Proteinuria and proteoglycans
Proteinuria in diabetes is related to changes in proteoglycans in kidneys of persons with diabetes and we study this in biopsies, blood samples and isolated monocytes from such patients. Our focus is on structural changes of proteoglycans, changes in the matrix composition of the glomeruli and in enzymes important for biossyntheis and turnover of extracellular matrix. Parallel studies are performed in a mouse model of diabetes.
Syndecan shedding and disease
Syndecans are proteoglycans that are shed from the endothelial cells surface into circulation during different types of stress. We have shown that syndecan-1 is elevated in patients with type 1 diabetes and microalbuminuria. We are investigating the molecular mechanisms for syndecan-1- and syndecan-4-shedding under hyperglycemic and inflammatory conditions, and in wound healing.
Endothelial dysfunction and signal transduction
Endothelial dysfunction and changes in signal transduction in diabetes is studied in primary cultures of human endothelial cells after exposure to hyperglycemic and inflammatory conditions.
Atherosclerosis is a process that also involves matrix accumulation in plaques formed in the intima. We study the role of serglycin, which is expressed by endothelial cells and macrophages, in serglycin knock-out animals. Animals are fed a high fed diet and the extent of atherosclerosis in aorta is compared in control and knock-out animals.
Health, Nutrition and Living Arrangements
We study nutritional-related health challenges for persons with Prader-Willis syndrome, Williams’ syndrome and Down’s syndrome 16 to 40 years of age. We are comparing persons living in community-based care homes for persons with intellectual disabilities, with those living with relatives.