Lars Eide

Image of Lars Eide
Norwegian version of this page
Phone +47-23071062
Mobile phone +4793241242
Room B1.3054
Visiting address Rikshospitalet sognsvannsveien 20 0027 Oslo
Postal address Postboks 4950 Nydalen 0424 OSLO

Scientitic Interests

Mitochondrial DNA (mtDNA), modifications ("damage"), repair and mutations, mitochondrial function associated to mtDNA dynamics



PhD course MF9135 - "Biomarkers in Clinical Research". Course responsible



  • Appointed Head of Research, Divisions KDI UiO, KRN OUS, KLM OUS since 1.10.2015
  • N5 Head Dept. Medical Biochemistry (MBK), OUS; N4 Head (FUI), MBK, OUS
  • Professor of Medical Biochemistry since 2011
  • Ass. professor of Medical Biochemistry 2006 - 2011
  • Dr. Scient, Faculty of Mathematics and Natural Sciences, Departmen of Biology, UiO, 1997
  • MSc ("Sivilingeniør") Chemistry, Trondheim, 1992


Tags: mitochondria, mtDNA, mitochondrial DNA repair


  • Distante, Sonia; Eikeland, Joakim; Pawar, Tina; Skinnes, Ragnhild; Høie, Kari; You, Panpan; Mørkrid, Lars & Eide, Lars (2016). Blood removal therapy in hereditary hemochromatosis induces a stress response resulting in improved genome integrity. Transfusion.  ISSN 0041-1132.  56(6), s 1435- 1441 . doi: 10.1111/trf.13588
  • Khuu, Cuong; Sehic, Amer; Eide, Lars & Osmundsen, Harald (2016). Anti-proliferative properties of miR-20b and miR-363 from the miR-106a-363 cluster on human carcinoma cells. MicroRNA.  ISSN 2211-5366.
  • Bjørge, Monica Dahl; Hildrestrand, Gunn Annette; Scheffler, Katja; Suganthan, Rajikala; Rolseth, Veslemøy; Kusnierczyk, Anna; Rowe, Alexander D.; Vågbø, Cathrine Broberg; Vetlesen, Susanne; Eide, Lars; Slupphaug, Geir; Yusaku, Nakabeppu; Timothy, Bredy; Klungland, Arne & Bjørås, Magnar (2015). Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice. Cell reports.  ISSN 2211-1247.  13(12), s 2671- 2678 . doi: 10.1016/j.celrep.2015.12.001
  • Bliksøen, Marte; Baysa, Anton; Eide, Lars; Bjørås, Magnar; Suganthan, Rajikala; Vaage, Ingvar Jarle; Stensløkken, Kåre-Olav & Valen, Guro (2015). Mitochondrial DNA damage and repair during ischemia-reperfusion injury of the heart. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  78, s 9- 22 . doi: 10.1016/j.yjmcc.2014.11.010
  • Lauritzen, Knut Husø; Kleppa, Liv; Aronsen, Jan Magnus; Eide, Lars; Carlsen, Harald; Haugen, Øyvind Pernell; Sjaastad, Ivar; Klungland, Arne; Rasmussen, Lene Juel; Attramadal, Håvard; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2015). Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure. American Journal of Physiology. Heart and Circulatory Physiology.  ISSN 0363-6135.  309(3), s H434- H449 . doi: 10.1152/ajpheart.00253.2014
  • Yang, Mingyi; Lin, Xiaolin; Rowe, Alexander D.; Rognes, Torbjørn; Eide, Lars & Bjørås, Magnar (2015). Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway. Scientific Reports.  ISSN 2045-2322.  5 . doi: 10.1038/srep17409
  • Hereng, Tuva Holt; Elgstøen, Katja B. Prestø; Eide, Lars; Rosendal, Ken Roger & Skålhegg, Bjørn Steen (2014). Serum albumin and HCO<sub>3</sub><sup>-</sup> regulate separate pools of ATP in human spermatozoa. Human Reproduction.  ISSN 0268-1161.  29(5), s 918- 930 . doi: 10.1093/humrep/deu028
  • Hystad, Eva Marit; Amdam, Gro Vang & Eide, Lars (2014). Mitochondrial DNA integrity changes with age but does not correlate with learning performance in honey bees. Experimental Gerontology.  ISSN 0531-5565.  49, s 12- 18 . doi: 10.1016/j.exger.2013.10.013
  • Jalland, Clara; Benestad, Sylvie Lafond; Ersdal, Cecilie; Scheffler, Katja; Suganthan, Rajikala; Nakabeppu, Yusaku; Eide, Lars; Bjørås, Magnar & Tranulis, Michael A. (2014). Accelerated clinical course of prion disease in mice compromised in repair of oxidative DNA damage. Free Radical Biology & Medicine.  ISSN 0891-5849.  68, s 1- 7 . doi: 10.1016/j.freeradbiomed.2013.11.013
  • Strand, Janne Maren; Scheffler, Katja; Bjørås, Magnar & Eide, Lars (2014). The distribution of DNA damage is defined by region-specific susceptibility to DNA damage formation rather than repair differences. DNA Repair.  ISSN 1568-7864.  18(1), s 44- 51 . doi: 10.1016/j.dnarep.2014.03.003
  • Strand, Janne Maren; Skinnes, Ragnhild; Scheffler, Katja; Rootwelt, Terje; Woldseth, Berit; Bjørås, Magnar & Eide, Lars (2014). Genome instability in Maple Syrup Urine Disease correlates with impaired mitochondrial biogenesis. Metabolism: Clinical and Experimental.  ISSN 0026-0495.  63(8), s 1063- 1070 . doi: 10.1016/j.metabol.2014.05.003
  • Wang, Wei; Scheffler, Katja; Esbensen, Qin Ying; Strand, Janne Maren; Stewart, James B.; Bjørås, Magnar & Eide, Lars (2014). Addressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age. PLoS ONE.  ISSN 1932-6203.  9(5) . doi: 10.1371/journal.pone.0096940
  • Yang, Mingyi; Luna, Linda; Sørbø, Jan Gunnar; Alseth, Ingrun; Johansen, Rune Forstrøm; Backe, Paul Hoff; Danbolt, Niels Christian; Eide, Lars & Bjørås, Magnar (2014). Human OXR1 maintains mitochondrial DNA integrity and counteracts hydrogen peroxide-induced oxidative stress by regulating antioxidant pathways involving p21. Free Radical Biology & Medicine.  ISSN 0891-5849.  77, s 41- 48 . doi: 10.1016/j.freeradbiomed.2014.09.003
  • Yuzefovych, Larysa V.; Schuler, A. Michele; Chen, Jemimah; Alvarez, Diego F.; Eide, Lars; Ledoux, Susan P.; Wilson, Glenn L. & Rachek, Lyudmila I. (2013). Alteration of Mitochondrial Function and Insulin Sensitivity in Primary Mouse Skeletal Muscle Cells Isolated From Transgenic and Knockout Mice: Role of OGG1. Endocrinology.  ISSN 0013-7227.  154(8), s 2640- 2649 . doi: 10.1210/en.2013-1076
  • Halsne, Ruth; Esbensen, Qin Ying; Wang, Wei; Scheffler, Katja; Suganthan, Rajikala; Bjørås, Magnar & Eide, Lars (2012). Lack of the DNA glycosylases MYH and OGG1 in the cancer prone double mutant mouse does not increase mitochondrial DNA mutagenesis. DNA Repair.  ISSN 1568-7864.  11(3), s 278- 285 . doi: 10.1016/j.dnarep.2011.12.001
  • Hereng, Tuva Holt; Elgstøen, Katja B. Prestø; Cederkvist, Fritjof Henning; Eide, Lars; Jahnsen, Tore; Skålhegg, Bjørn Steen & Rosendal, K.R (2011). Exogenous pyruvate accelerates glycolysis and promotes capacitation in human spermatozoa. Human Reproduction.  ISSN 0268-1161.  26(12), s 3249- 3263 . doi: 10.1093/humrep/der317
  • Kaarbø, Mari; Ager-Wick, Eirill; Osenbroch, Pia Madeleine Øistad; Kilander, Anette; Skinnes, Ragnhild; Müller, Fredrik & Eide, Lars (2011). Human cytomegalovirus infection increases mitochondrial biogenesis. Mitochondrion (Amsterdam. Print).  ISSN 1567-7249.  11(6), s 935- 945 . doi: 10.1016/j.mito.2011.08.008
  • Wang, Wei; Esbensen, Ying; Kunke, David; Suganthan, Rajikala; Rachek, Lyudmila; Bjørås, Magnar & Eide, Lars (2011). Mitochondrial DNA Damage Level Determines Neural Stem Cell Differentiation Fate. Journal of Neuroscience.  ISSN 0270-6474.  31(26), s 9746- 9751 . doi: 10.1523/JNEUROSCI.0852-11.2011
  • Brodtkorb, Else; Strand, Janne Maren; Backe, Paul Hoff; Lund, Anne Marie; Bjørås, Magnar; Rootwelt, Terje; Rootwelt, Helge; Woldseth, Berit & Eide, Lars (2010). Four novel mutations identified in Norwegian patients result in intermittent maple syrup urine disease when combined with the R301C mutation. Molecular Genetics and Metabolism.  ISSN 1096-7192.  100(4), s 324- 332 . doi: 10.1016/j.ymgme.2010.04.017
  • Lauritzen, Knut Husø; Moldestad, Olve; Eide, Lars; Carlsen, Harald; Nesse, Gaute; Storm, Johan Frederik; Mansuy, Isabelle M.; Bergersen, Linda Hildegard & Klungland, Arne (2010). Mitochondrial DNA Toxicity in Forebrain Neurons Causes Apoptosis, Neurodegeneration, and Impaired Behavior. Molecular and Cellular Biology.  ISSN 0270-7306.  30(6), s 1357- 1367 . doi: 10.1128/MCB.01149-09
  • Wang, Wei; Osenbroch, Pia Madeleine Øistad; Skinnes, Ragnhild; Esbensen, Qin Ying; Bjørås, Magnar & Eide, Lars (2010). Mitochondrial DNA Integrity Is Essential for Mitochondrial Maturation During Differentiation of Neural Stem Cells. Stem Cells.  ISSN 1066-5099.  28(12), s 2195- 2204 . doi: 10.1002/stem.542
  • Osenbroch, Pia Madeleine Øistad; Auk, Pia Nenseth; Halsne, Ruth; Strand, Janne Maren; Johansen, Rune Forstrøm; van der Pluijm, I & Eide, Lars (2009). Accumulation of mitochondrial DNA damage and bioenergetic dysfunction in CSB defective cells. The FEBS Journal.  ISSN 1742-464X.  276(10), s 2811- 2821 . doi: 10.1111/j.1742-4658.2009.07004.x
  • Sejersted, Yngve; Aasland, Anne Leikny; Bjørås, Magnar; Eide, Lars & Saugstad, Ola Didrik (2009). Accumulation of 8-Oxoguanine in Liver DNA During Hyperoxic Resuscitation of Newborn Mice. Pediatric Research.  ISSN 0031-3998.  66(5), s 533- 538 . doi: 10.1203/PDR.0b013e3181ba1a42
  • Yndestad, Arne; Neurauter, Christine Gran; Øie, Erik; Johansen, Rune Forstrøm; Vinge, Leif Erik; Eide, Lars; Luna, Gomez Luisa; Aukrust, Pål & Bjørås, Magnar (2009). Up-regulation of myocardial DNA base excision repair activities in experimental heart failure. Mutation research.  ISSN 0027-5107.  666(1-2), s 32- 38 . doi: 10.1016/j.mrfmmm.2009.03.008
  • Ringvoll, Jeanette; Uldal, Lene; Røed, Marie Aslaksen; Stenersen, Karen Oppland; Baynton, K; Klungland, Arne & Eide, Lars (2007). Mutations in the RAD27 and SGS1 genes differentially affect the chronological and replicative lifespan of yeast cells growing on glucose and glycerol. FEMS yeast research (Print).  ISSN 1567-1356.  7, s 848- 859 . doi: 10.1111/j.1567-1364.2007.00248.x
  • Eide, Lars & McMurray, Cynthia T. (2005). Culture of adult mouse neurons. BioTechniques.  ISSN 0736-6205.  38(1), s 99- 104
  • Trushina, E; Dyer, RB; Badger, JD; Ure, D; Eide, Lars; Tran, DD; Vrieze, BT; Legendre-Guillemin, V; McPherson, PS; Mandavilli, BS; Van Houten, B; Zeitlin, S; McNiven, M; Aebersold, R; Hayden, M; Parisi, JE; Seeberg, Erling Christen; Dragatsis, I; Doyle, K; Bender, A; Chacko, C & McMurray, CT (2004). Muntant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro. Molecular and Cellular Biology.  ISSN 0270-7306.  24, s 8195- 8209
  • Ulbert, S; Eide, Lars; Seeberg, Erling Christen & Borst, P. (2004). Base J, found in nuclear DNA of Trypanosoma brucei, is not a target for DNA glycosylases. DNA Repair.  ISSN 1568-7864.  3(2), s 145- 154

View all works in Cristin

  • Wang, Wei; Scheffler, Katja; Esbensen, Qin Ying & Eide, Lars (2016). Quantification of DNA Damage by Real-Time qPCR, In John M Walker (ed.),  Mitochondrial DNA Methods and Protocols.  Springer.  ISBN 978-1-4939-3039-5.  3.  s 27 - 32
  • Yuzefovych, Larysa V.; Kahn, Andrea G.; Schuler, Michele A.; Eide, Lars; Arora, Ritu; Wilson, Glenn L.; Tan, Ming & Rachek, Lyudmila I. (2016). Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis. Cancer Research.  ISSN 0008-5472.  76(1), s 30- 34 . doi: 10.1158/0008-5472.CAN-15-0692
  • Jackson, Catherine; Eidet, Jon Roger; Reppe, Sjur; Eide, Lars; Tønseth, Kim Aleksander; Bergersen, Linda Hildegard; Dartt, Darlene A.; Griffith, May & Utheim, Tor Paaske (2015). Storage of cultured skin cell sheets for treatment of limbal stem cell deficiency.
  • Jackson, Catherine; Eidet, Jon Roger; Tønseth, Kim Aleksander; Eide, Lars; Messelt, Edward B. & Utheim, Tor Paaske (2015). 12oC is the Optimal Storage Temperature for Retention of Viability and Undifferentiated Cell Character of Cultured Epidermal Cells.
  • Wang, Wei; Esbensen, Qin Ying; Scheffler, Katja & Eide, Lars (2015). Analysis of Mitochondrial DNA and RNA Integrity by a Real-Time qPCR-Based Method, In John M Walker (ed.),  Mitochondrial Medicine.  Springer.  ISBN 978-1-4939-2256-7.  10.  s 97 - 106
  • Distante, Sonia; Høie, Kari; Mørkrid, Lars & Eide, Lars (2013). ASSESSING THE MITOCHONDRIAL IRON METABOLISM IN HEREDITARY HEMOCHROMATOSIS. American Journal of Hematology.  ISSN 0361-8609.  88(5), s E207- E207
  • Halsne, Ruth & Eide, Lars (2011). Mitochondrial and cellular effects of mitochondrial DNA damage.
  • Osenbroch, Pia Madeleine Øistad & Eide, Lars (2011). Characterization of mitochondrial function in Cockayne syndrome, human cytomegalovirus infection and neural stem cell differentiation.
  • Bugge, Markus; Eide, Lars; Grünfeld, Leo A. & Thune, Taran Mari (2010). Brukerstyrte innovasjonsprosjekter og samfunnsøkonomisk avkastning.

View all works in Cristin

Published Apr 13, 2011 02:54 PM - Last modified Apr 5, 2016 02:45 PM