Tor Skomedal

Professor Emeritus - Department of Pharmacology
Image of Tor Skomedal
Norwegian version of this page
Phone +47-22840257
Fax +47-22840202
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Visiting address Sognsvannsveien 20 Rikshospitalet 0372 OSLO

Publications

  • Tvete, Ingunn Fride; Bjørner, Trine & Skomedal, Tor (2017). New benzodiazepine and Z-hypnotic users and disability pension: an eight-year nationwide observational follow-up study. . Scandinavian Journal of Primary Health Care.  ISSN 0281-3432. . doi: 10.1080/02813432.2017.1358436
  • Eikemo, Hilde; Moltzau, Lise Roman; Hussain, Rizwan; Nguyen, Hong Cam Thi; Qvigstad, Eirik; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2016). CaMKII in addition to MLCK contributes to phosphorylation of regulatory light chain in cardiomyocytes. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  471(1), s 219- 225 . doi: 10.1016/j.bbrc.2016.01.132
  • Eikemo, Hilde; Moltzau, Lise Roman; Nguyen, Hong Cam Thi; Levy, Finn Olav; Skomedal, Tor & Osnes, Jan-Bjørn (2016). CaMKII and at least two unidentified kinases phosphorylate regulatory light chain in non-contracting cardiomyocytes. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  477(1), s 14- 19 . doi: 10.1016/j.bbrc.2016.05.138
  • Tvete, Ingunn Fride; Bjørner, Trine & Skomedal, Tor (2016). A 5-year follow-up study of users of benzodiazepine: starting with diazepam versus oxazepam. British Journal of General Practice.  ISSN 0960-1643.  66(645), s e241- e247 . doi: 10.3399/bjgp16X684385
  • Tvete, Ingunn Fride; Bjørner, Trine & Skomedal, Tor (2015). Risk factors for excessive benzodiazepine use in a working age population – a nationwide 5-year survey in Norway. Scandinavian Journal of Primary Health Care.  ISSN 0281-3432.  33(4), s 252- 259 . doi: 10.3109/02813432.2015.1117282
  • Ørstavik, Øivind; Manfra, Ornella; Andressen, Kjetil Wessel; Andersen, Geir Øystein; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Krobert, Kurt Allen (2015). The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium. PLoS ONE.  ISSN 1932-6203.  10(3) . doi: 10.1371/journal.pone.0115547 Full text in Research Archive
  • Bach, Trond; Bergholtz, Stine Louise; Riise, Jon; Qvigstad, Eirik; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2014). Identification of small molecule NPR-B antagonists by high throughput screening - potential use in heart failure. Naunyn-Schmiedeberg's Archives of Pharmacology.  ISSN 0028-1298.  387(1), s 5- 14 . doi: 10.1007/s00210-013-0940-6
  • Melsom, Elin Maria Caroline Bull; Hussain, Rizwan; Ørstavik, Øivind; Aronsen, Jan Magnus; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Krobert, Kurt Allen (2014). Non-classical regulation of β1- and β2 adrenoceptor- mediated inotropic responses in rat ventricle by the G protein Gi. Naunyn-Schmiedeberg's Archives of Pharmacology.  ISSN 0028-1298.  387(12), s 1177- 1186 . doi: 10.1007/s00210-014-1036-7
  • Melsom, Elin Maria Caroline Bull; Ørstavik, Øivind; Osnes, Jan-Bjørn; Skomedal, Tor; Levy, Finn Olav & Krobert, Kurt Allen (2014). Gi proteins regulate adenylyl cyclase activity independent of receptor activation. PLoS Medicine.  ISSN 1549-1277.  9:e0106608(9) . doi: 10.1371/journal.pone.0106608 Full text in Research Archive
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Skogestad, Jonas; Ørstavik, Øivind; Lothe, Gustav B; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2014). Different compartmentation of responses to brain natriuretic peptide and C-type natriuretic peptide in failing rat ventricle. Journal of Pharmacology and Experimental Therapeutics.  ISSN 0022-3565. . doi: 10.1124/jpet.114.214882
  • Moltzau, Lise Roman; Meier, Silja; Aronsen, Jan Magnus; Afzal, Faraz; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2014). Differential regulation of C-type natriuretic peptide-induced cGMP and functional responses by PDE2 and PDE3 in failing myocardium. Naunyn-Schmiedeberg's Archives of Pharmacology.  ISSN 0028-1298.  387(5), s 407- 417 . doi: 10.1007/s00210-013-0953-1
  • Ørstavik, Øivind; Ata, Salmana H; Riise, Jon; Dahl, Christen Peder; Andersen, Geir Øystein; Levy, Finn Olav; Skomedal, Tor; Osnes, Jan-Bjørn & Qvigstad, Eirik (2014). Inhibition of phosphodiesterase-3 by levosimendan is sufficient to account for its inotropic effect in failing human heart. British Journal of Pharmacology.  ISSN 0007-1188.  171(23), s 5169- 5181 . doi: 10.1111/bph.12647
  • Bjørner, Trine; Tvete, Ingunn Fride; Aursnes, Ivar & Skomedal, Tor (2013). Utlevering av benzodiazepiner og z-hypnotika fra norske apotek 2004-2011. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  133(20), s 2149- 2153 . doi: 10.4045/tidsskr.11.0543
  • Gravning, Jørgen A.; Ahmed, Muhammad Shakil; Qvigstad, Eirik; Krobert, Kurt Allen; Edvardsen, Thor; Moe, Ingvild Tronstad; Hagelin, Else Marie Valbjørn; Sagave, Julia Fritzi; Valen, Guro; Levy, Finn Olav; Osnes, Jan-Bjørn; Skomedal, Tor & Attramadal, Håvard (2013). Connective Tissue Growth Factor/CCN2 Attenuates beta-Adrenergic Receptor Responsiveness and Cardiotoxicity by Induction of G Protein-Coupled Receptor Kinase-5 in Cardiomyocytes. Molecular Pharmacology.  ISSN 0026-895X.  84(3), s 372- 383 . doi: 10.1124/mol.113.087312
  • Hussain, Rizwan; Aronsen, Jan Magnus; Afzal, Faraz; Sjaastad, Ivar; Osnes, Jan-Bjørn; Skomedal, Tor; Levy, Finn Olav & Krobert, Kurt Allen (2013). The functional activity of inhibitory G protein (Gi) is not increased in failing heart ventricle. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  56, s 129- 138 . doi: 10.1016/j.yjmcc.2012.11.015
  • Lei, Peng; Baysa, Anton; Nebb, Hilde Irene; Valen, Guro; Skomedal, Tor; Osnes, Jan-Bjørn; Yang, Zaiqing & Haugen, Fred (2013). Activation of liver X receptors in the heart leads to accumulation of intracellular lipids and attenuation of ischemia-reperfusion injury. Basic Research in Cardiology.  ISSN 0300-8428.  108 . doi: 10.1007/s00395-012-0323-z
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Nguyen, Hong Cam Thi; Hougen, Karina; Ørstavik, Øivind; Sjaastad, Ivar; Christensen, Geir Arve; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2013). SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium. British Journal of Pharmacology.  ISSN 0007-1188.  170(2), s 366- 379 . doi: 10.1111/bph.12282
  • Tvete, Ingunn Fride; Bjørner, Trine; Aursnes, Ivar & Skomedal, Tor (2013). A 3-year survey quantifying the risk of dose escalation of benzodiazepines and congeners to identify risk factors to aid doctors to more rationale prescribing. BMJ Open.  ISSN 2044-6055.  3(10) . doi: 10.1136/bmjopen-2013-003296
  • Brattelid, Trond; Qvigstad, Eirik; Moltzau, Lise Roman; Bekkevold, Silje Veslemøy; Sandnes, Dagny Lise; Birkeland, Jon Arne; Skomedal, Tor; Osnes, Jan-Bjørn; Sjaastad, Ivar & Levy, Finn Olav (2012). The Cardiac Ventricular 5-HT4 Receptor Is Functional in Late Foetal Development and Is Reactivated in Heart Failure. PLoS ONE.  ISSN 1932-6203.  7(9) . doi: 10.1371/journal.pone.0045489 Full text in Research Archive
  • Riise, Jon; Nguyen, Hong Cam Thi; Hussain, Rizwan; Dahl, Christen Peder; Ege, Maren Stapnes; Osnes, Jan-Bjørn; Skomedal, Tor; Sandnes, Dagny Lise; Levy, Finn Olav & Krobert, Kurt Allen (2012). Prostanoid-mediated inotropic responses are attenuated in failing human and rat ventricular myocardium. European Journal of Pharmacology.  ISSN 0014-2999.  686(1-3), s 66- 73 . doi: 10.1016/j.ejphar.2012.04.022
  • Riise, Jon; Ørstavik, Øivind; Qvigstad, Eirik; Dahl, Christen Peder; Osnes, Jan-Bjørn; Skomedal, Tor; Levy, Finn Olav & Krobert, Kurt Allen (2012). Prostaglandin E-1 facilitates inotropic effects of 5-HT4 serotonin receptors and beta-adrenoceptors in failing human heart. Basic Research in Cardiology.  ISSN 0300-8428.  107(5) . doi: 10.1007/s00395-012-0295-z
  • Afzal, Faraz; Aronsen, Jan Magnus; Moltzau, Lise Roman; Sjaastad, Ivar; Levy, Finn Olav; Skomedal, Tor; Osnes, Jan-Bjørn & Qvigstad, Eirik (2011). Differential regulation of beta(2)-adrenoceptor-mediated inotropic and lusitropic response by PDE3 and PDE4 in failing and non-failing rat cardiac ventricle. British Journal of Pharmacology.  ISSN 0007-1188.  162(1), s 54- 71 . doi: 10.1111/j.1476-5381.2010.00890.x
  • Afzal, Faraz; Qvigstad, Eirik; Aronsen, Jan Magnus; Moltzau, Lise Roman; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2011). Agents increasing cyclic GMP amplify 5-HT4-elicited positive inotropic response in failing rat cardiac ventricle. Naunyn-Schmiedeberg's Archives of Pharmacology.  ISSN 0028-1298.  384(6), s 543- 553 . doi: 10.1007/s00210-011-0670-6
  • Hussain, Rizwan; Afzal, Faraz; Mørk, Halvor Kjeang; Aronsen, Jan Magnus; Sjaastad, Ivar; Osnes, Jan-Bjørn; Skomedal, Tor; Levy, Finn Olav & Krobert, Kurt Allen (2011). Cyclic AMP-dependent inotropic effects are differentially regulated by muscarinic G(i)-dependent constitutive inhibition of adenylyl cyclase in failing rat ventricle. British Journal of Pharmacology.  ISSN 0007-1188.  162(4), s 908- 916 . doi: 10.1111/j.1476-5381.2010.01097.x
  • Klemp, Marianne; Tvete, Ingunn Fride; Skomedal, Tor; Gåsemyr, Jørund Inge; Natvig, Bent & Aursnes, Ivar (2011). A Review and Bayesian Meta-Analysis of Clinical Efficacy and Adverse Effects of 4 Atypical Neuroleptic Drugs Compared With Haloperidol and Placebo. Journal of Clinical Psychopharmacology.  ISSN 0271-0749.  31(6), s 698- 704 . doi: 10.1097/JCP.0b013e31823657d9
  • Qvigstad, Eirik; Moltzau, Lise Roman; Aronsen, Jan Magnus; Nguyen, Hong Cam Thi; Hougen, Karina; Sjaastad, Ivar; Levy, Finn Olav; Skomedal, Tor & Osnes, Jan-Bjørn (2010). Natriuretic peptides increase beta(1)-adrenoceptor signalling in failing hearts through phosphodiesterase 3 inhibition. Cardiovascular Research.  ISSN 0008-6363.  85(4), s 763- 772 . doi: 10.1093/cvr/cvp364
  • Ansteinsson, V; Refsnes, Magne; Skomedal, T; Osnes, JB; Schiander, I; Gutowska-Schiander, Iwona & Låg, Marit (2009). Zinc- and copper-induced interleukin-6 release in primary cell cultures from rat heart. Cardiovascular Toxicology.  ISSN 1530-7905.  9(2), s 86- 94 . doi: 10.1007/s12012-009-9043-5
  • Hussain, RI; Qvigstad, Eirik; Birkeland, Jon Arne; Eikemo, Hilde; Glende, A; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Krobert, Kurt Allen (2009). Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation. British Journal of Pharmacology.  ISSN 0007-1188.  156(4), s 575- 586 . doi: 10.1111/j.1476-5381.2009.00016.x
  • Kjekshus, John; Torp-Pedersen, C; Gullestad, Lars; Kober, L; Edvardsen, Thor; Olsen, IC; Sjaastad, Ivar; Qvigstad, Eirik; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2009). Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure. European Journal of Heart Failure.  ISSN 1388-9842.  11(8), s 771- 778 . doi: 10.1093/eurjhf/hfp087
  • Afzal, Faraz; Andressen, Kjetil Wessel; Mørk, Halvor Kjeang; Aronsen, Jan Magnus; Sjaastad, Ivar; Dahl, Christen Peder; Skomedal, Tor; Levy, Finn Olav; Osnes, Jan-Bjørn & Qvigstad, Eirik (2008). 5-HT4-elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricles. British Journal of Pharmacology.  ISSN 0007-1188.  155(7), s 1005- 1014 . doi: 10.1038/bjp.2008.339
  • Levy, Finn Olav; Qvigstad, Eirik; Krobert, Kurt Allen; Skomedal, Tor & Osnes, Jan-Bjørn (2008). Effects of serotonin in failing cardiac ventricle: Signalling mechanisms and potential therapeutic implications. Neuropharmacology.  ISSN 0028-3908.  55(6), s 1066- 1071 . doi: 10.1016/j.neuropharm.2008.07.010
  • Riise, J; Nguyen, Hong Cam Thi; Qvigstad, Eirik; Sandnes, Dagny Lise; Osnes, Jan-Bjørn; Skomedal, Tor; Levy, Finn Olav & Krobert, Kurt Allen (2008). Prostanoid F receptors elicit an inotropic effect in rat left ventricle by enhancing myosin light chain phosphorylation. Cardiovascular Research.  ISSN 0008-6363.  80(3), s 407- 415 . doi: 10.1093/cvr/cvn216
  • Totlandsdal, Annike Irene; Refsnes, Magne; Skomedal, Tor; Osnes, Jan-Bjørn; Schwarze, Per E & Låg, Marit (2008). Particle-induced cytokine responses in cardiac cell cultures-the effect of particles versus soluble mediators released by particle-exposed lung cells. Toxicological Sciences.  ISSN 1096-6080.  106(1), s 233- 241 . doi: 10.1093/toxsci/kfn162
  • Totlandsdal, Annike Irene; Skomedal, Tor; Låg, Marit; Osnes, Jan-Bjørn & Refsnes, Magne (2008). Pro-inflammatory potential of ultrafine particles in mono- and co-cultures of primary cardiac cells. Toxicology.  ISSN 0300-483X.  247(1), s 23- 32 . doi: 10.1016/j.tox.2008.01.019
  • Vinge, Leif Erik; von Lueder, Thomas Gero; Aasum, E; Qvigstad, Eirik; Gravning, Jørgen Amundsen; How, OJ; Edvardsen, Thor; Bjornerheim, Reidar; Ahmed, Muhammad Shakil; Mikkelsen, Birthe Viftrup; Oie, E; Attramadal, T.; Skomedal, Tor; Smiseth, Otto A.; Koch, WJ; Larsen, TS & Attramadal, Håvard (2008). Cardiac-restricted expression of the carboxyl-terminal fragment of GRK3 uncovers distinct functions of GRK3 in regulation of cardiac contractility and growth - GRK3 controls cardiac alpha(1)-adrenergic receptor responsiveness. Journal of Biological Chemistry.  ISSN 0021-9258.  283 . doi: 10.1074/jbc.M708912200
  • Birkeland, Jon Arne; Sjaastad, Ivar; Brattelid, Trond; Qvigstad, Eirik; Moberg, Enrica Ratti; Krobert, Kurt Allen; Bjørnerheim, Reidar; Skomedal, Tor; Sejersted, Ole M; Osnes, Jan-Bjørn & Levy, Finn Olav (2007). Effects of treatment with a 5-HT4 receptor antagonist in heart failure. British Journal of Pharmacology.  ISSN 0007-1188.  150, s 143- 152 . doi: 10.1038/sj.bjp.0706966
  • Brattelid, Trond; Qvigstad, E; Birkeland, Jan Magne; Birkeland, Jon Arne; Swift, F; Bekkevold, SVS; Krobert, KA; Sejersted, Ole M.; Skomedal, T; Osnes, JB; Levy, F. & Sjaastad, I (2007). Serotonin responsiveness through 5-HT2A and 5-HT4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  43, s 767- 779 . doi: 10.1016/j.yjmcc.2007.08.019
  • Brattelid, Trond; Tveit, Kristine; Birkeland, Jon Arne; Sjaastad, Ivar; Qvigstad, Eirik; Krobert, Kurt Allen; Rizwan, Hussain; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2007). Expression of mRNA encoding G protein-coupled receptors involved in congestive heart failure : A quantitative RT-PCR study and the question of normalisation. Basic Research in Cardiology.  ISSN 0300-8428.  102, s 198- 208 . doi: 10.1007/s00395-007-0648-1
  • Skomedal, Tor & Osnes, Jan-Bjørn (2007). Endring av anbefalt terapeutisk serumkonsentrasjonsområde for digoksin og digitoksin. Hjerteforum.  ISSN 0802-1465.  20(4), s 27- 31
  • Vinge, Leif Erik; Andressen, Kjetil Wessel; Attramadal, Toril; Andersen, Geir Øystein; Ahmed, Muhammad Shakil; Peppel, K; Koch, WJ; Freedman, NJ; Levy, Finn Olav; Skomedal, Tor; Osnes, Jan-Bjørn & Attramadal, Håvard (2007). Substrate specificities of G protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function. Molecular Pharmacology.  ISSN 0026-895X.  72, s 582- 591
  • Andersen, Geir Øystein; Øie, Erik; Vinge, Leif Erik; Yndestad, Arne; Attramadal, Håvard; Skomedal, Tor & Osnes, Jan-Bjørn (2006). Increased expression and function of the myocardial Na-K-2Cl cotransporter in failing rat hearts. Basic Research in Cardiology.  ISSN 0300-8428.  101(6), s 471- 478
  • Qvigstad, Eirik; Brattelid, Trond; Sjaastad, Ivar; Molenaar, P.; Birkeland, Jon Arne; Andressen, Kjetil Wessel; Krobert, Kurt Allen; Sejersted, Ole M; Skomedal, Tor; Osnes, Jan-Bjørn; Kaumann, Alberto Julio & Levy, Finn Olav (2005). Rationale for treatment of heart failure by blockade of ventricular serotonin receptors appearing in heart failure , In  Proceedings of the 25th European Section Meeting, International Society for Heart Research, Tromsø, Norway, June 21-25, 2005.  Medimond.  ISBN 88-7587-164-7.  Invited Lectures.  s 7 - 12
  • Qvigstad, Eirik; Sjaastad, I; Bøkenes, Janny; Schiander, Iwona; Solberg, Line; Sejersted, Ole M; Osnes, Jan-Bjørn & Skomedal, Tor (2005). Carvedilol blockade of alpha(1)- and beta-adrenoceptor induced inotropic responses in rats with congestive heart failure. European Journal of Pharmacology.  ISSN 0014-2999.  516, s 51- 59
  • Øie, Erik; Vinge, Leif Erik; Andersen, Geir Øystein; Yndestad, Arne; Krobert, Kurt Allen; Sandberg, Cecilie; Ahmed, Muhammad Shakil; Haug, Terje; Levy, Finn Olav; Skomedal, Tor & Attramadal, Håvard (2005). RAMP2 and RAMP3 rnRNA levels are increased in failing rat cardiomyocytes and associated with increased responsiveness to adrenomedullin. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  38, s 145- 151
  • Kemi, Ole Johan; Haram, Per Magnus; Loennechen, Jan Pål; Osnes, Jan-Bjørn; Skomedal, Tor; Wisloff, U; Wisløff, Ulrik; Ellingsen, O & Ellingsen, Øyvind (2005). Moderate vs. high exercise intensity: Differential effects on aerobic fitness, cardiomyocyte contractility, and endothelial function. Cardiovascular Research.  ISSN 0008-6363.  67, s 161- 172
  • Qvigstad, Eirik; Brattelid, Trond; Sjaastad, Ivar; Andressen, Kjetil Wessel; Krobert, Kurt Allen; Birkeland, Jon Arne; Sejersted, Ole M; Kaumann, Alberto Julio; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2005). Appearance of a ventricular 5-HT4 receptor-mediated inotropic response to serotonin in heart failure . Cardiovascular Research.  ISSN 0008-6363.  65

View all works in Cristin

  • Tvete, Ingunn Fride; Bjørner, Trine & Skomedal, Tor (2016). Nye brukere av benzodiazepiner og Z-hypnotika og uførhet.
  • Marshall, Serena; Aronsen, Jan Magnus; Skogestad, Jonas; Albert, Ingrid; Lothe, Gustav B; Lunde, Per Kristian; Monteresi, Stefania; Moltzau, Lise Roman; Qvigstad, Eirik; Skomedal, Tor; Zaccolo, Manuela; Carlson, Cathrine Rein & Sjaastad, Ivar (2015). Dual PDE3A coupling to AKAP18 and SERCA2 Controls SERCA2 Activity in adult cardiomyocytes.
  • Meier, Silja; Andressen, Kjetil Wessel; Aronsen, Jan Magnus; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Qvigstad, Eirik; Levy, Finn Olav & Moltzau, Lise Roman (2015). Enhancement of cAMP-mediated inotropic responses by CNP is regulated differently by PDE2 in normal and failing hearts. BMC Pharmacology & Toxicology.  ISSN 2050-6511.  16, s A66- A66 . doi: 10.1186/2050-6511-16-S1-A66
  • Tvete, Ingunn Fride; Bjørner, Trine & Skomedal, Tor (2015). Benzodiazepinbruk over tid og risiko for doseeskalering: å starte med diazepam versus oxazepam.
  • Tvete, Ingunn Fride; Bjørner, Trine & Skomedal, Tor (2015). Differences in starting with diazepam versus oxazepam: a five year follow-up prescription registry study.
  • Tvete, Ingunn Fride; Bjørner, Trine & Skomedal, Tor (2015). Long-term benzodiazepine use and risk factors for dose escalation.
  • Tvete, Ingunn Fride; Bjørner, Trine & Skomedal, Tor (2015). Risiko for å utvikle et høyt benzodiazepinforbruk.
  • Tvete, Ingunn Fride; Bjørner, Trine & Skomedal, Tor (2015). Risiko for å utvikle et høyt benzodiazepinforbruk over tid.
  • Meier, Silja; Moltzau, Lise Roman; Aronsen, Jan Magnus; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Qvigstad, Eric & Levy, Finn Olav (2014). Enhancement of B1 - adrenoceptor signaling by CNP through NPR-B and regulation by phosphodiesterases in normal and failing hearts.
  • Tvete, Ingunn Fride; Bjørner, Trine & Skomedal, Tor (2014). Benzodiazepine drug dispensing and risk of abuse.
  • Tvete, Ingunn Fride; Bjørner, Trine & Skomedal, Tor (2014). Bruk av benzodiazepiner og risikofaktorer for overforbruk.
  • Tvete, Ingunn Fride; Bjørner, Trine & Skomedal, Tor (2014). Risk of excessive Benzodiazepine redeeming over time -a nationwide observational study.
  • Tvete, Ingunn Fride; Gåsemyr, Jørund Inge; Natvig, Bent; Meland, Nils; Marianne, Roine; Skomedal, Tor & Klemp, Marianne (2014). A Mixed Treatment Comparison analysis of drugs for treating patients with Rheumatoid arthritis.
  • Tvete, Ingunn Fride; Natvig, Bent; Gåsemyr, Jørund Inge; Meland, Nils; Røine, Marianne; Skomedal, Tor & Klemp, Marianne (2014). Treating patients with Rheumatoid arthritis: a Mixed Treatment Comparison analysis of anti-TNF drug effects.
  • Aronsen, Jan Magnus; Hougen, Karina; Skogestad, Jonas; Lunde, Marianne; Enger, Ulla Helene; Moltzau, Lise Roman; Qvigstad, Eirik; Skomedal, Tor; Tasken, Kjetil; Carlson, Cathrine Rein & Sjaastad, Ivar (2013). PDE3A is part of the SERCA2-AKAP18 macromolecular complex in cardiomyocytes.
  • Skomedal, Tor; Hanem, Sigrid; Dybvik, Terje & Ilner, Stein Opjordsmoen (2013). Olanzapin depot kan gi en tilstand som er forenlig med sentralt antikolinergt syndrom. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  133(21), s 2238- 2239
  • Tvete, Ingunn Fride; Bjørner, Trine; Aursnes, Ivar & Skomedal, Tor (2013). Bruk av benzodiazepiner og risiko for doseeskalering.
  • Tvete, Ingunn Fride; Bjørner, Trine & Skomedal, Tor (2013). Benzodiazepinbruk i Norge over tid.
  • Tvete, Ingunn Fride; Bjørner, Trine; Skomedal, Tor & Aursnes, Ivar (2013). En flerårig studie av benzodiazepinbruk i Norge - risikofaktorer for doseøkning.
  • Tvete, Ingunn Fride; Klemp, Marianne; Natvig, Bent; Gåsemyr, Jørund Inge; Skomedal, Tor; Roine, Marianne & Meland, Nils (2013). Multiple treatment comparison analysis.
  • Aronsen, Jan Magnus; Aronsen, Jan Magnus; Hougen, Karina; Skogestad, Jonas; Enger, Ulla Helene; Moltzau, Lise Roman; Qvigstad, Erik; Skomedal, Tor; Tasken, Kjetil; Carlson, Cathrine Rein & Sjaastad, Ivar (2012). PDE3A is part of the SERCA2-AKAP18 macromolecular complex in cardiomyocytes.
  • Hougen, Karina; Aronsen, Jan Magnus; Skogestad, Jonas; Enger, Ulla Helene; Moltzau, Lise Roman; Qvigstad, Eirik; Skomedal, Tor; Tasken, Kjetil; Carlson, Cathrine Rein & Sjaastad, Ivar (2012). PDE3A is part of the SERCA2-AKAP18delta macromolecular complex in cardiomyocytes.
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2012). NPR-A and NPR-B signal in different functional compartments in failing rat left ventricle. Cardiovascular Research.  ISSN 0008-6363.  93, s S18- S18 . doi: 10.1093/cvr/cvr332
  • Tvete, Ingunn Fride; Bjørner, Trine; Skomedal, Tor & Aursnes, Ivar (2012). Dose Escalation of Benzodiazepines and Congeners.
  • Meier, Silja; Aronsen, Jan Magnus; Sjaastad, Ivar; Levy, Finn Olav; Skomedal, Tor; Osnes, Jan-Bjørn & Qvigstad, Eirik (2011). Enhancement of B1-adrenoceptor signaling by C-type natriuretic peptide through natriuretic peptide receptor B in normal and failing hearts: regulation by phosphodiesterases.
  • Melsom, CB; Hussain, Rizwan; Aronsen, Jan Magnus; Sjaastad, Ivar; Osnes, Jan-Bjørn; Skomedal, Tor; Levy, Finn Olav & Krobert, Kurt Allen (2011). The role of inhibitory G protein upon beta-adrenoceptor-mediated signalling and inotropic responses in normal and failing rat heart left ventricle: Functional evidence of "tonic" Gi activation.
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Nguyen, Cam; Christensen, Geir Arve; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2011). The mechanism of CNP-induced negative inotropic and positive lusitropic responses are dependent on SERCA activity in failing rat ventricle.
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Nguyen, Cam; Christensen, Geir Arve; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2011). The negative inotropic and positive lusitropic responses to CNP are dependent on SERCA2 activity in failing rat ventricle.
  • Meier, Silja; Aronsen, Jan Magnus; Levy, Finn Olav; Skomedal, Tor; Osnes, Jan-Bjørn & Qvigstad, Eirik (2010). C-type natriuretic peptide signalling through NPR-B enhances the B1-AR signalling both in non-failing and failing rat hearts.
  • Meier, Silja; Levy, Finn Olav; Skomedal, Tor; Qvigstad, Eirik & Osnes, Jan-Bjørn (2010). Cardiac tissue hypothyroidism and receptor functions in heart failure.
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Nguyen, Hong Cam Thi; Afzal, Faraz; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2010). Compartmentation of the cGMP signal causes differential functional responses after CNP and BNP stimulation in failing myocardium.
  • Qvigstad, Eirik; Afzal, Faraz; Aronsen, Jan Magnus; Moltzau, Lise Roman; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2010). The NO/cyclic GMP signalling pathway differentially affects 5-HT4 - and B1-AR mediated inotropic responses in failing ventricle.
  • Tvete, Ingunn Fride; Klemp, Marianne; Skomedal, Tor; Gaasemyr, Jørund; Natvig, Bent & Aursnes, Ivar Andreas (2010). Clinical efficacy and adverse effects of several antipsychotics.
  • Tvete, Ingunn Fride; Klemp, Marianne; Skomedal, Tor; Gaasemyr, Jørund; Natvig, Bent & Aursnes, Ivar Andreas (2010). Clinical efficacy and adverse effects of the partial dopaminergic agonist aripiprazole compared with other antipsychotics.
  • Afzal, Faraz; Aronsen, Jon magnus; Moltzau, Lise Roman; Sjaastad, Ivar; Levy, Finn Olav; Skomedal, Tor; Osnes, Jan-Bjørn & Qvigstad, Eirik (2009). Differential regulation of b2-adrenoceptor-mediated responses by PDE3 and PDE4 in failing and non-failing rat myocardium.
  • Gravning, Jørgen A.; Ahmed, Muhammad Shakil; Qvigstad, Eirik; Sagave, Julia Fritzi; Krobert, Kurt Allen; Edvardsen, Thor; Valen, Guro; Skomedal, Tor; Osnes, Jan-Bjørn & Attramadal, Håvard (2009). CCN2/CTGF - Connective Tissue Growth Factor - Reduces beta-Adrenergic Receptor Responsiveness and Catecholamine-Induced Cardiotoxicity by Upregulation of Cardiac Myocyte G Protein-Coupled Receptor Kinase-5. Circulation.  ISSN 0009-7322.  120(18), s S720- S720
  • Klemp, Marianne; Tvete, Ingunn Fride; Skomedal, Tor; Gaasemyr, Jørund; Natvig, Bent & Aursnes, Ivar Andreas (2009). BAYESIAN STATISTICAL APPROACH FOR COMPARING THE CLINICAL EFFICACY OF THE PARTIAL DOPAMINERGIC AGONIST ARIPIPRAZOLE TO OTHER ANTIPSYCHOTICS.
  • Krobert, Kurt Allen; Hussain, Rizwan; Afzal, Faraz; Aronsen, Jon magnus; Sjaastad, Ivar; Osnes, Jan-Bjørn; Skomedal, Tor & Levy, Finn Olav (2009). Inreased Gi activity does not contribute to the reduced beta-adrenergic inotropic effect in failing rat ventricle but Gi acts as a tonic brake on basal adenylyl cyclase activity.
  • Eikemo, Hilde; Nguyen, Hong Cam Thi; Levy, Finn Olav; Skomedal, Tor & Osnes, Jan-Bjørn (2008). Evidence for an unidentified kinase activity phosphorylating myosin light chain-2 in quiescent cardiomyocytes. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  44, s 782- 782 . doi: 10.1016/j.yjmcc.2008.02.170
  • Eikemo, Hilde; Skomedal, Tor; Levy, Finn Olav & Osnes, Jan-Bjørn (2008). Calculating reaction rate constants and estimating the efficacy of selective enzyme inhibitors. Analytical Biochemistry.  ISSN 0003-2697.  383(2), s 323- 325 . doi: 10.1016/j.ab.2008.09.011
  • Gravning, Jørgen Amundsen; Ahmed, Muhammad Shakil; Qvigstad, Erik; Sagave, Julia Fritzi; Krobert, Kurt Allen; Edvardsen, Thor; Valen, Guro; Skomedal, Tor; Osnes, Jan-Bjørn & Attramadal, Håvard (2008). Connective tissue growth factor (CTGF/CCN2) desensitizes myocardial beta-adrenergic receptor signaling and inhibits isoproterenol induced hypertrophy.
  • Kjekshus, John; Edvardsen, Thor; Gullestad, Lars; Koeber, L; Osnes, Jan-Bjørn; Qvigstad, Erik; Sjaastad, Ivar; Skomedal, Tor; Torp-Pedersen, C & Levy, Finn Olav (2008). The effect of Piboserod a 5-HT4-receptor antagonist on left ventricular function in patients with symptomatic heart failure.
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Nguyen, Hong Cam Thi; Sjaastad, Ivar; Afzal, Faraz; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2008). Phospodiesterases regulating the negative inotropic response of C-type natriuretic peptide in heart failure. Fundamental & Clinical Pharmacology.  ISSN 0767-3981.  22, s 17- 17
  • Afzal, Faraz; Andressen, Kjetil Wessel; Mørk, Halvor Kjeang; Aronsen, Jon magnus; Moltzau, Lise Roman; Sjaastad, Ivar; Skomedal, Tor; Levy, Finn Olav; Osnes, Jan-Bjørn & Qvigstad, Eirik (2007). 5-HT4-mediated positive inotropic effect is regulated by phosphodiesterase 3 in failing rat heart and human ventricle. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  42(6), s S152- S152
  • Aronsen, Jon magnus; Qvigstad, Eirik; Hougen, Karina; Birkeland, Jon Arne; Levy, Finn Olav; Osnes, Jan-Bjørn; Andersson, Kristin Brevik; Christensen, Geir Arve; Sejersted, Ole M; Skomedal, Tor & Sjaastad, Ivar (2007). Role of alpha-1-adrenergic signallling in Serca2 knockout mice.
  • Krobert, Kurt Allen; Hussain, Rizwan; Mørk, Halvor Kjeang; Qvigstad, Eirik; Sjaastad, Ivar; Osnes, Jan-Bjørn; Skomedal, Tor & Levy, Finn Olav (2007). cAMP-dependent inotropic effects are differentially regulated by muscarinic inhibition in failing rat ventricle. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  42(6), s S35- S35
  • Birkeland, Jon Arne; Sjaastad, Ivar; Brattelid, Trond; Qvigstad, Eirik; Moberg, Enrica Ratti; Krobert, Kurt Allen; Bjørnerheim, Reidar; Skomedal, Tor; Sejersted, Ole M; Osnes, Jan-Bjørn & Levy, Finn Olav (2006). Treatment with a 5-HT4 serotonin receptor antagonist improves function of the failing heart. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  40, s 943- 944
  • Birkeland, Jon Arne; Sjaastad, Ivar; Brattelid, Trond; Qvigstad, Eirik; Moberg, Enrica Ratti; Krobert, Kurt Allen; Bjørnerheim, Reidar; Skomedal, Tor; Sejersted, Ole M; Osnes, Jan-Bjørn & Levy, Finn Olav (2006). Treatment with a 5-HT4 serotonin receptor antagonist improves function of the failing heart. Journal of Pharmacological Sciences.  ISSN 1347-8613.  101, s 75- 75
  • Brattelid, Trond; Qvigstad, Eirik; Birkeland, Jon Arne; Swift, Fredrik; Bekkevold, Silje Veslemøy; Krobert, Kurt Allen; Sejersted, Ole M; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Sjaastad, Ivar (2006). Serotonin responsiveness through 5-HT2A and 5-HT4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle. Journal of Pharmacological Sciences.  ISSN 1347-8613.  101, s 74- 74
  • Brattelid, Trond; Qvigstad, Eirik; Birkeland, Jon Arne; Swift, Fredrik; Bekkevold, SVS; Krobert, Kurt Allen; Sejersted, Ole M; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Sjaastad, Ivar (2006). Serotonin responsiveness through 5-HT2A and 5-HT4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  40, s 944- 945
  • Eikemo, Hilde; Qvigstad, Eirik; Krobert, Kurt Allen; Nunn, Caroline; Levy, Finn Olav; Skomedal, Tor & Osnes, Jan-Bjørn (2006). Kinetics of myosin light chain phosphorylation in the heart. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  40, s 994- 995
  • Qvigstad, Eirik; Sjaastad, Ivar; Brattelid, Trond; Nunn, Caroline; Swift, Fredrik; Birkeland, Jon Arne; Krobert, Kurt Allen; Andersen, Geir Øystein; Sejersted, Ole M; Osnes, Jan-Bjørn; Levy, Finn Olav & Skomedal, Tor (2006). Induction of functional serotonin 5-HT2A and 5-HT4 receptors in the acute failing cardiac ventricle. Journal of Pharmacological Sciences.  ISSN 1347-8613.  101, s 73- 73
  • Birkeland, Jon Arne; Qvigstad, Eirik; Sjaastad, Ivar; Brattelid, Trond; Krobert, Kurt Allen; Sejersted, Ole M; Ferrier, GR; Louch, W; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2005). Induction of a 5-HT4 receptor-mediated inotropic response to serotonin in failing ventricular cardiomyocytes. Biophysical Journal.  ISSN 0006-3495.  88
  • Qvigstad, Eirik; Birkeland, Jon Arne; Sjaastad, Ivar; Brattelid, Trond; Andressen, Kjetil Wessel; Krobert, Kurt Allen; Bjornerheim, Reidar; Sejersted, Ole M; Kaumann, Alberto Julio; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2005). Treatment of heart failure by blockade of ventricular myocardial serotonin receptors appearing in heart failure. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  38, s 1041- 1041

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Published Apr. 13, 2011 2:55 PM - Last modified May 27, 2011 4:10 PM