Torkel Hafting

Bilde av Torkel Hafting
English version of this page
Telefon +47-22856300
Mobiltelefon nittini647444
Rom 1354
Brukernavn
Besøksadresse Domus Medica
Postadresse Postboks 1103 Blindern 0317 OSLO
Andre tilknytninger Avdeling for molekylærmedisin

Faglige interesser

I min forskning er jeg interessert i å identifisere mekanismene som ligger til grunn for hjernens fantastiske evne til å prosessere sanseinformasjon og lagre erfaringer i nevrale nettverk. Vår forskningsgruppe jobber in vivo med elektrofysiologiske registreringer av store populasjoner av nerveceller. For å se sammenhengen mellom nervecellenes struktur og funksjon benytter vi genteknologi og to-foton laser-scanning mikroskopi.

Undervisning

Mesteparten av min undervisning er i nevrofysiologi på medisinstudiet, Modul 2. 

Bakgrunn

  • 1991-1992 Undergraduate courses in Electronic Engineering, NTNU
  • 1992-1995 Bachelor in Biology, University of Oslo
  • 1995-1996 Arctic biology, The University Courses on Svalbard
  • 1997-1998 Master of Sciences, University of Oslo
  • 1998-2001 PhD in Physiology, University of Oslo. Supervisor Olav Sand

Priser

 

Emneord: Hjernen og nervesystemet, Nevrobiologi, Hukommelse, Korteks, Plastisitet

Publikasjoner

  • Aasebø, Ida E. J.; Lepperød, Mikkel Elle; Stavrinou, Maria; Nøkkevangen, Sandra; Einevoll, Gaute; Hafting, Torkel & Fyhn, Marianne (2017). Temporal processing in the visual cortex of the awake and anesthetized rat. eNeuro.  ISSN 2373-2822.  4:e0059-17.2017(4), s 1- 26 . doi: 10.1523/ENEURO.0059-17.2017 Vis sammendrag
  • Dragly, Svenn-Arne; Mobarhan, Milad; Solbrå, Andreas Våvang; Tennøe, Simen; Hafreager, Anders; Malthe-Sørenssen, Anders; Fyhn, Marianne; Hafting, Torkel & Einevoll, Gaute (2017). Neuronify: An educational simulator for neural circuits. eNeuro.  ISSN 2373-2822.  4(2:e0022-17.2017), s 1- 13 . doi: 10.1523/ENEURO.0022-17.2017
  • Lensjø, Kristian Kinden; Christensen, Ane Charlotte; Tennøe, Simen; Fyhn, Marianne & Hafting, Torkel (2017). Differential Expression and Cell-Type Specificity of Perineuronal Nets in Hippocampus, Medial Entorhinal Cortex and Visual Cortex Examined in the Rat and Mouse. eNeuro.  ISSN 2373-2822. . doi: 10.1523/ENEURO.0379-16.2017
  • Lensjø, Kristian Kinden; Lepperød, Mikkel Elle; Dick, Gunnar; Hafting, Torkel & Fyhn, Marianne (2017). Removal of perineuronal nets unlocks juvenile plasticity through network mechanisms of decreased inhibition and increased gamma Activity. Journal of Neuroscience.  ISSN 0270-6474.  37(5), s 1269- 1283 . doi: 10.1523/JNEUROSCI.2504-16.2016
  • Hagen, Espen; Ness, Torbjørn; Khosrowshahi, Amir; Sørensen, Christina; Fyhn, Marianne; Hafting, Torkel; Franke, Felix & Einevoll, Gaute (2015). ViSAPy: A Python tool for biophysics-based generation of virtual spiking activity for evaluation of spike-sorting algorithms. Journal of Neuroscience Methods.  ISSN 0165-0270.  245, s 182- 204 . doi: 10.1016/j.jneumeth.2015.01.029
  • Bonnevie, Tora; Dunn, Benjamin Adric; Fyhn, Marianne; Hafting, Torkel; Derdikman, Dori Moshe; Kubie, J. L.; Roudi, Yasser; Moser, Edvard Ingjald & Moser, May-Britt (2013). Grid cells require excitatory drive from the hippocampus. Nature Neuroscience.  ISSN 1097-6256.  16(3), s 309- 317 . doi: 10.1038/nn.3311
  • Colgin, Laura Lee; Denninger, Tobias; Fyhn, Marianne; Hafting, Torkel; Bonnevie, Tora; Jensen, Ole; Moser, May-Britt & Moser, Edvard Ingjald (2009). Frequency of gamma oscillations routes flow of information in the hippocampus. Nature.  ISSN 0028-0836.  462(7271), s 353- U119 . doi: 10.1038/nature08573
  • Derdikman, Dori Moshe; Whitlock, Jonathan; Tsao, Albert; Fyhn, Marianne; Hafting, Torkel; Moser, May-Britt & Moser, Edvard Ingjald (2009). Fragmentation of grid cell maps in a multicompartment environment. Nature Neuroscience.  ISSN 1097-6256.  12(10), s 1325- U155 . doi: 10.1038/nn.2396
  • Fyhn, Marianne; Hafting, Torkel; Witter, Menno; Moser, Edvard Ingjald & Moser, May-Britt (2008). Grid cells in mice. Hippocampus.  ISSN 1050-9631.  18(12), s 1230- 1238 . doi: 10.1002/hipo.20472
  • Hafting, Torkel; Fyhn, Marianne; Bonnevie, Tora; Moser, May-Britt & Moser, Edvard Ingjald (2008). Hippocampus-independent phase precession in entorhinal grid cells. Nature.  ISSN 0028-0836.  453, s 1248- U50 . doi: 10.1038/nature06957
  • Kjelstrup, Kirsten Gjerstad; Solstad, Trygve; Brun, Vegard Heimly; Hafting, Torkel; Leutgeb, Stefan; Witter, Menno; Moser, Edvard Ingjald & Moser, May-Britt (2008). Finite scale of spatial representation in the hippocampus. Science.  ISSN 0036-8075.  321, s 140- 143 . doi: 10.1126/science.1157086
  • Fyhn, Marianne; Hafting, Torkel; Treves, Alessandro; Moser, May-Britt & Moser, Edvard Ingjald (2007). Hippocampal remapping and grid realignment in entorhinal cortex. Nature.  ISSN 0028-0836.  446 . doi: 10.1038/nature05601
  • Sargolini, Francesca; Fyhn, Marianne; Fyhn, Torkel Hafting; McNaughton, Bruce; Witter, Menno; Moser, May-Britt & Moser, Edvard Ingjald (2006). Conjunctive representation of position, direction, and velocity in entorhinal cortex. Science.  ISSN 0036-8075.  312
  • Fyhn, Marianne & Hafting, Torkel (2006). "Gridceller" i hjernen danner et mentalt kart over omgivelsene. Det Kongelige Norske Videnskabers Selskab. Årbok.  ISSN 0803-1983.  s 47- 53
  • Hafting, Torkel; Fyhn, Marianne; Molden, Sturla; Moser, May-Britt & Moser, Edvard Ingjald (2005). Microstructure of a spatial map in the entorhinal cortex. Nature.  ISSN 0028-0836.  436, s 801- 806
  • Aasebø, Ida E. J.; Mobarhan, Milad; Røe, Malin Benum; Lensjø, Kristian Kinden; Einevoll, Gaute; Hafting, Torkel & Fyhn, Marianne (2017). Movement-resistant orientation-selective units in the deep layers of the visual cortex.
  • Buccino, Alessio Paolo; Ness, Torbjørn Vefferstad; Einevoll, Gaute; Cauwenberghs, Gert; Fyhn, Marianne; Hafting, Torkel & Häfliger, Philipp (2017). Classification of Neural Cell-types from Extracellular Signatures on Multi-Electrode Arrays using Deep Learning.
  • Dinh, Tovy; Lensjø, Kristian Kinden; Lanton, Rune Alexander; Dick, Gunnar; Fyhn, Marianne & Hafting, Torkel (2017). Increased ocular dominance plasticity in adult visual cortex after genetic knock out of aggrecan, an essential component of perineuronal nets.
  • Thompson, Elise Holter; Lensjø, Kristian Kinden; Wigestrand, Mattis B; Hafting, Torkel; Malthe-Sørenssen, Anders & Fyhn, Marianne (2017). The perineuronal nets in the lateral secondary visual cortex are essential for remote visual fear memory.
  • Bjerke, Line; Wigestrand, Mattis B; Aasebø, Ida E. J.; Fyhn, Marianne & Hafting, Torkel (2016). Inhibitory outputs from lateral hypothalamus to paraqueductal grey control innate defensive behavior.
  • Hafting, Torkel (2016). Extracellular registration of neural activity in freely behaving animals.
  • Hafting, Torkel (2016). From Science Fiction to Neuroscience.
  • Hafting, Torkel (2016). Optogenetic dissection of neural circuits underlying defensive behaviours.
  • Lensjø, Kristian Kinden; Lepperød, Mikkel Elle; Dick, Gunnar; Hafting, Torkel & Fyhn, Marianne (2016). Removal of perineuronal nets affects information processing and plasticity in the primary visual cortex.
  • Lepperød, Mikkel Elle; Wigestrand, Mattis B; Frey, M.M.; Lensjø, Kristian Kinden; Einevoll, Gaute; Solstad, Trygve; Fyhn, Marianne & Hafting, Torkel (2016). Role of input-specific perturbations of medial septal projections to the grid cell network.
  • Lepperød, Mikkel Elle; Wigestrand, Mattis B; Frey, Mina Martine; Lensjø, Kristian Kinden; Einevoll, Gaute; Solstad, Trygve; Fyhn, Marianne & Hafting, Torkel (2016). On the role of input-specific perturbations of medial septal projections to the grid cell network.
  • Lepperød, Mikkel Elle; Wigestrand, Mattis B; Lensjø, Kristian Kinden; Frey, M.M.; Dragly, Svenn-Arne; Einevoll, Gaute; Solstad, Trygve; Fyhn, Marianne & Hafting, Torkel (2016). Grid cell network resilient to input-specific medial septum perturbations.
  • Røe, Malin Benum; Aasebø, Ida E. J.; Lensjø, Kristian Kinden; Hafting, Torkel & Fyhn, Marianne (2016). Orientation selective cells in layer six of the primary visual cortex are resistant to the animal's movement.
  • Thompson, Elise Holter; Lensjø, Kristian Kinden; Wigestrand, Mattis B; Hafting, Torkel & Fyhn, Marianne (2016). The perineuronal nets in the lateral secondary visual cortex and their impact on remote visual fear memory.
  • Thompson, Elise Holter; Lensjø, Kristian Kinden; Wigestrand, Mattis B; Hafting, Torkel; Fyhn, Marianne & Malthe-Sørenssen, Anders (2016). The perineuronal nets in the lateral secondary visual cortex are essential for remote visual memory.
  • Wigestrand, Mattis B; Aasebø, Ida E. J.; Tully, Annabelle; Dinh, Vy To; Lepperød, Mikkel Elle; Hafting, Torkel & Fyhn, Marianne (2016). Lateral hypothalamic outputs control innate defensive responses.
  • Wigestrand, Mattis B; Aasebø, Ida E. J.; Tully, Annabelle; Lepperød, Mikkel Elle; Hafting, Torkel & Fyhn, Marianne (2016). Lateral hypothalamic outputs control innate defensive responses. Vis sammendrag
  • Aasebø, Ida E. J.; Hafting, Torkel; Maria, Stavrinou; Sandra, Nøkkevangen; Lepperød, Bjørn Mikkel Elle & Fyhn, Marianne (2015). Temporal processing in the visual cortex in the awake and anesthetized rat.
  • Christensen, Ane Charlotte; Lensjø, Kristian Kinden; Lepperød, Bjørn Mikkel Elle; Fyhn, Marianne & Hafting, Torkel (2015). The role of extracellular matrix molecules for spatial representations and plasticity in entorhinal cortex.
  • Hafting, Torkel (2015). Hjernens plastisitet.
  • Hafting, Torkel (2015). The Nobel Prize in Physiology 2014 - neural representation of space.
  • Hafting, Torkel (2015). The adaptive brain: Storage of long-term memories.
  • Lensjø, Kristian Kinden; Lepperød, Bjørn Mikkel Elle; Dick, Gunnar; Hafting, Torkel & Fyhn, Marianne (2015). Removal of perineuronal nets in the visual cortex leads to a reduced inhibition and mimics critical period plasticity.
  • Lepperød, Mikkel Elle; Lensjø, Kristian Kinden; Christensen, Ane Charlotte; Fyhn, Marianne; Hafting, Torkel & Einevoll, Gaute (2015). Building an entorhinal cortex network.
  • Hafting, Torkel (2014). Hukommelse og læring - et innblikk i hvordan hjernen virker.
  • Hafting, Torkel; Lensjø, Kristian Kinden; Christensen, Ane Charlotte; Dick, Gunnar & Fyhn, Marianne (2014). Perineuronal nets, plasticity and information-processing in visual cortex, medial entorhinal cortex and hippocampus..
  • Aasebø, Ida E. J.; Norheim, Eivind Skjønsberg; Lensjø, Kristian Kinden; Fyhn, Marianne & Fyhn, Torkel Hafting (2013). The effect of anesthesia on activity and modulation of visually responsive neurons in cortical and subcortical areas.
  • Hafting, Torkel (2013). Moderne nevrovitenskap - når science fiction blir virkelighet.
  • Hagen, Espen; Ness, Torbjørn Bækø; Khosrowshahi, Amir; Sørensen, Christina; Fyhn, Marianne; Hafting, Torkel; Franke, Felix & Einevoll, Gaute Tomas (2013). Modeling of extracellular spike signatures.
  • Hagen, Espen; Ness, Torbjørn Bækø; Khosrowshahi, Amir; Sørensen, Christina; Fyhn, Torkel Hafting; Franke, Felix & Einevoll, Gaute Tomas (2013). Generation of biophysically realistic model extracellular recordings for evaluation of spike sorting algorithms.
  • Lensjø, Kristian Kinden; Dick, Gunnar; Fyhn, Torkel Hafting & Fyhn, Marianne (2013). Cortical processing in awake, behaving rats after removal of perineuronal nets.
  • Fyhn, Marianne; Hafting, Torkel & Stryker, MP (2011). Long-term in vivo imaging of dendritic spines in layer II/III of visual cortex during the critical period. Vis sammendrag
  • Derdikman, Dori Moshe; Whitlock, JR; Tsao, Albert; Fyhn, Marianne; Hafting, Torkel; Moser, May-Britt & Moser, Edvard Ingjald (2009). Fragmentation of grid maps is influenced by geometry of the environement.
  • Colgin, Laura Lee; Denninger, T; Fyhn, Marianne; Hafting, Torkel; Bonnevie, Tora; Jensen, O; Moser, May-Britt & Moser, Edvard Ingjald (2009). Frequency of gamma oscillations routes flow of information in the hippocampus.
  • Kjelstrup, K.B; Brun, V.H; Solstad, Trygve; Hafting, Torkel; Leutgeb, Stefan; Fyhn, Marianne; Witter, Menno; Moser, May-Britt & Moser, Edvard Ingjald (2008). Spatial coding along the dorsal-to-ventral axis of the hippocampus and medial entorhinal cortex.
  • canto, Cathrin Barbara; Kwag, J; Hafting, Torkel; Fyhn, Marianne; Mann, EO; Moser, Edvard Ingjald; Moser, May-Britt; Witter, Menno & Paulsen, Ole (2007). Rate-to-phase transformation in layer II principal neurons of the rat medial entorhinal cortex. Society for Neuroscience : Abstracts.  33
  • Fyhn, Marianne; Hafting, Torkel; Witter, Menno; Moser, Edvard Ingjald & Moser, May-Britt (2007). Grid cells in medial entorhinal cortex of mice. Society for Neuroscience : Abstracts.  33
  • Kjelstrup, Kirsten Gjerstad; Solstad, Trygve; Brun, Vegard Heimly; Hafting, Torkel; Fyhn, Marianne; Leutgeb, Stefan; Moser, Edvard Ingjald; Moser, May-Britt & Witter, Menno (2007). Very large place fields at the ventral pole of the hippocampal CA3 area. Abstracts - Society for Neuroscience.  ISSN 0190-5295.  33
  • Colgin, Laura Lee; Fyhn, Marianne; Hafting, Torkel; Jensen, Ole; Moser, Edvard Ingjald & Moser, May-Britt (2007). Medial entorhinal cortex and CA3 synchronize with fast and slow gamma rhythms in CA. Society for Neuroscience : Abstracts.  33
  • Hafting, Torkel (2007). Hjerneceller som danner kart over omgivelsene.
  • Hafting, Torkel (2007). Interactions between entorhinal grid cells and hippocampal place cells. Vis sammendrag
  • Hafting, Torkel; Fyhn, Marianne; Moser, Edvard Ingjald & Moser, May-Britt (2007). Experience-dependent backward shift of entorhinal grid fields. Society for Neuroscience : Abstracts.  33
  • Hafting, Torkel (2006). Hukommelse og stedsans - hjerneceller som danner mentale kart.
  • Kjelstrup, Kirsten Brun; Solstad, Trygve; Brun, Vegard Heimly; Fyhn, Marianne; Hafting, Torkel; Leutgeb, Stefan; Witter, Menno; Moser, Edvard Ingjald & Moser, May-Britt (2006). Spatial scale expansion along dorsal-to-ventral axis of hippocampal area CA3 in the rat.
  • Sargolini, Francesca; Fyhn, Marianne; Hafting, Torkel; McNaughton, Bruce; Witter, Menno; Moser, Edvard Ingjald & Moser, May-Britt (2006). Integration of position, direction and velocity information in the medial entorhinal cortex.
  • Sargolini, Francesca; Fyhn, Marianne; Hafting, Torkel; McNaughton, Bruce; Witter, Menno; Moser, May-Britt & Moser, Edvard Ingjald (2006). Spatial navigation and entorhinal grid cells. Chemical Senses.  ISSN 0379-864X.  31, s E24- E24
  • Bonnevie, Tora; Fyhn, Marianne; Hafting, Torkel; Moser, Edvard Ingjald & Moser, May-Britt (2006). Misalignment of entorhinal grid fields after hippocampal inactivation.
  • Derdikman, Dori Moshe; Fyhn, Marianne; Hafting, Torkel; Moser, May-Britt & Moser, Edvard Ingjald (2006). Breaking up the entorhinal grid in a hairpin maze.
  • Fyhn, Marianne; Hafting, Torkel; Moser, May-Britt & Moser, Edvard Ingjald (2006). Theta modulation and phase precession in grid cells in the medical entorhinal cortex.
  • Fyhn, Marianne; Hafting, Torkel; Treves, Alessandro; Moser, Edvard Ingjald & Moser, May-Britt (2006). Coherence in ensembles of entorhinal grid cells.
  • Hafting, Torkel; Fyhn, Marianne; Treves, Alessandro; Moser, Edvard Ingjald & Moser, May-Britt (2006). Coherent realignment of entorhinal grid cells coincides global remapping in the hippocampus.
  • Hafting, Torkel (2005). Grid cells and head direction cells in entorhinal cortex.
  • Fyhn, Torkel Hafting; Fyhn, Marianne; Moser, Edvard Ingjald & Moser, May-Britt (2004). Mnemonic propeties of position-modulated neurons in dorsocaudal medial entorhinal cortex. Society for Neuroscience : Abstracts.  30
  • Fyhn, Marianne; Fyhn, Torkel Hafting; Treves, Alessandro; Moser, May-Britt & Moser, Edvard Ingjald (2004). Pattern separation in hippocampus but not layers II and III of entorhinal cortex. Society for Neuroscience : Abstracts.  30
  • Otnæss, Mona; Hafting, Torkel; Tuvnes, Frode Alexander; Molden, Sturla; Moser, Edvard Ingjald & Moser, May-Britt (2004). Does the hippocampus contribute to simple non – spatial associations?.
Publisert 11. nov. 2013 09:39 - Sist endret 30. aug. 2017 16:27