Seminar: T-cell receptor structure and function
It is a great pleasure to welcome you a to an open seminar hosted by the KG Jebsen Coeliac Disease Research Centre. The key lecturers, Professors Arnold Han and David Price, are visiting Oslo in relation to Louise F. Risnes's doctoral defense.
13:00 – 13:50 T cell function and specificity in human disease. Dr. Arnold Han. Columbia University, New York, US.
13:50 – 14:10 A TCRα framework-centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions. Dr. Lene S. Høydahl. KG Jebsen Coeliac Disease Research Centre, University of Oslo.
14:10 – 14:25 Coffee break
14:25 – 15:15 Innate-like recognition in the adaptive immune system. Dr. David Price. Cardiff University, UK.
15:15 – 15:35 Discriminative T-cell recognition of gluten epitopes despite similar peptide:MHC topologies. Dr. Shiva Dahal-Koirala, KG Jebsen Coeliac Disease Research Centre, University of Oslo.
More about the lecturers
Abstract David Price:
Adaptive immunity is based on clonal selection from a vast repertoire of somatically rearranged antigen receptors, yet biased usage of germline-encoded segments is commonly observed among epitope-specific memory T-cell populations. In this talk, I will demonstrate that T-cell receptor (TCR) bias can arise as a consequence of innate-like recognition within the αβ TCR repertoire, dictating immune response profiles in mice and potentially impacting the outcome of a widespread viral infection in humans.