Jason Matthews

Bilde av Jason Matthews
English version of this page
Telefon +47-22851102
Brukernavn
Besøksadresse Sognsvannsveien 9 Domus Medica 0372 OSLO
Postadresse Postboks 1046 Blindern 0317 OSLO
Andre tilknytninger Avdeling for ernæringsvitenskap

Faglige interesser

Vi studerer mekanismene som involvert i aryl hydrokarbon reseptor (AHR)-signalering, påvirket activitet av endogene forbindelser, næringsstoffer og som miljøgifter. Vi studerer hvordan AHR regulerer genuttrykk og hvordan den påvirker andre reseptor-medierte signalveier og hvordan AHR fungerer under normale fysiologiske forhold, i metabolske sykdommer, i kreft og i forbindelse med inflammasjon. Vi er spesielt interessert i hvordan disse prosessene påvirkes av det AHR-regulerte målgenet TIPARP (TCDD inducible poly-ADP-ribose polymerase).

Undervisning

  • MED3003 – Epigenetisk analyse av stam- og kreftceller
  • ERN3120 – Molecular, cellular and clinical nutrition
  • ERN2300 – Mikronæringsstoffer – fra molekylære mekanismer til klinikk
  • MED1100 – Medisinstudiet, modul 1
  • ERN4120 – Humanforsøk
  • ERN4210 – Masteremne i ernæringsbiologi

Bakgrunn

Undervisning

  • 2001: Ph.D. - Dept of biochemistry and Molecular Biology, Michigan State University, USA
  • 1997: B.Sc. Toxicology and Environmental Science, Faculty of Medicine, University of Western, Canada

Arbeidserfaring

  • 2015- Professor, Avdeling for ernæringsvitenskap, Institutt for medisinske basalfag, Universitetet i Oslo
  • 2011-2015 Associate Professor, Dept of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Canada
  • 2012-2013 Gjesteprofessor, Avdeling for ernæringsvitenskap, Institutt for medisinske basalfag, Universitetet i Oslo
  • 2006-2011 Assistant Professor, Dept of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Canada
  • 2001-2006 Postdoktor, Institutt for biovitenskap og ernæring, Det Karolinska instituttet, Sverige. Veileder: Prof. Jan-Åke Gustafsson

Priser

  • 2011 - V. E. Henderson Award – Society of Toxicology Canada
  • 2011 - Early Researcher Award – Ministry of Research and Innovation Ontario Canada
  • 2009 - R. Gaurth Hansen Award Lectureship, Michigan State University
  • 2008 - Canadian Institutes of Health New Investigator Award

Samarbeid

  • Prof. Hilde Irene Nebb, Assoc. Prof. Knut Tomas Dalen og Prof. Bjørn Skålhegg, Avdeling for ernæringsvitenskap, Institutt for medisinske basalfag, Universitetet i Oslo
  • Dr. Jan Haug Anonsen og Anders Moen, Institutt for biovitenskap, Universitetet i Oslo
  • Prof. Akinori Takaoka, M.D., Ph.D. Director of the Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
  • Dr. Carolyn Baglole, Meakins-Christie Laboratories, McGill University, Montreal, QC Canada
  • Prof. Tim Zacharewski, Department of Biochemistry, Michigan State University, East Lansing Michigan USA

 

Publikasjoner

Forskningsartikler og bokkapitler

•    Nault, R., Fader, K.A., Kirby, M.P., Ahmed, S., Matthews, J., Jones, D.A., Lunt, S.Y., Zacharewski, T.R. Pyruvate kinase isoform switching and hepatic metabolic reprogramming by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicol Sci In press. 

•    Sarill, M., Zago, M., Shreidan, J.A., Nair, P., Matthews, J., Gomez, A., Hamid, Q., Eidelman, D.H., and Baglole, C.J. (2015) The aryl hydrocarbon receptor suppresses cigarette smoke-induced oxidative stress via dioxin response element (DRE)-independent regulation of sulfiredoxin 1. Free Radical Biology and Medicine 89:342-357.

•    Ahmed, S., Bott, D., Gomez, A., Tamblyn, L., Raheed, A., MacPherson, L., Sugamuri, K.S., Cho, T. Yang, S., Grant, D.M. Cummins, C. and Matthews, J. (2015) Loss of the Mono-ADP-Ribosyltransferase, TIPARP, increases sensitivity to dioxin-induced steatohepatitis and lethality. J. Biol. Chem 290(27):16824-40.

•    Bindesboll, C., Fan, Q., Ruan, H-B., MacPherson, L., Wu, J., Norgaard, R.C., Steffensen, K.R., Yang, X., Matthews, J., Mandrup, S., Nebb, H.I., Gronning-Wang, L. (2015) Liver X Receptor Regulates Hepatic Nuclear O-GlcNAc Cycling and Carbohydrate Responsive Element-Binding Protein Activity. J of Lipid Res 56(4):771-85. 

•    Hecht, E., Zago, M., Rico de Souza, A., Gomez, A., Matthews, J., Hamid, Q., Eidelman, D.H., and Baglole, C.J. (2014) Aryl hydrocarbon receptor-dependent regulation of miR-196a expression controls lung fibroblast apoptosis but not proliferation. Toxicol Appl Pharmacol. Nov 280(3):511-25. 

•    MacPherson, L., Ahmed, S., Tamblyn, L., Krutmann, J., Forster, I., Weighardt, H., and Matthews, J. (2014) Aryl hydrocarbon receptor repressor and TiPARP (ARTD14) use similar, but also distinct mechanisms to repress aryl hydrocarbon receptor signaling. Int J Mol Sci. 15(5):7939-57.

•    Ahmed, S., Wang, A., Celius, T, and Matthews, J. (2014) Zinc finger nuclease-mediated knockout of AHR or ARNT in human breast cancer cells abolishes basal and ligand-dependent regulation of CYP1B1 and differentially affects estrogen receptor  transactivation Toxicol Sci. Mar;138(1):89-103

•    Lo, R., and Matthews, J. (2013) The aryl hydrocarbon receptor and estrogen receptor alpha differentially modulate nuclear factor erythroid-2-related factor 2 (NRF2) transactivation in MCF-7 breast cancer cells. Toxicol Appl Pharmacol Jul 15;270(2):139-48.

•    MacPherson, L., Tamblyn, L., Rajendra, S., Bralha, F., McPherson, J.P., and Matthews, J. (2013) 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) poly(ADP-ribose) polymerase (TiPARP) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation. Nucleic Acid Res. Feb 1;41(3):1604-21.

•    Wu, A., Dalvi, P., Lu, X., Yang, M., Riddick, D., Matthews, J., Clevenger, C.V., Ross, D.D., Harper, P., and Ito, S. (2013) Induction of multidrug resistance transporter ABCG2 by prolactin in human breast cancer cells. Mol. Pharm Feb;83(2):377-88.

•    Matthews, J. and Ahmed, S. AHR and ER mediated toxicology and chemoprevention, In Advances in Molecular Toxicology volume 7. Editor: James C Fishbein. Elsevier Amsterdam, The Netherlands 2013.

•    Lo, R and Matthews, J. (2012) High-resolution genome-wide mapping of AHR and ARNT binding sites by ChIP-Seq. Toxicol Sci August 30(2):349-61. 

•    Ahmed, S., Al-Saigh, Sarra and Matthews, J (2012) FOXA1 is essential for aryl hydrocarbon receptor-dependent regulation of cyclin G2. Mol Can Res. May 10(5):636-48.

•    Lo, R., Forgacs, A., Celius, T., MacPherson, L., Harper, P., Zacharewski, T., and Matthews, J. (2011) Identification of Aryl Hydrocarbon Receptor Binding Targets in mouse hepatic tissue treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol Nov 257(1):38-47

•    Dere, E., Lo, R., Celius, T. Matthews, J., and Zacharewski, T. (2011) Integration of Genome-Wide Computation DRE Search, AhR ChIP-chip and Gene Expression Analyses of TCDD-Elicited Responses in the Mouse Liver. BMC Genomics Jan 12(1):365.

•    Powis, M., Celius, T., and Matthews, J. (2011) Differential ligand-dependent activation and a role for Y322 in aryl hydrocarbon receptor-mediated transcription. Biochem Biophys Res Comm. Jul 410(4):859-65.

•    Celius, T and Matthews, J. (2010) Functional analysis of six aryl hydrocarbon receptor variants in human breast cancer and mouse hepatoma cell lines. Toxicology Nov 277, 59-65. 

•    MacPherson. L. and Matthews, J. (2010) Inhibition of AHR-dependent transcription by resveratrol or kaempferol is independent of estrogen receptor alpha in T-47D human breast cancer cells. Cancer Lett, Dec 299, 119-129. 

•    Pansoy, A., Ahmed, S., Valen, E., Sandelin, A., and Matthews, J. (2010) 3-methylcholanthrene-induces differential recruitment of aryl hydrocarbon receptor to human promoters. Toxicol Sci Sept 117, 90–100. 

•    Celius, T., Pansoy, A., Matthews, J. Okey, A.B. Henderson, M., Krueger, S., and Williams, D. (2010) Flavin-containing monooxygenase-3: induction by 3-methylcholanthrene and complex regulation by xenobiotic chemicals in hepatoma cells and mouse liver. Toxicol Appl Pharmacol Aug 247(1), 60-69. 

•    Lo, R and Matthews, J A New Class of Estrogen Receptor Beta–Selective Activators  (2010) Mol Interventions Jun;10(3):133-6 

•    Lo, R., Burgoon, L., MacPherson, L., Ahmed, S. and Matthews, J. (2010) Estrogen receptor and estrogen dependent regulation of CYP2B6 in human breast cancer cells. BBA Gen Regulatory Mechanisms. May 1799 (5-6), 469-479. 

•    Ahmed, S, Valen, E., Sandelin, A., and Matthews, J. (2009). Dioxin increases the interaction between aryl hydrocarbon receptor and estrogen receptor alpha at human promoters. Toxicol Sci 111, 254-266. 

•    Wihlen, B., Ahmed, S., Inzunza, J., and Matthews, J. (2009) Estrogen receptor subtype- and promoter-specific modulation of aryl hydrocarbon receptor transactivation. Mol Cancer Res June 7 (6), 977-986. 

•    MacPherson, L., Lo, R., Ahmed, S, Pansoy, P., and Matthews, J. (2009) Activation Function 2 mediates dioxin-induced recruitment of estrogen receptor alpha to CYP1A1 and CYP1B1. Biochem Biophys Res Comm July 385, 263-268. 

•    Celius, T., Roblin, S., Harper, P.A., Boutros, P.C., Moffat, I.D., Wendelin, D., Matthews, J., Pohjanvirta, R., and Okey, A.B. (2008) Aryl hydrocarbon receptor-dependent induction of flavin-containing monooxygenase mRNAs in mouse liver. Drug Metab Dispos 36, 2499-2505. 

•    Matthews, J., Wihlen, B., Heldring, N., Helguero, L., Macpherson, L., Treuter, E., Haldosen, L- A. and Gustafsson, J-A. (2007) Coplanar 3,3’,4,4’,5-pentachlorinated biphenyl and non-coplanar 2,2’,4,6,6’-pentachlorinated biphenyl differentially induce recruitment of estrogen receptor  to aryl hydrocarbon receptor target genes. Biochem J Sept 406(2), 343–353. 

•    Heldring, N., Pike, A., Andersson, S., Matthews, J., Cheng, G., Hartman, J., Tujague, M., Strom, A., Treuter, E., Warner, M., and Gustafsson, J-A. (2007) Estrogen receptors: how do they signal and what are their targets. Physiol Rev Jul 87(3), 905-931. 

•    Zhao, C., Matthews, J., Tujague, M., Wan, J., Strom, A., Toresson, G., Lam, E., Cheng, G., Gustafsson, J-A and Dahlman-Wright, K. (2007) Estrogen receptor 2 negatively regulates the transactivation of estrogen receptor in human breast cancer cells. Cancer Res 67, 3955-3962. 

•    Matthews, J. and Gustafsson, J-A. (2006) Estrogen receptor and aryl hydrocarbon receptor signalling pathways. Nucl Recept Signal e016 Epub 2006 Jul 7 (perspective) 

•    Matthews, J. Wihlen, B., Strom, A., and Gustafsson, J-A. (2006) ERbeta modulates ERalpha-mediated transcriptional activation by altering the recruitment of c-Fos and c-Jun to estrogen responsive promoters. Mol Endocrinol Mar;20(3):534-43. 

•    Matthews, J., Almlof, T, Kietz, S. Leers, Jörg, L., and Gustafsson, J-A. (2005) Estrogen regulation of SOCS-3 in human breast cancer cells. Biochem Biophys Res Comm Sep 16;335(1), 168-174. 

•    Huang, Y-W., Matthews, J., Fertuck, K., and Zacharewski, T.R. (2005) Use of Xenopus laevis as a model for investigating in vitro and in vivo endocrine disruption in amphibians. Toxicol Appl Pharmacol Aug;24(8), 2002-2009. 

•    Matthews, J.  Whilen, B., Thomsen, J., and Gustafsson, J-A. (2005) Aryl hydrocarbon receptor-mediated transcription: ligand-dependent recruitment of estrogen receptor  to TCDD responsive promoters. Mol Cell Biol Jul;25(13), 5317-5328. 

•    Bavner, A., Matthews, J.,  Gustafsson, J-A. and Treuter, E. (2005) A role of EID3 in tissue-specific coactivator antagonism. Nucl Acids Res Jun 24;33(11), 3561-3569. 

•    Kietz, S., Thomsen, J.S., Matthews, J.,  Pettersson, K., Strom, A., and Gustafsson, J-A. (2004) The AhR inhibits estrogen-induced estrogen receptor beta in breast cancer cells. Biochem Biophys Res Comm Jul 16;320(1), 76-82. 

•    Antonson, P., Al-Beidh, F., Matthews, J. and Gustafsson, J-A (2004) RAP250 gene: genomic structure and promoter analysis. Gene Mar 3;327(2), 233-238. 

•    Sanyal, S., Matthews, J., Bouton, D., Choi, H-S., Treuter, E., and Gustafsson, J-A. (2004) DNA-response element-dependent regulation of transcription by orphan nuclear receptor estrogen receptor- related receptor gamma (ERRgamma), Mol Endocrinol Feb;18(2), 312-325. 

•    Brunnberg, S., Pettersson, K., Rydin, E., Matthews, J., Hanberg, A., and Pongratz, I. (2003) The basic helix-loop-helix-PAS protein ARNT functions as a potent coactivator of estrogen receptor-dependent transcription. Proc Natl Acad Sci USA May 27;100(11), 6517-6522. 

•    Matthews, J. and Gustafsson, J-A. (2003) Estrogen signalling: a subtle balance between ERalpha and ERbeta.  Mol Intervent Aug;3(5) 281-292. 

•    Matthews, J., Celius, C., Fertuk, K., Huang, Y-W., Fong, C., and Zacharewski, T.R. (2002) Ability of several natural and synthetic estrogenic chemicals to induce gene expression mediated by estrogen receptors from several vertebrate species. J Steroid Biochem Mol Bio Oct;82(2-3), 181-194. 

•    Rosen, G., O’Bryant, E., Matthews, J., Zacharewski, T.R., and Wade, J. (2002) Distribution of androgen receptor mRNA expression and immunoreactivity in the brain of the green anole lizard.  J Neuroendocrinol Jan;14(1), 19-28. 

•    Fielden, M.F., Matthews, J., Fertuck, K.F., Halgren, R.G., and Zacharewski, T.R. (2002) In silico approaches to mechanistic and predictive toxicology: an introduction to bioinformatics for toxicologists. Crit Rev Toxicol Mar;32(2), 67-112. 

•    Matthews, J., Clemons, J.H., and Zacharewski, T.R. (2001) Reciprocal mutagenesis between human alpha L349/M528 and rainbow trout M317/I496 estrogen receptor residues demonstrates their importance in ligand binding and gene expression at different temperatures. Mol Cell Endocrinol Oct 25;183(1-2), 127-139. 

•    Fertuck, K.F., Kumar, S., Sikka, H.C., Matthews, J., and Zacharewski, T.R.  (2001) Interaction of PAH-related compounds with the alpha and beta isoforms of the estrogen receptor. Toxicol Lett May 19;121(3), 167-177. 

•    Celius, T, Matthews, J., Giesy, J.P., and Zacharewski, T.R. (2001) Quantification of vitellogenin and zona radiata proteins from rainbow trout (Oncorhynchus mykiss) liver after in vivo treatment with alpha-zearalenol and estradiol-17beta using the TaqMan assay. J Steroid Biochem Mol Bio Dec 15;75(2-3), 109-119. 

•    Matthews, J., Twomey, K., and Zacharewski, T.R. (2001) Comparison of the interactions of bisphenol A and its metabolite bisphenol A glucuronide with estrogen receptors alpha and beta. Chem Res Toxicol Feb 14(2), 149-157. 

•    Fertuck, K.F., Matthews, J., and Zacharewski, T.R. (2000) Hydroxylated benzo[a]pyrene metabolites are responsible for in vitro estrogen receptor-mediated gene expression induced by benzo[a]pyrene, but do not elicit uterotrophic effects in vivo. Toxicol Sci Feb;59(2), 231-240. 

•    Matthews, J., Celius, T., Halgren, R., and Zacharewski, T.R. (2000) Differential estrogen receptor binding of estrogenic substances: a species comparison. J Steroid Biochem Mol Biol Nov 15;74(4), 223-234. 

•    Matthews, J., and Zacharewski, T.R. (1999) Differential binding affinities of PCBs, HO-PCBs and Aroclors with recombinant human, rainbow trout (Oncorhynchus mykiss) and reptilian (Anolis carolinensis) estrogen receptors using a semi-high throughput competitive binding assay. Toxicol Sci . Feb;53(2), 326-339. 

•    Zacharewski, T., Meek, M.D., Clemons, J.H., Wu, Z.F., Fielden, M.R. and Matthews, J. (1998) Examination of the in vitro and in vivo estrogenic activities of eight commercial phthalate esters. Toxicol Sci Dec;46 (2), 282-293.

Bokkapitler

  • Matthews, J. (2013) Alternative Negative Feedback Control in the Aryl Hydrocarbon Receptor Signaling Pathway. J of Drug Metabolism and Toxicol. Jan 4 (1) Invited Editorial 
  • Matthews, J. Aryl Hydrocarbon Receptor (AhR) Targeted by Xenobiotic Compounds and Dietary Phytochemicals, In Hormone-Disruptive Chemical Contaminants in Food. Editor: Ingemar Pongratz. RSC Issues in Toxicology Series. Cambridge, UK. 2011. 
  • Matthews, J. (2009) Estrogens as endogenous toxins. In Endogenous Toxins. Editors: P. O'Brien and R. Bruce. STMS Books Wiley-VCH Verlag GmbH & Co. Weinheim, Germany.
  • Zacharewski, T., Fertuck, K., Fielden, M., and Matthews, J. (2002) Mechanistically-based assays for the identification and characterization of endocrine disruptors. In Comprehensive Toxicology XIV: Cellular and Molecular Toxicology (Volume Editors: J.P. Vanden Heuvel, W.F. Greenlee, G.H. Perdew, W. Mattes, Editors-in-Chief: I.G. Sipes, C.A. McQueen, A.J. Gandolfi). Elsevier Science B.V., Amsterdam, The Netherlands 559-582.
  • Fan, Qiong; Nørgaard, Rikke Christine; Bindesbøll, Christian; Lucas, Christin; Dalen, Knut Tomas; Babaie, Eshrat; Itkonen, Harri; Matthews, Jason; Nebb, Hilde Irene & Grønning-Wang, Line Mariann (2017). LXR? regulates hepatic ChREBP? activity and lipogenesis upon glucose, but not fructose feeding in mice. Nutrients.  ISSN 2072-6643.  9(7) . doi: 10.3390/nu9070678
  • Rogers, Sarah; De Souza, Angela Rico; Zago, Michela; Iu, Matthew; Guerrina, Necola; Gomez, Alvin; Matthews, Jason & Baglole, Carolyn J. (2017). Aryl hydrocarbon receptor (AhR)-dependent regulation of pulmonary miRNA by chronic cigarette smoke exposure. Scientific Reports.  ISSN 2045-2322.  7 . doi: 10.1038/srep40539
  • Zago, Michela; Sheridan, Jared A; Traboulsi, Hussein; Hecht, Emelia; Zhang, Yelu; Guerrina, Necola; Matthews, Jason; Nair, Parameswaran; Eidelman, David H; Hamid, Qutayba & Baglole, Carolyn J. (2017). Low levels of the AhR in chronic obstructive pulmonary disease (COPD)-derived lung cells increases COX-2 protein by altering mRNA stability. PLoS ONE.  ISSN 1932-6203.  12(7) . doi: 10.1371/journal.pone.0180881
  • Bindesbøll, Christian; Tan, Susanna; Bott, Debbie; Cho, Tiffany; Tamblyn, Laura; MacPherson, Laura; Grønning-Wang, Line Mariann; Nebb, Hilde Irene & Matthews, Jason (2016). TCDD-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) mono-ADP-ribosylates and co-activates liver X receptors. Biochemical Journal.  ISSN 0264-6021.  473(7), s 899- 910 . doi: 10.1042/BJ20151077
  • Nault, Rance; Fader, Kelly A. Fader; Kirby, Mathew P.; Ahmed, Shaimaa; Matthews, Jason; Jones, Daniel; Lunt, Sophia Y. & Zacharewski, Tim R. (2016). Pyruvate kinase isoform switching and hepatic metabolic reprogramming by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicological Sciences.  ISSN 1096-6080.  149(2), s 358- 371 . doi: 10.1093/toxsci/kfv245
  • Yamada, Taisho; Horimoto, Hiromasa; Kameyama, Takeshi; Hayakawa, Sumio; Yamato, Hiroaki; Dazai, Masayoshi; Takada, Ayato; Kida, Hiroshi; Bott, Debbie; Zhou, Angela C.; Hutin, David; Watts, Tania H.; Asaka, Masahiro; Matthews, Jason & Takaoka, Akinori (2016). Constitutive aryl hydrocarbon receptor signaling constrains type I interferon-mediated antiviral innate defense. Nature Immunology.  ISSN 1529-2908.  17(6), s 687- 694 . doi: 10.1038/ni.3422
  • Bindesbøll, Christian; Fan, Qiong; Nørgaard, Rikke Christine; MacPherson, Laura; Ruan, Hai-Bin; Wu, Jing; Pedersen, Thomas Å; Steffensen, Knut R.; Yang, Xiaoyong; Matthews, Jason; Mandrup, Susanne; Nebb, Hilde Irene & Grønning-Wang, Line Mariann (2015). Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activity[S. Journal of Lipid Research.  ISSN 0022-2275.  56, s 771- 785 . doi: 10.1194/jlr.M049130

Se alle arbeider i Cristin

  • Bindesbøll, Christian; Tan, Susanna; MacPherson, Laura; Moen, Anders; Anonsen, Jan Haug; Grønning-Wang, Line Mariann; Nebb, Hilde Irene & Matthews, Jason (2015). TIPARP MONO-ADP-RIBOSYLATES & INCREASES LIVER X RECEPTOR TRANSACTIVATION.
  • Matthews, Jason (2015). The Intriguing world of AHR and ER crosstalk.

Se alle arbeider i Cristin

Publisert 29. sep. 2015 16:00 - Sist endret 13. des. 2016 18:01