DNA: damage and repair
Our research focus is on DNA damage and DNA repair, in relation to nutrition and cancer.
Illustration: Andrew Collins
About the group
We have demonstrated the ability of dietary antioxidants to protect DNA against damage, in cell culture and in humans. DNA oxidation in healthy individuals is, however, maintained at a low level by endogenous antioxidant defences, and we have questioned the biological importance of further reduction.
DNA repair plays a crucial role in preventing carcinogenesis; we have demonstrated significant nutritional influences on the major cellular DNA repair pathways. We have made important technical innovations, developing novel DNA repair assays for biomonitoring, and high throughput DNA damage analysis methods