Knut Tomas Dalen

Førsteamanuensis - Transgene dyr og lipidlagring
Bilde av Knut Tomas Dalen
English version of this page
Telefon +47-22851515
Mobiltelefon +47-91134097
Rom L-162
Brukernavn
Besøksadresse Sognsvannsveien 9 Domus Medica 0372 OSLO
Postadresse Postboks 1046 Blindern 0317 OSLO
Andre tilknytninger Avdeling for ernæringsvitenskap

Faglige interesser

  • Molekylær ernæring
  • Lipidmetabolisme
  • Lipiddråper
  • Transkripsjonell regulering
  • Livsstilssykdommer som metabolsk syndrom,  type 2 diabetes og hjerte- og karsykdom

Undervisning

Bakgrunn

Utdannelse:

  • June 2005: Dr. Philos, (veileder Prof. Hilde Nebb), Avdeling for ernæringsvitenskap, Universitet i Oslo.
  • 1997-1999: Candidatus Scientiarum - biokjemi, Institutt for Biovitenskap og Avdeling for ernæringsvitenskap, Universitet i Oslo.
  • 1995-1996: Kjemi/Biokjemi – diverse kurs. Universitet i Oslo..
  • 1992-1995: Kjemiingeniør – med spesialisering i Bioteknologi, Høgskolen i Østfold, Sarpsborg.

Arbeidserfaring:

  • 2009-2013: Post doktor (UiO, Refsum/Nebb), Avdeling for ernæringsvitenskap, Universitet i Oslo.
  • 01-09.2009: Post doktor (Chaudhry-gruppen), Bioteknologisenteret, Universitet i Oslo.
  • 2007-2008: Forsker (UiO, Nebb), Avdeling for ernæringsvitenskap, Universitet i Oslo.
  • 2005-2007: Gjesteforsker (Londos), Membrane Regulation Section, Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (NIH), US.
  • 2000-2005: Stipendiat (UiO, Nebb), Avdeling for ernæringsvitenskap, Universitet i Oslo.
  • 01-06.2000: Gjesteforsker. (Auwerx). ”Institut de Génétique et de Biologie Molélulaire et Cellulaire (IGBMC)”, INSERM, Illkirch, France.
  • 1999-2000: Laboratorieassistent ( Nebb), Avdeling for ernæringsvitenskap, Universitet i Oslo.

Priser

  • 2005: Intramural Visiting Fellow Award: NIDDK, NIH, Bethesda, US.
  • 2005: Research Travel Award: Henning och Johan Throne-Holst Foundation
  • 2007: Research Travel Award: Henning och Johan Throne-Holst Foundation

Samarbeid

  • Prof. Alan Kimmel, NIDDK, National Institutes of Health, (NIH), US.
  • Prof. Hilde Nebb, Avdeling for ernæringsvitenskap, Universitetet I Oslo.
  • Prof. Helga Refsum, Avdeling for ernæringsvitenskap, Universitetet I Oslo.
  • Prof. Christian Drevon og Dr. Torgeir Holen, Avdeling for ernæringsvitenskap, Universitetet I Oslo.
  • Prof. Jan Boren, og Prof. Malin Levin, Sahlgranska Center for Cardiovascular and Metabolic Research (CMR), Gøteborg, Sverige.
  • Profs. Arild Rustan og Hege Thoresen, Farmasøytisk institutt, Universitetet i Oslo.
Emneord: Ernæring, Diabetes og hormoner, Muskel og skjelett, Lipider, Lipiddråper, Transkripsjon, Kjernereseptorer

Publikasjoner

  • Dahl, John Arne; Jung, Inkyung; Aanes, Håvard; Greggains, Gareth; Manaf, Adeel; Lerdrup, Mads; Li, Guoqiang; Kuan, Samantha; Li, Bin; Lee, Ah Young; Preissl, Sebastian; Jermstad, Ingunn; Haugen, Mads Haugland; Suganthan, Rajikala; Bjørås, Magnar; Hansen, Klaus; Dalen, Knut Tomas; Fedorcsák, Péter; Ren, Bing & Klungland, Arne (2016). Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition. Nature.  ISSN 0028-0836.  537(7621), s 548- 552 . doi: 10.1038/nature19360
  • Drevinge, Christina; Dalen, Knut Tomas; Mannila, Maria Nastase; Täng, Margareta Scharin; Ståhlman, Marcus; Klevstig, Martina; Lundqvist, Annika; Mardani, Ismena; Haugen, Fred; Fogelstrand, Per; Adiels, Martin; Asin-Cayuela, Jorge; Ekestam, Charlotte; Gådin, Jesper R; Lee, Yun K; Nebb, Hilde Irene; Svedlund, Sara; Johansson, Bengt R; Hulten, Lillemor Mattsson; Romeo, Stefano; Redfors, Björn; Omerovic, Elmir; Levin, Max; Gan, Li; Eriksson, Per; Andersson, Linda; Ehrenborg, Ewa; Kimmel, Alan R; Boren, Jan & Levin, M (2016). Perilipin 5 is protective in the ischemic heart. International Journal of Cardiology.  ISSN 0167-5273.  219, s 446- 454 . doi: 10.1016/j.ijcard.2016.06.037
  • Pourteymour, Shirin; Lee, Sindre; Langleite, Torgrim Mikal; Eckardt, Kristin; Hjorth, Marit; Bindesbøll, Christian; Dalen, Knut Tomas; Birkeland, Kåre I.; Drevon, Christian A; Holen, Torgeir & Norheim, Frode (2015). Perilipin 4 in human skeletal muscle: localization and effect of physical activity. Physiological Reports.  ISSN 2051-817X.  3:e12481(8), s 1- 15 . doi: 10.14814/phy2.12481
  • Norheim, Frode; Hjorth, Marit; Langleite, Torgrim Mikal; Lee, Sindre; Holen, Torgeir; Bindesbøll, Christian; Stadheim, Hans Kristian; Gulseth, Hanne Lovdal; Birkeland, Kåre I.; Kielland, Anders; Jensen, Jørgen; Dalen, Knut Tomas & Drevon, Christian A (2014). Regulation of angiopoietin-like protein 4 Production during and after exercise. Physiological Reports.  ISSN 2051-817X.  2(8) . doi: 10.14814/phy2.12109
  • Bindesbøll, Christian; Berg, Ole; Arntsen, Borghild M; Nebb, Hilde Irene & Dalen, Knut Tomas (2013). Fatty acids regulate perilipin5 in muscle by activating PPARdelta. Journal of Lipid Research.  ISSN 0022-2275.  54(7), s 1949- 1963 . doi: 10.1194/jlr.M038992
  • Haj-Yasein, Nadia Nabil; Dalen, Knut Tomas; Berg, Ole; Bastani, Nasser Ezzatkhah; Refsum, Helga & Nebb, Hilde Irene (2013). Low Cysteine Interferes With PPARγ Activity And Reduces Adipocyte Differentiation. Journal of Inherited Metabolic Disease.  ISSN 0141-8955.  36, s S44 . doi: 10.1007/s10545-013-9631-1
  • Telle, Vibeke Helen; Halvorsen, Bente; Dalen, Knut Tomas; Narverud, Ingunn; Rao, Nima; Granlund, L; Ulven, Stine Marie & Holven, Kirsten Bjørklund (2013). Altered expression of genes involved in lipid metabolism in obese subjects with unfavourable phenotype. Genes & Nutrition.  ISSN 1555-8932.  8(4), s 425- 434 . doi: 10.1007/s12263-012-0329-z Fulltekst i vitenarkiv
  • Hsieh, Kai; Lee, Yen-Kun; Londos, C; Raaka, BM; Dalen, Knut Tomas & kimmel, Alan (2012). Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesteryl-ester-specific intracellular lipid storage droplets. Journal of Cell Science.  ISSN 0021-9533.  125(17), s 4067- 4076 . doi: 10.1242/jcs.104943
  • Norheim, Frode; Gjelstad, Ingrid Merethe Fange; Hjorth, Marit; Vinknes, Kathrine; Langleite, Torgrim Mikal; Holen, Torgeir; Jensen, Jørgen; Dalen, Knut Tomas; Karlsen, Anette; Kielland, Anders; Rustan, Arild & Drevon, Christian A (2012). Molecular nutrition research - the modern way of performing nutritional science. Nutrients.  ISSN 2072-6643.  4(12), s 1898- 1944 . doi: 10.3390/nu4121898
  • Wang, H; Bell, H; Sreenevasan, u; Hu, H; Liu, J; Dalen, Knut Tomas; Londos, C; Yamaguchi, t; rizzo, ma; Coleman, r; Gong, d; Brasaemle, d & Sztalryd, C (2011). Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-associated protein. Journal of Biological Chemistry.  ISSN 0021-9258.  286(6), s 15707- 15715
  • Weedon, Mina Susanne; Dalen, Knut Tomas; Solaas, Karianne; Staff, Anne Cathrine; Duttaroy, Asim K. & Nebb, Hilde Irene (2010). Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells. Journal of Lipid Research.  ISSN 0022-2275.  51(7), s 1886- 1896 . doi: 10.1194/jlr.M004978
  • Qin, Yan; Dalen, Knut Tomas; Gustafsson, Jan Åke & Nebb, Hilde Irene (2009). Regulation of hepatic fatty acid elongase 5 by LXRalpha-SREBP-1c. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.  ISSN 1388-1981.  1791(2), s 140- 147 . doi: 10.1016/j.bbalip.2008.12.003
  • Wang, H; hu, l; Dalen, Knut Tomas; dorward, h; Marcinkiewicz, a; Russell, d; gond, d; Londos, C; Yamaguchi, t; holm, c; rizzo, ma; Brasaemle, d & Sztalryd, C (2009). Activation of hormone-sensitive lipase requires two steps, protein phosphorylation and binding to the PAT-1 domain of lipid droplet coat proteins. Journal of Biological Chemistry.  ISSN 0021-9258.  46(284), s 32116- 32125
  • Dalen, Knut Tomas; Dahl, Tuva Børresdatter; Holter, Elin; Arntsen, Borghild M; Londos, C; Sztalryd, C & Nebb, Hilde Irene (2007). LSDP5 is a PAT protein specifically expressed in fatty acid oxidizing tissues. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.  ISSN 1388-1981.  1771, s 210- 227 . doi: 10.1016/j.bbalip.2006.11.011
  • Dalen, Knut Tomas; Ulven, Stine Marie; Arntsen, Borghild M; Solaas, Karianne & Nebb, Hilde Irene (2006). PPAR alpha activators and fasting induce the expression of adipose differentiation-related protein in liver. Journal of Lipid Research.  ISSN 0022-2275.  47, s 931- 943
  • Tobin, Kari Anne Risan; Harsem, NK; Dalen, Knut Tomas; Staff, AC; Nebb, Hilde Irene & Duttaroy, Asim K. (2006). Regulation of ADRP expression by long-chain polyunsaturated fatty acids in BeWo cells, a human placental choriocarcinoma cell line. Journal of Lipid Research.  ISSN 0022-2275.  47, s 815- 823
  • Wang, Line M. Grønning; Tingsabadh, R; Hardy, K; Dalen, Knut Tomas; Jat, PS; Gnudi, L & Shepherd, P.R. (2006). Glucose induces increases in levels of the transcriptional repressor Id2 via the hexosamine pathway. American Journal of Physiology. Endocrinology and Metabolism.  ISSN 0193-1849.  290(4), s 599- 606
  • Zernichow, L; Dalen, Knut Tomas; Dalen, L.; Prydz, K; Winberg, Jan-Olof & Kolset, S O (2006). Secretion of proteases in serglycin transfected Madin-Darby canine kidney cells. The FEBS Journal.  ISSN 1742-464X.  273
  • Haugen, Fred; Zahid, N; Dalen, Knut Tomas; Hollung, K; Nebb, Hilde Irene & Drevon, Christian A (2005). Resistin expression in 3T3-L1 adipocytes is reduced by arachidonic acid. Journal of Lipid Research.  ISSN 0022-2275.  46
  • Ulven, Stine Marie; Dalen, Knut Tomas; Gustafsson, JA & Nebb, Hilde Irene (2005). LXR is crucial in lipid metabolism. Prostaglandins, Leukotrienes and Essential Fatty Acids.  ISSN 0952-3278.  73, s 59- 63
  • Dalen, Knut Tomas; Schoonjans, K; Ulven, SM; Weedon, Mina Susanne; Bentzen, Trine Gjesti; Koutnikova, H; Auwerx, J & Nebb, Hilde Irene (2004). Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma. Diabetes.  ISSN 0012-1797.  53(5), s 1243- 1252
  • Ulven, Stine Marie; Dalen, Knut Tomas; Gustafsson, Jan-Åke & Nebb, Hilde Irene (2004). Tissue-specific autoregulation of the LXRalpha gene facilitates induction of apoE in mouse adipose tissue. Journal of Lipid Research.  ISSN 0022-2275.  45(11), s 2052- 2062
  • Dalen, Knut Tomas; Ulven, Stine Marie & Nebb, Hilde Irene (2003). Expresssion of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha. Journal of Biological Chemistry.  ISSN 0021-9258.  278(48), s 48283- 48291
  • Juvet, Lene Kristine; Schuster, Gertrud U.; Dalen, Knut Tomas; Tobin, Kari Anne Risan; Hollung, Kristin; Haugen, Fred; Ulven, Stine Marie & Nebb, Hilde Irene (2003). On the role of liver X receptors in lipid accumulation in adipocytes. Molecular Endocrinology.  ISSN 0888-8809.  17, s 172- 182
  • Alvik, Astrid & Dalen, Knut (2002). Det føtale alkoholsyndrom - FAS, I: Bente Gjærum & Bjørn Ellertsen (red.),  Hjerne og atferd; Utviklingsforstyrrelser hos barn og ungdom i et nevrobiologisk perspektiv.  Gyldendal Akademisk.  ISBN 82-05-30434-3.  i.  s 333 - 350
  • Prydz, Kristian & Dalen, Knut Tomas (2000). Synthesis and sorting of proteoglycans. Journal of Cell Science.  ISSN 0021-9533.  113, s 193- 205

Se alle arbeider i Cristin

  • Dalen, Knut Tomas; londos, constantine & kimmel, Alan (2011). Adipocyte Fat Mobilization: The Regulatory Roles of Perilipin 1, Adipose Triglyceride Lipase, and Hormone Sensitive Lipase. Elsevier.  ISBN 978-0-12-443710-4.

Se alle arbeider i Cristin

  • Meadow, Richard; Asare, Nana Yaa Ohene; Dalen, Knut Tomas; Finne, Merethe Aasmo; Junttila, Olavi; Kirkendall, Lawrence R.; Måren, Inger Elisabeth; Yazdankhah, Siamak Pour; Dahl, Knut Helkås; Nielsen, Kaare Magne; Sanden, Monica; Vikse, Rose & Sorteberg, Hilde-Gunn Opsahl (2017). Risk assessment of insect-resistant and herbicide-tolerant genetically modified maize Bt11 for cultivation, import, processing, food and feed uses under Directive 2001/18/EC and Regulation (EC). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety . Fulltekst i vitenarkiv
  • Meadow, Richard; Asare, Nana Yaa Ohene; Finne, Merethe Aasmo; Junttila, Olavi; Kirkendall, Lawrence R.; Måren, Inger Elisabeth; Yazdankhah, Siamak Pour; Dahl, Knut Helkås; Dalen, Knut Tomas; Nielsen, Kaare Magne; Sanden, Monica; Vikse, Rose & Sorteberg, Hilde-Gunn Opsahl (2017). Risk assessment of insect-resistant and herbicide-tolerant genetically modified maize 1507 for cultivation, import, processing, food and feed uses under Directive 2001/18/EC (C/ES/01/01, C/NL/00/10) and Regulation (EC) No 1829/2003 (EFSA/GMO/NL/2004/02, EFSA/GMO/RX/1507). Opinion of the Panel on Genetically Modified Organisms of the Norwegian Scientific Committee for Food Safety . Fulltekst i vitenarkiv
  • Catterall, Tara Cherie; Johnson, Inna; Khan, Shaista; Jermstad, Ingunn; Nesse, Gaute; Klungland, Arne & Dalen, Knut Tomas (2015). The Norwegian Transgenic Centre.
  • Feng, Yuan Zeng; knabenes, Irlin Knivsland; Bakke, Siril S.; Lund, Jenny; Lee, Y.K.; kimmel, Alan; Thoresen, G. Hege; Rustan, Arild & Dalen, Knut Tomas (2015). Increased lipid oxidation and decreased lipid storage in myotubes lacking the lipid droplet binding protein perilipin2.
  • Bindesbøll, Christian; Berg, Ole; Arntsen, Borghild M; Nebb, Hilde Irene & Dalen, Knut Tomas (2014). Fatty acids regulate perilipin5 in muscle by activating PPARdelta.
  • Dalen, Knut Tomas (2014). Transgenic techniques provided by the Norwegian Transgenic Centre.
  • Dalen, Knut Tomas; Haj-Yasein, Nadia Nabil; Berg, Ole; Refsum, Helga & Nebb, Hilde Irene (2014). Cysteine and adipocyte differentiation.
  • Feng, Yuan Zeng; knabenes, Irlin Knivsland; Lund, Jenny; Lee, Y.K.; kimmel, Alan; Thoresen, G. Hege; Rustan, Arild & Dalen, Knut Tomas (2014). Increased lipid oxidation and decreased lipid storage in myotubes lacking perilipin2.
  • Khan, Shaista; Jermstad, Ingunn; Catterall, Tara Cherie; Nesse, Gaute; Klungland, Arne & Dalen, Knut Tomas (2014). The Norwegian Transgenic Centre.
  • Bindesbøll, Christian; Fan, Qiong; Sæther, Thomas; Dalen, Knut Tomas; Nebb, Hilde Irene & Grønning-Wang, Line Mariann (2013). Nuclear receptors as targets for treatment and prevention of metabolic diseases.
  • Telle-Hansen, Vibeke; Halvorsen, Bente; Dalen, Knut Tomas; Narverud, Ingunn; Wesseltoft-Rao, Nima; Granlund, Linda; Ulven, Stine Marie & Holven, Kirsten Bjørklund (2013). Altered expression of genes involved in lipid metabolism in obese subjects with unfavourable phenotype.
  • Dalen, Knut Tomas (2011). Lipid droplet binding proteins and lipid accumulation.
  • Dalen, Knut Tomas; Londos, C & Nebb, Hilde Irene (2009). PAT proteins and their function on intracellular lipid droplets.
  • Dalen, Knut Tomas; Ulven, Stine Marie; Weedon, Mina Susanne; Bentzen, Trine Gjesti & Nebb, Hilde Irene (2004). The perioxisome proliferator-activated receptor gamma coordinately regulates the members of the lipid droplet associating protein gene family.
  • Dalen, Knut Tomas; Ulven, Stine Marie & Nebb, Hilde Irene (2003). Insulin regulation of the insulin responsive glucose transporter (GLUT4) in adipocytes is dependent on Liver X receptor alpha.
  • Dalen, Knut Tomas; Weedon, Mina Susanne; Bentzen, Trine Gjesti & Nebb, Hilde Irene (2002). The nuclear receptor PPARgamma regulates the expression of S3-12 and other members of the lipid droplet binding protein gene family in adipocytes.
  • Prydz, Kristian; Vuong, Tram Thu; Dalen, Knut Tomas; Kulseth, M. A. & Kolset, Svein Olav (1997). Chondroitin sulfate glycosaminoglycan chains contain apical sorting information in epithelial MDCK cells.

Se alle arbeider i Cristin

Publisert 13. apr. 2011 10:35 - Sist endret 4. mai 2017 15:13