Essential nutrients and energy supply to pregnant women and severely premature infants. We focus on total energy supply, proteins, essential fatty acids as well as fat-soluble vitamins.
Energy balance related to sulfated amino acids like cystein and methionine. In collaboration with Helga Refsum and Hilde I. Nebb we search for the mechanism behind the finding that plasma concentration of cysteine is strongly and positively associated with fat mass of the body.
We have also had a significant research activity within the field of cachexia in search for mechanisms balancing energy storage and combustion.
Based on our expertise in culturing human skeletal muscle cells we have discovered 20 new myokines, which are secretory proteins from skeletal muscle cells with signal functions either locally (auto- or paracrine effects) or to more distant tissues (endocrine effects). We search for the underlying mechanisms why physical activity turns out to be a very strong factor for keeping populations healthy. Our hypothesis is that the working or restructuring skeletal muscle sends beneficial signals to many organs and tissues.
Personalized nutrition to examine if the use of classical nutritional biomarkers and genetic information on an individual basis will enhance the compliance and risk factor scenario beyond what can be achieved by regular population-based life-style advice.
We are searching for new methods to describe individual food and nutrient intake more precisely than today. This includes testing new biomarkers for food and nutrient intake and development of internet-based tools to register daily habits.
Based on data about food intake among different cohorts we are collaborating to find nutritional habits that may be beneficial to health in relation to cognitive function, osteoporosis, cardio-vascular disease, oro-facial clefts (lip and palate), diabetes and certain types of cancer.