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Virology research group

The group is a collaboration between clinical and laboratory research experts of human immunodeficiency virus type 1 (HIV) and cytomegalovirus (CMV).

About the group

The Virology Research Group at the Department of Microbiology (MIK), Oslo University Hospital/University of Oslo (UiO) is interested in the molecular and clinical aspects of human virus infections.

We use human immunodeficiency virus type 1 (HIV) and human cytomegalovirus (CMV) as model systems for chronic virus infections and our main focus is how these viruses affect their host cells with regard to latency, genome stability and their interaction with the immune system. In the light of the SARS-CoV-2 pandemic, we also have a number of projects involving this virus. We are in close collaboration with the Clinical Virology Research Group.

Projects

  • The role of epitranscriptomic regulation during latent and active HIV infection
  • Molecular studies of immunological non responders during combined antiretroviral treatment. 
  • DNA repair and chromatin remodeling in CMV infection 
  • Role of APOBEC deaminases during CMV infection 
  • Dynamic methylome regulation during CMV latency and reactivation
  • Studies of HIV and CMV anti-retroviral resistance using next generation sequencing 
  • Dynamic regulation of the transcriptome during SARS-CoV-2-infection 

 

International Collaborations

  • Professor Stephen Goff, Department of Biochemistry and Molecular Biophysics and the Department of Microbiology and Immunology, Columbia University, USA 
  • Professor Seppo Vainio, Faculty of Biochemistry and Molecular Medicine, Oulu University, Finland 

 

We study the pathogenesis and immune responses during these viral infections in order to better understand virus-host cell interactions. This may unravel mechanisms of importance for improved treatment strategies and principles.

Published July 11, 2013 1:41 PM - Last modified June 19, 2023 1:33 PM

Contact

Group leader

Participants

Detailed list of participants

Projects