(8):1133-45.

  • Yamamoto A and Simonsen A. The elimination of accumulated and aggregated proteins: A role for aggrephagy in neurodegeneration. Neurobiol Dis. 2011 Jul;43(1):17-28.

  • Knaevelsrud H, Simonsen A. Fighting disease by selective autophagy of aggregate-prone proteins. FEBS Lett. 2010 Jun 18;584(12):2635-45.

  • Simonsen A and Tooze SA. Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes, J Cell Biol. (2009) Sep 21;186(6):773-82.

  • Bartlett BJ, Isakson P, Lewerenz J, Sanchez H, Kotzebue RW, Cumming RC, Harris GL, Neziz IP, Schubert DR, Simonsen A and Finley KD. p62, Ref(2)P and ubiquitinated proteins are conserved markers of nuronal aging, aggregate formation and progressive autophagic defects. Autophagy. June 2011; 7(6), 572-583.

  • Isakson P, Bjørås M, Bøe SO and Simonsen A, Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein. Blood. 2010 Sep 30;116(13):2324-31. Epub 2010 Jun 23.

  • Filimonenko M, Isakson P., Finley K., Anderson M., Jeong H, Melia T.J., Bartlett B.J., Myers K., Birkeland H.G., Lamark T., Krainc D, Brech H., Stenmark H, Simonsen A*, Yamamoto A.* The selective macroautophagic degradation of aggregated proteins requires the phosphatidylinositol 3-phosphate binding protein Alfy, Mol Cell. 2010 Apr 23;38(2):265-79. *shared corresponding. This paper was commented in DevCell Volume 18, Issue 5, 18 May 2010, Pages 694-696

  • Claussen T.H., Lamark T., Isakson P., Finley K., Brech A., Øvervatn A., Stenmark H., Bjørkøy G., Simonsen A.* and Johansen T* p62/SQSTM1 and Alfy interact to facilitate formation of ubiquitinated protein aggregates that become degraded by autophagy, Autophagy 2010, 6:3, 1-15, April 1 *shared corresponding.
  • Knævelsrud H, Ahlquist T, Stenmark H, Merok MA, Nesbakken A, Lothe RA and Simonsen A UVRAG mutations associated with microsatellite unstable colon cancer do not affect autophagy. Autophagy 2010, 6:7, 1-8; October 1.

  • Nezis I.P., Simonsen A., Sagona A.P., Finley K., Gaumer S., Contamine D., Rusten T.E., Stenmark H. and Brech A. (2008) Ref(2)P, the Drosophila homologue of mammalian p62, is required for the formation of protein aggregates in adult brain, J.Cell Biol., Mar24;180(6):1065-71. Epub 2008 Mar 17.

  • Simonsen A., Cumming RC., Brech A., Isakson P., Schubert D. and Finley K.D. (2008) Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy, 2008 Feb 16;4(2):176-84. Epub 2007 Nov 6. This paper got the cover picture of the same issue of Autophagy and was commented in ‘Editors’ choice’, Science (2007), 318:1697

  • Filimonenko M., Stuffers S., Raiborg C., Yamamoto A., Malerød L., Fisher E.M., Isaacs A., Brech A., Stenmark H. and Simonsen A. (2007) Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease J.Cell Biol., 179(3):485-500. This paper was commented in ‘In this issue’, J.Cell Biol., 179(3):360 and got the cover picture of the same issue.

  • Simonsen A., Cumming RC., Lindmo K., Galavis V., Cheng S., Rusten TE. and Finley K.D. (2007) Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles. Genetics, 176(2):1283-97

  • Simonsen, A., Birkeland, H. C., Gillooly, D., Mizushima, N., Kuma, A., Yoshimori, T., Slagsvold, T., Brech, A., and Stenmark, H. (2004) Alfy, a novel FYVE domain-containing protein associated with protein granules and autophagic membranes. J Cell Sci., 117(Pt 18):4239-51.

  • Simonsen, A, Lippé, R, Christoforidis, S, Gaullier, JM, Brech A, Callaghan, J, Toh, B-H, Murphy, C; Zerial, M and Stenmark, H (1998) EEA1 links PI(3)K function to Rab5 regulation of endosome fusion, Nature, 394 (6692), 494-498. This paper was commented in ‘News and Views’, Nature, 394 (6692), 426-427

Published Feb. 23, 2011 2:58 PM - Last modified Dec. 8, 2016 12:09 PM