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Signaling and Membrane Trafficking

We investigate how membranes of the secretory pathway are regulated by signal transduction pathways and, we want to understand how spatial organization of signaling molecules contributes to the outcome of signaling pathways.

Painting of a cell

Illustration: Hesso Farhan/UiO

The regulation of cell growth, cell migration, and cell polarity

Our group is interested in exploring the relationship between the secretory pathway and cellular signaling pathways. On one hand, we investigate how membranes of the secretory pathway are regulated by signal transduction pathways. On the other hand, we want to understand how spatial organization of signaling molecules contributes to the outcome of signaling pathways.

We aim at determining the relevance of this crosstalk in the regulation of cell growth, cell migration, and cell polarity to ultimately understand the impact of dys-regulation of cellular signaling and secretion in human diseases such as cancer and neurodegeneration.

Pseudoenzymes

Another research area in our lab is the investigation of the role of Pseudoenzymes in health and disease. In particular we are interested in the pseudophosphatase STYX and explore its relevance in the regulation of kinase and ubiquitin signaling.

Interdisciplinary approach

To address these challenges, our group employes an interdisciplinary approach combining biochemistry, a wide variety of advanced microscopic techniques, siRNA screening, mathematical modeling and in vivo models

Published Oct. 7, 2016 9:54 AM - Last modified Apr. 24, 2017 2:01 PM