Kjetil Wessel Andressen

Associate Professor - Department of Pharmacology
Image of Kjetil Wessel Andressen
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Phone +47-22840372
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Visiting address Sognsvannsveien 20 Rikshospitalet 0372 OSLO
Postal address Postboks 1057 Blindern 0316 OSLO
Other affiliations Institute of Clinical Medicine

Interest

  • Research on heart failure, cellular signal transduction and development of new pharmacological entities.

Teaching

  • Medical students: Pharmacology in module 3-6
  • Courses: Co-responsible for MF9180 Mechanisms of cellular signal transduction

Administrative duties

Background

Tags: FRET, GPCR, cAMP, cGMP, Receptor, Hart Failure, Biosensor

Publications

  • Meier, Silja; Andressen, Kjetil Wessel; Aronsen, Jan Magnus; Sjaastad, Ivar; Hougen, Karina; Skomedal, Tor; Osnes, Jan-Bjørn; Qvigstad, Eirik; Levy, Finn Olav & Moltzau, Lise Roman (2017). PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts. European Journal of Pharmacology.  ISSN 0014-2999.  812, s 174- 183 . doi: 10.1016/j.ejphar.2017.07.014
  • Olberg, Dag Erlend; Bauer, Nadine; Andressen, Kjetil Wessel; Hjornevik, Trine; Cumming, Paul; Levy, Finn Olav; Klaveness, Jo; Haraldsen, Ira Hebold & Sutcliffe, Julie L. (2016). Brain penetrant small molecule 18F-GnRH receptor (GnRH-R) antagonists: Synthesis and preliminary positron emission tomography imaging in rats. Nuclear Medicine and Biology.  ISSN 0969-8051.  43(8), s 478- 489 . doi: doi:10.1016/j.nucmedbio.2016.05.003
  • Andressen, Kjetil Wessel; Manfra, Ornella; Brevik, Christian Hellesylt; Ulsund, Andrea Hembre; Vanhoenacker, Peter; Levy, Finn Olav & Krobert, Kurt Allen (2015). The atypical antipsychotics clozapine and olanzapine promote down-regulation and display functional selectivity at human 5-HT7 receptors. British Journal of Pharmacology.  ISSN 0007-1188.  172(15), s 3846- 3860 . doi: 10.1111/bph.13169
  • Impellizzeri, Agata Antonina Rita; Pappalardo, Matteo; Basile, Livia; Manfra, Ornella; Andressen, Kjetil Wessel; Krobert, Kurt Allen; Messina, Angela; Levy, Finn Olav & Guccione, Salvatore (2015). Identification of essential residues for binding and activation in the human 5-HT7(a) serotonin receptor by molecular modeling and site-directed mutagenesis. Frontiers in Behavioral Neuroscience.  ISSN 1662-5153.  9(MAY) . doi: 10.3389/fnbeh.2015.00092 Full text in Research Archive.
  • Manfra, Ornella; Van Craenenbroeck, Kathleen; Skieterska, Kamila; Frimurer, Thomas; Schwartz, Thue W.; Levy, Finn Olav & Andressen, Kjetil Wessel (2015). Downregulation of 5-HT7 Serotonin Receptors by the Atypical Antipsychotics Clozapine and Olanzapine. Role of Motifs in the C-Terminal Domain and Interaction with GASP-1. ACS Chemical Neuroscience.  ISSN 1948-7193.  6(7), s 1206- 1218 . doi: 10.1021/cn500339p
  • Olberg, Dag Erlend; Hausner, Sven H.; Bauer, Nadine; Klaveness, Jo; Indrevoll, Bård; Andressen, Kjetil Wessel; Dahl, Marie; Levy, Finn Olav; Sutcliffe, Julie L. & Haraldsen, Ira Hebold (2015). Radiosynthesis of high affinity fluorine-18 labeled GnRH peptide analogues: in vitro studies and in vivo assessment of brain uptake in rats. MedChemComm.  ISSN 2040-2503.  6, s 708- 714 . doi: 10.1039/c4md00486h
  • Ørstavik, Øivind; Manfra, Ornella; Andressen, Kjetil Wessel; Andersen, Geir Øystein; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Krobert, Kurt Allen (2015). The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium. PLoS ONE.  ISSN 1932-6203.  10(3) . doi: 10.1371/journal.pone.0115547 Full text in Research Archive.
  • Brudeli, Bjarne; Navaratnarajah, Mirusha; Andressen, Kjetil Wessel; Manfra, Ornella; Moltzau, Lise Roman; Nilsen, Nils Olav; Levy, Finn Olav & Klaveness, Jo (2014). Discovery and pharmacological profile of new hydrophilic 5-HT4 receptor antagonists. Bioorganic & Medicinal Chemistry Letters.  ISSN 0960-894X.  24(18), s 4598- 4602 . doi: 10.1016/j.bmcl.2014.06.083
  • Kilander, Michael Brita Christina; Petersen, Julian; Andressen, Kjetil Wessel; Ganji, Ranjani Sri; Levy, Finn Olav; Schuster, Jens; Dahl, Niklas; Bryja, Vítězslav & Schulte, Gunnar (2014). Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6. The FASEB Journal.  ISSN 0892-6638.  28(5), s 2293- 2305 . doi: 10.1096/fj.13-246363
  • Olberg, Dag Erlend; Andressen, Kjetil Wessel; Levy, Finn Olav; Klaveness, Jo; Haraldsen, Ira Hebold & Sutcliffe, Julie L. (2014). Synthesis and in vitro evaluation of small-molecule [18F] labeled gonadotropin-releasing hormone (GnRH) receptor antagonists as potential PET imaging agents for GnRH receptor expression. Bioorganic & Medicinal Chemistry Letters.  ISSN 0960-894X.  24(7), s 1846- 1850 . doi: 10.1016/j.bmcl.2014.02.002
  • Brudeli, Bjarne; Andressen, Kjetil Wessel; Moltzau, Lise Roman; Nilsen, Nils Olav; Levy, Finn Olav & Klaveness, Jo (2013). Acidic biphenyl derivatives: Synthesis and biological activity of a new series of potent 5-HT4 receptor antagonists. Bioorganic & Medicinal Chemistry.  ISSN 0968-0896.  21(22), s 7134- 7145 . doi: 10.1016/j.bmc.2013.09.004
  • Brudeli, Bjarne; Moltzau, Lise Roman; Nguyen, Hong Cam Thi; Andressen, Kjetil Wessel; Nilsen, Nils Olav; Levy, Finn Olav & Klaveness, Jo (2013). Synthesis and pharmacological properties of a new hydrophilic and orally bioavailable 5-HT4 antagonist. European Journal of Medicinal Chemistry.  ISSN 0223-5234.  64, s 629- 637 . doi: 10.1016/j.ejmech.2013.03.060
  • Gellynck, Evelien; Heyninck, Karen; Andressen, Kjetil Wessel; Haegeman, Guy; Levy, Finn Olav; Vanhoenacker, Peter & Van Craenenbroeck, Kathleen (2013). The serotonin 5-HT7 receptors: two decades of research. Experimental Brain Research.  ISSN 0014-4819.  230(4), s 555- 568 . doi: 10.1007/s00221-013-3694-y
  • Gellynck, Evelien; Andressen, Kjetil Wessel; Lintermans, Béatrice; Haegeman, Guy; Levy, Finn Olav; Vanhoenacker, Peter & Van Craenenbroeck, Kathleen (2012). Biochemical and pharmacological study of N-linked glycosylation of the human serotonin 5-HT7(a) receptor. The FEBS Journal.  ISSN 1742-464X.  279(11), s 1994- 2003 . doi: 10.1111/j.1742-4658.2012.08581.x
  • Brudeli, Bjarne; Moltzau, Lise Roman; Andressen, Kjetil Wessel; Krobert, Kurt Allen; Klaveness, Jo & Levy, Finn Olav (2010). Synthesis and pharmacological properties of novel hydrophilic 5-HT4 receptor antagonists. Bioorganic & Medicinal Chemistry.  ISSN 0968-0896.  18(24), s 8600- 8613 . doi: doi:10.1016/j.bmc.2010.10.011
  • Afzal, Faraz; Andressen, Kjetil Wessel; Mørk, Halvor Kjeang; Aronsen, Jan Magnus; Sjaastad, Ivar; Dahl, Christen Peder; Skomedal, Tor; Levy, Finn Olav; Osnes, Jan-Bjørn & Qvigstad, Eirik (2008). 5-HT4-elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricles. British Journal of Pharmacology.  ISSN 0007-1188.  155(7), s 1005- 1014 . doi: 10.1038/bjp.2008.339
  • Gellynck, E; Laenen, K; Andressen, Kjetil Wessel; Lintermans, B; De Martelaere, K; Matthys, A; Levy, Finn Olav; Haegeman, G; Vanhoenacker, P & Van Craenenbroeck, K (2008). Cloning, genomic organization and functionality of 5-HT7 receptor splice variants from mouse brain. Gene.  ISSN 0378-1119.  426(1-2), s 23- 31 . doi: 10.1016/j.gene.2008.08.011
  • Ngai, Jacob; Iversen, Trond Methi; Andressen, Kjetil Wessel; Levy, Finn Olav; Torgersen, Knut Martin; Vang, Torkel; Wettschureck, N & Tasken, Kjetil (2008). The heterotrimeric G-protein α-subunit Gαq regulates TCR-mediated immune responses through an Lck-dependent pathway. European Journal of Immunology.  ISSN 0014-2980.  38(11), s 3208- 3218
  • Vinge, Leif Erik; Andressen, Kjetil Wessel; Attramadal, Toril; Andersen, Geir Øystein; Ahmed, Muhammad Shakil; Peppel, K; Koch, WJ; Freedman, NJ; Levy, Finn Olav; Skomedal, Tor; Osnes, Jan-Bjørn & Attramadal, Håvard (2007). Substrate specificities of G protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function. Molecular Pharmacology.  ISSN 0026-895X.  72, s 582- 591
  • Andressen, Kjetil Wessel; Norum, Jens Henrik; Levy, Finn Olav & Krobert, Kurt Allen (2006). Activation of adenylyl cyclase by endogenous G(s)-coupled receptors in human embryonic kidney 293 cells is attenuated by 5-HT7 receptor expression. Molecular Pharmacology.  ISSN 0026-895X.  69, s 207- 215
  • Krobert, Kurt Allen; Andressen, Kjetil Wessel & Levy, Finn Olav (2006). Heterologous desensitization is evoked by both agonist and antagonist stimulation of the human 5-HT7 serotonin receptor. European Journal of Pharmacology.  ISSN 0014-2999.  532, s 1- 10
  • Qvigstad, Eirik; Brattelid, Trond; Sjaastad, Ivar; Molenaar, P.; Birkeland, Jon Arne; Andressen, Kjetil Wessel; Krobert, Kurt Allen; Sejersted, Ole M; Skomedal, Tor; Osnes, Jan-Bjørn; Kaumann, Alberto Julio & Levy, Finn Olav (2005). Rationale for treatment of heart failure by blockade of ventricular serotonin receptors appearing in heart failure, In  Proceedings of the 25th European Section Meeting, International Society for Heart Research, Tromsø, Norway, June 21-25, 2005.  Medimond.  ISBN 88-7587-164-7.  Invited Lectures.  s 7 - 12 Show summary
  • Qvigstad, Eirik; Brattelid, Trond; Sjaastad, Ivar; Andressen, Kjetil Wessel; Krobert, Kurt Allen; Birkeland, Jon Arne; Sejersted, Ole M; Kaumann, Alberto Julio; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2005). Appearance of a ventricular 5-HT4 receptor-mediated inotropic response to serotonin in heart failure. Cardiovascular Research.  ISSN 0008-6363.  65 Show summary
  • Brattelid, Trond; Kvingedal, Ane Marit; Krobert, Kurt Allen; Andressen, Kjetil Wessel; Bach, Trond; Hystad, Marit Elise; Kaumann, Alberto Julio & Levy, Finn Olav (2004). Cloning, pharmacological characterisation and tissue distribution of a novel 5-HT4 receptor splice variant, 5-HT4(i). Naunyn-Schmiedeberg's Archives of Pharmacology.  ISSN 0028-1298.  369(6), s 616- 628 . doi: 15118808 Show summary

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  • Meier, Silja; Andressen, Kjetil Wessel; Aronsen, Jan Magnus; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Qvigstad, Eirik; Levy, Finn Olav & Moltzau, Lise Roman (2015). Enhancement of cAMP-mediated inotropic responses by CNP is regulated differently by PDE2 in normal and failing hearts. BMC Pharmacology & Toxicology.  ISSN 2050-6511.  16, s A66- A66 . doi: 10.1186/2050-6511-16-S1-A66
  • Dugstad, K.; Ulsund, Andrea Hembre; Aronsen, Jan Magnus; Sjaastad, Ivar; Zaccolo, Manuela; Levy, Finn Olav & Andressen, Kjetil Wessel (2014). Unraveling tight spatial regulation of 5-HT4 receptor-mediated inotropic effects using targeted FRET-based cAMP sensors.
  • Dugstad, Kari Sandanger; Andressen, Kjetil Wessel; Aronsen, Jan Magnus; Sjaastad, Ivar; Zaccolo, Manuela & Levy, Finn Olav (2012). Compartmented production and degradation of cAMP by beta-adrenergic, prostanoid and 5-HT4 receptors in CHF, visualized by FRET-based cAMP sensors.
  • Andressen, Kjetil Wessel; Dugstad, KS; Aronsen, Jan Magnus; Sjaastad, Ivar; Zaccolo, Manuela & Levy, Finn Olav (2011). Unraveling tight spatiotemporal regulation of cAMP-mediated inotropic effects using targeted FRET-based cAMP sensors.
  • Andressen, Kjetil Wessel & Levy, Finn Olav (2008). The 5-HT₇ serotonin receptor : G protein preassociation and functional selectivity. Dissertation for the degree of Dr.Med.. 601.
  • Afzal, Faraz; Andressen, Kjetil Wessel; Mørk, Halvor Kjeang; Aronsen, Jon magnus; Moltzau, Lise Roman; Sjaastad, Ivar; Skomedal, Tor; Levy, Finn Olav; Osnes, Jan-Bjørn & Qvigstad, Eirik (2007). 5-HT4-mediated positive inotropic effect is regulated by phosphodiesterase 3 in failing rat heart and human ventricle. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  42(6), s S152- S152
  • Andressen, Kjetil Wessel; Norum, Jens Henrik; Levy, Finn Olav & Krobert, Kurt Allen (2006). Activation of adenylyl cyclase in HEK293 cells by endogenous G(s)-coupled receptors is attenuated by 5-HT7 receptor expression. Journal of Pharmacological Sciences.  ISSN 1347-8613.  101, s 128- 128
  • Qvigstad, Eirik; Birkeland, Jon Arne; Sjaastad, Ivar; Brattelid, Trond; Andressen, Kjetil Wessel; Krobert, Kurt Allen; Bjornerheim, Reidar; Sejersted, Ole M; Kaumann, Alberto Julio; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2005). Treatment of heart failure by blockade of ventricular myocardial serotonin receptors appearing in heart failure. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  38, s 1041- 1041

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Published Aug. 23, 2012 12:14 PM - Last modified Dec. 1, 2017 12:52 PM