Thomas Sæther

Førsteamanuensis - Kjernereseptorgruppa
Bilde av Thomas Sæther
English version of this page
Telefon +47-22851510
Rom 4120
Brukernavn
Besøksadresse Sognsvannsveien 9 Domus Medica 0372 Oslo
Postadresse Postboks 1046 Blindern 0317 OSLO
Andre tilknytninger Avdeling for ernæringsvitenskap

Faglige interesser

Jeg jobber som førsteamanuensis i forskningsgruppen for molekylær ernæring. Der studerer vi energibalanse og livsstilssykdommer. Prosjektet jeg jobber med er et samarbeid mellom IMB, Universitetet i Tromsø og MabCent - SFI, der vi forsøker å identifisere nye kjernereseptorligander fra marine invertebrater. Disse vil deretter kunne testes ut som kandidatforbindelser for behandling av type 2 diabetes og metabolsk syndrom.

Undervisning

Sosiale medier

Bakgrunn

  • Postdoktor i MYB-gruppa ved IMBV, UiO, fra 2008 til 2012 hvor jeg studerte transkripsjonsfaktoren c-Myb, eukaryot genregulering, transkripsjon, kromatin, epigenetikk og posttranslasjonell modifisering, spesielt SUMOylering.
  • PhD i molekylær biovitenskap, UiO, 2008: Positive and negative modulation of the transactivation potential of the transcription factor c-Myb - novel regulatory mechanisms for a classical proto-oncoprotein. Les mer
  • Hovedfag i biokjemi, UiO, 2003: Metabolism of polyunsaturated fatty acids in rat testis. Les mer

Priser

  • Direktør Throne Holst Stiftelse for ernæringsforsknings pris for beste poster 2016: Anti-diabetic activity from marine lipids: new anti-diabetic drugs.
  • Nordic Association for Andrology’s Young Scientist Award, 2001: Effect of dietary fats, insulin and dexamethasone on delta-6-desaturase expression in rat testis.

Samarbeid

  • Prof. Trond Vidar Hansen, Farmasøytisk institutt, UiO: kjemisk syntese av PPAR-aktiverende forbindelser.
  • Prof. Ingebrigt Sylte, Institutt for medisinsk biologi, UiT Norges arktiske universitet: 3D in silico docking av PPAR-agonister.
  • Seniorforsker Steinar Paulsen, MabCent - SFI, UiT Norges arktiske universitet: HTS etter nye kjernereseptorligander fra marine invertebrater.
  • Prof. Dan Voytas, University of Minnesota: Design av zinkfingernukleaser for målrettet modifisering av gener.
  • Prof. Tom Gonda, University of Queensland: Studier av de transformerende egenskapene til transkripsjonsfaktoren c-Myb.
Emneord: Ernæring, Molekylær ernæring, Livsstilssykdommer, Diabetes og hormoner, Kjernereseptorer, Transkripsjon

Publikasjoner

Moldes-Anaya, A, Sæther T, Uhlig S, Nebb HI, Larsen T, Eilertsen HC, Paulsen SM (2017). Two Isomeric C16 Oxo-Fatty Acids from the Diatom Chaetoceros karianus Show Dual Agonist Activity towards Human Peroxisome Proliferator-Activated Receptors (PPARs) α/γ. Mar Drugs 15(6):148.

Lorenzo PI, Brendeford EM, Gilfillan S, Gavrilov AA, Leedsak M, Razin SV, Eskeland R, Sæther T, Gabrielsen OS (2011) Identification of c-Myb target genes in K562 cells reveals a role for c-Myb as a master regulator. Genes Cancer 2(8):805-17.

Haugen TB, Tefre T, Malm G, Jönsson BA, Rylander L, Hagmar L, Bjørsvik C, Henrichsen T, Sæther T, Figenschau Y, Giwercman A (2011) Differences in serum levels of CB-153 and p,p'-DDE, and reproductive parameters between men living south and north in Norway. Reprod Toxicol 32(3):261-7.

Alm-Kristiansen AH, Lorenzo PI, Molværsmyr AK, Matre V, Ledsaak M, Sæther T, Gabrielsen OS (2011) PIAS1 interacts with FLASH and enhances its co-activation of c-Myb. Mol Cancer 10:21.

Sæther T, Pattabiraman DR, Alm-Kristiansen AH, Vogt-Kielland LT, Gonda TJ, Gabrielsen OS (2011) A functional SUMO-interacting motif in the transactivation domain of c-Myb regulates its myeloid transforming ability. Oncogene 30(2):212-22.

Molværsmyr AK, Sæther T, Gilfillan S, Lorenzo PI, Kvaløy H, Matre V, Gabrielsen OS (2010) A SUMO-regulated activation function controls synergy of c-Myb through a repressor-activator switch leading to differential p300 recruitment. Nucleic Acids Res 38(15):4970-84.

Rylander L, Wetterstrand B, Haugen TB, Malm G, Malm J, Bjørsvik C, Henrichsen T, Sæther T, Giwercman A (2009) Single semen analysis as a predictor of semen quality: clinical and epidemiological implications. Asian J Androl 11(6):723-30.

Alm-Kristiansen AH, Sæther T, Matre V, Gilfillan S, Dahle O, Gabrielsen OS (2008). FLASH acts as a co-activator of the transcription factor c-Myb and localizes to active RNA polymerase II foci. Oncogene 27(34):4644-56.

Berge T, Matre V, Brendeford EM, Sæther T, Lüscher B, Gabrielsen OS (2007) Revisiting a selection of target genes for the hematopoietic transcription factor c-Myb using chromatin immunoprecipitation and c-Myb knockdown. Blood Cells Mol Dis 39(3):278-86.

Ruhayel Y, Malm G, Haugen TB, Henrichsen T, Bjørsvik C, Grotmol T, Sæther T, Malm J, Figenschau Y, Rylander L, Levine RJ, Giwercman A (2007) Seasonal variation in serum concentrations of reproductive hormones and urinary excretion of 6-sulfatoxymelatonin in men living north and south of the Arctic Circle: a longitudinal study. Clin Endocrinol (Oxf). 67(1):85-92.

Sæther T, Berge T, Ledsaak M, Matre V, Alm-Kristiansen AH, Dahle O, Aubry F, Gabrielsen OS (2007) The chromatin remodeling factor Mi-2alpha acts as a novel co-activator for human c-Myb. J Biol Chem 282(19):13994-4005.

Sæther T, Tran TN, Rootwelt H, Grav HJ, Christophersen BO, Haugen TB (2007) Essential fatty acid deficiency induces fatty acid desaturase expression in rat epididymis, but not in testis. Reproduction 133(2):467-77.

Aschim EL, Sæther T, Wiger R, Grotmol T, Haugen TB (2004). Differential distribution of splice variants of estrogen receptor beta in human testicular cells suggests specific functions in spermatogenesis. J Steroid Biochem Mol Biol 92(1-2):97-106.

Malm G, Haugen TB, Henrichsen T, Bjørsvik C, Grotmol T, Sæther T, Malm J, Figenschau Y, Hagmar L, Rylander L, Levine RJ, Giwercman A (2004) Reproductive function during summer and winter in Norwegian men living north and south of the Arctic circle. J Clin Endocrinol Metab 89(9):4397-402.

Sæther T, Tran TN, Rootwelt H, Christophersen BO, Haugen TB (2003) Expression and regulation of delta5-desaturase, delta6-desaturase, stearoyl-coenzyme A (CoA) desaturase 1, and stearoyl-CoA desaturase 2 in rat testis. Biol Reprod 69(1):117-24.

  • Moldes-Anaya, Angel; Sæther, Thomas; Uhlig, Silvio; Nebb, Hilde Irene; Larsen, Terje; Eilertsen, Hans Christian & Paulsen, Steinar Martin (2017). Two Isomeric C16 Oxo-Fatty Acids from the Diatom Chaetoceros karianus Show Dual Agonist Activity towards Human Peroxisome Proliferator-Activated Receptors (PPARs) α/γ. Marine Drugs.  ISSN 1660-3397.  15(148) . doi: 10.3390/md15060148 Fulltekst i vitenarkiv. Vis sammendrag
  • Alm-Kristiansen, Anne Hege; Lorenzo, Petra Isabel O.; Molværsmyr, Ann-Kristin; Matre, Vilborg; Ledsaak, Marit; Sæther, Thomas & Gabrielsen, Odd Stokke (2011). PIAS1 interacts with FLASH and enhances its co-activation of c-Myb. Molecular Cancer.  ISSN 1476-4598.  10 . doi: 10.1186/1476-4598-10-21
  • Haugen, Trine B.; Tefre, Toril; Malm, Gunilla; Jønsson, Bo AG; Rylander, Lars; Hagmar, Lars; Bjørsvik, Cathrine; Henrichsen, Trine; Sæther, Thomas; Figenschau, Yngve & Giwercman, Aleksander (2011). Differences in serum levels of CB-153 and p,p '-DDE, and reproductive parameters between men living south and north in Norway. Reproductive Toxicology.  ISSN 0890-6238.  32(3), s 261- 267 . doi: 10.1016/j.reprotox.2011.06.072
  • Lorenzo, Petra Isabel O.; Brendeford, Elen Margrethe; Gilfillan, Siv; Gavrilov, Alexey A; Ledsaak, Marit; Razin, Sergey V; Eskeland, Ragnhild; Sæther, Thomas & Gabrielsen, Odd Stokke (2011). Identification of c-Myb target genes in K562 cells reveals a role for c-Myb as a master regulator. Genes & cancer.  ISSN 1947-6019.  2(8), s 805- 817 . doi: 10.1177/1947601911428224 Vis sammendrag
  • Sæther, Thomas; Pattabiraman, D.R.; Alm-Kristiansen, Anne Hege; Vogt- Kielland, Linn Troye; Gonda, T.J. & Gabrielsen, Odd Stokke (2011). A functional SUMO-interacting motif in the transactivation domain of c-Myb regulates its myeloid transforming ability. Oncogene.  ISSN 0950-9232.  30(2), s 212- 222 . doi: 10.1038/onc.2010.397
  • Molværsmyr, Ann-Kristin; Sæther, Thomas; Gilfillan, Siv; Lorenzo, Petra Isabel O.; Kvaløy, Heidi; Matre, Vilborg & Gabrielsen, Odd Stokke (2010). A SUMO-regulated activation function controls synergy of c-Myb through a repressor-activator switch leading to differential p300 recruitment. Nucleic Acids Research.  ISSN 0305-1048.  38(15), s 4970- 4984 . doi: 10.1093/nar/gkq245
  • Rylander, Lars; Wetterstrand, Boel; Haugen, Trine B.; Malm, Gunilla; Malm, Johan; Bjørsvik, Cathrine; Henrichsen, Trine; Sæther, Thomas & Giwercman, Aleksander (2009). Single semen analysis as a predictor of semen quality: clinical and epidemiological implications. Asian Journal of Andrology.  ISSN 1008-682X.  11(6), s 723- 730 . doi: 10.1038/aja.2009.64
  • Alm-Kristiansen, Anne Hege; Sæther, Thomas; Matre, Vilborg; Otnæss, Siv Kolstø; Dahle, Øyvind & Gabrielsen, Odd Stokke (2008). FLASH acts as a co-activator of the transcription factor c-Myb and localizes to active RNA polymerase II foci. Oncogene.  ISSN 0950-9232.  27, s 4644- 4656 . doi: 10.1038/onc.2008.105
  • Berge, Tone; Matre, Vilborg; Brendeford, Elen Margrethe; Sæther, Thomas; Lüscher, Bernhard & Gabrielsen, Odd Stokke (2007). Revisiting a selection of target genes for the hematopoietic transcription factor c-Myb using chromatin immunoprecipitaion and c-Myb knockdown. Blood Cells, Molecules & Diseases.  ISSN 1079-9796.  39(3), s 278- 286 . doi: 10.1016/j.bcmd.2007.05.007
  • Ruhayel, Yasir; Malm, Gunilla; Haugen, Trine B.; Henrichsen, Trine; Bjørsvik, Cathrine; Grotmol, Tom; Sæther, Thomas; Malm, Johan; Figenschau, Yngve; Rylander, Lars; Levine, Richard J. & Giwercman, Aleksander (2007). Seasonal variation in serum concentrations of reproductive hormones and urinary excretion of 6-sulfatoxymelatonin in men living north and south of the Arctic Circle: a longitudinal study. Clinical Endocrinology.  ISSN 0300-0664.  67 . doi: 10.1111/j.1365-2265.2007.02843.x
  • Sæther, Thomas; Berge, T; Ledsaak, Marit; Matre, Vilborg; Alm-Kristiansen, Anne Hege; Dahle, O; Aubry, F & Gabrielsen, Odd Stokke (2007). The chromatin remodeling factor Mi-2 alpha acts as a novel co-activator for human c-Myb. Journal of Biological Chemistry.  ISSN 0021-9258.  282 . doi: 10.1074/jbc.M700755200
  • Sæther, Thomas; Tran, TN; Rootwelt, H; Grav, HJ; Christophersen, BO & Haugen, Trine B. (2007). Essential fatty acid deficiency induces fatty acid desaturase expression in rat epididymis, but not in testis. Reproduction.  ISSN 1470-1626.  133(2), s 467- 477 . doi: 10.1530/REP-06-00294
  • Aschim, Elin L.; Sæther, Thomas; Wiger, Richard; Grotmol, Tom & Haugen, Trine B. (2004). Differential distribution of splice variants of estrogen receptor β in human testicular cells suggests specific functions in spermatogenesis. Journal of Steroid Biochemistry and Molecular Biology.  ISSN 0960-0760.  92(1-2), s 97- 106
  • Malm, Gunilla; Haugen, Trine B.; Henrichsen, Trine; Bjørsvik, Cathrine; Grotmol, Tom; Sæther, Thomas; Malm, Johan; Figenschau, Yngve; Hagmar, Lars; Rylander, Lars; Levine, Richard J. & Giwercman, Aleksander (2004). Reproductive function during summer and winter in Norwegian men living north and south of the Arctic Circle. Journal of Clinical Endocrinology and Metabolism.  ISSN 0021-972X.  89(9), s 4397- 4402
  • Sæther, Thomas; Tran, Thien Ngoc; Rootwelt, Helge; Christophersen, Bjørn & Haugen, Trine Berit (2003). Expression and Regulation of delta 5-Desaturase, delta 6-Desaturase, Stearoyl-Coenzyme A (CoA) Desaturase 1, and Stearoyl-CoA Desaturase 2 in Rat Testis. Biology of Reproduction.  ISSN 0006-3363.  69, s 117- 124

Se alle arbeider i Cristin

  • Sæther, Thomas; Moldes-Anaya, Angel; Tungen, Jørn Eivind; Vik, Anders; Paulsen, Steinar Martin; Sylte, Ingebrigt; Hansen, Trond Vidar & Nebb, Hilde Irene (2015). Anti-diabetic activity from marine lipids: new anti-diabetic drugs.
  • Sæther, Thomas (2014). Anti-diabetic activity from marine lipids (ADAM): New anti-diabetic drugs.
  • Bindesbøll, Christian; Fan, Qiong; Sæther, Thomas; Dalen, Knut Tomas; Nebb, Hilde Irene & Grønning-Wang, Line Mariann (2013). Nuclear receptors as targets for treatment and prevention of metabolic diseases. Vis sammendrag
  • Matre, Vilborg; Aabel, Linn Ingeborg; Ledsaak, Marit; Vollsund, Pernille; Sæther, Thomas & Gabrielsen, Odd Stokke (2013). PTM-crosstalk: SUMO1 acts as a docking domain for the nuclear kinase HIPK1 mediating SUMO-linked phosphorylation of c-Myb and other targets. Vis sammendrag
  • Moldes-Anaya, Angel; Sæther, Thomas; Larsen, Laila Norrheim; Larsen, Terje; Nebb, Hilde Irene & Paulsen, Steinar (2013). Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae.
  • Moldes-Anaya, Angel; Sæther, Thomas; Norrheim-Larsen, Laila; Nebb, Hilde Irene; Larsen, Terje & Paulsen, Steinar (2013). Identifying natural products with agonist or modulatory activity against human nuclear receptors in extracts from cultured marine microalgae.
  • Sæther, Thomas; Moldes-Anaya, Angel; Larsen, Laila Norrheim; Larsen, Terje; Paulsen, Steinar & Nebb, Hilde Irene (2013). Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae. Vis sammendrag
  • Matre, Vilborg; Aabel, Linn Ingeborg; Ledsaak, Marit; Vollsund, Pernille; Sæther, Thomas & Gabrielsen, Odd Stokke (2012). PTM-crosstalk: SUMO1 acts as a docking domain for the nuclear kinase HIPK1 mediating SUMO-linked phosphorylation of c-Myb and other targets.
  • Molværsmyr, Ann-Kristin; Ledsaak, Marit; Alm-Kristiansen, Anne Hege; Lorenzo, Petra Isabel O.; Matre, Vilborg; Sæther, Thomas & Gabrielsen, Odd Stokke (2012). The SUMO E3 ligase PIAS1 interacts with c-Myb and enhances its transcriptional activity. Vis sammendrag
  • Sæther, Thomas; Bengtsen, Mads; Molværsmyr, Ann-Kristin; Pattabiraman, D.R.; Alm-Kristiansen, Anne Hege; Ledsaak, Marit; Gonda, T.J. & Gabrielsen, Odd Stokke (2012). Regulating the regulator: SUMO functions as a master switch for the transcription factor c-Myb. Vis sammendrag
  • Sæther, Thomas; Molværsmyr, Ann-Kristin; Gilfillan, Siv; Alm-Kristiansen, Anne Hege; Aabel, Linn Ingeborg; Matre, Vilborg & Gabrielsen, Odd Stokke (2011). The hematopoietic transcription factor c-Myb functions as an epigenetic organizer. Vis sammendrag
  • Rangberg, Anbjørg; Sæther, Thomas & Gabrielsen, Odd Stokke (2010). Design of a system for inducible SUMOylation of the transcription factor c-Myb. Vis sammendrag
  • Sæther, Thomas & Erling, Hobøl (2010). Hekkefugltaksering på Fautøya og Rossholmens vesttange, Sesongrapport 2010.
  • Sæther, Thomas; Molværsmyr, Ann-Kristin; Lorenzo, Petra Isabel O.; Gilfillan, Siv; Kvaløy, Heidi; Matre, Vilborg & Gabrielsen, Odd Stokke (2010). A SUMO-regulated activation function (SRAF) controls synergy of c-Myb through a repressor-activator switch. Vis sammendrag
  • Sæther, Thomas; Pattabiraman, D.R.; Aabel, Linn Ingeborg; Matre, Vilborg; Gonda, T.J. & Gabrielsen, Odd Stokke (2010). A functional SUMO-interacting motif in the transactivation domain of c-Myb regulates its myeloid transforming ability. Vis sammendrag
  • Kvebæk, Yngve; Sæther, Thomas; Aspelund, Trond & Hobøl, Erling (2009). NORDRE ØYEREN - Trend, trekkprofil og preferanseområde for viktige vannfuglarter - Komplett statusliste og øvrige artsvurderinger. Vis sammendrag
  • Sæther, Thomas; Molværsmyr, Ann-Kristin; Lorenzo, Petra Isabel O.; Kvaløy, Heidi; Matre, Vilborg & Gabrielsen, Odd Stokke (2009). A SUMO-regulated activation function (SRAF) controls synergy of c-Myb through a repressor-activator switch. Vis sammendrag
  • Vollsund, Pernille; Bergholtz, Stine Louise; Sæther, Thomas; Aasland, Rein & Gabrielsen, Odd Stokke (2009). Understanding the phosphorylation-sumoylation cross talk in the transcription factor c-Myb. Vis sammendrag
  • Sæther, Thomas (2008). Positive and negative modulation of the transactivation potential of the transcription factor c-Myb - novel regulatory mechanisms for a classical proto-oncoprotein.
  • Sæther, Thomas; Molværsmyr, Ann-Kristin; Matre, Vilborg; Lorenzo, Petra Isabel O. & Gabrielsen, Odd Stokke (2008). SUMO-conjugation of the transcription factor c-Myb controls cooperative behaviour and induces an activator-to-repressor switch in the negative regulatory domain. Vis sammendrag
  • Molværsmyr, Ann-Kristin; Kvaløy, Heidi; Sæther, Thomas; Matre, Vilborg & Gabrielsen, Odd Stokke (2007). Controlling gene expression through SUMO-conjugation - the importance of synergy. Vis sammendrag
  • Sæther, Thomas; Berge, Tone; Ledsaak, Marit; Matre, Vilborg; Alm-Kristiansen, Anne Hege; Dahle, Øyvind; Aubry, Florence & Gabrielsen, Odd Stokke (2007). The chromatin remodelling factor Mi-2alpha acts as a novel co-activator for human c-Myb. Vis sammendrag
  • Sæther, Thomas; Tran, Thien N.; Rootwelt, Helge; Grav, Hans J.; Christophersen, Bjørn O. & Haugen, Trine B. (2006). Desaturase expression, lipid profile, and sperm morphology are differently affected by fat free diet in cauda and caput epididymis in the rat.
  • Alm-Kristiansen, Anne Hege; Sæther, Thomas; Ledsaak, Marit; Matre, Vilborg & Gabrielsen, Odd Stokke (2006). FLASH is a coregulator of the transcription factor c-Myb.
  • Ruhayel, Yasir; Malm, Gunilla; Haugen, Trine B.; Henrichsen, Trine; Bjørsvik, Cathrine; Grotmol, Tom; Sæther, Thomas; Malm, Johan; Figenschau, Yngve; Hagmar, Lars; Rylander, Lars; Levine, Richard J. & Giwercman, Aleksander (2004). Seasonal Variation in Melatonin, Reproductive Hormones and Semen Parameters in Men living North and South of the Arctic Circle.
  • Sæther, Thomas; Christophersen, Bjørn O. & Haugen, Trine B. (2004). Essential fatty acid deficiency does not induce desaturases in testis, like in epididymis and liver.
  • Sæther, Thomas; Berge, Tone; Ledsaak, Marit; Dahle, Øyvind; Matre, Vilborg; Lüscher, Bernhard & Gabrielsen, Odd Stokke (2004). Human c-Myb interacts with the Mi-2alpha subunit of the NuRD complex. Vis sammendrag
  • Sæther, Thomas (2003). Lipid Dynamics And Sperm Function. Vis sammendrag
  • Sæther, Thomas (2003). Metabolism of Polyunsaturated Fatty Acids in Rat Testis - Expression and regulation of delta5-desaturase, delta6-desaturase, stearoyl-CoA desaturase 1, stearoyl-CoA desaturase 2 and the nuclear receptors peroxisome proliferator-activated receptor alpha, delta and gamma.
  • Malm, Gunilla; Haugen, Trine Berit; Henrichsen, Trine; Bjørsvik, Cathrine; Grotmol, Tom; Sæther, Thomas; Malm, Johan; Figenschau, Y.; Levine, Richard J. & Giwercman, Aleksander (2002). No Seasonal Variation in Sperm Parameters despite Extreme Differences in Daylight Conditions North of the Arctic Circle.
  • Sæther, Thomas; Tran, Thien Ngoc; Christophersen, Bjørn & Haugen, Trine Berit (2002). Effect of Dietary Fats, Insulin and Dexamethasone on delta6-desaturase Expression in Rat Testis.
  • Sæther, Thomas; Tran, Thien Ngoc; Christophersen, Bjørn & Haugen, Trine Berit (2002). Effect of Dietary Fats, Insulin and Dexamethasone on delta6-desaturase Expression in Rat Testis. Vis sammendrag
  • Sæther, Thomas; Tran, Thien Ngoc; Christophersen, Bjørn & Haugen, Trine Berit (2001). Effect of Dietary Fats, Insulin and Dexamethasone on delta6-desaturase Expression in Rat Testis.
  • Tran, Thien Ngoc; Sæther, Thomas; Christophersen, Bjørn; Rootwelt, Helge; Retterstøl, Kjetil & Haugen, Trine Berit (2001). Expression of delta6- and delta5-desaturase in Rat Testis. Vis sammendrag

Se alle arbeider i Cristin

Publisert 14. aug. 2012 13:04 - Sist endret 25. sep. 2017 13:29

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