Anne Carine Østvold

Professor emeritus - Seksjon for Biokjemi
Bilde av Anne Carine Østvold
English version of this page
Telefon +47-22851097
Rom 1241
Brukernavn
Besøksadresse Sognsvannsveien 9 Domus Medica 0372 OSLO

Faglige interesser

  • Regulering av cellecyclus
  • DNA reparasjon
  • Apoptose
  • Protein fosforylering
  • Signaloverføring

Undervisning

Biokjemi og Cellebiologi

  • Forelesninger i 1. semester
  • Forelesninger i 2. semester
  • PBL grupper i 2. semester
  • Laboratoriekurs i 2. semester

Bakgrunn

Utdannelse

  • Kjemiingeniør 1968
  • Cand Scient i biokjemi 1986
  • Ph.D. i biokjemi i januar 1992

Arbeidserfaring

  • 1968-1975 : Forskningsingeniør, Riksospitalet
  • 1975-1983 : Forskningsingeniør Biokjemisk Institutt (Mat.Nat.)
  • 1986-1989 : Stipendiat , Norges Forskningsråd
  • 1989-1991 : 1. Amanuensis Biokjemisk Institutt (Mat.Nat.)
  • 1991-1998 : 1. Amanuensis IMB, Avd. Biokjemi
  • 1998- :  Professor IMB, Avd. Biokjemi

Verv

  • 1996-1999 : Medlem av styret i Norsk Biokjemisk Selskap
  • 1987-1995 : Medlem av Borgarting Lagmannsrett

Samarbeid

DNA reparasjon:

  • Professor David Schild (Project Manager, Lawrence researcher National Lab), Berkley, US.

Uttrykking av NUCKS proteinet under fosterutviklingen hos gnagere:

  • Professor Evangelos Marinos, University of Athens, Greece.  

Regulering av cellecyclus:

  • Professor Laurent Meijer, CNRS Roscoff, France
Emneord: Cellebiologi, Kreft

Publikasjoner

Haug, L.S., Østvold, A.C., Cowburn, R.F., Garlind, A., Winblad, B., Bogdanovich and Walaas, S.I. (1996): Decreased Inositol (1,4,5)-trisphosphate receptor levels in Alzheimer's disease cerebral cortex: selectivity of changes and correlation to pathological severity. Neurodegeneration  5 (2),  169-176 

Haug, L.S., Østvold, A.C., Torgner, I., Roberg, B., Dvorakova, L. and Walaas, S.I. (1997): Type I IP3-receptor and phosphate activated glutaminase are highly enriched in neurons as compared to glia cells in rat neostriatum. Neurochemistry: Cellular, Molecular and Clinical Aspects (A.Teelken, and J. Korf, eds.) Plenum Press, New York, pp.389-394

Haug, L.S., Østvold, A.C., Torgner, I. Roberg, B., Dvorakova, L. Stastny, F. and Walaas, S.I. (1998): Intracerebroventricular administration of quinolinic acid induces a selective decrease of inositol(1,4,5)-trisphosphate receptor in rat brain.  Neurochem. Int. 33, 109-119

Haug, L.S., Jensen, V., Hvalby, Ø., Walaas, S.I. and  Østvold, A.C. (1999):

Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic nucleotide-dependent kinases in vitro and in rat cerebellar slices in situ.  J.Biol. Chem. 274 (11), 7467-7473

Borgne, A., Østvold, A.C., Flament, S. and Meijer, L. (1999): Intra-MPF phosphorylation of cyclin B at the prophase/metaphase transition.J.Biol. Chem. 274 (17), 11977-11987

Dahl, C., Haug, L.S., Spilsberg, B. Johansen, J., Østvold, A.C. and Diemer, N.H. (1999): Reduced [3H]IP3 binding but unchanged IP3 receptor levels in the rat hippocanpus CA1 region following transient global ischemia and tolerance induction. Neurochem. Int. 36, 379-388

Haug, L.S., Walaas, S.I. and Østvold, A.C.(2000): Degradation of the Type I Inositol 1,4,5-Trisphosphate Receptor by Caspase-3 in SHSY5Y Neuroblastoma cells Undergoing Apoptosis. J. Neurochem. 75 (5), 1852-1861

Haug, L.S. and Østvold, A.C.(2000): Regulation of type I IP3 receptors and neurodegeneration. Current Topics in Biochemical Research Vol.2, 77-89

Østvold, A.C., Norum, J.H., Mathiesen; S., Wanvik, B., Sefland, I and Grundt, K. (2001): Molecular cloning of a mammalian nuclear phosphoprotein NUCKS which serves as substrate for Cdk1 in vivo. Eur. J. Biochem. 268, 2430-2440

Johannesen,L.E., Haugen, K.E., Østvold, A.C., Stang, E. and Madshus, I.H.(2001): Heterodimerisation of the epidermal growth factor (EGF) receptor and ErbB2 and the affinity of EGF binding are regulated by different mechanisms. Biochem.J. 356 (1), 87-96

Oksvold, M.P., Huitfeldt, H.S., Østvold, A.C. and Skarpen, E. (2002): UV Induces tyrosin kinase- independent internalization and endosome arrest of the EGF receptor.J. Cell Sci. 115(Pt4), 793-803

Slagvold, H.H., Østvold, A.C., Fallgren, Å.B. and Paulsen, R.E. (2002): Transcription Factor and apoptose initiator NGFI-B is a substrate for the mitogen activated protein kinase ERK.  BBRC 291(5), 1146-1150

Grundt, K., Skjeldal, L., Anthonsen, H.W., Skauge, T., Huidtfeldt, H. and Østvold, A.C. (2002): A putative DNA binding domain in the NUCKS protein. Archives of Biochemistry and Biophysics 407, 168-175

Grundt, K., Vågslid Haga, I., Drosos, Y., Aleporou-Marinou, V., Wanvik, B. and Østvold, A.C. (2004): Characterisation of the NUCKS gene on human chromosome 1q32.1 and the presence of a homologous gene in different species. Biochem. Biophys. Res. Comm. 323, 796-801

Rosseland C.M., Wierød, L., Oksvold, M.P., Werner, H., Østvold, A.C., Thoresen, G.H., Paulsen, R.E., Huitfeldt, H.S., Skarpen, E. (2005): Cytoplasmic retention of peroxide-activated ERK provides survival in primary cultures of rat hepatocytes. Hepatology 42(1), 200-207

Grundt, K., Haga, I.V., and Østvold Anne Carine (2007): Identification and characterization of two putative nuclear localization signals (NLS) in the DNA-binding protein NUCKS. BBA Mol. Cell Res. 1773, 1398-1406

Sargent, L., Ensell, M.X., Ostvold, A.C., Baldwin, K.T., Kashon, M.L., Lowry, D.T, Senft J.R., Jefferson, A.M., Johnson, R.C., Li, Z., Tyson, F.L. and Reynolds, S.H. (2008): Chromosomal changes in high and low-invasive mouse lung adenocarcinoma cell strains derived from early passage mouse lung adenocarcinoma cell strains. Toxicology and Applied Pharmacology,233, 81-91

Drosos Y., Kouloukoussa M., Østvold A.C., Grundt, K., Goutas, N., Vlachodimitropoulos D., Havaki, S., Kollia, P., Kittas C., Marinos, E. and Alepourou-Marinou, V. (2009): NUCKS overexpression in breast cancer. Cancer Cell International  10, 9-19.

  • Grundt, Kirsten; Thiede, Bernd & Østvold, Anne Carine (2017). Identification of kinases phosphorylating 13 sites in the nuclear, DNA-binding protein NUCKS. Biochimica et Biophysica Acta - Proteins and Proteomics.  ISSN 1570-9639.  1865(3), s 359- 369 . doi: 10.1016/j.bbapap.2016.12.009
  • Yue, Yangbo; Leung, Stanley G.; Liu, Yueyong; Huang, Yurong; Grundt, Kirsten; Østvold, Anne Carine; Jen, Kuang-Yu; Schild, David; Mao, Jian-Hua & Wiese, Claudia (2016). Nucks1 synergizes with Trp53 to promote radiation lymphomagenesis in mice. OncoTarget.  ISSN 1949-2553.  7(38), s 61874- 61889 . doi: 10.18632/oncotarget.11297
  • Parplys, Ann C.; Zhao, Weixing; Sharma, Neelam; Groesser, Torsten; Liang, Fengshan; Maranon, David G.; Leung, Stanley G.; Grundt, Kirsten; Dray, Eloise; Idate, Rupa; Østvold, Anne Carine; Schild, David; Sung, Patrick & Wiese, Claudia (2015). NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability. Nucleic Acids Research.  ISSN 0305-1048.  43(20), s 9817- 9834 . doi: 10.1093/nar/gkv859
  • Drosos, Yiannis; Kouloukoussa, Mirsini; Østvold, Anne Carine; Havaki, Sophia; Katsantoni, Eleni; Marinos, Evangelos & Aleporou-Marinou, V (2014). Dynamic expression of the vertebrate-specific protein Nucks during rodent embryonic development. Gene Expression Patterns.  ISSN 1567-133X.  14(1), s 19- 29 . doi: 10.1016/j.gep.2013.10.001
  • Drosos, Y; Kouloukoussa, M; Østvold, Anne Carine; Grundt, Kirsten; Goutas, N; Vlachodimitropoulos, D; Havaki, S; Kollia, P; Kittas, C; Marinos, E & Aleporou-Marinou, V (2009). NUCKS overexpression in breast cancer. Cancer Cell International.  ISSN 1475-2867.  9 . doi: 10.1186/1475-2867-9-19
  • Sargent, L M; Ensell, Mang X; Østvold, Anne Carine; Baldwin, Kimberly T; Kashon, Michael L; Lowry, David T; Senft, Jamie R; Jefferson, Amy M; Johnson, Robert C; Li, Zhi; Tyson, Fredrick L & Reynolds, Steven H (2008). Chromosomal changes in high- and low-invasive mouse lung adenocarcinoma cell strains derived from early passage mouse lung adenocarcinoma cell strains. Toxicology and Applied Pharmacology.  ISSN 0041-008X.  233(1), s 81- 91 . doi: 10.1016/j.taap.2008.01.031
  • Grundt, Kirsten; Haga, Ingvild Vågslid; Huitfeldt, Henrik & Østvold, Anne Carine (2007). Identification and characterization of two putative nuclear localization signals (NLS) in the DNA-binding protein MUCKS. Biochimica et Biophysica Acta. Molecular Cell Research.  ISSN 0167-4889.  1773, s 1398- 1406 . doi: 10.1016/j.bbamcr.2007.05.013
  • Grundt, Kirsten; Haga, Ingvild Vågslid; Aleporou-Marinou, V; Drosos, Y; Wanvik, Birgit & Østvold, Anne Carine (2004). Characterization of the NUCKS gene on human chromosome 1q32.1 and the presence of a homologous gene in different species. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  323, s 796- 801 . doi: 10.1016/j.bbrc.2004.08.153
  • Grundt, Kirsten; Skjeldal, Lars; Anthonsen, Henrik W.; Skauge, Tormod; Huitfeldt, Henrik & Østvold, Anne Carine (2002). A putative DNA-binding domain in the NUCKS protein. Archives of Biochemistry and Biophysics.  ISSN 0003-9861.  407, s 168- 175
  • Grundt, Kirsten; Skjeldal, Lars; Anthonsen, Henrik W.; Skauge, Tormod; Huitfeldt, Henrik & Østvold, Anne Carine (2002). A putative DNA-binding domain in the NUCKS protein. Archives of Biochemistry and Biophysics.  ISSN 0003-9861.  407(2), s 168- 175
  • Oksvold, Morten Pedersen; Huitfeldt, Henrik; Østvold, Anne Carine & Skarpen, Ellen (2002). UV induces tyrosine kinase-independent internalisation and endosome arrest of the EGF receptor. Journal of Cell Science.  ISSN 0021-9533.  115(4), s 793- 803
  • Slagsvold, Hege H.; Østvold, Anne Carine; Fallgren, Åsa Birgitta & Paulsen, Ragnhild Elisabeth (2002). Nuclear receptor and apoptosis initiator NGFI-B is a substrate for kinase ERK2. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  291, s 1146- 1150
  • Johannessen, Lene E.; Haugen, Karianne Eide; Østvold, Anne Carine; Stang, Espen & Madshus, Inger Helene (2001). Heterodimerization of the epidermal growth factor (EGF) receptor and ErbB2 and the affinity of EGF binding are regulated by different mechanisms. Biochemical Journal.  ISSN 0264-6021.  356, s 87- 96
  • Haug, Lise Sofie; Walaas, Sven Ivar & Østvold, Anne Carine (2000). Degradation of the Type I Inositol 1,4,5-Trisphosphate Receptor by Caspase-3 in SH-SY5Y Neuroblastoma Cells Undergoing Apoptosis. Journal of Neurochemistry.  ISSN 0022-3042.  75(5), s 1852- 1861
  • Haug, Lise Sofie & Østvold, Anne Carine (2000). Regulation of type I IP3 receptors and neurodegeneration. Current Topics in Biochemical Research.  ISSN 0972-4583.  2, s 77- 89
  • Borgne, Annie; Østvold, Anne Carine; Flament, Stéphane & Meijer, Laurent (1999). Intra-M phase-promoting factor phosphorylation of cyclin B at the prophase/metaphase transition. Journal of Biological Chemistry.  ISSN 0021-9258.  274(17), s 11977- 11986
  • Haug, Lise Sofie; Jensen, Vidar; Hvalby, Øyvind Christian; Walaas, Sven Ivar & Østvold, Anne Carine (1999). Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic nucleotide-dependent kinases in vitro and in rat cerebellar slices in situ. Journal of Biological Chemistry.  ISSN 0021-9258.  274(11), s 7467- 7473
  • Walaas, Sven Ivar & Østvold, Anne Carine (1999). Analysis of protein phosphorylation, In S.J. Higgins & B.D. Hames (ed.),  Post-Translational Processing. A Practical Approach.  Oxford University Press.  ISBN 0-19-963794-6.  s 95 - 133
  • Haug, Lise Sofie; Østvold, Anne Carine; Torgner, Ingeborg Aasland; Roberg, Bjørg Åse; Dvoráková, Lenka; Stastný, F. & Walaas, Sven Ivar (1998). Intracerebroventricular administration of quinolinic acid induces a selective decrease of inositol (1,4,5)-trisphosphate receptor in rat brain. Neurochemistry International.  ISSN 0197-0186.  33, s 109- 119
  • Haug, Lise Sofie; Østvold, Anne Carine; Cowburn, Richard F.; Garlind, Anita; Winblad, Bengt; Bogdanovich, Nenad & Walaas, Sven Ivar (1996). Decreased Inositol (1,4,5)-Trisphosphate Receptor Levels in Alzheimer's Disease Cerebral Cortex: Selectivety of Changes and Possible Correlation of Pathological Severity. Neurodegeneration.  ISSN 1055-8330.  5, s 169- 176
  • Walaas, Sven Ivar & Østvold, Anne Carine (1996). Analysis of Protein Phosphorylation in Intact Cells and Extracts, In H. C. Jr Hemmings (ed.),  Neuromethods, Vol. 30: Regulatory Protein Modification: Techniques and Protocols.  Humana Press Inc., Totowa, NJ, USA.  s 1 - 43
  • Magnusson, Andres; Haug, Lise Sofie; Walaas, Sven Ivar & Østvold, Anne Carine (1993). Calcium-induced degradation of the Inositol (1,4,5)-trisphosphate receptor/Ca(2+)-channel. FEBS Letters.  ISSN 0014-5793.  323(3), s 229- 232
  • Mælandsmo, Gunhild Mari; Østvold, Anne Carine & Laland, S. G. (1989). Phosphorylation of the high mobility-group-like protein P1 by casein kinase-2. European Journal of Biochemistry.  ISSN 0014-2956.  s 529- 534

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  • Østvold, Anne Carine & Grundt, Kirsten (2008). NUCKS expression is correlated with early onset of breast adenocarcinomas. Histopathology.  ISSN 0309-0167.  53, s 34- 35
  • Skjeldal, Lars; Anthonsen, Henrik W.; Skauge, Tormod & Østvold, Anne Carine (2003). NMR and computer modeling of NUCKS binding to DNA.
  • Skjeldal, Lars; Grundt, Kirsten; Østvold, Anne Carine; Anthonsen, Henrik W. & Skauge, Tormod (2003). NMR and graphic modeling of a protein-DNA complex.
  • Skjeldal, Lars; Østvold, Anne Carine; Anthonsen, Henrik W. & Skauge, Tormod (2002). DNA binding of NUCKS.
  • Skjeldal, Lars; Østvold, Anne Carine; Skauge, Tormod & Anthonsen, Henrik W. (2002). Computer modeling of NUCKS binding to DNA.
  • Hankø, Erik; Hansen, Thor Willy Ruud; Østvold, Anne Carine & Walaas, Sven Ivar (2001). Magnitude of bilirubin-mediated inhibition of protein phosphorylation is dependent on substrate characteristics.
  • Johannessen, Lars Erik; Haugen, Karianne Eide; Østvold, Anne Carine; Stang, Espen & Madshus, Inger Helene (2001). Dimerisation of the epidermal growth factor receptor.
  • Haug, Lise Sofie; Torgner, Ingeborg Aasland & Østvold, Anne Carine (1999). Characterization of the cell death process in SH-SY5Y human neuroblastoma cells induced by bilirubin.
  • Haug, Lise Sofie; Dvoráková, Lenka; Walaas, Sven Ivar & Østvold, Anne Carine (1998). The inositol (1,4,5)-trisphosphate receptor/Ca2+ channel protein is selectively decreased in rat brains treated with quinolinic acid.
  • Haug, Lise Sofie; Jensen, Vidar; Hvalby, Øyvind Christian; Walaas, Sven Ivar & Østvold, Anne Carine (1998). Stimulation of cyclic GMP-dependent protein kinase leads to phosphorylation of type I inositol trisphosphate-receptor in rat cerebellar slices.
  • Aschim, Elin Leirvoll; Østvold, Anne Carine & Eskild, Winnie (1997). Regulation of CRBP1 function.
  • Hansen, Thor Willy Ruud; Mathiesen, Siri B. W.; Østvold, Anne Carine & Walaas, Sven Ivar (1997). Bilirubin inhibits casein kinase 2 by a non-competitive mechanism.
  • Haug, Lise Sofie; Østvold, Anne Carine & Walaas, Sven Ivar (1997). Regulation of the neuronal IP3-receptor: a possible correlation to Alzheimer's disease.
  • Eskild, Winnie & Østvold, Anne Carine (1996). Regulation of CRBP1 activity - Possible involvement of protein kinase C.
  • Haug, Lise Sofie; Østvold, Anne Carine; Torgner, Ingeborg Aasland; Roberg, Bjørg Åse; Dvoráková, Lenka & Walaas, Sven Ivar (1996). Type I inositol (1,4,5)-trisphosphate receptor and phosphate-activated glutaminase are highly enriched in neurons as compared to glial cells in rat neostriatum.
  • Haug, Lise Sofie; Cowburn, Richard F.; Walaas, Sven Ivar & Østvold, Anne Carine (1995). The Inositol (1,4,5)-trisphosphate receptor is selectively degraded in brain tissues from patients with Alzheimer's disease.
  • Haug, Lise Sofie; Walaas, Sven Ivar & Østvold, Anne Carine (1994). Phosphorylation of purified IP3-receptor from rat cerebellum by cyclic GMP-dependent protein kinase.
  • Haug, Lise Sofie; Østvold, Anne Carine & Walaas, Sven Ivar (1993). Calcium-induced degradation of the IP3-receptor/Ca(2+)-channel.

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Publisert 13. apr. 2011 10:42 - Sist endret 3. juni 2016 08:56