Genetic and epigenetic dispositions in different childhood diseases

There are several ongoing projects involving childhood diseases and epigenetics and genetics. The main focus of these projects is to explore gene-environment interactions and epigenetic changes through specific periods of childhood, and impact on childhood diseases such as childhood asthma, allergies and cancer.

About the project

The childhood asthma and allergy studies are in collaboration with Professors Karin Lødrup Carlsen and Kai Håkon Carlsen at the Department of Paediatrics, Oslo University Hospital (OUS), while the childhood cancer project is in collaboration with Dr Camilla Stoltenberg and Dr Siri Håberg at the National Institute of Public Health (NIPH), Dr Zdenco Herceg at the International Agency of Cancer Research in Lyon France, and Dr Terry Dwyer at the International Childhood Cancer Consortium.

The study groups consist of two birth cohort populations, the Environment and Childhood Asthma cohort from OUS, and the Mother-Child cohort from NIPH, both with unique longitudinal information on clinical status and environmental exposures, as well as blood samples from birth and childhood years. Monica Cheng Munthe-Kaas (MD PhD) is coordinator of these projects at the Department of Medical Genetics, in a 40% post-doc position. Analyses include SNP analyses, and whole genome and epigenome arrays. The post-doc position is financed by the OUS, while the genetic and epigenetic analyses are financed by OUS and IARC.

Published Jan. 9, 2013 9:24 AM