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Nicoll, Roger A; Storm, Johan Frederik & Storm-Mathisen, Jon
(2020).
Obituary. Per Andersen 1930–2020.
Neuron.
ISSN 0896-6273.
106,
s. 366–368.
doi:
10.1016/j.neuron.2020.04.016.
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Øverberg, Linda Thøring; Andersson, Krister Andreas; Lambertus, Marvin; Hadzic, Alena; Haugen, Øyvind Pernell & Storm-Mathisen, Jon
[Vis alle 8 forfattere av denne artikkelen]
(2018).
Adult neurogenesis:
A regulatory role of lactate through the lactate receptor HCAR1?
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Andersson, Krister; Morland, Cecilie; Haugen, Øyvind Pernell; Hadzic, Alena; Kleppa, Liv & Gille, Andreas
[Vis alle 21 forfattere av denne artikkelen]
(2017).
Exercise benefits brain through the lactate receptor HCAR1, increasing VEGF and capillary density in hippocampus and cortex.
Vis sammendrag
While physical exercise is known to improve brain function and delay neurodegeneration, the signal from muscle to brain has not been identified. We show here that the lactate receptor, hydroxycarboxylic acid receptor 1 (HCAR1 also known as GPR81), mediates exercise induced increase in the content of vascular endothelial growth factor A (VEGFA) and in capillary density in the hippocampus and cerebral cortex. Mice were subjected to high intensity interval exercise 5 days per week for 7 weeks. Increases in VEGFA and capillary density were observed in wild-type (wt) mice, but not in knockout (ko) mice lacking HCAR1. Subcutaneous injections of L-lactate 5 days per week for 7 weeks, to achieve intermittently high blood lactate levels comparable to those after exercise, reproduced the findings in wt mice. No changes were observed in ko mice. The intermittent nature of the stimulation may be important since continuously high extracellular lactate has previously been observed to down-regulate HCAR1. To our knowledge, the present finding is the first demonstration that a substance released by exercising skeletal muscle induces supportive effects in brain through an identified receptor. No changes in VEGFA or capillary density were observed in the cerebellar cortex. HCAR1 was highly expressed in pial fibroblast-like cells that line the vessels supplying blood to the brain, and in fibroblast-/pericyte-like cells along intracerebral microvessels. These cells are strategically placed to monitor changes in blood-born lactate as well as in brain extracellular lactate (which equilibrate across the vascular endothelium via monocarboxylate transporter 1). Skeletal muscle showed no vascular HCAR1 expression and no HCAR1-dependent change in vascularization induced by exercise or lactate. As VEGFA governs neuronal functions such as LTP as well as vascular growth, the increases may have direct effects on neurons as well as indirect effects through enhancement of vascularization. Both disturbed vascularization and impaired synaptic function are components of the pathogenesis in neurodegenerative dementias such as Alzheimer’s disease. The lactate receptor HCAR1 may prove a useful nutraceutical target for intervention in persons at risk for dementia who are unable to exercise sufficiently to achieve optimal HCAR1 stimulation through rises in blood lactate.
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Andersson, Krister; Morland, Cecilie; Haugen, Øyvind Pernell; Bergersen, Linda Hildegard & Storm-Mathisen, Jon
(2017).
Physical exercise promotes brain angiogenesis through a lactate receptor.
Vis sammendrag
Physical exercise can improve brain function and delay neurodegeneration, but the initial signal from muscle to brain is unknown. Here we show that the lactate receptor (HCAR1) is highly enriched in fibroblast-like cells that line and surround the pial blood vessels supplying the brain, and that activation of HCAR1 stimulates vascular endothelial growth factor A (VEGFA) levels and angiogenesis in hippocampus. High intensity interval exercise (five days weekly for seven weeks), as well as L-lactate injected subcutaneously to similarly increase blood lactate levels, caused a substantial increase in brain VEGFA protein and microvessel density in wild-type mice, but not in knockout mice lacking HCAR1. In contrast, skeletal muscle showed no vascular HCAR1 expression and no HCAR1 dependent change in vascularization induced by exercise or lactate. To our knowledge, this is the first demonstration that a substance released by exercising skeletal muscle induces supportive effects in brain through an identified receptor.
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Storm-Mathisen, Jon
(2017).
How glutamate and GABA 'became' neurotransmitters.
Vis sammendrag
How Glutamate and GABA “Became” Neurotransmitters
• I will speak on how glutamate and GABA came to be recognized as THE excitatory and THE inhibitory transmitters of brain signals.
• GABA’s role was established before that of glutamate.
• The recognition of glutamate was delayed for decades ̶ a psychological barrier was posed by glutamate’s ubiquitous excitatory action, high concentration, and diverse other roles: metabolic 'currency', nutrient, main building block of proteins, umami taste, precursor of GABA.
• This historic tale is largely based on my own experiences.
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Jensen, Jørgen; Storm-Mathisen, Jon; Bergersen, Linda Hildegard; Wærhaug, Ola; Samuelsen, Gunnar & Osen, Kirsten Kjelsberg
(2017).
Minneord: Hans A. Dahl.
Tidsskrift for Den norske legeforening.
ISSN 0029-2001.
137,
s. 14–15.
doi:
10.4045/tidsskr.17.0487.
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Lind, Anne; Ford, Ann-Turi & Storm-Mathisen, Jon
(2017).
Går det en vei fra kvad til kveding?
[Tidsskrift].
Kvedarposten, organ for Norsk kvedarforum, nr 2.
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Storm-Mathisen, Jon
(2016).
How glutamate and GABA became neurotransmitters.
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Morland, Cecilie; Andersson, Krister; Haugen, Øyvind Pernell; Hadzic, Alena; Kleppa, Liv & Gille, Andreas
[Vis alle 18 forfattere av denne artikkelen]
(2016).
A novel mechanism for cerebral angiogenesis via lactate receptor HCAR1 at pial vessels.
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Hadzic, Alena; Andersson, Krister; Haugen, Øyvind Pernell; Storm-Mathisen, Jon; Stølen, Tomas & Wisløff, Ulrik
[Vis alle 8 forfattere av denne artikkelen]
(2016).
Lactate receptor HCAR1 mediates synaptic plasticity.
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Moretti, Laura; Stølen, Tomas; Wisløff, Ulrik; Storm-Mathisen, Jon; Bergersen, Linda Hildegard & Morland, Cecilie
(2016).
Effects of intrinsic fitness level on mitochondria during exercise
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Morland, Cecilie; Andersson, Krister; Haugen, Øyvind Pernell; Hadzic, Alena; Kleppa, Liv & Gille, Andreas
[Vis alle 18 forfattere av denne artikkelen]
(2016).
Exercise induces cerebral angiogenesis via lactate receptor HCAR1 at pial vessels.
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Kolko, Miriam; Vosborg, Fia; Henriksen, Ulrik L.; Hasan-Olive, Md Mahdi; Diget, Elisabeth Holm & Vohra, Rupali
[Vis alle 13 forfattere av denne artikkelen]
(2016).
Erratum to: Lactate Transport and Receptor Actions in Retina: Potential Roles in Retinal Function and Disease.
Neurochemical Research.
ISSN 0364-3190.
41(6),
s. 1237–1237.
doi:
10.1007/s11064-016-1916-y.
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Blackstad, Jan Sigurd Beddari; Osen, Kirsten Kjelsberg; Scharfman, HE; Storm-Mathisen, Jon; Blackstad, Theodor W. & Leergaard, Trygve Brauns
(2015).
Hippocampal mossy cells in mink (Neovison vison).
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Storm-Mathisen, Jon
(2015).
In quest for the “ney” & “yes” signals at CNS synapses: GABA & Glutamate.
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Storm-Mathisen, Jon
(2015).
Glutamate – The Lingua Franca of Brain Cells, Substance of Life, and Savory Spice.
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Storm-Mathisen, Jon
(2014).
Anatomy of the Hippocampus - Basic Cell Types, connections.
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Storm-Mathisen, Jon
(2014).
Glutamate, NeuroCampus Special Guest Lecture.
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Storm-Mathisen, Jon
(2013).
Glutamate.
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Storm-Mathisen, Jon
(2013).
Hjerneforskning ved UiO.
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Storm-Mathisen, Jon & Bergersen, Linda Hildegard
(2012).
Unikard oppstart - hjertet og hjernen.
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Bergersen, Linda Hildegard & Storm-Mathisen, Jon
(2012).
Kavliprisvinnerne i nevrovitenskap 2012
(Cover illustration / story).
NSB-nytt.
36(4),
s. 6–8.
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Storm-Mathisen, Jon
(2012).
Hvordan virker fysisk aktivitet på læring?
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Storm-Mathisen, Jon
(2012).
The scientific background of NNN: From neuroscience research to the Nansen Neuroscience Network.
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Bergersen, Linda Hildegard; Sander, M. & Storm-Mathisen, Jon
(2011).
What the nose knows, what the eyes see, how we feel, how we learn, how we understand motor acts, why “YY” is essential for ion transport, how epigenetics meet neurobiology in Rett syndrome: seven topics at the 2010 Kavli Prize Symposium on Neuroscience.
Neuroscience.
ISSN 0306-4522.
190,
s. 1–11.
doi:
10.1016/j.neuroscience.2011.05.036.
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Buntup, D; Thangnipon, W; Solbu, Tom Tallak; Chaudhry, Farrukh Abbas & Storm-Mathisen, Jon
(2008).
Effects of -amyloid25-35 on the expression of glutamine transporters and vesicular glutamate transporters in rat cortical cell cultures.
Journal of Neurochemistry.
ISSN 0022-3042.
s. 357–357.
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Boulland, Jean-Luc; Jenstad, Monica; Boekel, AJ; Wouterlood, FG; Edwards, RH & Storm-Mathisen, Jon
[Vis alle 7 forfattere av denne artikkelen]
(2008).
VGLUT2 and VGAT are targeted to different subsets of vesicles within a single terminal.
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Chaudhry, Farrukh Abbas; Jenstad, Monica; Boekel, AJ; Wouterlood, FG; Edwards, R. H. & Storm-Mathisen, Jon
[Vis alle 7 forfattere av denne artikkelen]
(2008).
331.2. VGLUT2 and VGAT reside on different subpopulations of vesicles suggesting differential release of glutamate and GABA from a single nerve terminal.
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Owe, Simen Gylterud; Jensen, Vidar; Evergren, Emma; Ruiz, Arnaud; Shupliakov, Oleg & Kullmann, Dimitri
[Vis alle 10 forfattere av denne artikkelen]
(2008).
Facilitation of glutamate release at hippocampal mossy fibre synapses is dependent on synapsin and actin.
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Quazi, Abrar Zaheer; Jenstad, Monica; Haglerød, Camilla Margrete; Saddique, N; Ottersen, Ole Petter & Davanger, Svend
[Vis alle 11 forfattere av denne artikkelen]
(2005).
Glutamine shuttling by the system N and system A transporters is important for the regeneration of the neurotransmitter glutamate during high frequency firing.
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Gammelsaeter, Runhild; Frøyland, Marianne; Aragon, C.; Danbolt, Niels Christian; Edwards, R. H. & Storm-Mathisen, Jon
[Vis alle 8 forfattere av denne artikkelen]
(2004).
A paracrine transmitter interplay: The amino acid transmitters glycine and GABA and their transport proteins in the islets of Langerhans.
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Gammelsæter, Runhild; Vervaeke, Koen Gerard Alois; Storm-Mathisen, Jon & Storm, Johan Frederik
(2004).
Evidence for targeting of Kv4.2 Potassium channel protein to dendritic spine membrane in hippocampal CA1 pyramidal cells.
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Solbu, Tom Tallak; Zahid, W.; Boulland, JL; Qureshi, T.; Storm-Mathisen, Jon & Chaudhry, Farrukh Abbas
(2003).
Targeting of the proton-coupled glutamine transporter, SN1, suggests roles in synaptic functions and pH.
Glia.
ISSN 0894-1491.
s. 32–32.
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Chaudhry, Farrukh Abbas; Boulland, Jean-Luc; Solbu, Tom Tallak; Jenstad, Monica; Haglerød, Camilla Margrete & Zahid, W
[Vis alle 7 forfattere av denne artikkelen]
(2003).
Glutamine transporters involved in the glutamine-glutamate/GABA cycle.
Journal of Neurochemistry.
ISSN 0022-3042.
87,
s. 4–4.
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Ottersen, Ole Petter & Storm-Mathisen, Jon
(2005).
Chemical architecture of the synapse.
Lundbeck Foundation Report 2004.