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Ear, nose and throat, Ahus

The ENT Department has three major research foci: the treatment of chronic ear infection, obstructive sleep apnoea, and diagnostics of rhinological diseases.

About the group

Our otological research aims to engineer new autologous tissue for in vivo implantation. Assessment is performed on genetic, structural and functional properties of cultivated human cells from the tympanic membrane. Our sleep apnoea research evaluates a novel measuring devise and correlations between structural nose defects and sleep apnoea. Our rhinological research investigates the correlations between chronic rhinosinusitis and biofilm, as well as the role of the nasal cycle for sleep disordered breathing.

Our aims are on different scientific and clinical levels. We wish to implement regenerative medicine into otology, by gathering now knowledge on otological stem cells and their characteristics.  We also aim to evaluate or improve current diagnostic methods  for ear dieases (intra-operative laser-Doppler vibrometry), sleeping disorders (the ASADaTE study), and chronic rhinosinusitis (the biofilm study). Furthermore, we aim to improve the outcome after surgical treatments in ear surgery as well as ventilation tube treatment and of facial fractures.

Projects

The cultivation of epidermal keratinocytes for improved treatment of tympanic membrane perforations. Stem cells from human tympanic membranes are cultivated and their characteristics, such as morphology, phenotypes, viabilities, and gene, protein and enzyme expressions are assessed. The genetic code for the inherent migration capacity of ear keratinocytes was revealed and the down-stream proteomics assessed.

Assessment of the epithelial regeneration centres in the human tympanic membrane in normal and activated conditions. A structural and functional study of the regeneration centres in the skin cells layer of the human tympanic membrane.

Does shape and material in ventilation tubes influence their duration in situ and their complication rates? A prospective, randomised, comparative study in 800 ears assessing the duration and complication rates of the most commonly used ventilation tube types and materials, with a four year follow-up.

Taste disturbance in middle ear diseases and after middle ear surgery. A clinical, prospective study of 300 surgical patients in which the nerve function is assess by objective measures both pre- and postoperatively with a one-year follow-up and both QoL and symptom questionnaires.

Laser-Doppler vibrometry: Intra-operative measurement of hearing bone mobility. An intra-operative method to measure the hearing bones mobility in a partial fixation situation may help to direct the surgeon in choosing the most favourable technical solution in regards to the operation’s hearing outcome. A laser-Doppler vibrometry method was evaluated in human temporal bones and an electromagnetic system was developed to stimulate the outermost hearing bone (i.e., the hammer) with calibrated signals.

The presence of biofilms chronic rhinosinusitis with or without polyposis nasi. Biopsies were harvested in the nasal cavity during surgery and studied with confocal microscopy. The findings were correlated with clinical symptom scores, follow-up data at 6 months, and histologic parameters for inflammation.

Post-treatment outcome for facial fractures: A quality study at Akershus University Hospital. A database has been established to investigate the outcome after conservative or surgical treatment for facial fractures of facial fractures.

Akershus Sleep Apnoea Diagnostics and Treatment Evaluation (ASADaTE). The study compare diagnostic properties of «Apneagraph Spiro» with automatically and manually scored polysomnography and the differences in treatment decision between patients with and without known objective level of obstruction. Furthermore, assess the relation between shared decision making and CPAP adherence and the relation between shared decision making and surgical outcome.

The role of the nasal cycle in sleep disordered breathing. In a prospective diagnostic study, the nasal cycle will be measured for 24 h in a subgroup of patients from the ASADaTE project in comparison with healthy controls.

 

Cooperation

  • Biomedical Physics Group, University of Antwerp, Belgia,  Prof J. Dirckx
  • Ear Science Institute of Australia and University of Western Australia, Perth, Australia, Porfessors M. Atlas and R. Dilley
  • Inst. For Surgical Sciences, University of Uppsala, Sweden,  Prof H. Rask-Anderssen
  • Oslo University Hospital, T.P.Utheim, T. Lyberg and J.R. Eidet
  • Dept. ENT, Rikshospitalet, Oslo,  Doc J. Silvola
  • Epigen, Akershus University hospital, Prof H. Nilsen
  • Högskolan i Jönköping, Prof. Anders Broström
  • Dept. of behavioural science, University of Oslo, Prof. Toril Dammen,
  • Lund University,Sweden, Docent Morgan Andersson

 

Published Jan. 25, 2016 1:35 PM - Last modified Feb. 4, 2016 12:38 PM

Contact

Gruppeleder

Participants

Detailed list of participants