Christian André Drevon

• Lövden, Martin; Pagin, Amos; Bartres-Faz, David; Boraxbekk, Carl-Johan; Brandmaier, Andreas M. & Demnitz, Naiara [Vis alle 15 forfattere av denne artikkelen] (2023). No moderating influence of education on the association between changes in hippocampus volume and memory performance in aging. Aging Brain. ISSN 2589-9589. 4. doi: 10.1016/j.nbas.2023.100082. Fulltekst i vitenarkiv
• Pourteymour, Shirin; Drevon, Christian André; Dalen, Knut Tomas & Norheim, Frode Amador (2023). Mechanisms Behind NAFLD: a System Genetics Perspective. Current Atherosclerosis Reports. ISSN 1523-3804. 25(11), s. 869–878. doi: 10.1007/s11883-023-01158-3.
• Fjell, Anders Martin; Sørensen, Øystein; Wang, Yunpeng; Amlien, Inge; Baaré, William F. C. & Bartrés-Faz, David [Vis alle 24 forfattere av denne artikkelen] (2023). No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy. Nature Human Behaviour. ISSN 2397-3374. 7, s. 2008–2022. doi: 10.1038/s41562-023-01707-5. Fulltekst i vitenarkiv
• Jersin, Regine Åsen; Tallapragada, Divya Sri; Skartveit, Linn; Bjune, Mona Synnøve; Muniandy, Maheswary & Lee-Ødegård, Sindre [Vis alle 16 forfattere av denne artikkelen] (2023). Impaired Adipocyte SLC7A10 Promotes Lipid Storage in Association With Insulin Resistance and Altered BCAA Metabolism. Journal of Clinical Endocrinology and Metabolism (JCEM). ISSN 0021-972X. 108(9), s. 2217–2229. doi: 10.1210/clinem/dgad148. Fulltekst i vitenarkiv
• Rundle, Milena; Fiamoncini, Jarlei; Thomas, E Louise; Wopereis, Suzan; Afman, Lydia A. & Brennan, Lorraine [Vis alle 15 forfattere av denne artikkelen] (2023). Diet-induced Weight Loss and Phenotypic Flexibility Among Healthy Overweight Adults: A Randomized Trial. American Journal of Clinical Nutrition. ISSN 0002-9165. 118(3), s. 591–604. doi: 10.1016/j.ajcnut.2023.07.002. Fulltekst i vitenarkiv
• Binnewies, Julia; Nawijn, Laura; Brandmaier, Andreas M.; Baaré, William F.C.; Boraxbekk, Carl-Johan & Demnitz, Naiara [Vis alle 15 forfattere av denne artikkelen] (2023). Lifestyle-related risk factors and their cumulative associations with hippocampal and total grey matter volume across the adult lifespan: A pooled analysis in the European Lifebrain consortium. Brain Research Bulletin. ISSN 0361-9230. 200. doi: 10.1016/j.brainresbull.2023.110692. Fulltekst i vitenarkiv
• Fjell, Anders Martin; Sørensen, Øystein; Wang, Yunpeng; Amlien, Inge; Baaré, William F C & Bartrés-Faz, David [Vis alle 21 forfattere av denne artikkelen] (2023). Is Short Sleep Bad for the Brain? Brain Structure and Cognitive Function in Short Sleepers. Journal of Neuroscience. ISSN 0270-6474. 43(28), s. 5241–5250. doi: 10.1523/JNEUROSCI.2330-22.2023. Fulltekst i vitenarkiv
• Moore, Timothy M.; Lee-Ødegård, Sindre; Olsen, Thomas; Morselli, Marco; Strumwasser, Alexander R. & Lin, Amanda J. [Vis alle 40 forfattere av denne artikkelen] (2023). Conserved multi-tissue transcriptomic adaptations to exercise training in humans and mice. Cell reports. ISSN 2211-1247. 42(5). doi: 10.1016/j.celrep.2023.112499. Fulltekst i vitenarkiv
• Ljøsne, Isabelle Sylvie Budin; Bodorkos Friedman, Barbara; Baaré, William F. C.; Bartrés-Faz, David; Carver, Rebecca Bruu & Drevon, Christian André [Vis alle 17 forfattere av denne artikkelen] (2023). Stakeholder engagement in European brain research: Experiences of the Lifebrain consortium. Health Expectations. ISSN 1369-6513. 26(3), s. 1318–1326. doi: 10.1111/hex.13747. Fulltekst i vitenarkiv
• Fragoso-Bargas, Nicolas; Elliott, Hannah R.; Lee-Ødegård, Sindre; Opsahl, Julia Onsrud; Sletner, Line & Jenum, Anne Karen [Vis alle 12 forfattere av denne artikkelen] (2022). Cross-Ancestry DNA Methylation Marks of Insulin Resistance in Pregnancy: An Integrative Epigenome-Wide Association Study. Diabetes. ISSN 0012-1797. 72(3), s. 415–426. doi: 10.2337/db22-0504.
• Sommer, Christine; Vangberg, Kjersti G; Moen, Gunn-Helen Øiseth; Evans, David M.; Lee-Ødegård, Sindre & Høgestøl, Ingvild Kristine [Vis alle 11 forfattere av denne artikkelen] (2022). Insulin and Body Mass Index Decrease Serum Soluble Leptin Receptor Levels in Humans. Journal of Clinical Endocrinology and Metabolism (JCEM). ISSN 0021-972X. 108(5), s. 1110–1119. doi: 10.1210/clinem/dgac699. Fulltekst i vitenarkiv
• Carver, Rebecca Bruu; Fredheim, Nanna Alida Grit; Mowinckel, Athanasia Monika; Ebmeier, Klaus P.; Bodorkos Friedman, Barbara & Rosness, Tor Atle [Vis alle 20 forfattere av denne artikkelen] (2022). People's interest in brain health testing: Findings from an international, online cross-sectional survey. Frontiers in Public Health. ISSN 2296-2565. 10, s. 1–19. doi: 10.3389/fpubh.2022.998302. Fulltekst i vitenarkiv
• Lee-Ødegård, Sindre; Ueland, Thor; Thorsby, Per Medbøe; Aukrust, Pål; Michelsen, Annika Elisabet & Halvorsen, Bente [Vis alle 8 forfattere av denne artikkelen] (2022). Fetuin-A mediates the difference in adipose tissue insulin resistance between young adult pakistani and norwegian patients with type 2 diabetes. BMC Endocrine Disorders. ISSN 1472-6823. 22. doi: 10.1186/s12902-022-01127-y. Fulltekst i vitenarkiv Vis sammendrag

  Background South-Asian immigrants to Western countries have a high prevalence of type 2 diabetes mellitus (T2DM) and increased adipose tissue insulin resistance (AT-IR), as compared to their Western counterparts. Fetuin-A is a hepatokine known to influence AT-IR. Aim Can plasma fetuin-A concentrations explain an ethnic difference in adipose tissue insulin resistance? Methods We performed a two-step euglycemic-hyperinsulinaemic clamp and measured plasma concentrations of fetuin-A and non-esterified fatty acids (NEFA), in 18 Pakistani and 21 Norwegians with T2DM (age 29–45y) in Norway. AT-IR was calculated as NEFA-suppression during the clamp. The adipokines/cytokines leptin, adiponectin, visfatin, PTX3, IL-1β, INF-γ, and IL-4 were measured in fasting plasma. Liver fat was estimated by CT-scans. Results Despite a lower BMI, Pakistani patients displayed higher AT-IR than Norwegians. NEFA-suppression during clamp was lower in Pakistani than Norwegians (mean=-20.6%, 95%CI=[-40.8, -0.01] and p = 0.046). Plasma fetuin-A concentration was higher in Pakistani than Norwegians (43.4 ng/mL[12.7,74.0], p = 0.007) and correlated negatively to %NEFA-suppression during clamp (rho=-0.39, p = 0.039). Plasma fetuin-A concentration explained 22% of the ethnic difference in NEFA-suppression during the clamp. Pakistani patients exhibited higher plasma leptin and lower PTX3 levels than Norwegian, and plasma visfatin correlated positively to plasma fetuin-A levels in the Pakistani patients. We observed no correlation between plasma fetuin-A and liver fat, but fetuin-A correlated negatively with plasma IL-1β, INF-γ, and IL-4 concentrations. Plasma IL-4 concentration was lower in Pakistani than in Norwegian patients. Conclusion Fetuin-A may contribute to explain the discrepancy in T2DM prevalence between Pakistani and Norwegians patients by influencing AT-IR.

• Strømmen, Kenneth; Lyche, Jan Ludvig; Moltu, Sissel Jennifer; Müller, Mette Helen Bjørge; Blakstad, Elin Wahl & Brække, Kristin [Vis alle 12 forfattere av denne artikkelen] (2022). Estimated daily intake of phthalates, parabens, and bisphenol A in hospitalised very low birth weight infants . Chemosphere. ISSN 0045-6535. 309(Part 1). doi: 10.1016/j.chemosphere.2022.136687. Fulltekst i vitenarkiv
• Nyberg, Lars Erik; Andersson, Micael; Lundquist, Anders; Baaré, William F C; Bartrés-Faz, David & Bertram, Lars [Vis alle 29 forfattere av denne artikkelen] (2022). Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates. Cerebral Cortex. ISSN 1047-3211. 33(9), s. 5075–5081. doi: 10.1093/cercor/bhac400. Fulltekst i vitenarkiv
• Binnewies, Julia; Nawijn, Laura; Brandmaier, Andreas M.; Baaré, William F.C.; Bartres-Faz, David & Drevon, Christian André [Vis alle 22 forfattere av denne artikkelen] (2022). Associations of depression and regional brain structure across the adult lifespan: Pooled analyses of six population-based and two clinical cohort studies in the European Lifebrain consortium. NeuroImage: Clinical. ISSN 2213-1582. 36. doi: 10.1016/j.nicl.2022.103180.
• Fiamoncini, Jarlei; Donado-Pestana, Carlos M.; Duarte, Graziela Biude Silva; Rundle, Milena; Thomas, Elizabeth Louise & Kiselova-Kaneva, Yoana [Vis alle 20 forfattere av denne artikkelen] (2022). Plasma Metabolic Signatures of Healthy Overweight Subjects Challenged With an Oral Glucose Tolerance Test. Frontiers in Nutrition. ISSN 2296-861X. 9. doi: 10.3389/fnut.2022.898782. Fulltekst i vitenarkiv Vis sammendrag

  Insulin secretion following ingestion of a carbohydrate load affects a multitude of metabolic pathways that simultaneously change direction and quantity of interorgan fluxes of sugars, lipids and amino acids. In the present study, we aimed at identifying markers associated with differential responses to an OGTT a population of healthy adults. By use of three metabolite profiling platforms, we assessed these postprandial responses of a total of 202 metabolites in plasma of 72 healthy volunteers undergoing comprehensive phenotyping and of which half enrolled into a weight-loss program over a three-month period. A standard oral glucose tolerance test (OGTT) served as dietary challenge test to identify changes in postprandial metabolite profiles. Despite classified as healthy according to WHO criteria, two discrete clusters (A and B) were identified based on the postprandial glucose profiles with a balanced distribution of volunteers based on gender and other measures. Cluster A individuals displayed 26% higher postprandial glucose levels, delayed glucose clearance and increased fasting plasma concentrations of more than 20 known biomarkers of insulin resistance and diabetes previously identified in large cohort studies. The volunteers identified by canonical postprandial responses that form cluster A may be called pre-pre-diabetics and defined as “at risk” for development of insulin resistance. Moreover, postprandial changes in selected fatty acids and complex lipids, bile acids, amino acids, acylcarnitines and sugars like mannose revealed marked differences in the responses seen in cluster A and cluster B individuals that sustained over the entire challenge test period of 240 min. Almost all metabolites, including glucose and insulin, returned to baseline values at the end of the test (at 240 min), except a variety of amino acids and here those that have been linked to diabetes development. Analysis of the corresponding metabolite profile in a fasting blood sample may therefore allow for early identification of these subjects at risk for insulin resistance without the need to undergo an OGTT.

• Doncheva, Atanaska Ivanova; Romero, Silvana Angelica Troncoso; Ramirez-Garrastacho, Manuel; Lee-Ødegård, Sindre; Kolnes, Kristoffer Jensen & Tangen, Daniel S. [Vis alle 11 forfattere av denne artikkelen] (2022). Extracellular vesicles and microRNAs are altered in response to exercise, insulin sensitivity and overweight. Acta Physiologica. ISSN 1748-1708. 236(4). doi: 10.1111/apha.13862. Fulltekst i vitenarkiv
• Solé-Padullés, Cristina; Macià, Dídac; Andersson, Micael; Stiernstedt, Mikael; Pudas, Sara & Düzel, Sandra [Vis alle 19 forfattere av denne artikkelen] (2022). No Association Between Loneliness, Episodic Memory and Hippocampal Volume Change in Young and Healthy Older Adults: A Longitudinal European Multicenter Study. Frontiers in Aging Neuroscience. ISSN 1663-4365. 14. doi: 10.3389/fnagi.2022.795764. Fulltekst i vitenarkiv
• Ljøsne, Isabelle Sylvie Budin; Mowinckel, Athanasia Monika; Bodorkos Friedman, Barbara; Ebmeier, Klaus P; Drevon, Christian A & Carver, Rebecca Bruu [Vis alle 22 forfattere av denne artikkelen] (2022). Public perceptions of brain health: an international, online cross-sectional survey. BMJ Open. ISSN 2044-6055. 12(4). doi: 10.1136/bmjopen-2021-057999. Fulltekst i vitenarkiv
• Livingstone, Katherine M.; Brayner, Barbara; Celis-Morales, Carlos; Moschonis, George; Manios, Yannis & Traczyk, Iwona [Vis alle 15 forfattere av denne artikkelen] (2022). Associations between dietary patterns, FTO genotype and obesity in adults from seven European countries. European Journal of Nutrition. ISSN 1436-6207. 61, s. 2953–2965. doi: 10.1007/s00394-022-02858-3. Fulltekst i vitenarkiv Vis sammendrag

  Purpose High-fat and low-fibre discretionary food intake and FTO genotype are each associated independently with higher risk of obesity. However, few studies have investigated links between obesity and dietary patterns based on discretionary food intake, and the interaction effect of FTO genotype are unknown. Thus, this study aimed to derive dietary patterns based on intake of discretionary foods, saturated fatty acids (SFA) and fibre, and examine cross-sectional associations with BMI and waist circumference (WC), and interaction effects of FTO genotype. Methods Baseline data on 1280 adults from seven European countries were included (the Food4Me study). Dietary intake was estimated from a Food Frequency Questionnaire. Reduced rank regression was used to derive three dietary patterns using response variables of discretionary foods, SFA and fibre density. DNA was extracted from buccal swabs. Anthropometrics were self-measured. Linear regression analyses were used to examine associations between dietary patterns and BMI and WC, with an interaction for FTO genotype. Results Dietary pattern 1 (positively correlated with discretionary foods and SFA, and inversely correlated with fibre) was associated with higher BMI (β:0.64; 95% CI 0.44, 0.84) and WC (β:1.58; 95% CI 1.08, 2.07). There was limited evidence dietary pattern 2 (positively correlated with discretionary foods and SFA) and dietary pattern 3 (positively correlated with SFA and fibre) were associated with anthropometrics. FTO risk genotype was associated with higher BMI and WC, with no evidence of a dietary interaction. Conclusions Consuming a dietary pattern low in discretionary foods and high-SFA and low-fibre foods is likely to be important for maintaining a healthy weight, regardless of FTO predisposition to obesity. Trial registration Clinicaltrials.gov NCT01530139. Registered 9 February 2012 https://clinicaltrials.gov/ct2/show/NCT01530139

• Lee-Ødegård, Sindre; Olsen, Thomas; Norheim, Frode Amador; Drevon, Christian A & Birkeland, Kåre Inge (2022). Potential Mechanisms for How Long-Term Physical Activity May Reduce Insulin Resistance. Metabolites. ISSN 2218-1989. 12(3)(208). doi: 10.3390/metabo12030208. Fulltekst i vitenarkiv
• Navas-Carretero, Santiago; San-Cristobal, Rodrigo; Alvarez-Alvarez, Ismael; Celis-Morales, Carlos; Livingstone, Katherine M. & O'Donovan, Clare B. [Vis alle 23 forfattere av denne artikkelen] (2021). Interactions of Carbohydrate Intake and Physical Activity with Regulatory Genes Affecting Glycaemia: A Food4Me Study Analysis. Lifestyle Genomics. ISSN 2504-3161. 14(3), s. 63–72. doi: 10.1159/000515068. Fulltekst i vitenarkiv
• Livingstone, Katherine M.; Celis-Morales, Carlos; Navas-Carretero, Santiago; San-Cristobal, Rodrigo; Forster, Hannah & Woolhead, Clara [Vis alle 24 forfattere av denne artikkelen] (2021). Personalised nutrition advice reduces intake of discretionary foods and beverages: findings from the Food4Me randomised controlled trial. International Journal of Behavioral Nutrition and Physical Activity. ISSN 1479-5868. 18. doi: 10.1186/s12966-021-01136-5. Fulltekst i vitenarkiv
• Nyberg, Lars Erik; Magnussen, Fredrik; Lundquist, Anders; Baaré, William; Bartrés-Faz, David & Bertram, Lars [Vis alle 24 forfattere av denne artikkelen] (2021). Educational attainment does not influence brain aging. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 118(18), s. 1–3. doi: 10.1073/pnas.2101644118.
• Maak, Steffen; Norheim, Frode Amador; Drevon, Christian A & Erickson, Harold P (2021). Progress and Challenges in the Biology of FNDC5 and Irisin. Endocrine reviews. ISSN 0163-769X. 42(4), s. 436–456. doi: 10.1210/endrev/bnab003. Fulltekst i vitenarkiv
• Norheim, Frode Amador; Chella Krishnan, Karthickeyan; Bjellaas, Thomas; Vergnes, Laurent; Pan, Calvin & Parks, Brian W. [Vis alle 18 forfattere av denne artikkelen] (2021). Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis. Molecular Systems Biology. ISSN 1744-4292. 17. doi: 10.15252/msb.20209684. Fulltekst i vitenarkiv
• Wang, Yunpeng; Grydeland, Håkon; Roe, James Michael; Pan, Mengyu; Magnussen, Fredrik & Amlien, Inge [Vis alle 17 forfattere av denne artikkelen] (2021). Associations of circulating C-reactive proteins, APOE ε4, and brain markers for Alzheimer’s disease in healthy samples across the lifespan. Brain, Behavior, and Immunity. ISSN 0889-1591. 100. doi: 10.1016/j.bbi.2021.12.008. Fulltekst i vitenarkiv
• Vidal-Piñeiro, Didac; Wang, Yunpeng; Krogsrud, Stine Kleppe; Amlien, Inge; Baaré, William FC & Bartres-Faz, David [Vis alle 31 forfattere av denne artikkelen] (2021). Individual variations in ‘brain age’ relate to early-life factors more than to longitudinal brain change. eLIFE. ISSN 2050-084X. 10. doi: 10.7554/eLife.69995. Fulltekst i vitenarkiv
• Walhovd, Kristine Beate; Fjell, Anders Martin; Wang, Yunpeng; Amlien, Inge; Mowinckel, Athanasia Monika & Lindenberger, Ulman [Vis alle 29 forfattere av denne artikkelen] (2021). Education and income show heterogeneous relationships to lifespan brain and cognitive differences across European and US cohorts. Cerebral Cortex. ISSN 1047-3211. 32(4), s. 839–854. doi: 10.1093/cercor/bhab248. Fulltekst i vitenarkiv
• Li, Yuchuan; Khanal, Prabhat; Norheim, Frode; Hjorth, Marit; Bjellaas, Thomas & Drevon, Christian A [Vis alle 9 forfattere av denne artikkelen] (2021). Plin2 deletion increases cholesteryl ester lipid droplet content and disturbs cholesterol balance in adrenal cortex. Journal of Lipid Research. ISSN 0022-2275. 62. doi: 10.1016/J.JLR.2021.100048. Fulltekst i vitenarkiv
• Strømmen, Kenneth; Lyche, Jan Ludvig; Moltu, Sissel; Müller, Mette Helen Bjørge; Blakstad, Elin Wahl & Almaas, Astrid Nylander [Vis alle 12 forfattere av denne artikkelen] (2021). High urinary concentrations of parabens and bisphenol A in very low birth weight infants. Chemosphere. ISSN 0045-6535. 271, s. 1–9. doi: 10.1016/j.chemosphere.2021.129570. Fulltekst i vitenarkiv Vis sammendrag

  Very low birth weight infants (VLBW; birth weight < 1500 g) are treated with pharmaceuticals and medical equipment containing parabens and bisphenol A (BPA). Parabens are used in pharmaceuticals, whereas BPA in medical equipment where concentrations are rarely reported in hospitalised VLBW infants. We measured urinary concentrations of parabens and BPA and hypothesised high and increasing concentrations in infants born at lower gestational ages (GAs), and among infants with bronchopulmonary dysplasia (BPD) and late-onset septicaemia (LOS) due to higher exposure from pharmaceuticals and medical equipment. Urinary samples were collected during the first (n = 38) and fifth (n = 36) week of life. Methylparaben, ethylparaben, propylparaben, butylparaben, and BPA concentrations were measured using ultra high-performance liquid chromatography coupled to tandem mass spectrometry. VLBW infants had very high urinary concentrations of parabens and BPA compared to term infants and older children. The Σ paraben concentration was higher than detected in previous studies on premature infants. Lower GA at birth was associated with higher concentrations of parabens and BPA. Infants born before 28 weeks GA had higher first week concentrations of propylparaben (38.6 vs. 9.05 ng/mL, p = 0.007), butylparaben (0.28 vs. 0.09 ng/mL, p = 0.05) and fifth week concentrations of BPA (15.1 vs. 6.02 ng/mL, p = 0.02) than infants born after 28 weeks GA. Infants with LOS and BPD had higher fifth week concentrations of BPA than infants without LOS and BPD (LOS: 14.2 vs. 6.77 ng/mL, p = 0.07; BPD: 18.6 vs. 7.62 ng/mL, p = 0.05).

• Ljøsne, Isabelle Sylvie Budin; Bodorkos Friedman, Barbara; Suri, Sana; Solé-Padullés, Cristina; Düzel, Sandra & Drevon, Christian André [Vis alle 24 forfattere av denne artikkelen] (2020). The Global Brain Health Survey: Development of a Multi-Language Survey of Public Views on Brain Health. Frontiers in Public Health. ISSN 2296-2565. doi: 10.3389/fpubh.2020.00387.
• Livingstone, Katherine M.; Celis-Morales, Carlos; Navas-Carretero, Santiago; San-Cristobal, Rodrigo; Forster, Hannah & Woolhead, Clara [Vis alle 24 forfattere av denne artikkelen] (2020). Characteristics of participants who benefit most from personalised nutrition: findings from the pan-European Food4Me randomised controlled trial. British Journal of Nutrition. ISSN 0007-1145. 123(12), s. 1396–1405. doi: 10.1017/S0007114520000653.
• Fjell, Anders Martin; Sørensen, Øystein; Amlien, Inge Kasbohm; Bartrés-Faz, David; Brandmaier, Andreas M. & Buchmann, Nikolaus [Vis alle 32 forfattere av denne artikkelen] (2020). Poor Self-Reported Sleep is Related to Regional Cortical Thinning in Aging but not Memory Decline-Results From the Lifebrain Consortium. Cerebral Cortex. ISSN 1047-3211. s. 1–17. doi: 10.1093/cercor/bhaa332. Fulltekst i vitenarkiv Vis sammendrag

  We examined whether sleep quality and quantity are associated with cortical and memory changes in cognitively healthy participants across the adult lifespan. Associations between self-reported sleep parameters (Pittsburgh Sleep Quality Index, PSQI) and longitudinal cortical change were tested using five samples from the Lifebrain consortium (n = 2205, 4363 MRIs, 18–92 years). In additional analyses, we tested coherence with cell-specific gene expression maps from the Allen Human Brain Atlas, and relations to changes in memory performance. “PSQI # 1 Subjective sleep quality” and “PSQI #5 Sleep disturbances” were related to thinning of the right lateral temporal cortex, with lower quality and more disturbances being associated with faster thinning. The association with “PSQI #5 Sleep disturbances” emerged after 60 years, especially in regions with high expression of genes related to oligodendrocytes and S1 pyramidal neurons. None of the sleep scales were related to a longitudinal change in episodic memory function, suggesting that sleep-related cortical changes were independent of cognitive decline. The relationship to cortical brain change suggests that self-reported sleep parameters are relevant in lifespan studies, but small effect sizes indicate that self-reported sleep is not a good biomarker of general cortical degeneration in healthy older adults.

• Albrecht, Elke; Schering, Lisa; Buck, Friedrich; Vlach, Konrad; Schober, Hans-Christof & Drevon, Christian A [Vis alle 7 forfattere av denne artikkelen] (2020). Irisin: Still chasing shadows. Molecular Metabolism. ISSN 2212-8778. 34, s. 124–135. doi: 10.1016/j.molmet.2020.01.016. Fulltekst i vitenarkiv
• Lee-Ødegård, Sindre; Gulseth, Hanne Løvdal; Langleite, Torgrim Mikal; Norheim, Frode; Olsen, Thomas & Refsum, Helga [Vis alle 9 forfattere av denne artikkelen] (2020). Branched-chain amino acid metabolism, insulin sensitivity and liver fat response to exercise training in sedentary dysglycaemic and normoglycaemic men. Diabetologia. ISSN 0012-186X. 64, s. 410–423. doi: 10.1007/s00125-020-05296-0. Fulltekst i vitenarkiv
• Ljøsne, Isabelle Sylvie Budin; Friedman, Barbara Bodorkos; Suri, Sana; Solé-Padullés, Cristina; Düzel, Sandra & Drevon, Christian A [Vis alle 24 forfattere av denne artikkelen] (2020). The global brain health survey: Development of a multi-language survey of public views on brain health. Frontiers in Public Health. ISSN 2296-2565. 8:387, s. 1–13. doi: 10.3389/fpubh.2020.00387. Fulltekst i vitenarkiv
• Zhou, Zhenqi; Moore, Timothy M.; Drew, Brian G.; Ribas, Vicent; Wanagat, Jonathan & Civelek, Mete [Vis alle 31 forfattere av denne artikkelen] (2020). Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling. Science Translational Medicine. ISSN 1946-6234. 12(555). doi: 10.1126/SCITRANSLMED.AAX8096. Fulltekst i vitenarkiv Vis sammendrag

  Obesity is heightened during aging, and although the estrogen receptor  (ER) has been implicated in the prevention of obesity, its molecular actions in adipocytes remain inadequately understood. Here, we show that adipose tissue ESR1/Esr1 expression inversely associated with adiposity and positively associated with genes involved in mitochondrial metabolism and markers of metabolic health in 700 Finnish men and 100 strains of inbred mice from the UCLA Hybrid Mouse Diversity Panel. To determine the anti-obesity actions of ER in fat, we selectively deleted Esr1 from white and brown adipocytes in mice. In white adipose tissue, Esr1 controlled oxidative metabolism by restraining the targeted elimination of mitochondria via the E3 ubiquitin ligase parkin. mtDNA content was elevated, and adipose tissue mass was reduced in adipose-selective parkin knockout mice. In brown fat centrally involved in body temperature maintenance, Esr1 was requisite for both mitochondrial remodeling by dynamin-related protein 1 (Drp1) and uncoupled respiration thermogenesis by uncoupled protein 1 (Ucp1). In both white and brown fat of female mice and adipocytes in culture, mitochondrial dysfunction in the context of Esr1 deletion was paralleled by a reduction in the expression of the mtDNA polymerase γ subunit Polg1. We identified Polg1 as an ER target gene by showing that ER binds the Polg1 promoter to control its expression in 3T3L1 adipocytes. These findings support strategies leveraging ER action on mitochondrial function in adipocytes to combat obesity and metabolic dysfunction.

• Hansen, Anne-Marte; Wium, Cecilie; Lee-Ødegård, Sindre; Tierney, Audrey C.; McCarthy, Danielle & Roche, Helen M. [Vis alle 9 forfattere av denne artikkelen] (2020). Substantial inter-individual variations in insulin secretion and sensitivity across the glucometabolic spectrum. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 80(4), s. 282–290. doi: 10.1080/00365513.2020.1730433. Fulltekst i vitenarkiv
• Olsen, Thomas; Øvrebø, Bente; Haj Yasein, Nadia; Lee-Ødegård, Sindre; Svendsen, Karianne & Hjorth, Marit [Vis alle 11 forfattere av denne artikkelen] (2020). Effects of dietary methionine and cysteine restriction on plasma biomarkers, serum fibroblast growth factor 21, and adipose tissue gene expression in women with overweight or obesity: a double-blind randomized controlled pilot study. Journal of Translational Medicine. ISSN 1479-5876. 18(122). doi: 10.1186/s12967-020-02288-x. Fulltekst i vitenarkiv
• Celis-Morales, Carlos; Livingstone, Katherine M.; Petermann-Rocha, Fanny; Navas-Carretero, Santiago; San-Cristobal, Rodrigo & O'Donovan, Clare B. [Vis alle 22 forfattere av denne artikkelen] (2019). Frequent nutritional feedback, personalized advice, and behavioral changes: Findings from the European Food4Me Internet-Based RCT. American Journal of Preventive Medicine. ISSN 0749-3797. 57(2), s. 209–219. doi: 10.1016/j.amepre.2019.03.024.
• Friedman, Barbara Bodorkos; Suri, Sana; Sole-Padulles, Cristina; Düzel, Sandra; Drevon, Christian A & Baaré, William F. C. [Vis alle 16 forfattere av denne artikkelen] (2019). Are People Ready for Personalized Brain Health? Perspectives of Research Participants in the Lifebrain Consortium. The gerontologist. ISSN 0016-9013. doi: 10.1093/geront/gnz155. Fulltekst i vitenarkiv
• Fjell, Anders Martin; Sørensen, Øystein; Amlien, Inge Kasbohm; Bartrés-Faz, David; Bros, Didac Macia & Buchmann, Nikolaus [Vis alle 28 forfattere av denne artikkelen] (2019). Self-reported sleep relates to hippocampal atrophy across the adult lifespan – results from the Lifebrain consortium. Sleep. ISSN 0161-8105. doi: 10.1093/sleep/zsz280. Fulltekst i vitenarkiv
• Olsen, Thomas; Vinknes, Kathrine; Blomhoff, Rune; Lysne, Vegard; Midttun, Øivind & Dhar, Indu [Vis alle 12 forfattere av denne artikkelen] (2019). Creatinine, total cysteine and uric acid are associated with serum retinol in patients with cardiovascular disease. European Journal of Nutrition. ISSN 1436-6207. doi: 10.1007/s00394-019-02086-2. Fulltekst i vitenarkiv
• Lee-Ødegård, Sindre; Kolset, Svein Olav; Birkeland, Kåre I.; Drevon, Christian A & Reine, Trine M. (2019). Acute exercise increases syndecan-1 and -4 serum concentrations. Glycoconjugate Journal. ISSN 0282-0080. 36(2), s. 113–125. doi: 10.1007/s10719-019-09869-z. Fulltekst i vitenarkiv
• Blakstad, Elin Wahl; Korpela, Katri; Lee-Ødegård, Sindre; Nakstad, Britt; Moltu, Sissel & Strømmen, Kenneth [Vis alle 11 forfattere av denne artikkelen] (2019). Enhanced nutrient supply and intestinal microbiota development in very low birth weight infants. Pediatric Research. ISSN 0031-3998. doi: 10.1038/s41390-019-0412-x.
• Lee-Ødegård, Sindre; Norheim, Frode; Langleite, Torgrim Mikal; Gulseth, Hanne Løvdal; Birkeland, Kåre I. & Drevon, Christian A (2019). Effects of long-term exercise on plasma adipokine levels and inflammation-related gene expression in subcutaneous adipose tissue in sedentary dysglycaemic, overweight men and sedentary normoglycaemic men of healthy weight. Diabetologia. ISSN 0012-186X. 62(6), s. 1048–1064. doi: 10.1007/s00125-019-4866-5. Fulltekst i vitenarkiv
• Gulseth, Hanne Løvdal; Gjelstad, Ingrid Merethe Fange; Tiereny, Audrey C.; McCarthy, Danielle; Lovegrove, Julie A. & Defoort, Catherine [Vis alle 13 forfattere av denne artikkelen] (2019). Effects of dietary fat on insulin secretion in subjects with the metabolic syndrome. European Journal of Endocrinology (EJE). ISSN 0804-4643. 180(5), s. 321–328. doi: 10.1530/EJE-19-0022. Fulltekst i vitenarkiv
• Aryal, Sanjay; Hussain, Suleman; Drevon, Christian A; Nagelhus, Erlend Arnulf; Hvalby, Øyvind & Jensen, Vidar [Vis alle 8 forfattere av denne artikkelen] (2019). Omega-3 fatty acids regulate plasticity in distinct hippocampal glutamatergic synapses. European Journal of Neuroscience. ISSN 0953-816X. 49(1), s. 40–50. doi: 10.1111/ejn.14224.
• Lee-Ødegård, Sindre; Olsen, Thomas; Vinknes, Kathrine; Refsum, Helga; Gulseth, Hanne Løvdal & Birkeland, Kåre I. [Vis alle 7 forfattere av denne artikkelen] (2019). Plasma Sulphur-Containing Amino Acids, Physical Exercise and Insulin Sensitivity in Overweight Dysglycemic and Normal Weight Normoglycemic Men. Nutrients. ISSN 2072-6643. 11(1). doi: 10.3390/nu11010010. Fulltekst i vitenarkiv
• Walhovd, Kristine B; Fjell, Anders Martin; Westerhausen, Rene; Nyberg, L; Ebmeier, K.P. & Lindenberger, U. [Vis alle 18 forfattere av denne artikkelen] (2018). Healthy minds from 0-100 years: Optimising the use of European brain imaging cohorts ("Lifebrain"). European psychiatry. ISSN 0924-9338. 47, s. 76–87. doi: 10.1016/j.eurpsy.2017.10.005.
• Moore, Timothy M.; Zhou, Zhenqi; Cohn, Whitaker; Norheim, Frode; Lin, Amanda J. & Kalajian, Nareg [Vis alle 23 forfattere av denne artikkelen] (2018). The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle. Molecular Metabolism. ISSN 2212-8778. 21, s. 51–67. doi: 10.1016/j.molmet.2018.11.012. Fulltekst i vitenarkiv
• Navas-Carretero, Santiago; San-Cristobal, Rodrigo; Livingstone, Katherine M.; Celis-Morales, Carlos; Marsaux, Cyril F. & Macready, Anna L. [Vis alle 24 forfattere av denne artikkelen] (2018). Higher vegetable protein consumption, assessed by an isoenergetic macronutrient exchange model, is associated with a lower presence of overweight and obesity in the web-based Food4me European study. International Journal of Food Sciences and Nutrition. ISSN 0963-7486. 70(2), s. 240–253. doi: 10.1080/09637486.2018.1492524.
• Fallaize, Rosalind; Livingstone, Katherine M.; Celis-Morales, Carlos; Macready, Anna L.; San-Cristobal, Rodrigo & Navas-Carretero, Santiago [Vis alle 24 forfattere av denne artikkelen] (2018). Association between diet-quality scores, adiposity and biomarkers of cardiometabolic risk in European adults: findings from the Food4Me study. Nutrients. ISSN 2072-6643. 10(1). doi: 10.3390/nu10010049. Fulltekst i vitenarkiv
• Seldin, Marcus M.; Koplev, Simon; Rajbhandari, Prashant; Vergnes, Laurent; Rosenberg, Gregory M & Meng, Yonghong [Vis alle 27 forfattere av denne artikkelen] (2018). A strategy for discovery of endocrine interactions with application to whole-body metabolism. Cell Metabolism. ISSN 1550-4131. 27(5), s. 1138–1155.e6. doi: 10.1016/j.cmet.2018.03.015.
• Puaschitz, Nathalie Genevieve; Assmus, Jörg; Strand, Elin; Karlsson, Therese; Vinknes, Kathrine & Lysne, Vegard [Vis alle 10 forfattere av denne artikkelen] (2018). Adherence to the Healthy Nordic Food Index and the incidence of acute myocardial infarction and mortality among patients with stable angina pectoris. Journal of human nutrition and dietetics. ISSN 0952-3871. 32, s. 86–97. doi: 10.1111/jhn.12592. Fulltekst i vitenarkiv
• Rosendahl-Riise, Hanne; Sulo, Gerhard; Karlsson, Therese; Drevon, Christian A; Dierkes, Jutta & Tell, Grethe S. (2018). Limited benefit of fish consumption on risk of hip fracture among men in the community-based Hordaland health study. Nutrients. ISSN 2072-6643. 10(7). doi: 10.3390/nu10070873. Fulltekst i vitenarkiv
• Wanders, Anne J.; Alssema, Marjan; De Hoon, Sabine E.M.; Feskens, Edith J.M.; van Woudenbergh, Geertruida J. & Van Der Kallen, Carla J. [Vis alle 14 forfattere av denne artikkelen] (2018). Circulating Polyunsaturated Fatty Acids as Biomarkers for Dietary Intake across Subgroups: The CODAM and Hoorn Studies. Annals of Nutrition and Metabolism. ISSN 0250-6807. 72(2), s. 117–125. doi: 10.1159/000486244.
• Lee-Ødegård, Sindre; Norheim, Frode; Gulseth, Hanne Løvdal; Langleite, Torgrim Mikal; Aker, Andreas Helge Mikael & Gundersen, Thomas Erik [Vis alle 9 forfattere av denne artikkelen] (2018). Skeletal muscle phosphatidylcholine and phosphatidylethanolamine respond to exercise and influence insulin sensitivity in men. Scientific Reports. ISSN 2045-2322. 8:6531, s. 1–12. doi: 10.1038/s41598-018-24976-x. Fulltekst i vitenarkiv
• Korpela, Katri; Blakstad, Elin Wahl; Moltu, Sissel; Strømmen, Kenneth; Nakstad, Britt & Rønnestad, Arild Erlend [Vis alle 10 forfattere av denne artikkelen] (2018). Intestinal microbiota development and gestational age in preterm neonates. Scientific Reports. ISSN 2045-2322. 8:2453, s. 1–9. doi: 10.1038/s41598-018-20827-x. Fulltekst i vitenarkiv
• Rosendahl-Riise, Hanne; Karlsson, Therese; Drevon, Christian A; Apalset, Ellen M; Nygård, Ottar & Tell, Grethe S. [Vis alle 7 forfattere av denne artikkelen] (2018). Total and lean fish intake is positively associated with bone mineral density in older women in the community-based Hordaland Health Study. European Journal of Nutrition. ISSN 1436-6207. s. 1–11. doi: 10.1007/s00394-018-1665-6.
• Norheim, Frode; Bjellaas, Thomas; Hui, Simon T; Chella Krishnan, Karthickeyan; Lee, Jakleen & Gupta, Sonul [Vis alle 21 forfattere av denne artikkelen] (2018). Genetic, dietary, and sex-specific regulation of hepatic ceramides and relationship between hepatic ceramides and insulin resistance. Journal of Lipid Research. ISSN 0022-2275. 59(7), s. 1164–1174. doi: 10.1194/jlr.M081398.
• Sommer, Christine; Lee, Sindre; Gulseth, Hanne Løvdal; Jensen, Jørgen; Drevon, Christian A & Birkeland, Kåre I. (2018). Soluble leptin receptor predicts insulin sensitivity and correlates with upregulation of metabolic pathways in men. Journal of Clinical Endocrinology and Metabolism (JCEM). ISSN 0021-972X. 103(3), s. 1024–1032. doi: 10.1210/jc.2017-02126.
• Brouwer-Brolsma, Elske M.; Brennan, Lorraine; Drevon, Christian A; Van Kranen, Henk; Manach, Claudine & Dragsted, Lars Ove [Vis alle 26 forfattere av denne artikkelen] (2017). Combining traditional dietary assessment methods with novel metabolomics techniques: Present efforts by the Food Biomarker Alliance. Proceedings of the Nutrition Society. ISSN 0029-6651. 76(4), s. 619–627. doi: 10.1017/S0029665117003949.
• Celis-Morales, C; Livingstone, Katherine M; Affleck, A; Navas-Carretero, S; San-Cristobal, R & Martinez, JA [Vis alle 27 forfattere av denne artikkelen] (2017). Correlates of overall and central obesity in adults from seven European countries: findings from the Food4Me Study. European Journal of Clinical Nutrition. ISSN 0954-3007. s. 1–13. doi: 10.1038/s41430-017-0004-y.
• San-Cristobal, R; Navas-Carretero, S; Celis-Morales, C; Livingstone, KM; Stewart-Knox, B & Rankin, A [Vis alle 28 forfattere av denne artikkelen] (2017). Capturing health and eating status through a nutritional perception screening questionnaire (NPSQ9) in a randomised internet-based personalised nutrition intervention: the Food4Me study. International Journal of Behavioral Nutrition and Physical Activity. ISSN 1479-5868. 11(14). doi: 10.1186/s12966-017-0624-6.
• Brouwer-Brolsma, EM; Brennan, L; Drevon, Christian A; van Kranen, H; Manach, C & Dragsted, LO [Vis alle 26 forfattere av denne artikkelen] (2017). Combining traditional dietary assessment methods with novel metabolomics techniques: Current efforts by the Food Biomarker Alliance. Proceedings of the Nutrition Society. ISSN 0029-6651. 76(4), s. 619–627. doi: 10.1017/S00029665117003949.
• O´Donovan, CB; Walsh, MC; Woodhead, C; Forster, Hannah; Celis-Morales, Carlos & Fallaize, Rosalind [Vis alle 28 forfattere av denne artikkelen] (2017). Metabotyping for the development of tailored dietary advice solutions in a European population: the Food4Me study. British Journal of Nutrition. ISSN 0007-1145. 118(5), s. 561–569. doi: 10.1017/S0007114517002069.
• Fallaize, Rosalind; Carvalho-Wells, AL; Tierny, AC; Marin, C; Kiec-Wilk, B & Dembinska-Kiec, A [Vis alle 14 forfattere av denne artikkelen] (2017). APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome. Scientific Reports. ISSN 2045-2322. 7(1). doi: 10.1038/s41598-017-05802-2.
• Goergens, SW; Benninghoff, T; Eckardt, Kristin; Springer, C.; Chadt, A & Melior, A [Vis alle 13 forfattere av denne artikkelen] (2017). Hypoxia in Combination With Muscle Contraction Improves Insulin Action and Glucose Metabolism in Human Skeletal Muscle via the HIF-1a Pathway. Diabetes. ISSN 0012-1797. 66(11), s. 2800–2807. doi: 10.2337/DB16-1488.
• Livingstone, Katherine M.; Celis-Morales, Carlos; Macready, Anna L.; Fallaize, Rosalind; Forster, Hannah & Woolhead, Clara [Vis alle 27 forfattere av denne artikkelen] (2017). Characteristics of European adults who dropped out from the Food4Me Internet-based personalised nutrition intervention. Public Health Nutrition (PHN). ISSN 1368-9800. 20(1), s. 53–63. doi: 10.1017/S1368980016002020.
• Celis-Morales, Carlos; Marsaux, Cyril F.M.; Livingstone, Katherine M.; Navas-Carretero, Santiago; San-Cristobal, Rodrigo & Fallaize, Rosalind [Vis alle 28 forfattere av denne artikkelen] (2017). Can genetic-based advice help you lose weight? Findings from the Food4Me European randomized controlled trial. American Journal of Clinical Nutrition. ISSN 0002-9165. 105(5), s. 1204–1213. doi: 10.3945/ajcn.116.145680.
• San-Cristobal, Rodrigo; Navas-Carretero, Santiago; Livingstone, Katherine M.; Celis-Morales, Carlos; Macready, Anna L. & Fallaize, Rosalind [Vis alle 26 forfattere av denne artikkelen] (2017). Mediterranean diet adherence and genetic background roles within a web-based nutritional intervention: The food4me study. Nutrients. ISSN 2072-6643. 9:1107(10), s. 1–17. doi: 10.3390/nu9101107.
• Pérez-Martínez, Pablo; Mikhailidis, Dimitri P.; Athyros, Vasilios G.; Bullo, Monica; Couture, Patrick & Covas, Maria I. [Vis alle 34 forfattere av denne artikkelen] (2017). Lifestyle recommendations for the prevention and management of metabolic syndrome: An international panel recommendation. Nutrition reviews. ISSN 0029-6643. 75(5), s. 307–326. doi: 10.1093/nutrit/nux014.
• Albani, Viviana; Celis-Morales, Carlos; O'Donovan, Clare B; Walsh, Marianne C; Woolhead, Clara & Forster, Hannah [Vis alle 30 forfattere av denne artikkelen] (2017). Within-person reproducibility and sensitivity to dietary change of C15:0 and C17:0 levels in dried blood spots: Data from the European Food4Me Study. Molecular Nutrition & Food Research. ISSN 1613-4125. 61(10). doi: 10.1002/mnfr.201700142.
• Pourteymour, Shirin; Hjorth, Marit; Lee-Ødegård, Sindre; Holen, Torgeir; Langleite, Torgrim Mikal & Jensen, Jørgen [Vis alle 9 forfattere av denne artikkelen] (2017). Dual specificity phosphatase 5 and 6 are oppositely regulated in human skeletal muscle by acute exercise. Physiological Reports. ISSN 2051-817X. 5:e13459(19), s. 1–14. doi: 10.14814/phy2.13459. Fulltekst i vitenarkiv
• Gjevestad, Gyrd Omholt; Hamarsland, Håvard; Raastad, Truls; Ottestad, Inger; Christensen, Jacob J. & Eckardt, Kristin [Vis alle 10 forfattere av denne artikkelen] (2017). Gene expression is differentially regulated in skeletal muscle and circulating immune cells in response to an acute bout of high-load strength exercise. Genes & Nutrition. ISSN 1555-8932. 12:8, s. 1–11. doi: 10.1186/s12263-017-0556-4. Vis sammendrag

  Background: High-intensity exercise induces many metabolic responses. In is unknown whether the response in the peripheral blood mononuclear cells (PBMCs) reflects the response in skeletal muscle and whether mRNA expression after exercise can be modulated by nutritional intake. The aims were to (i) investigate the effect of dairy proteins on acute responses to exercise in skeletal muscle and PBMCs measuring gene expression and (ii) compare this response in young and older subjects. Methods: We performed two separate studies in young (20–40 years) and older subjects (≥70 years). Subjects were randomly allocated to a milk group or a whey group. Supplements were provided immediately after a standardized exercise session. We measured mRNA expression of selected genes after a standardized breakfast and 60/120 min after finishing the exercise, using RT-qPCR. Results: We observed no significant differences in mRNA expression between the milk and the whey group; thus, we merged both groups for further analysis. The mRNA expression of IL6, TNF, and CCL2 in skeletal muscle increased significantly after exercise compared with smaller or no increase, in mRNA expression in PBMCs in all participants. The mRNA expression of IL1RN, IL8, and IL10 increased significantly in skeletal muscle and PBMCs. Some mRNA transcripts were differently regulated in older compared to younger participants in PBMCs. Conclusions: An acute bout of heavy-load strength exercise, followed by protein supplementation, caused overlapping, but also unique, responses in skeletal muscle and PBMCs, suggesting tissue-specific functions in response to exercise. However, no different effects of the different protein supplements were observed. Altered mRNA expressions in PBMCs of older participants may affect regenerative mechanisms.

• Lund, Jenny; Rustan, Arild; Løvsletten, Nils Gunnar; Mudry, Jonathan M.; Langleite, Torgrim Mikal & Feng, Yuan Zeng [Vis alle 19 forfattere av denne artikkelen] (2017). Exercise in vivo marks human myotubes in vitro: Training-induced increase in lipid metabolism. PLOS ONE. ISSN 1932-6203. 12:e0175441(4), s. 1–24. doi: 10.1371/journal.pone.0175441. Fulltekst i vitenarkiv
• Karlsson, Therese; Rosendahl-Riise, Hanne; Dierkes, Jutta; Drevon, Christian A; Tell, Grethe S. & Nygård, Ottar (2017). Associations between fish intake and the metabolic syndrome and its components among middle-aged men and women: the Hordaland Health Study. Food & Nutrition Research (FNR). ISSN 1654-6628. 61. doi: 10.1080/16546628.2017.1347479. Fulltekst i vitenarkiv
• Strømmen, Kenneth; Haag, Alexander; Moltu, Sissel; Veierød, Marit Bragelien; Blakstad, Elin Wahl & Nakstad, Britt [Vis alle 12 forfattere av denne artikkelen] (2017). Enhanced nutrient supply to very low birth weight infants is associated with higher blood amino acid concentrations and improved growth. Clinical Nutrition ESPEN. ISSN 2405-4577. 18, s. 16–22. doi: 10.1016/j.clnesp.2017.01.003.
• Øyen, Jannike; Gjesdal, Clara Gram; Karlsson, Therese; Svingen, Gard Frodahl Tveitevåg; Tell, Grethe S. & Strand, Elin [Vis alle 11 forfattere av denne artikkelen] (2017). Dietary choline intake is directly associated with bone mineral density in the Hordaland Health Study. Journal of Nutrition. ISSN 0022-3166. 147(4), s. 572–578. doi: 10.3945/jn.116.243006.
• Olsen, Thomas; Vinknes, Kathrine; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Tell, Grethe S. & Blomhoff, Rune [Vis alle 11 forfattere av denne artikkelen] (2017). Cardiovascular disease risk associated with serum apolipoprotein B is modified by serum vitamin A. Atherosclerosis. ISSN 0021-9150. s. 325–330. doi: 10.1016/j.atherosclerosis.2017.07.020.
• Manios, Yannis; Moschonis, George; Lambrinou, Christina P.; Mavrogianni, Christina; Tsirigoti, Lydia & Hoeller, Ulrich [Vis alle 37 forfattere av denne artikkelen] (2017). Associations of vitamin D status with dietary intakes and physical activity levels among adults from seven European countries: the Food4Me study. European Journal of Nutrition. ISSN 1436-6207. Published ahead of print, s. 1–12. doi: 10.1007/s00394-017-1415-1.
• Lee, Sindre; Norheim, Frode; Gulseth, Hanne Løvdal; Langleite, Torgrim Mikal; Kolnes, Kristoffer Jensen & Tangen, Daniel S. [Vis alle 12 forfattere av denne artikkelen] (2017). Interaction between plasma fetuin-A and free fatty acids predicts changes in insulin sensitivity in response to long-term exercise. Physiological Reports. ISSN 2051-817X. 5(5). doi: 10.14814/phy2.13183. Fulltekst i vitenarkiv Vis sammendrag

  The hepatokine fetuin‐A can together with free fatty acids (FFAs) enhance adipose tissue (AT) inflammation and insulin resistance via toll‐like receptor 4 (TLR4). Although some of the health benefits of exercise can be explained by altered release of myokines from the skeletal muscle, it is not well documented if some of the beneficial effects of exercise can be explained by altered secretion of hepatokines. The aim of this study was to examine the effect of interaction between fetuin‐A and FFAs on insulin sensitivity after physical exercise. In this study, 26 sedentary men who underwent 12 weeks of combined endurance and strength exercise were included. Insulin sensitivity was measured using euglycemic‐hyperinsulinemic clamp, and AT insulin resistance was indicated by the product of fasting plasma concentration of FFAs and insulin. Blood samples and biopsies from skeletal muscle and subcutaneous AT were collected. Several phenotypic markers were measured, and mRNA sequencing was performed on the biopsies. AT macrophages were analyzed based on mRNA markers. The intervention improved hepatic parameters, reduced plasma fetuin‐A concentration (~11%, P < 0.01), slightly changed FFAs concentration, and improved glucose infusion rate (GIR) (~33%, P < 0.01) across all participants. The change in circulating fetuin‐A and FFAs interacted to predict some of the change in GIR (β = −42.16, P = 0.030), AT insulin resistance (β = 0.579, P = 0.003), gene expression related to TLR‐signaling in AT and AT macrophage mRNA (β = 94.10, P = 0.034) after exercise. We observed no interaction effects between FFAs concentrations and leptin and adiponectin on insulin sensitivity, or any interaction effects between Fetuin‐A and FFAs concentrations on skeletal muscle TLR‐signaling. The relationship between FFAs levels and insulin sensitivity seemed to be specific for fetuin‐A and the AT. Some of the beneficial effects of exercise on insulin sensitivity may be explained by changes in circulating fetuin‐A and FFAs, promoting less TLR4 signaling in AT perhaps by modulating AT macrophages.

• Pourteymour, Shirin; Eckardt, Kristin; Holen, Torgeir; Langleite, Torgrim Mikal; Lee, Sindre & Jensen, Jørgen [Vis alle 9 forfattere av denne artikkelen] (2017). Global mRNA sequencing of human skeletal muscle: Search for novel exercise-regulated myokines. Molecular Metabolism. ISSN 2212-8778. 6(4), s. 352–365. doi: 10.1016/j.molmet.2017.01.007. Fulltekst i vitenarkiv Vis sammendrag

  Objective: Skeletal muscle is an important secretory organ, producing and releasing numerous myokines, which may be involved in mediating beneficial health effects of physical activity. More than 100 myokines have been identified by different proteomics approaches, but these techniques may not detect all myokines. We used mRNA sequencing as an untargeted approach to study gene expression of secreted proteins in skeletal muscle upon acute as well as long-term exercise. Methods: Twenty-six middle-aged, sedentary men underwent combined endurance and strength training for 12 weeks. Skeletal muscle biopsies from m. vastus lateralis and blood samples were taken before and after an acute bicycle test, performed at baseline as well as after 12 weeks of training intervention. We identified transcripts encoding secretory proteins that were changed more than 1.5-fold in muscle after exercise. Secretory proteins were defined based on either curated UniProt annotations or predictions made by multiple bioinformatics methods. Results: This approach led to the identification of 161 candidate secretory transcripts that were up-regulated after acute exercise and 99 that where increased after 12 weeks exercise training. Furthermore, 92 secretory transcripts were decreased after acute and/or long-term physical activity. From these responsive transcripts, we selected 17 candidate myokines sensitive to short- and/or long-term exercise that have not been described as myokines before. The expression of these transcripts was confirmed in primary human skeletal muscle cells during in vitro differentiation and electrical pulse stimulation (EPS). One of the candidates we identified was macrophage colony-stimulating factor-1 (CSF1), which influences macrophage homeostasis. CSF1 mRNA increased in skeletal muscle after acute and long-term exercise, which was accompanied by a rise in circulating CSF1 protein. In cultured muscle cells, EPS promoted a significant increase in the expression and secretion of CSF1. Conclusion: We identified 17 new, exercise-responsive transcripts encoding secretory proteins. We further identified CSF1 as a novel myokine, which is secreted from cultured muscle cells and up-regulated in muscle and plasma after acute exercise.

• Karlsson, Therese; Strand, Elin; Dierkes, Jutta; Drevon, Christian A; Øyen, Jannike & Midttun, Øivind [Vis alle 10 forfattere av denne artikkelen] (2017). Associations between intake of fish and n-3 long-chain polyunsaturated fatty acids and plasma metabolites related to the kynurenine pathway in patients with coronary artery disease. European Journal of Nutrition. ISSN 1436-6207. 56(1), s. 261–272. doi: 10.1007/s00394-015-1077-9.
• Kirwan, Laura; Walsh, Marianne C; Celis-Morales, Carlos; Marsaux, Cyril F M; Livingstone, Katherine M & Navas-Carretero, Santiago [Vis alle 25 forfattere av denne artikkelen] (2016). Phenotypic factors influencing the variation in response of circulating cholesterol level to personalised dietary advice in the Food4Me study. British Journal of Nutrition. ISSN 0007-1145. 116(12), s. 2011–2019. doi: 10.1017/S0007114516004256.
• Celis-Morales, Carlos; Livingstone, Katherine M; Marsaux, Cyril F M; Macready, Anna; Fallaize, Rosalind & O´Donovan, CB [Vis alle 35 forfattere av denne artikkelen] (2016). Effect of personalized nutrition on health-related behavior change: evidence from the Food4Me European randomized controlled trial. International Journal of Epidemiology. ISSN 0300-5771. doi: 10.1093/ije/dyw186.
• O´Donovan, CB; Walsh, MC; Förster, H; Woolhead, Clara; Celis-Morales, Carlos & Fallaize, Rosalind [Vis alle 29 forfattere av denne artikkelen] (2016). The impact of MTHFR 677C→T risk knowledge on changes in folate intake: findings from the Food4Me study. Genes & Nutrition. ISSN 1555-8932. doi: 10.1186/s12263-016-0539-x.
• Livingstone, KM; Celis-Morales, Carlos; Hoeller, Ulrich; Lambrinou, CP; Moschonis, George & Macready, AL [Vis alle 26 forfattere av denne artikkelen] (2016). Weekday sunlight exposure, but not vitamin D intake, influences the association between vitamin D receptor genotype and circulating concentration 25-hydroxyvitamin D in a pan-European population: the Food4Me study. Molecular Nutrition & Food Research. ISSN 1613-4125. 61(2). doi: 10.1002/mnfr.201600476.
• Livingstone, KM; Celis-Morales, Carlos; Lara, J; Woolhead, Clara; O´Donovan, CB & Förster, H [Vis alle 28 forfattere av denne artikkelen] (2016). Clustering of adherence to personalized dietary recommendations and changes in healthy eating index within the Food4Me Study. Public Health Nutrition (PHN). ISSN 1368-9800. 19(18), s. 3296–3305. doi: 10.1017/S1368980016001932.
• Møller, M; Gjelstad, Ingrid Merethe Fange; Baksaas, I; Aukrust, IR & Drevon, Christian A (2016). Bioavailability and chemica/functional aspects of synthetic MK-7 vs fermentation-derived MK-7 in randomised controlled trials. International Journal for Vitamin and Nutrition Research. ISSN 0300-9831. doi: 10.1024/0300-9831/a000258.

Se alle arbeider i Cristin

• Retterstøl, Kjetil; Drevon, Christian A & Blomhoff, Rune (2019). Kapittel 28: Hjerte-karsykdommer. Cappelen Damm Akademisk. ISBN 9788202643904. 540 s.

Se alle arbeider i Cristin

• Lee-Ødegård, Sindre; Norheim, Frode Amador; Langleite, Torgrim Mikal; Gulseth, Hanne Løvdal; Birkeland, Kåre Inge & Drevon, Christian A (2022). Correction to: Effects of long-term exercise on plasma adipokine levels and inflammation-related gene expression in subcutaneous adipose tissue in sedentary dysglycaemic, overweight men and sedentary normoglycaemic men of healthy weight (Diabetologia, (2019), 62, 6, (1048-1064), 10.1007/s00125-019-4866-5). Diabetologia. ISSN 0012-186X. doi: 10.1007/s00125-022-05841-z.
• Strømmen, Kenneth; Lyche, Jan Ludvig; Moltu, Sissel; Müller, Mette Helen Bjørge; Blakstad, Elin Wahl & Almaas, Astrid Nylander [Vis alle 12 forfattere av denne artikkelen] (2021). Corrigendum to “High urinary concentrations of parabens and bisphenol A in very low birth weight infants”. Chemosphere. ISSN 0045-6535. 275. doi: 10.1016/j.chemosphere.2021.130613.
• Livingstone, Katherine M.; Celis-Morales, Carlos; Lara, Jose; Woolhead, Clara; O'Donovan, Clare B. & Forster, Hannah [Vis alle 28 forfattere av denne artikkelen] (2019). Corrigendum: Clustering of adherence to personalised dietary recommendations and changes in healthy eating index within the Food4Me study (Public Health Nutrition 19:18 (3296-305) DOI: 10.1017/S1368980016001932). Public Health Nutrition (PHN). ISSN 1368-9800. 22(11), s. 2141–2146. doi: 10.1017/S1368980019001502.
• Lee-Ødegård, Sindre; Norheim, Frode Amador; Gulseth, Hanne Løvdal; Langleite, Torgrim Mikal; Aker, Andreas Helge Mikael & Gundersen, Thomas Erik [Vis alle 9 forfattere av denne artikkelen] (2018). Author Correction: Skeletal muscle phosphatidylcholine and phosphatidylethanolamine respond to exercise and influence insulin sensitivity in men. Scientific Reports. ISSN 2045-2322. 8(1). doi: 10.1038/s41598-018-26061-9.
• Henriksen, Christine; Almaas, Astrid; Westerberg, Ane Cecilie; Drevon, Christian A; Iversen, Per Ole & Nakstad, Britt (2017). Growth, metabolic profile and IQ in 8 years old children born preterm: Follow-up of an RCT with essential fatty acids (foredraget ble holdt på norsk).
• Eckardt, Kristin; Pourteymour, Shirin; Hjorth, Marit; Lee, Sindre; Langleite, Torgrim Mikal & Holen, Torgeir [Vis alle 9 forfattere av denne artikkelen] (2016). Dual specificity phosphatase 5 and 6 are oppositely regulated in human skeletal muscle by acute exercise.

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