Sigbjørn Fossum

Professor emeritus - Seksjon for anatomi
Bilde av Sigbjørn Fossum
English version of this page
Telefon +47-22851213
Rom 2361
Brukernavn
Besøksadresse Sognsvannsveien 9 Domus Medica 0372 OSLO
Andre tilknytninger Institutt for medisinske basalfag

Faglige interesser

  • Immunologi
  • Molekylærbiologi
  • Genetikk
  • Evolusjon

Undervisning

  • Forelesninger, immunology, Medisin, 1. semester
  • Forelesninger og PBL, Cellebiologi, Medisin, 2. semester

Bakgrunn

  • Grunnla Immunbiologisk laboratorium (sammen med kollega Bent Rolstad og ingeniør Wendi Jensen)
  • Professor, Anatomisk Institutt (nå Avdeling for Anatomi, Institutt for medisinske basalfag) 1992 -
  • Vitenskapelig assistent, amanuensis, 1. amanuensis,  Anatomisk Institutt, 1973 - 1992
  • Dr. med. 1983
  • Autorisert lege, 1973
  • Turnustjeneste 1971 - 73
  • Cand med, Oslo Universitet, 1971

Verv

  • Prodekan for forskning, Det medisinske Fakultet, UiO, 2007 - 2010. Som forskningsdaken ex officio medlem og leder for ulike  styrer, utvalg og komiteer
  • Leder for Anatomisk Institutt, 2000 - 2003
  • Medlem av styret for Bioteknologisenteret ved UiO, 1990 - 97
  • Medlem av Fakultetsstyret, 1980 - 5 og 1993 - 7

Samarbeid

  • Erik Dissen
  • Michael R. Daws
Emneord: Immunologi, Molekylærbiologi, Genetikk og epidemiologi, Evolusjon

Publikasjoner

  • Lobato Pascual, Ana; Sæther, Per Christian; Dahle, Maria Krudtaa; Gaustad, Peter; Dissen, Erik; Fossum, Sigbjørn & Daws, Michael Rory (2013). Rat Macrophage C-type Lectin is an Activating Receptor Expressed by Phagocytic Cells. PLoS ONE.  ISSN 1932-6203.  8(2) . doi: 10.1371/journal.pone.0057406
  • Lobato Pascual, Ana; Sæther, Per Christian; Fossum, Sigbjørn; Dissen, Erik & Daws, Michael Rory (2013). Mincle, the receptor for mycobacterial cord factor, forms a functional receptor complex with MCL and FcεRI-γ. European Journal of Immunology.  ISSN 0014-2980.  43(12), s 3167- 3174 . doi: 10.1002/eji.201343752
  • Fossum, Sigbjørn; Sæther, Per Christian; Vaage, John Torgils; Daws, Michael Rory & Dissen, Erik (2011). Paired opposing leukocyte receptors recognizing rapidly evolving ligands are subject to homogenization of their ligand binding domains. Immunogenetics.  ISSN 0093-7711.  63(12), s 809- 820 . doi: 10.1007/s00251-011-0553-5
  • Kveberg, Lise; Dai, Kezheng; Inngjerdingen, Marit; Brooks, Colin G.; Fossum, Sigbjørn & Vaage, John Torgils (2011). Phylogenetic and functional conservation of the NKR-P1F and NKR-P1G receptors in rat and mouse. Immunogenetics.  ISSN 0093-7711.  63(7), s 429- 436 . doi: 10.1007/s00251-011-0520-1
  • Sæther, Per Christian; Hoelsbrekken, Sigurd Erik; Fossum, Sigbjørn & Dissen, Erik (2011). Rat and Mouse CD94 Associate Directly with the Activating Transmembrane Adaptor Proteins DAP12 and DAP10 and Activate NK Cell Cytotoxicity. Journal of Immunology.  ISSN 0022-1767.  187(12), s 6365- 6373 . doi: 10.4049/jimmunol.1102345
  • Flornes, Line Mari; Nylenna, Øyvind; Sæther, Per Christian; Daws, Michael Rory; Dissen, Erik & Fossum, Sigbjørn (2010). The complete inventory of receptors encoded by the rat natural killer cell gene complex. Immunogenetics.  ISSN 0093-7711.  62(8), s 521- 530 . doi: 10.1007/s00251-010-0455-y
  • Orr, Mark T; Wu, Jun; Fang, Min; Sigal, Luis J.; Spee, Pieter; Egebjerg, Thomas; Dissen, Erik; Fossum, Sigbjørn; Phillips, Joseph H & Lanier, Lewis L. (2010). Development and Function of CD94-Deficient Natural Killer Cells. PLoS ONE.  ISSN 1932-6203.  5(11) . doi: 10.1371/journal.pone.0015184
  • Kveberg, Lise; Dai, Kezheng; Westgaard, Ingunn Hagen; Daws, Michael Rory; Fossum, Sigbjørn; Naper, Christian & Vaage, John Torgils (2009). Two major groups of rat NKR-P1 receptors can be distinguished based on chromosomal localization, phylogenetic analysis and Clr ligand binding. European Journal of Immunology.  ISSN 0014-2980.  39(2), s 541- 551 . doi: 10.1002/eji.200838891
  • Dissen, Erik; Hoelsbrekken, Sigurd Erik; Sæther, Per Christian & Fossum, Sigbjørn (2008). NK cell receptors in rodents and cattle. Seminars in Immunology.  ISSN 1044-5323.  20(6), s 369- 375
  • Sæther, Per Christian; Westgaard, Ingunn Hagen; Hoelsbrekken, Sigurd Erik; Benjamin, J; Lanier, LL; Fossum, Sigbjørn & Dissen, Erik (2008). KLRE/I1 and KLRE/I2: A novel pair of heterodimeric receptors that inversely regulate NK cell cytotoxicity. Journal of Immunology.  ISSN 0022-1767.  181, s 3177- 3182
  • Lorentzen, JC; Flornes, Line Marie; Eklow, C; Backdahl, L; Ribbhammar, U; Guo, JP; Smolnikova, M; Dissen, Erik; Seddighzadeh, M; Brookes, AJ; Alfredsson, L; Klareskog, L; Padyukov, L & Fossum, Sigbjørn (2007). Association of arthritis with a gene complex encoding C-type lectin-like receptors. Arthritis and Rheumatism.  ISSN 0004-3591.  56, s 2620- 2632 . doi: 10.1002/art.22813
  • Bryceson, Yenan T.; Torgersen, Knut Martin; Inngjerdingen, Marit; Berg, Siri Fuglem; Hoelsbrekken, Sigurd Erik; Fossum, Sigbjørn & Dissen, Erik (2005). The rat orthologue to the inhibitory receptor gp49B is expressed by neutrophils and monocytes, but not by NK cells or mast cells. European Journal of Immunology.  ISSN 0014-2980.  35(4)
  • Hoelsbrekken, Sigurd Erik; Fossum, Sigbjørn & Dissen, Erik (2005). Molecular cloning of LILRC1 and LILRC2 in the mouse and the rat, two novel immunoglobulin-like receptors encoded by the leukocyte receptor gene complex. Immunogenetics.  ISSN 0093-7711.  57(7), s 479- 486
  • Nylenna, Øyvind; Naper, Christian; Vaage, John Torgils; Woon, P.Y.; Gauguier, D; Dissen, Erik; Ryan, JC & Fossum, Sigbjørn (2005). The genes and gene organization of the Ly49 region of the rat natural killer cell gene complex. European Journal of Immunology.  ISSN 0014-2980.  35
  • Sæther, Per Christian; Westgaard, Ingunn Hagen; Flornes, Line Marie; Hoelsbrekken, Sigurd Erik; Ryan, James C.; Fossum, Sigbjørn & Dissen, Erik (2005). Molecular cloning of KLRI1 and KLRI2, a novel pair of lectin-like natural killer-cell receptors with opposing signalling motifs. Immunogenetics.  ISSN 0093-7711.  56
  • Westgaard, Ingunn Hagen; Berg, Siri F.; Vaage, John Torgils; Wang, Lawrence L; Yokoyama, Wayne M.; Dissen, Erik & Fossum, Sigbjørn (2004). Rat NKp46 activates natural killer cell cytotoxicity and is associated with Fc{epsilon}RI{gamma} and CD3{zeta}. Journal of Leukocyte Biology.  ISSN 0741-5400.  76, s 1200- 1206 . doi: 10.1189/jlb.0903428 Vis sammendrag
  • Flornes, Line Marie; Bryceson, Yenan T.; Spurkland, Anne; Lorentzen, JC; Dissen, Erik & Fossum, Sigbjørn (2004). Identification of lectin-like receptors expressed by antigen presenting cells and neutrophils and their mapping to a novel gene complex. Immunogenetics.  ISSN 0093-7711.  56, s 506- 517 Vis sammendrag
  • Hoelsbrekken, Sigurd E.; Nylenna, Øyvind; Sæther, Per Christian; Slettedal, Imer Ö; Ryan, James C.; Fossum, Sigbjørn & Dissen, Erik (2003). Cutting edge: molecular cloning of a killer cell Ig-like receptor in the mouse and rat. Journal of Immunology.  ISSN 0022-1767.  170(5), s 2259- 2263
  • Ribbhammar, Ulrica; Flornes, Line Marie; Bäckdahl, Liselotte; Luthman, Holger; Fossum, Sigbjørn & Lorentzen, Johnny (2003). High resolution mapping of an arthritis susceptibility locus on rat chromosome 4, and characterization of regulated phenotypes. Human Molecular Genetics.  ISSN 0964-6906.  12, s 2087- 2096
  • Westgaard, Ingunn Hagen; Dissen, Erik; Torgersen, Knut Martin; Lazetic, Sascha; Lanier, Lewis L.; Phillips, JH & Fossum, Sigbjørn (2003). The lectin-like receptor KLRE1 inhibits natural killer cell cytotoxicity. Journal of Experimental Medicine.  ISSN 0022-1007.  197(11), s 1551- 1561
  • Berg, Siri Fuglem; Fossum, Sigbjørn & Dissen, Erik (1999). NILR-1, a novel immunoglobulin-like receptor expressed by neutrophilic granulocytes, is encoded by a leukocyte receptor gene complex on rat chromosome 1. European Journal of Immunology.  ISSN 0014-2980.  29, s 2000- 2006
  • Berg, Siri Fuglem; Westgaard, Ingunn Hagen; Fossum, Sigbjørn & Dissen, Erik (1999). A rat gene homologous to human granule membrane protein 17 is expressed by natural killer cells, CD8+ T cells and a mast cell line. Immunogenetics.  ISSN 0093-7711.  29, s 815- 818
  • Berg, Siri Fuglem; Dissen, Erik; Westgaard, Ingunn Hagen & Fossum, Sigbjørn (1998). Molecular characterization of rat NKR-P2, a lectin-like receptor expressed by NK cells and resting T cells. International Immunology.  ISSN 0953-8178.  10, s 379- 385
  • Berg, Siri Fuglem; Dissen, Erik; Westgaard, Ingunn Hagen & Fossum, Sigbjørn (1998). Two genes in the rat homologous to human NKG2. European Journal of Immunology.  ISSN 0014-2980.  28, s 444- 450
  • Westgaard, Ingunn Hagen; Berg, Siri Fuglem; Ørstavik, Sigurd; Fossum, Sigbjørn & Dissen, Erik (1998). Identification of a human member of the Ly-49 multigene family. European Journal of Immunology.  ISSN 0014-2980.  28, s 1839- 1846
  • Dissen, Erik; Berg, Siri Fuglem; Westgaard, Ingunn Hagen & Fossum, Sigbjørn (1997). Molecular characterization of a gene in the rat homologous to human CD94. European Journal of Immunology.  ISSN 0014-2980.  27, s 2080- 2086
  • Dissen, Erik & Fossum, Sigbjørn (1996). Chromosomal localization of the genes encoding rat CD4, CD8 and CD8. Immunogenetics.  ISSN 0093-7711.  44, s 312- 314
  • Dissen, Erik; Ryan, James C.; Seaman, W. E. & Fossum, Sigbjørn (1996). An autosomal dominant locus, Nka, mapping to the Ly-49 region of a rat natural killer (NK) gene complex, controls NK cell lysis of allogeneic lymphocytes. Journal of Experimental Medicine.  ISSN 0022-1007.  183, s 2197- 2207

Se alle arbeider i Cristin

  • Wisløff, Finn Georg B & Fossum, Sigbjørn (2012). Forskning viser at ... Vurdering og formidling av medisinske forskningsresultater. Gyldendal Akademisk.  ISBN 978-82-05-42551-4.  359 s.

Se alle arbeider i Cristin

  • Kristensen, Petter; Levy, Finn; Grahnstedt, Svein G; Martinsen, Aud; Schiel, Anja Elisabeth; Flornes, Line Mari; Daws, Michael Rory; Dissen, Erik & Fossum, Sigbjørn (2011). Oils and Health. Report to the Ministry of Health and Care Services.
  • Nakken, Britt; Jensen, Wendi; Szodoray, Peter; Daws, Michael Rory & Fossum, Sigbjørn (2011). Role of the C-Type Lectin-Like Receptor Dcar1 in Oil Induced Arthritis. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 375- 376
  • Lobato Pascual, Ana; Sæther, Per Christian; Fossum, Sigbjørn & Daws, Michael Rory (2010). Exploring expression and function of the rat Macrophage C-type Lectin, Clecsf8. Vis sammendrag
  • Kveberg, Lise; Dai, Kezheng; Martinsen, Stine; Fossum, Sigbjørn & Vaage, John Torgils (2009). Phylogenetic and functional conservation of the NKR-P1G NK receptor in rat and mouse.
  • Kveberg, Lise; Fossum, Sigbjørn & Vaage, John Torgils (2009). Phylogenetic and functional conservation of the NKR-P1G receptor in rat and mouse.
  • Kveberg, Lise; Westgaard, Ingunn Hagen; Dai, Kezheng; Daws, Michael Rory; Fossum, Sigbjørn; Naper, Christian & Vaage, John Torgils (2007). The NKR-P1 family of receptors in rat recognizes C-type lectin related molecules.
  • Kveberg, Lise; Westgaard, Ingunn Hagen; Dai, Kezheng; Daws, Michael Rory; Fossum, Sigbjørn; Naper, Christian & Vaage, John Torgils (2007). The NKR-P1 family of receptors in rat recognizes C-type lectin-related molecules.
  • Rolstad, Bent & Fossum, Sigbjørn (1999). Natural killer celler, enfant terrible i immunologien. NBS-nytt.  ISSN 0801-3535.  23, s 7- 13

Se alle arbeider i Cristin

Publisert 13. apr. 2011 10:36 - Sist endret 14. mars 2012 15:19