Kjetil Wessel Andressen

Associate Professor - Department of Pharmacology
Image of Kjetil Wessel Andressen
Norwegian version of this page
Phone +47-22840372
Username
Visiting address Sognsvannsveien 20 Rikshospitalet 0372 OSLO
Postal address Postboks 1057 Blindern 0316 OSLO
Other affiliations Institute of Clinical Medicine

Interest

  • Research on heart failure, cellular signal transduction and development of new pharmacological entities.

Teaching

  • Medical students: Pharmacology in module 3-6
  • Courses: Co-responsible for MF9180 Mechanisms of cellular signal transduction

Administrative duties

Background

Tags: FRET, GPCR, cAMP, cGMP, Receptor, Hart Failure, Biosensor

Publications

  • Olberg, Dag Erlend; Bauer, Nadine; Andressen, Kjetil Wessel; Hjornevik, Trine; Cumming, Paul; Levy, Finn Olav; Klaveness, Jo; Haraldsen, Ira Hebold & Sutcliffe, Julie L. (2016). Brain penetrant small molecule 18F-GnRH receptor (GnRH-R) antagonists: Synthesis and preliminary positron emission tomography imaging in rats. Nuclear Medicine and Biology.  ISSN 0969-8051.  43(8), s 478- 489 . doi: doi:10.1016/j.nucmedbio.2016.05.003
  • Andressen, Kjetil Wessel; Manfra, Ornella; Brevik, Christian Hellesylt; Ulsund, Andrea Hembre; Vanhoenacker, Peter; Levy, Finn Olav & Krobert, Kurt Allen (2015). The atypical antipsychotics clozapine and olanzapine promote down-regulation and display functional selectivity at human 5-HT7 receptors. British Journal of Pharmacology.  ISSN 0007-1188.  172(15), s 3846- 3860 . doi: 10.1111/bph.13169
  • Impellizzeri, Agata Antonina Rita; Pappalardo, Matteo; Basile, Livia; Manfra, Ornella; Andressen, Kjetil Wessel; Krobert, Kurt Allen; Messina, Angela; Levy, Finn Olav & Guccione, Salvatore (2015). Identification of essential residues for binding and activation in the human 5-HT7(a) serotonin receptor by molecular modeling and site-directed mutagenesis. Frontiers in Behavioral Neuroscience.  ISSN 1662-5153.  9(MAY) . doi: 10.3389/fnbeh.2015.00092 Full text in Research Archive
  • Manfra, Ornella; Van Craenenbroeck, Kathleen; Skieterska, Kamila; Frimurer, Thomas; Schwartz, Thue W.; Levy, Finn Olav & Andressen, Kjetil Wessel (2015). Downregulation of 5-HT7 Serotonin Receptors by the Atypical Antipsychotics Clozapine and Olanzapine. Role of Motifs in the C-Terminal Domain and Interaction with GASP-1. ACS Chemical Neuroscience.  ISSN 1948-7193.  6(7), s 1206- 1218 . doi: 10.1021/cn500339p
  • Olberg, Dag Erlend; Hausner, Sven H.; Bauer, Nadine; Klaveness, Jo; Indrevoll, Bård; Andressen, Kjetil Wessel; Dahl, Marie; Levy, Finn Olav; Sutcliffe, Julie L. & Haraldsen, Ira Hebold (2015). Radiosynthesis of high affinity fluorine-18 labeled GnRH peptide analogues: in vitro studies and in vivo assessment of brain uptake in rats. MedChemComm.  ISSN 2040-2503.  6, s 708- 714 . doi: 10.1039/c4md00486h
  • Ørstavik, Øivind; Manfra, Ornella; Andressen, Kjetil Wessel; Andersen, Geir Øystein; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Krobert, Kurt Allen (2015). The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium. PLoS ONE.  ISSN 1932-6203.  10(3) . doi: 10.1371/journal.pone.0115547 Full text in Research Archive
  • Brudeli, Bjarne; Navaratnarajah, Mirusha; Andressen, Kjetil Wessel; Manfra, Ornella; Moltzau, Lise Roman; Nilsen, Nils Olav; Levy, Finn Olav & Klaveness, Jo (2014). Discovery and pharmacological profile of new hydrophilic 5-HT4 receptor antagonists. Bioorganic & Medicinal Chemistry Letters.  ISSN 0960-894X.  24(18), s 4598- 4602 . doi: 10.1016/j.bmcl.2014.06.083
  • Kilander, Michael Brita Christina; Petersen, Julian; Andressen, Kjetil Wessel; Ganji, Ranjani Sri; Levy, Finn Olav; Schuster, Jens; Dahl, Niklas; Bryja, Vítězslav & Schulte, Gunnar (2014). Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6. The FASEB Journal.  ISSN 0892-6638.  28(5), s 2293- 2305 . doi: 10.1096/fj.13-246363
  • Olberg, Dag Erlend; Andressen, Kjetil Wessel; Levy, Finn Olav; Klaveness, Jo; Haraldsen, Ira Hebold & Sutcliffe, Julie L. (2014). Synthesis and in vitro evaluation of small-molecule [18F] labeled gonadotropin-releasing hormone (GnRH) receptor antagonists as potential PET imaging agents for GnRH receptor expression. Bioorganic & Medicinal Chemistry Letters.  ISSN 0960-894X.  24(7), s 1846- 1850 . doi: 10.1016/j.bmcl.2014.02.002
  • Brudeli, Bjarne; Andressen, Kjetil Wessel; Moltzau, Lise Roman; Nilsen, Nils Olav; Levy, Finn Olav & Klaveness, Jo (2013). Acidic biphenyl derivatives: Synthesis and biological activity of a new series of potent 5-HT4 receptor antagonists. Bioorganic & Medicinal Chemistry.  ISSN 0968-0896.  21(22), s 7134- 7145 . doi: 10.1016/j.bmc.2013.09.004
  • Brudeli, Bjarne; Moltzau, Lise Roman; Nguyen, Hong Cam Thi; Andressen, Kjetil Wessel; Nilsen, Nils Olav; Levy, Finn Olav & Klaveness, Jo (2013). Synthesis and pharmacological properties of a new hydrophilic and orally bioavailable 5-HT4 antagonist. European Journal of Medicinal Chemistry.  ISSN 0223-5234.  64, s 629- 637 . doi: 10.1016/j.ejmech.2013.03.060
  • Gellynck, Evelien; Heyninck, Karen; Andressen, Kjetil Wessel; Haegeman, Guy; Levy, Finn Olav; Vanhoenacker, Peter & Van Craenenbroeck, Kathleen (2013). The serotonin 5-HT7 receptors: two decades of research. Experimental Brain Research.  ISSN 0014-4819.  230(4), s 555- 568 . doi: 10.1007/s00221-013-3694-y
  • Gellynck, Evelien; Andressen, Kjetil Wessel; Lintermans, Béatrice; Haegeman, Guy; Levy, Finn Olav; Vanhoenacker, Peter & Van Craenenbroeck, Kathleen (2012). Biochemical and pharmacological study of N-linked glycosylation of the human serotonin 5-HT7(a) receptor. The FEBS Journal.  ISSN 1742-464X.  279(11), s 1994- 2003 . doi: 10.1111/j.1742-4658.2012.08581.x
  • Brudeli, Bjarne; Moltzau, Lise Roman; Andressen, Kjetil Wessel; Krobert, Kurt Allen; Klaveness, Jo & Levy, Finn Olav (2010). Synthesis and pharmacological properties of novel hydrophilic 5-HT4 receptor antagonists. Bioorganic & Medicinal Chemistry.  ISSN 0968-0896.  18(24), s 8600- 8613 . doi: doi:10.1016/j.bmc.2010.10.011
  • Afzal, Faraz; Andressen, Kjetil Wessel; Mørk, Halvor Kjeang; Aronsen, Jan Magnus; Sjaastad, Ivar; Dahl, Christen Peder; Skomedal, Tor; Levy, Finn Olav; Osnes, Jan-Bjørn & Qvigstad, Eirik (2008). 5-HT4-elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricles. British Journal of Pharmacology.  ISSN 0007-1188.  155(7), s 1005- 1014 . doi: 10.1038/bjp.2008.339
  • Gellynck, E; Laenen, K; Andressen, Kjetil Wessel; Lintermans, B; De Martelaere, K; Matthys, A; Levy, Finn Olav; Haegeman, G; Vanhoenacker, P & Van Craenenbroeck, K (2008). Cloning, genomic organization and functionality of 5-HT7 receptor splice variants from mouse brain. Gene.  ISSN 0378-1119.  426(1-2), s 23- 31 . doi: 10.1016/j.gene.2008.08.011
  • Ngai, Jacob; Iversen, Trond Methi; Andressen, Kjetil Wessel; Levy, Finn Olav; Torgersen, Knut Martin; Vang, Torkel; Wettschureck, N & Tasken, Kjetil (2008). The heterotrimeric G-protein α-subunit Gαq regulates TCR-mediated immune responses through an Lck-dependent pathway. European Journal of Immunology.  ISSN 0014-2980.  38(11), s 3208- 3218
  • Vinge, Leif Erik; Andressen, Kjetil Wessel; Attramadal, Toril; Andersen, Geir Øystein; Ahmed, Muhammad Shakil; Peppel, K; Koch, WJ; Freedman, NJ; Levy, Finn Olav; Skomedal, Tor; Osnes, Jan-Bjørn & Attramadal, Håvard (2007). Substrate specificities of G protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function. Molecular Pharmacology.  ISSN 0026-895X.  72, s 582- 591
  • Andressen, Kjetil Wessel; Norum, Jens Henrik; Levy, Finn Olav & Krobert, Kurt Allen (2006). Activation of adenylyl cyclase by endogenous G(s)-coupled receptors in human embryonic kidney 293 cells is attenuated by 5-HT7 receptor expression. Molecular Pharmacology.  ISSN 0026-895X.  69, s 207- 215
  • Krobert, Kurt Allen; Andressen, Kjetil Wessel & Levy, Finn Olav (2006). Heterologous desensitization is evoked by both agonist and antagonist stimulation of the human 5-HT7 serotonin receptor. European Journal of Pharmacology.  ISSN 0014-2999.  532, s 1- 10
  • Qvigstad, Eirik; Brattelid, Trond; Sjaastad, Ivar; Molenaar, P.; Birkeland, Jon Arne; Andressen, Kjetil Wessel; Krobert, Kurt Allen; Sejersted, Ole M; Skomedal, Tor; Osnes, Jan-Bjørn; Kaumann, Alberto Julio & Levy, Finn Olav (2005). Rationale for treatment of heart failure by blockade of ventricular serotonin receptors appearing in heart failure , In  Proceedings of the 25th European Section Meeting, International Society for Heart Research, Tromsø, Norway, June 21-25, 2005.  Medimond.  ISBN 88-7587-164-7.  Invited Lectures.  s 7 - 12
  • Qvigstad, Eirik; Brattelid, Trond; Sjaastad, Ivar; Andressen, Kjetil Wessel; Krobert, Kurt Allen; Birkeland, Jon Arne; Sejersted, Ole M; Kaumann, Alberto Julio; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2005). Appearance of a ventricular 5-HT4 receptor-mediated inotropic response to serotonin in heart failure . Cardiovascular Research.  ISSN 0008-6363.  65
  • Brattelid, Trond; Kvingedal, Ane Marit; Krobert, Kurt Allen; Andressen, Kjetil Wessel; Bach, Trond; Hystad, Marit Elise; Kaumann, Alberto Julio & Levy, Finn Olav (2004). Cloning, pharmacological characterisation and tissue distribution of a novel 5-HT4 receptor splice variant, 5-HT4(i) . Naunyn-Schmiedeberg's Archives of Pharmacology.  ISSN 0028-1298.  369(6), s 616- 628 . doi: 15118808

View all works in Cristin

  • Meier, Silja; Andressen, Kjetil Wessel; Aronsen, Jan Magnus; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Qvigstad, Eirik; Levy, Finn Olav & Moltzau, Lise Roman (2015). Enhancement of cAMP-mediated inotropic responses by CNP is regulated differently by PDE2 in normal and failing hearts. BMC Pharmacology & Toxicology.  ISSN 2050-6511.  16, s A66- A66 . doi: 10.1186/2050-6511-16-S1-A66
  • Dugstad, K.; Ulsund, Andrea Hembre; Aronsen, Jan Magnus; Sjaastad, Ivar; Zaccolo, Manuela; Levy, Finn Olav & Andressen, Kjetil Wessel (2014). Unraveling tight spatial regulation of 5-HT4 receptor-mediated inotropic effects using targeted FRET-based cAMP sensors.
  • Dugstad, Kari Sandanger; Andressen, Kjetil Wessel; Aronsen, Jan Magnus; Sjaastad, Ivar; Zaccolo, Manuela & Levy, Finn Olav (2012). Compartmented production and degradation of cAMP by beta-adrenergic, prostanoid and 5-HT4 receptors in CHF, visualized by FRET-based cAMP sensors.
  • Andressen, Kjetil Wessel; Dugstad, KS; Aronsen, Jan Magnus; Sjaastad, Ivar; Zaccolo, Manuela & Levy, Finn Olav (2011). Unraveling tight spatiotemporal regulation of cAMP-mediated inotropic effects using targeted FRET-based cAMP sensors.
  • Andressen, Kjetil Wessel & Levy, Finn Olav (2008). The 5-HT₇ serotonin receptor : G protein preassociation and functional selectivity .
  • Afzal, Faraz; Andressen, Kjetil Wessel; Mørk, Halvor Kjeang; Aronsen, Jon magnus; Moltzau, Lise Roman; Sjaastad, Ivar; Skomedal, Tor; Levy, Finn Olav; Osnes, Jan-Bjørn & Qvigstad, Eirik (2007). 5-HT4-mediated positive inotropic effect is regulated by phosphodiesterase 3 in failing rat heart and human ventricle. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  42(6), s S152- S152
  • Andressen, Kjetil Wessel; Norum, Jens Henrik; Levy, Finn Olav & Krobert, Kurt Allen (2006). Activation of adenylyl cyclase in HEK293 cells by endogenous G(s)-coupled receptors is attenuated by 5-HT7 receptor expression. Journal of Pharmacological Sciences.  ISSN 1347-8613.  101, s 128- 128
  • Qvigstad, Eirik; Birkeland, Jon Arne; Sjaastad, Ivar; Brattelid, Trond; Andressen, Kjetil Wessel; Krobert, Kurt Allen; Bjornerheim, Reidar; Sejersted, Ole M; Kaumann, Alberto Julio; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2005). Treatment of heart failure by blockade of ventricular myocardial serotonin receptors appearing in heart failure. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  38, s 1041- 1041

View all works in Cristin

Published Aug. 23, 2012 12:14 PM - Last modified Jan. 10, 2017 12:02 PM