The group focuses on the relationship between genetic risk, environmental factors and biological variables, and how these are related to clinical disease forms and brain organic relationship in serious mental illness.
Identify the causes and identify disease mechanisms in schizophrenia and bipolar disorder using a translational approach. The main focus is on genetic factors, since severe mental disorders have a high degree of heredity, but few genetic factors are known. There is also little knowledge about how genetic factors are related to environmental risk factors. Furthermore, the connection to different disease characteristics in patients, including clinical, cognitive and brain organic relationship is unknown. In charting such contexts, the goal is to gain more knowledge about disease mechanisms. Medications are an important part of treatment of diseases, and targets for the group is to gain more knowledge about how drugs work and how reactions occur.
Discover new disease genes by severe mental disorders through participation in international consortium, with special interest for polygenic effects. Exploring disease genes and examine the context of clinical, cognitive and brain organic changes in well-described clinical material. This operation uses biostatistical methods and analysis. An important part of the activity is to study the mechanism by drugs. The focus is currently on the immune system; which genes affect this, how it is related to psychological symptoms over time, and what role drugs play in this context. We also want to study the differences and similarities between disease groups, thus generating knowledge about what is disease-specific processes and what is phenotype-related processes.
- Polygenic architecture: We use major international genetics studies along with new analysis tools to identify the polygenic contribution to disease development in bipolar disorder, schizophrenia and related disorders.
- Genotype-phenotype mapping: We identify the clinical and brain organic correlate genetic vulnerability factors in well described national and local cohorts of patients, and how this is related to the proceeding.
- Immune System. We have a series of studies that studies genetic variants, serum markers, drugs and brain mechanisms related to different aspects of the immune system.
- Psychosis across disorders. We have several studies on developmental disorders and aging processes for finding common denominators for the development of psychosis.