Achievements

  • the first fully Bayesian analysis of a microarray experiment, with a method able to estimate absolute transcript concentrations;
  • a new approach to missing value imputation in microarray data, and an analysis of the importance of this operation;
  • a comparative analysis of several methods for p>>n regression, in the context of genomic effects on survival after cancer, recommending penalised approaches;
  • the proposal of a new Bayesian method in multiple testing which incorporates information from other studies: the covariate modulated fdr;
  • the application of dynamic path analysis to estimate pathways in genomics, identifying indirect genomic effects on survival;
  • a new generic approach to build multivariate models using pair copulae in a hierarchical fashion: the pair-copula constructions of multiple dependence is receiving major attention both from the theoretical and applied side;
  • the first fully statistical way to correct improper correlation matrices, in order to be useful multivariate Gaussian models;
  • we contributed to the discovery of certain genomic loci associated to psychotic disorders, including schizophrenia;
  • we contributed to the discovery of a role of gene CX3CL1 in heart failure;
  • we contributed to the discovery of eight genes, highly associated with bone marrow density variation, casting light on osteoporosis;
  • we developed a new stochastic model and inferential approach to investigate routes of spread of infectious diseases in aquaculture;
  • we designed a stochastic population dynamics and infectious disease modelling in plague studies in central Asia, developing new complex structured hierarchical models.
Published Feb. 22, 2011 6:29 PM - Last modified May 2, 2011 5:32 PM