Paediatric Research Institute (PFI)
Department of Pediatric Research (PFI) is a research unit at the Division of Pediatric and Adolescent Medicine. It was established as a joint university and hospital institute at the Rikshospitalet in 1959.
In the first years, research focused on hematology. However, soon a whole range of research topics was established, including metabolic diseases, pediatric cancer, adverse effects of bilirubin, and basic research on the effect of peptides on diseases.
During the last 30 years, the research at the Department has contributed to highlighting the mechanisms of hypoxia and reoxygenation, oxidative stress, and subsequent oxidative damage.
The PFI has substantially contributed to changing the guidelines for resuscitation of neonates in October 2010, while important research work on the effects of oxidative stress and possible intervention strategies to reduce the potential harmful effects of oxygen is still going on.
The department has established various animal models and cell culture models, in close cooperation with research environments in Norway and abroad.