John Torgils Vaage

Professor II - Department of Immunology
Image of John Torgils Vaage
Norwegian version of this page
Mobile phone 99713889
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Visiting address Sognsvannsveien 20 Rikshospitalet 0372 OSLO
Postal address Postboks 4950 Nydalen 0424 OSLO

Publications

  • Bliksøen, Marte; Rutkovskiy, Arkady; Vaage, John T. & Stensløkken, Kåre-Olav (2017). Mode of perfusion influences infarct size, coronary flow and stress kinases in the isolated mouse heart. Acta Physiologica.  ISSN 1748-1708.  220(1), s 36- 46 . doi: 10.1111/apha.12773
  • Sudworth, Amanda; Dai, Kezheng; Vaage, John T. & Kveberg, Lise (2016). Degranulation Response in Cytotoxic Rat Lymphocytes Measured with a Novel CD107a Antibody. Frontiers in Immunology.  ISSN 1664-3224.  7(572) . doi: 10.3389/fimmu.2016.00572 Full text in Research Archive
  • Kveberg, Lise; Sudworth, Amanda; Todros-Dawda, Izabela Malgorzata; Inngjerdingen, Marit & Vaage, John Torgils (2015). Functional characterization of a conserved pair of NKR-P1 receptors expressed by NK cells and T lymphocytes in liver and gut. European Journal of Immunology.  ISSN 0014-2980.  45(2), s 501- 512 . doi: 10.1002/eji.201444710
  • Leibelt, S; Friede, ME; Rohe, C; Gütle, D; Rutkowski, E; Weigert, A; Kveberg, Lise; Vaage, John Torgils; Hornef, MW & Steinle, Alexander (2015). Dedicated immunosensing of the mouse intestinal epithelium facilitated by a pair of genetically coupled lectin-like receptors. Mucosal Immunology.  ISSN 1935-3456.  8(2), s 232- 242 . doi: 10.1038/mi.2014.60
  • Smelt, Maaike J; Faas, Marijke M.; de Haan, Bart J.; de Haan, Aalzen; Vaage, John Torgils & de Vos, Paul (2014). The Role of Alloresponsive Ly49+ NK Cells in Rat Islet Allograft Failure in the Presence and Absence of Cytomegalovirus. Cell Transplantation.  ISSN 0963-6897.  23(11), s 1381- 1394 . doi: 10.3727/096368913X670930
  • Todros-Dawda, Izabela Malgorzata; Kveberg, Lise; Vaage, John Torgils & Inngjerdingen, Marit (2014). The tetraspanin CD53 modulates responses from activating NK cell receptors, promoting LFA-1 activation and dampening NK cell effector functions. PLoS ONE.  ISSN 1932-6203.  9(5) . doi: 10.1371/journal.pone.0097844
  • Daws, Michael Rory; Dai, Kezheng; Zinöcker, Severin; Naper, Christian; Kveberg, Lise; Hedrich, Hans J; Rolstad, Bent & Vaage, John Torgils (2012). Identification of an MHC Class I Ligand for the Single Member of a Killer Cell Lectin-like Receptor Family, KLRH1. Journal of Immunology.  ISSN 0022-1767.  189(11), s 5178- 5184 . doi: 10.4049/jimmunol.1201983
  • Inngjerdingen, Marit; Kveberg, Lise & Vaage, John Torgils (2012). A Novel NKR-P1B(bright) NK Cell Subset Expresses an Activated CD25(+)CX(3)CR1(+)CD62L(-)CD11b(-)CD27(-) Phenotype and Is Prevalent in Blood, Liver, and Gut-Associated Lymphoid Organs of Rats. Journal of Immunology.  ISSN 0022-1767.  188(6), s 2499- 2508 . doi: 10.4049/jimmunol.1003939
  • Zinöcker, Severin & Vaage, John Torgils (2012). Rat mesenchymal stromal cells inhibit T cell proliferation but not cytokine production through inducible nitric oxide synthase. Frontiers in Immunology.  ISSN 1664-3224.  3 . doi: 10.3389/fimmu.2012.00062
  • Zinöcker, Severin; Wang, Mengyu; Rolstad, Bent & Vaage, John Torgils (2012). Mesenchymal Stromal Cells Fail to Alleviate Experimental Graft-Versus-Host Disease in Rats Transplanted with Major Histocompatibility Complex-Mismatched Bone Marrow. Scandinavian Journal of Immunology.  ISSN 0300-9475.  76(5), s 464- 470 . doi: 10.1111/j.1365-3083.2012.02758.x
  • Fossum, Sigbjørn; Sæther, Per Christian; Vaage, John Torgils; Daws, Michael Rory & Dissen, Erik (2011). Paired opposing leukocyte receptors recognizing rapidly evolving ligands are subject to homogenization of their ligand binding domains. Immunogenetics.  ISSN 0093-7711.  63(12), s 809- 820 . doi: 10.1007/s00251-011-0553-5
  • Inngjerdingen, Marit; Kveberg, Lise; Naper, Christian & Vaage, John Torgils (2011). Natural killer cell subsets in man and rodents. Tissue Antigens.  ISSN 0001-2815.  78(2), s 81- 88 . doi: 10.1111/j.1399-0039.2011.01714.x
  • Kveberg, Lise; Dai, Kezheng; Inngjerdingen, Marit; Brooks, Colin G.; Fossum, Sigbjørn & Vaage, John Torgils (2011). Phylogenetic and functional conservation of the NKR-P1F and NKR-P1G receptors in rat and mouse. Immunogenetics.  ISSN 0093-7711.  63(7), s 429- 436 . doi: 10.1007/s00251-011-0520-1
  • Shegarfi, Hamid; Dai, Kezheng; Daws, Michael Rory; Ryan, James C.; Vaage, John Torgils; Rolstad, Bent & Naper, Christian (2011). The rat NK cell receptors Ly49s4 and Ly49i4 recognize nonclassical MHC-I molecules on Listeria monocytogenes-infected macrophages. Journal of Leukocyte Biology.  ISSN 0741-5400.  89(4), s 617- 623 . doi: 10.1189/jlb.1010593
  • Zinöcker, Severin; Wang, Mengyu; Gaustad, Peter; Kvalheim, Gunnar; Rolstad, Bent & Vaage, John Torgils (2011). Mycoplasma Contamination Revisited: Mesenchymal Stromal Cells Harboring Mycoplasma hyorhinis Potently Inhibit Lymphocyte Proliferation In Vitro. PLoS ONE.  ISSN 1932-6203.  6(1) . doi: 10.1371/journal.pone.0016005
  • Kveberg, Lise; Jiminèz-Royo, Pilar; Naper, Christian; Rolstad, Bent; Butcher, Geoffrey W; Vaage, John Torgils & Inngjerdingen, Marit (2010). Two complementary rat NK cell subsets, Ly49s3(+) and NKR-P1B(+), differ in phenotypic characteristics and responsiveness to cytokines. Journal of Leukocyte Biology.  ISSN 0741-5400.  88(1), s 87- 93 . doi: 10.1189/jlb.0110039
  • Naper, Christian; Kveberg, Lise; Engh, Espen; Nestvold, Janne M.; Rolstad, Bent & Vaage, John Torgils (2010). Partial NK cell tolerance induced by radioresistant host cells in rats transplanted with MHC-mismatched bone marrow. International Immunology.  ISSN 0953-8178.  22(12), s 973- 980 . doi: 10.1093/intimm/dxq452
  • Shegarfi, Hamid; Dai, Kezheng; Inngjerdingen, Marit; Ryan, James C.; Vaage, John Torgils; Rolstad, Bent & Naper, Christian (2010). The activating rat Ly49s5 receptor responds to increased levels of MHC class Ib molecules on Listeria monocytogenes-infected enteric epithelial cells. European Journal of Immunology.  ISSN 0014-2980.  40(12), s 3535- 3543 . doi: 10.1002/eji.201040651
  • Kveberg, Lise; Dai, Kezheng; Westgaard, Ingunn Hagen; Daws, Michael Rory; Fossum, Sigbjørn; Naper, Christian & Vaage, John Torgils (2009). Two major groups of rat NKR-P1 receptors can be distinguished based on chromosomal localization, phylogenetic analysis and Clr ligand binding. European Journal of Immunology.  ISSN 0014-2980.  39(2), s 541- 551 . doi: 10.1002/eji.200838891
  • Nestvold, Janne M.; Omdal, Bente Kahrs; Dai, K-Z; Martens, A; Benestad, Haakon Breien; Vaage, John Torgils & Rolstad, Bent (2008). A second prophylactic MHC-mismatched bone marrow transplantation protects against rat acute myeloid leukemia (BNML) without lethal graft-versus-host disease. Transplantation.  ISSN 0041-1337.  85(1), s 102- 111 . doi: 10.1097/01.tp.0000296856.53493.1f
  • Kveberg, Lise; Dai, Kezheng; Dissen, Erik; Ryan, James C.; Rolstad, Bent; Vaage, John Torgils & Naper, Christian (2006). Strain-dependent expression of four structurally related rat Ly49 receptors; correlation with NK gene complex haplotype and NK alloreactivity. Immunogenetics.  ISSN 0093-7711.  58(11), s 905- 916
  • Naper, Christian; Dai, Kezheng; Kveberg, Lise; Rolstad, Bent; Niemi, EC; Vaage, John Torgils & Ryan, JC (2005). Two structurally related rat Ly49 receptors with opposing functions (Ly49 stimulatory receptor 5 and Ly49 inhibitory receptor 5) recognize nonclassical MHC class Ib-encoded target ligands. Journal of Immunology.  ISSN 0022-1767.  174
  • Nylenna, Øyvind; Naper, Christian; Vaage, John Torgils; Woon, P.Y.; Gauguier, D; Dissen, Erik; Ryan, JC & Fossum, Sigbjørn (2005). The genes and gene organization of the Ly49 region of the rat natural killer cell gene complex. European Journal of Immunology.  ISSN 0014-2980.  35
  • Helgeland, Lars; Dissen, Erik; Dai, Kezheng; Midtvedt, Tore; Brandtzæg, Per & Vaage, John Torgils (2004). Microbial colonization induces oligoclonal expansions of intraepithelial CD8 T cells in the gut . European Journal of Immunology.  ISSN 0014-2980.  34, s 3389- 3400 . doi: 10.1002/eji.200425122
  • Westgaard, Ingunn Hagen; Berg, Siri F.; Vaage, John Torgils; Wang, Lawrence L; Yokoyama, Wayne M.; Dissen, Erik & Fossum, Sigbjørn (2004). Rat NKp46 activates natural killer cell cytotoxicity and is associated with Fc{epsilon}RI{gamma} and CD3{zeta} . Journal of Leukocyte Biology.  ISSN 0741-5400.  76, s 1200- 1206 . doi: 10.1189/jlb.0903428
  • Nejad, S; Bryceson, Yenan T.; Dissen, Erik; Sundvold-Gjerstad, V; Naper, Christian; Rolstad, Bent; Spurkland, Anne & Vaage, John Torgils (2004). cDNA cloning of a rat orthologue of SH2D2A encoding T-cell-specific adaptor protein (TSAd): expression in T and NK cells . Immunogenetics.  ISSN 0093-7711.  56(5), s 338- 342 . doi: 10.1007/s00251-004-0695-9
  • Naper, Christian; Hayashi, Shigenari; Joly, Etienne; Butcher, Geoffrey W; Rolstad, Bent; Vaage, John Torgils & Ryan, James C. (2002). Ly49i2 is an inhibitory rat natural killer cell receptor for an MHC class Ia molecule (RT1-A1c). European Journal of Immunology.  ISSN 0014-2980.  32, s 2031- 2036
  • Naper, Christian; Hayashi, Shigenari; Kveberg, Lise; Niemi, Eréne C.; Lanier, Lewis L.; Vaage, John Torgils & Ryan, James C. (2002). Ly-49s3 is a promiscuous activating rat NK cell receptor for nonclassical MHC class I-encoded target ligands. Journal of Immunology.  ISSN 0022-1767.  169, s 22- 30
  • Naper, Christian; Hayashi, Shigenari; Løvik, Guro; Kveberg, Lise; Niemi, Eréne C.; Rolstad, Bent; Dissen, Erik; Ryan, James C. & Vaage, John Torgils (2002). Characterization of a novel killer cell lectin-like receptor (KLRH1) expressed by alloreactive rat NK cells. Journal of Immunology.  ISSN 0022-1767.  s 5147- 5154
  • Løvik, Guro; Vaage, John Torgils; Rolstad, Bent & Naper, Christian (2001). The effect of in vivo depletion of NKR-P1+ or CD8+ lymphocytes on the acute rejection of allogeneic lymphocytes (ALC) in the rat. Scandinavian Journal of Immunology.  ISSN 0300-9475.  54, s 341- 347
  • Rolstad, Bent; Naper, Christian; Løvik, Guro; Vaage, John Torgils; Ryan, James C.; Kirsch, Ralph D.; Bäckman-Petersson, Eva & Butcher, Geoffrey W (2001). Rat natural killer cell receptor systems and recognition of MHC class I molecules. Immunological Reviews.  ISSN 0105-2896.  181, s 149- 157
  • Torgersen, Knut Martin; Vaage, John Torgils; Rolstad, Bent & Tasken, Kjetil (2001). A soluble LAT deletion mutant inhibits T-cell activation: reduced recruitment of signalling molecules to glycolipid-enriched microdomains. Cell Signal.  13, s 213- 220
  • Løvik, Guro; Vaage, John Torgils; Dissen, Erik; Szpirer, Claude; Ryan, James C. & Rolstad, Bent (2000). Characterization and molecular cloning of rat C1qRp, a receptor on NK cells. European Journal of Immunology.  ISSN 0014-2980.  30, s 3355- 3362
  • Leong, Louise Y. W.; Le Rolle, Anne-France; Deverson, Edward V.; Powis, Simon J.; Larkins, Audrey P.; Vaage, John Torgils; Stokland, Aasa; Lambracht-Washington, Doris; Rolstad, Bent; Joly, Etienne & Butcher, Geoffrey W (1999). RT1-U: Identification of a novel, active, class Ib alloantigen of the rat MHC. Journal of Immunology.  ISSN 0022-1767.  162, s 743- 752
  • Naper, Christian; Ryan, James C.; Kirsch, R.; Butcher, Geoffrey W; Rolstad, Bent & Vaage, John Torgils (1999). Genes in two major histocompatibility complex class I regions control selection, phenotype, and function of a rat Ly-49 natural killer cell subset. European Journal of Immunology.  ISSN 0014-2980.  29, s 2046- 2053
  • Engh, Espen; Benestad, Haakon Breien; Strøm-Gundersen, Inger; Vaage, John Torgils; Bell, Eric B. & Rolstad, Bent (1998). Role of classical (RT1.A) and nonclassical (RT1.c) MHC class I regions in natural killer cell-mediated bone marrow allograft rejection in rats. Transplantation.  ISSN 0041-1337.  65(3), s 319- 324
  • Weber, J.R.; Ørstavik, Sigurd; Torgersen, Knut Martin; Danbolt, Niels Christian; Berg, Siri Fuglem; Ryan, James C.; Tasken, Kjetil; Imboden, J.B. & Vaage, John Torgils (1998). Molecular cloning of the gene encoding pp36, a tyrosine-phosphorylated adapter protein selectively expressed by T-cells and natural killer cells. Journal of Experimental Medicine.  ISSN 0022-1007.  (187), s 1157- 1161
  • Naper, Christian; Ryan, James C.; Nakamura, Mary C.; Lambracht, Doris; Rolstad, Bent & Vaage, John Torgils (1998). Identification of an inhibitory MHC receptor on alloreactive rat natural killer cells. Journal of Immunology.  ISSN 0022-1767.  160, s 219- 224
  • Helgeland, Lars; Brandtzæg, Per; Rolstad, Bent & Vaage, John Torgils (1997). Sequential development of intraepithelial gamma delta and alpha beta T lymphocytes expressing CD8 alpha beta in neonatal rat intestine: requirement for the thymus. Immunology.  ISSN 0019-2805.  92, s 447- 456
  • Knudsen, Eirunn; Seierstad, Therese; Vaage, John Torgils; Naper, Christian; Benestad, Haakon Breien; Rolstad, Bent & Maghazachi, Azzam A. (1997). Cloning, functional activities and in vivo tissue distribution of rat NKR-P1+ TCR alpha beta + cells. International Immunology.  ISSN 0953-8178.  9(7), s 1043- 1051
  • Rolstad, Bent & Vaage, John Torgils (1997). The role of natural killer cells in allograft responses to MHC antigens in the rat. Research in Immunology.  ISSN 0923-2494.  148, s 159- 164
  • Rolstad, Bent; Vaage, John Torgils; Naper, Christian; Lambracht, Doris; Wonigeit, K.; Joly, Etienne & Butcher, Geoffrey W (1997). Positive and negative MHC class I recognition by rat NK cells. Immunological Reviews.  ISSN 0105-2896.  155, s 91- 104
  • Torgersen, Knut Martin; Salcedo, M.; Vaage, John Torgils; Naper, Christian; Rolstad, Bent; Ljunggren, H-G. & Höglund, P. (1997). Major histocompatibility complex class-I independent killing of xenogeneic targets by rat allospecific natural killer cells. Transplantation.  ISSN 0041-1337.  63, s 119- 123
  • Torgersen, Knut Martin; Vaage, John Torgils; Levy, Finn Olav; Hansson, Vidar; Rolstad, Bent & Tasken, Kjetil (1997). Selective activation of cAMP-dependent protein kinase type I inhibits rat natural killer cell cytotoxicity. Journal of Biological Chemistry.  ISSN 0021-9258.  272, s 5495- 5500
  • Helgeland, Lars; Vaage, John Torgils; Rolstad, Bent; Halstensen, Trond Sundby; Midtvedt, Tore & Brandtzæg, Per (1997). Regional phenotypic specialization of intraepithelial lymphocytes in the rat intestine does not depend on microbial colonization. Scandinavian Journal of Immunology.  ISSN 0300-9475.  46, s 349- 357
  • Helgeland, Lars; Vaage, John Torgils; Rolstad, Bent; Midtvedt, Tore & Brandtzæg, Per (1996). Microbial colonization influences composition and T-cell receptor V beta repertoire of intraepithelial lymphocytes in rat intestine: Differential V beta skewing in the CD8 alpha alpha and CD8 alpha beta subsets. Immunology.  ISSN 0019-2805.  89, s 494- 501
  • Naper, Christian; Rolstad, Bent; Wonigeit, K.; Butcher, Geoffrey W & Vaage, John Torgils (1996). Genes in two MHC class I regions control recognition of a single rat natural killer cell allodeterminant. International Immunology.  ISSN 0953-8178.  8, s 1779- 1785
  • Rolstad, Bent; Naper, Christian & Vaage, John Torgils (1996). Natural killer (NK) cell recognition of MHC class I molecules. The Immunologist.  ISSN 1192-5612.  4/5, s 165- 171

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  • Szodoray, Peter; Nakken, Britt; Osnes, Liv T. N.; Naper, Christian; Vaage, John Torgils & Egeland, Torstein (2012). IMMUNE REGULATORY EFFECTS OF HEMATOPOIETIC STEM CELL TRANSPLANTATION IN AUTOIMMUNE DISEASES. Cytometry.  ISSN 0196-4763.  82B(6), s 379- 380
  • Zinöcker, Severin & Vaage, John Torgils (2011). Rat Bone Marrow Stromal Cells Suppress T Cell Activation by Production of Nitric Oxide. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 379- 379
  • Zinöcker, Severin & Vaage, John Torgils (2011). Rat bone marrow-derived mesenchymal stromal cells suppress T cell activation by production of nitric oxide.
  • Zinöcker, Severin; Wang, Mengyu; Gaustad, Peter; Kvalheim, Gunnar; Rolstad, Bent & Vaage, John Torgils (2010). Mesenchymal Stem Cell Therapy for Graft-versus-Host Disease.
  • Kveberg, Lise; Dai, Kezheng; Martinsen, Stine; Fossum, Sigbjørn & Vaage, John Torgils (2009). Phylogenetic and functional conservation of the NKR-P1G NK receptor in rat and mouse.
  • Kveberg, Lise; Fossum, Sigbjørn & Vaage, John Torgils (2009). Phylogenetic and functional conservation of the NKR-P1G receptor in rat and mouse.
  • Zinöcker, Severin; Wang, Mengyu; Kvalheim, Gunnar; Nestvold, Janne M.; Rolstad, Bent & Vaage, John Torgils (2009). Mesenchymal Stromal Cells effectively suppress T cell alloreactivity in vitro but not Graft-versus-Host Disease in Rats.
  • Inngjerdingen, Marit; Kveberg, Lise; Naper, Christian; Dai, Kezheng; Rolstad, Bent & Vaage, John Torgils (2007). Functional characterization of two major NK cell subsets in the rat, a Ly49+ and a NKR-P1C+ subset.
  • Kveberg, Lise; Westgaard, Ingunn Hagen; Dai, Kezheng; Daws, Michael Rory; Fossum, Sigbjørn; Naper, Christian & Vaage, John Torgils (2007). The NKR-P1 family of receptors in rat recognizes C-type lectin related molecules.
  • Kveberg, Lise; Westgaard, Ingunn Hagen; Dai, Kezheng; Daws, Michael Rory; Fossum, Sigbjørn; Naper, Christian & Vaage, John Torgils (2007). The NKR-P1 family of receptors in rat recognizes C-type lectin-related molecules.
  • Zinöcker, Severin; Dai, Kezheng; Naper, Christian; Daws, Michael Rory; Rolstad, Bent & Vaage, John Torgils (2007). A novel reporter system to identify NK receptor-MHC ligand interactions.
  • Zinöcker, Severin; Nestvold, Janne M.; Wang, Mengyu; Kvalheim, Gunnar; Vaage, John Torgils & Rolstad, Bent (2007). Mesenchymal Stem Cell Therapy in a Rat Model for GvHD.
  • Zinöcker, Severin; Nestvold, Janne M.; Wang, Mengyu; Kvalheim, Gunnar; Vaage, John Torgils & Rolstad, Bent (2007). Mesenchymal Stem Cells as a treatment for Graft-vs-Host Disease.
  • Sollid, Ludvig Magne; Vaage, JT & Vaage, John Torgils (2006). Cross-dressing T cells go wild. Nature Medicine.  ISSN 1078-8956.  12, s 611- 612
  • Torgersen, Knut Martin; Vang, Torkel; Vaage, John Torgils; Ryan, James C.; Rolstad, Bent & Tasken, Kjetil (1999). Molecular events in the regulation of T and NK cell signalling.
  • Torgersen, Knut Martin; Vaage, John Torgils; Levy, Finn Olav; Hansson, Vidar; Tasken, Kjetil & Rolstad, Bent (1996). The Role of PKA type I in NK cell cytotoxicity.

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Published Apr. 13, 2011 2:54 PM - Last modified July 29, 2011 9:43 AM