Research groups from A to Z
We investigate basic biological processes associated with cellular responses to DNA damage, including DNA repair pathways and mechanisms for tolerance, cell cycle regulation and adaptation.
Chronic infections cause a substantial part of the global disease burden as well as the clinical challenges for the Department of Infectious Diseases.
Our research is focused on understanding the genetic mechanisms of autoimmune diseases (including rheumatoid arthritis, type 1 diabetes and multiple sclerosis) and cancer (mainly breast cancer) through studies of DNA, RNA, proteins and cells.
The main goal for the group has been elucidation of DNA repair pathways necessary for maintenance of genomic stability.
We perform detailed characterization of genomic variation in patients with neurodevelopmental diseases or syndromes. We reveal information about the genetic mechanisms underlying the aberrations, and obtain knowledge about biological consequences leading to the clinical presentation.
The projects carried out in the group center around how EGFR family members can be down-regulated physiologically and experimentally.
The research group focuses on the study of intrathecal cellular immune responses in neurological diseases, in particular multiple sclerosis (MS).
Our group is conducting experimental/translational research studying cardiac pathophysiology related to aortic stenosis and pressure overload.
The NK cell research group focuses on the biology and recognition mechanisms of Natural Killer (NK) cells, which constitute an important part of our innate immune defence against neoplastic and virally infected cells, and normal allogeneic cells.
Our research is described in more detail on our external webpage.
Primary sclerosing cholangitis (PSC) is a chronic inflammatory disorder of the bile ducts. Norwegian PSC Research Center was formally founded in 2008, but PSC research in Oslo dates back more than 30 years.
The main interest in our group is independent research using proteomics/system biology to study T-cell and Dendritic cell biology. Both cells are key players of the immune system and alteration in their molecular composition are strongly related to disease states such as autoimmunity.
Work performed in our group is directed towards the use stem and progenitor cells for tissue engineering of cartilage, bone and cardiovascular tissues.