Research at K.G. Jebsen Centre for Cancer Immunotherapy

A Translational Program for the Development of New Strategies for Immunotherapy Against Cancer

An outstanding challenge in immunotherapy of cancer is to overcome self-tolerance. Research by members of the K.G. Jebsen Center for Cancer Immunotherapy outlines several new strategies for immunotherapy that circumvent immunological tolerance. Three principally distinct approaches will be further developed in the center in an interdisciplinary and translational  program divided into six major work packages.

Work packages

  1. Target identification: Antibody and Protein Arrays
  2. Generation of tumor specific T-cells: Culture/Isolation of specific T-cells
  3. TCR: Molecular cloning/engineering of TCR
  4. Enhancement of T-cell function: Selective suppression of Tregs and Overcoming Inihibition
  5. Validation: In Vitro and Animal Models
  6. Translation: Clinical Trials

Approaches

  1. approach: Using T cells from another individual to overcome self-tolerance 
  2. approach: Enhancing effector T cell function by overcoming inhibitory mechanisms
  3. approach: Creating a tumor environment that resembles infectious disease

Methodologies

  1. Array based proteomics
  2. Generation and isolation of T cells that recognize defined cell types in another individual
  3. Molecular cloning, engineering and genetic transfer or production of (soluble) T cell receptors
Published Feb. 26, 2013 3:50 PM - Last modified May 29, 2013 2:36 PM