With the current obesity epidemic, it is of immediate importance to understand the key components and cellular signalling systems as well as the specific tissues involved in the development of impaired metabolic regulation.
Genetics and lifestyle factors (e.g. diet, exercise) contribute to the development of metabolic diseases. Today, there is compelling evidence that lipid activated nuclear receptors are nutrient sensors which play key roles in controlling metabolic homeostasis.
Our group has been a major contributor to understanding the role of lipid nuclear receptors in metabolic homeostasis.