Torgeir Holen

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Telefon +47-22851294
Rom 2158
Brukernavn
Besøksadresse Sognsvannsveien 9 Domus Medica 0372 OSLO
Postadresse Postboks 1046 Blindern 0317 OSLO
Andre tilknytninger Institutt for medisinske basalfag

Publikasjoner

  • Lee, Sindre; Norheim, Frode; Gulseth, Hanne Løvdal; Langleite, Torgrim Mikal; Kolnes, Kristoffer Jensen; Tangen, Daniel S.; Stadheim, Hans Kristian; Gilfillan, Gregor Duncan; Holen, Torgeir; Birkeland, Kåre I.; Jensen, Jørgen & Drevon, Christian A (2017). Interaction between plasma fetuin-A and free fatty acids predicts changes in insulin sensitivity in response to long-term exercise. Physiological Reports.  ISSN 2051-817X.  5(5) . doi: 10.14814/phy2.13183
  • Pourteymour, Shirin; Eckardt, Kristin; Holen, Torgeir; Langleite, Torgrim Mikal; Lee, Sindre; Jensen, Jørgen; Birkeland, Kåre I.; Drevon, Christian A & Hjorth, Marit (2017). Global mRNA sequencing of human skeletal muscle: Search for novel exercise-regulated myokines. Molecular Metabolism.  ISSN 2212-8778.  6(4), s 352- 365 . doi: 10.1016/j.molmet.2017.01.007
  • Görgens, Sven W.; Hjorth, Marit; Eckardt, Kristin; Wichert, Stefan; Norheim, Frode; Holen, Torgeir; Lee, Sindre; Langleite, Torgrim Mikal; Birkeland, Kåre I.; Stadheim, Hans Kristian; Kolnes, Kristoffer Jensen; Tangen, Daniel S.; Kolnes, Anders J.; Jensen, Jørgen; Drevon, Christian A & Eckel, Jürgen (2016). The exercise-regulated myokine chitinase-3-like protein 1 stimulates human myocyte proliferation. Acta Physiologica.  ISSN 1748-1708.  216(3), s 330- 345 . doi: 10.1111/apha.12579
  • Hjorth, Marit; Pourteymour, Shirin; Goergens, S W; Langleite, Torgrim Mikal; Lee, Sindre; Holen, Torgeir; Gulseth, Hanne Løvdal; Birkeland, Kåre I.; Jensen, Jørgen; Drevon, Christian A & Norheim, Frode (2016). Myostatin in relation to physical activity and dysglycaemia and its effect on energy metabolism in human skeletal muscle cells. Acta Physiologica.  ISSN 1748-1708.  217(1), s 45- 60 . doi: 10.1111/apha.12631
  • Holen, Torgeir; Norheim, Frode; Gundersen, Thomas Erik; Mitry, Patricia; Linseisen, Jakob; Iversen, Per Ole & Drevon, Christian A (2016). Biomarkers for nutrient intake with focus on alternative sampling techniques. Genes & Nutrition.  ISSN 1555-8932.  11:12 . doi: 10.1186/s12263-016-0527-1
  • Langleite, Torgrim Mikal; Jensen, Jørgen; Norheim, Frode; Gulseth, Hanne Løvdal; Tangen, Daniel S.; Kolnes, Kristoffer Jensen; Heck, Ansgar; Storås, Tryggve; Lie, Guro Grøthe; Dahl, Marius; Kielland, Anders; Holen, Torgeir; NORENG, HANS JØRGEN; Stadheim, Hans Kristian; Bjørnerud, Atle; Johansen, Egil Ivar; Nellemann, Birgitte; Birkeland, Kåre I. & Drevon, Christian A (2016). Insulin sensitivity, body composition and adipose depots following 12 w combined endurance and strength training in dysglycemic and normoglycemic sedentary men. Archives of Physiology and Biochemistry.  ISSN 1381-3455.  122(4), s 167- 179 . doi: 10.1080/13813455.2016.1202985
  • Lee, Sindre; Norheim, Frode; Langleite, Torgrim Mikal; NORENG, HANS JØRGEN; Storås, Tryggve; Afman, Lydia A.; Frost, Gary; Bell, Jimmy D.; Thomas, E. Louise; Kolnes, Kristoffer Jensen; Tangen, Daniel S.; Stadheim, Hans Kristian; Gilfillan, Gregor Duncan; Gulseth, Hanne Løvdal; Birkeland, Kåre I.; Jensen, Jørgen; Drevon, Christian A & Holen, Torgeir (2016). Effect of energy restriction and physical exercise intervention on phenotypic flexibility as examined by transcriptomics analyses of mRNA from adipose tissue and whole body magnetic resonance imaging. Physiological Reports.  ISSN 2051-817X.  4(21) . doi: 10.14814/phy2.13019
  • Li, Yuchuan; Hessvik, Nina Pettersen; Danbolt, Niels Christian & Holen, Torgeir (2016). A large-scale quantitative EM study on activation of olfactory glands shows no effect of cholinergic agents. Journal of Electron Microscopy.  ISSN 0022-0744.  65(5), s 438- 443 . doi: 10.1093/jmicro/dfw028
  • Albrecht, Elke; Norheim, Frode; Thiede, Bernd; Holen, Torgeir; Ohashi, Tomoo; Schering, Lisa; Lee, Sindre; Brenmoehl, Julia; Thomas, Selina; Drevon, Christian A; Erickson, Harold P & Maak, Steffen (2015). Irisin - A myth rather than an exercise-inducible myokine. Scientific Reports.  ISSN 2045-2322.  5 . doi: 10.1038/srep08889
  • Albrecht, Elke; norheim, frode; Thiede, Bernd; Lee, Sindre; Holen, Torgeir; Ohashi,, Tomoo; Schering, Lisa; Brenmoehl, Julia; Thomas, Selina; Drevon, Christian A; Erickson, Harold P & Maak, Steffen (2015). Irisin – a myth rather than an exercise-inducible myokine. Scientific Reports.  ISSN 2045-2322. . doi: 10.1038/srep08889
  • Hjorth, Marit; Norheim, Frode; Meen, Astri Jeanette; Pourteymour, Shirin; Lee, Sindre; Holen, Torgeir; Jensen, Jørgen; Birkeland, Kåre I.; Martinov, Vladimir Nikolkaev; Langleite, Torgrim Mikal; Eckardt, Kristin; Drevon, Christian A & Kolset, Svein Olav (2015). The effect of acute and long-term physical activity on extracelluar Matrix and serglycin in huuman skeletal muscle. Physiological Reports.  ISSN 2051-817X.  3:e12473(8), s 1- 19 . doi: 10.14814/phy2.12473
  • Pourteymour, Shirin; Lee, Sindre; Langleite, Torgrim Mikal; Eckardt, Kristin; Hjorth, Marit; Bindesbøll, Christian; Dalen, Knut Tomas; Birkeland, Kåre I.; Drevon, Christian A; Holen, Torgeir & Norheim, Frode (2015). Perilipin 4 in human skeletal muscle: localization and effect of physical activity. Physiological Reports.  ISSN 2051-817X.  3:e12481(8), s 1- 15 . doi: 10.14814/phy2.12481
  • Li, Yuchuan; Lee, Sindre; Langleite, Torgrim Mikal; Norheim, Frode; Pourteymour, Shirin; Jensen, Jørgen; Stadheim, Hans Kristian; Storås, Tryggve; Davanger, Svend; Gulseth, Hanne Løvdal; Birkeland, Kåre I.; Drevon, Christian A & Holen, Torgeir (2014). Subsarcolemmal lipid droplet responses to a combined endurance and strength exercise intervention. Physiological Reports.  ISSN 2051-817X.  2(11) . doi: 10.14814/phy2.12187
  • Norheim, Frode; Hjorth, Marit; Langleite, Torgrim Mikal; Lee, Sindre; Holen, Torgeir; Bindesbøll, Christian; Stadheim, Hans Kristian; Gulseth, Hanne Lovdal; Birkeland, Kåre I.; Kielland, Anders; Jensen, Jørgen; Dalen, Knut Tomas & Drevon, Christian A (2014). Regulation of angiopoietin-like protein 4 Production during and after exercise. Physiological Reports.  ISSN 2051-817X.  2(8) . doi: 10.14814/phy2.12109
  • Norheim, Frode; Langleite, Torgrim Mikal; Hjorth, Marit; Holen, Torgeir; Kielland, Anders; Stadheim, Hans Kristian; Gulseth, Hanne Løvdal; Birkeland, Kåre I.; Jensen, Jørgen & Drevon, Christian A (2014). The effects of acute and chronic exercise on PGC-1α, irisin and browning of subcutaneous adipose tissue in humans. The FEBS Journal.  ISSN 1742-464X.  281(3), s 739- 749 . doi: 10.1111/febs.12619
  • Kazak, Lawrence; Reyes, Aurelio; He, Jiuya; Wood, Stuart R.; Brea-Calvo, Gloria; Holen, Torgeir & Holt, Ian J. (2013). A Cryptic Targeting Signal Creates a Mitochondrial FEN1 Isoform with Tailed R-Loop Binding Properties. PLoS ONE.  ISSN 1932-6203.  8(5) . doi: 10.1371/journal.pone.0062340
  • Potokar, Maja; Stenovec, Matjaž; Jorgačevski, Jernej; Holen, Torgeir; Kreft, Marko; Ottersen, Ole Petter & Zorec, Robert (2013). Regulation of AQP4 surface expression via vesicle mobility in astrocytes. Glia.  ISSN 0894-1491.  61(6), s 917- 928 . doi: 10.1002/glia.22485
  • Norheim, Frode; Gjelstad, Ingrid Merethe Fange; Hjorth, Marit; Vinknes, Kathrine; Langleite, Torgrim Mikal; Holen, Torgeir; Jensen, Jørgen; Dalen, Knut Tomas; Karlsen, Anette; Kielland, Anders; Rustan, Arild & Drevon, Christian A (2012). Molecular nutrition research - the modern way of performing nutritional science. Nutrients.  ISSN 2072-6643.  4(12), s 1898- 1944 . doi: 10.3390/nu4121898
  • Solbu, Tom Tallak & Holen, Torgeir (2012). Aquaporin Pathways and Mucin Secretion of Bowman's Glands Might Protect the Olfactory Mucosa. Chemical Senses.  ISSN 0379-864X.  37(1), s 35- 46 . doi: 10.1093/chemse/bjr063
  • Sørbø, Jan Gunnar; Fleckenstein, Burkhard; Ottersen, Ole Petter & Holen, Torgeir (2012). Small-scale purification and mass spectrometry analysis reveal a third aquaporin-4 protein isoform of 36 kDa in rat brain. Journal of Neuroscience Methods.  ISSN 0165-0270.  211(1), s 31- 39 . doi: 10.1016/j.jneumeth.2012.07.021
  • Holen, Torgeir (2011). The Ultrastructure of Lamellar Stack Astrocytes. Glia.  ISSN 0894-1491.  59(7), s 1075- 1083 . doi: 10.1002/glia.21180
  • Lehre, Anne- Catherine W G; Rowley, Nicole; Zhou, Yun; Holmseth, Silvia; Guo, Chungang; Holen, Torgeir; Hua, Rui; Laake, Petter; Olofsson, Anna Maria; Poblete-Naredo, Irais; Rusakov, Dimitri A.; Madsen, Karsten K.; Clausen, Rasmus P.; Schousboe, Arne; White, H. Steve & Danbolt, Niels Christian (2011). Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice. Epilepsy Research.  ISSN 0920-1211.  95(1-2), s 70- 81 . doi: 10.1016/j.eplepsyres.2011.02.014
  • Thrane, Alexander Stanley; Rappold, Philip M; Fujita, Takumi; Torres, Arnulfo; Bekar, Lane K; Takano, Takahiro; Peng, Weiguo; Wang, Fushun; Thrane Rangroo, Vinita; Enger, Rune; Haj Yasein, Nadia Nabil; Skare, Øivind; Holen, Torgeir; Klungland, Arne; Ottersen, Ole Petter; Nedergaard, Maiken & Nagelhus, Erlend Arnulf (2011). Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  108(2), s 846- 851 . doi: 10.1073/pnas.1015217108
  • Fenton, Robert A.; Moeller, Hanne B.; Zelenina, Marina; Snæbjørnsson, Marteinn Thor; Holen, Torgeir & MacAulay, Nanna (2010). Differential water permeability and regulation of three aquaporin 4 isoforms. Cellular and Molecular Life Sciences (CMLS).  ISSN 1420-682X.  67(5), s 829- 840 . doi: 10.1007/s00018-009-0218-9
  • Haglerød, Camilla Margrete; Kapica, Aida; Boulland, Jean-Luc; Hussain, Suleman; Holen, Torgeir; Skare, Øivind; Laake, Petter; Ottersen, Ole Petter; Haug, Finn-Mogens Smejda & Davanger, Svend (2009). Protein interacting with C kinase 1 (PICK1) and GluR2 are associated with presynaptic plasma membrane and vesicles in hippocampal excitatory synapses. Neuroscience.  ISSN 0306-4522.  158(1), s 242- 252 . doi: 10.1016/j.neuroscience.2008.11.029
  • Strand, Line; Moe, Svein Erik E; Solbu, Tom Tallak; Vaadal, Marianne & Holen, Torgeir (2009). Roles of Aquaporin-4 Isoforms and Amino Acids in Square Array Assembly. Biochemistry.  ISSN 1520-4995.  48(25), s 5785- 5793 . doi: 10.1021/bi802231q
  • Utvik, Jo Kristian; Haglerød, Camilla Margrete; Mylonakou, Maria-Niki; Holen, Torgeir; Kropf, Michel; Hirling, H; Skare, Øivind; Laake, Petter; Ottersen, Ole Petter; Haug, Finn-Mogens Smejda & Davanger, Svend (2009). Neuronal enriched endosomal protein of 21 kDa colocalizes with glutamate receptor subunit GLUR2/3 at the postsynaptic membrane. Neuroscience.  ISSN 0306-4522.  158(1), s 96- 104 . doi: 10.1016/j.neuroscience.2008.11.030
  • Moe, Svein Erik E; Sørbø, Jan Gunnar & Holen, Torgeir (2008). Huntingtin triplet-repeat locus is stable under long-term Fen1 knockdown in human cells. Journal of Neuroscience Methods.  ISSN 0165-0270.  171, s 233- 238 . doi: 10.1016/j.jneumeth.2008.03.012
  • Moe, Svein Erik E; Sørbø, Jan Gunnar; Sogaard, R; Zeuthen, T; Ottersen, Ole Petter & Holen, Torgeir (2008). New isoforms of rat Aquaporin-4. Genomics.  ISSN 0888-7543.  91, s 367- 377 . doi: 10.1016/j.ygeno.2007.12.003
  • Sørbø, Jan Gunnar; Moe, Svein Erik E; Ottersen, Ole Petter & Holen, Torgeir (2008). The molecular composition of square Arrays. Biochemistry.  ISSN 1520-4995.  47 . doi: 10.1021/bi702146k
  • Sørbø, Jan Gunnar; Moe, Svein Erik & Holen, Torgeir (2007). Early upregulation in nasal epithelium and strong expression in olfactory bulb glomeruli suggest a role for Aquaporin-4 in olfaction. FEBS Letters.  ISSN 0014-5793.  581(25)
  • Amarzguioui, Mohammed; Peng, Qian; Wiiger, Merete Thune; Vasovic, V; Babaie, Eshrat; Holen, Torgeir; Nesland, Jahn M & Prydz, Hans Peter B (2006). Ex vivo and in vivo delivery of anti-tissue factor short interfering RNA inhibits mouse pulmonary metastasis of B16 melanoma cells. Clinical Cancer Research.  ISSN 1078-0432.  12, s 4055- 4061
  • Holen, Torgeir (2006). Efficient prediction of siRNAs with siRNArules 1.0: An open-source JAVA approach to siRNA algorithms. RNA: A publication of the RNA Society.  ISSN 1355-8382.  12, s 1620- 1625
  • Holen, Torgeir (2005). Mechanisms of RNAi: mRNA cleavage fragments may indicate stalled RISC. Journal of RNAi and Gene Silencing.  ISSN 1747-0854.  1(1), s 21- 25
  • Holen, Torgeir; Moe, Svein Erik E; Sørbø, Jan Gunnar; Meza, Trine Johansen; Ottersen, Ole Petter & Klungland, Arne (2005). Tolerated wobble mutations in siRNAs decrease specificity, but can enhance activity in vivo. Nucleic Acids Research.  ISSN 0305-1048.  33(15), s 4704- 4710 . doi: 10.1093/nar/gki785
  • Snove, O & Holen, Torgeir (2004). Many commonly used siRNAs risk off-target activity. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  319, s 256- 263
  • Amarzguioui, Mohammed; Holen, Torgeir; Babaie, Eshrat & Prydz, Hans Peter B (2003). Tolerance for mutations and chemical modifications in a siRNA. Nucleic Acids Research.  ISSN 0305-1048.  31, s 589- 595
  • Holen, Torgeir; Amarzguioui, Mohammed; Babaie, Eshrat & Prydz, Hans Peter B (2003). Similar behaviour of single-strand and double-strand siRNAs suggests they act through a common RNAi pathway. Nucleic Acids Research.  ISSN 0305-1048.  31, s 2401- 2407

Se alle arbeider i Cristin

  • Eckardt, Kristin; Pourteymour, Shirin; Hjorth, Marit; Lee, Sindre; Langleite, Torgrim Mikal; Holen, Torgeir; Jensen, Jørgen; Birkeland, Kåre I. & Drevon, Christian A (2016). Dual specificity phosphatase 5 and 6 are oppositely regulated in human skeletal muscle by acute exercise.
  • Eckardt, Kristin; Lee, Sindre; Langleite, Torgrim Mikal; Holen, Torgeir; Jensen, Jørgen; Birkeland, Kåre I. & Drevon, Christian A (2015). Stearoyl-CoA desaturase and its regulation in human skeletal muscle by exercise.
  • Zhou, Yun; Holmseth, Silvia; Holen, Torgeir & Danbolt, Niels Christian (2011). EVIDENCE AGAINST A ROLE OF THE BETAINE-GABA TRANSPORTER (BGT1, SLC6A12) IN THE CONTROL OF GABA RECEPTOR ACTIVATION. Glia.  ISSN 0894-1491.  59, s S69- S70
  • Holen, Torgeir (2004). RNA interferens – et nyoppdaget immunforsvar og et nytt genteknologisk verktøy. Naturen.  ISSN 0028-0887.  (4), s 252- 259
  • Holen, Torgeir & Mobbs, CV (2004). Lobotomy of genes: Use of RNA interference in neuroscience. Neuroscience.  ISSN 0306-4522.  126, s 1- 7
  • Holen, Torgeir (2003). Natural variation in siRNA activity and the influence of chemical and mutational modifications.

Se alle arbeider i Cristin

Publisert 16. jan. 2012 16:28 - Sist endret 26. nov. 2013 17:09