Faglige interesser
- Nyrer og nyresykdommer
- Indremedisin
- Nyretransplantasjon
- Diabetes før nyretransplantasjon
- Gruppeleder for forskningsgruppen Nyretransplantasjonsmedisin ved UiO
Bakgrunn
- Cand.med 1973
- Spesialist i Indremedisin 1987
- Ph.D 1987
- Spesialist i nyresykdommer 1990
- Professor i farmakologi, 1998
- Professor i nefrologi, 2007
Emneord:
Nyrer og urinveier,
Farmakologi
Publikasjoner
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Krogstad, Veronica; Elgstøen, Katja B. Prestø; Johnsen, Linda Flaa; Hartmann, Anders; Mørkrid, Lars & Åsberg, Anders
(2022).
High Plasma Oxalate Levels Early After Kidney Transplantation Are Associated With Impaired Long-Term Outcomes.
Transplant International.
ISSN 0934-0874.
35.
doi:
10.3389/ti.2022.10240.
Fulltekst i vitenarkiv
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Background: Elevated levels of oxalate are common in renal failure patients and non-hyperoxaluria disease, and may cause damage after transplantation. We examined outcomes after 15 years for 167 kidney transplant recipients who had plasma oxalate measured early after transplantation. Analyses included plasma oxalate, recipient age, donor age, live donor, HLA-DR mismatch, mGFR, and smoking.
Results: Median age was 52 years (range 18–81), 63% were male and 38% had live donors. Median plasma oxalate concentration 10 weeks after transplantation was 9.0 μmol/L (range 2.7–53.0), one third above the upper reference limit (11.0 μmol/L). Multivariable analysis revealed upper quartile plasma oxalate (>13.0 μmol/L, p = 0.008), recipient age (p < 0.001), deceased donor (p = 0.003), and current smoking (p < 0.001) as significant factors associated with patient survival. Upper quartile plasma oxalate (p = 0.021), recipient age (p = 0.001), deceased donor kidney (p = 0.001), HLA-DR mismatch (p = 0.015), and current smoking (p = 0.014) were also associated with graft loss. Factors associated with death censored graft losses were donor age (p = 0.012), deceased donor (p = 0.032), and HLA-DR mis-matched kidneys (p = 0.005) but plasma oxalate was not (p = 0.188).
Conclusions: Plasma oxalate in the upper quartile early after transplantation was significantly associated with impaired long-term patient survival and graft losses, but not when censored for death.
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Heldal, Torbjørn Fossum; Åsberg, Anders; Ueland, Thor; Reisæter, Anna Varberg; Pischke, Søren Erik & Mollnes, Tom Eirik
[Vis alle 10 forfattere av denne artikkelen]
(2022).
Inflammation in the early phase after kidney transplantation is associated with increased long-term all-cause mortality.
American Journal of Transplantation.
ISSN 1600-6135.
22,
s. 2016–2027.
doi:
10.1111/ajt.17047.
Fulltekst i vitenarkiv
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In the general population low-grade inflammation has been established as a risk factor for all-cause mortality. We hypothesized that an inflammatory milieu beyond the time of recovery from the surgical trauma could be associated with increased long-term mortality in kidney transplant recipients (KTRs). This cohort study included 1044 KTRs. Median follow-up time post-engraftment was 10.3 years. Inflammation was assessed 10 weeks after transplantation by different composite inflammation scores based on 21 biomarkers. We constructed an overall inflammation score and five pathway-specific inflammation scores (fibrogenesis, vascular inflammation, metabolic inflammation, growth/angiogenesis, leukocyte activation). Mortality was assessed with Cox regression models adjusted for traditional risk factors. A total of 312 (29.9%) patients died during the follow-up period. Hazard ratio (HR) for death was 4.71 (95% CI:2.85-7.81, p
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Heldal, Kristian; Åsberg, Anders; Abedini, Sadollah; Jenssen, Trond Geir; Reisæter, Anna Varberg & Bergan, Stein
[Vis alle 7 forfattere av denne artikkelen]
(2021).
Estimert glomerulær filtrasjonshastighet som mål på nyrefunksjon.
Tidsskrift for Den norske legeforening.
ISSN 0029-2001.
142(1),
s. 48–51.
doi:
10.4045/tidsskr.21.0501.
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Estimert glomerulær filtrasjonshastighet er etablert som
klinisk rutinemål for nyrefunksjon, men estimatet har
begrensninger og kan ikke brukes i alle kliniske situasjoner.
Estimert glomerulær filtrasjonshastighet har en høy
variasjonskoeffisient, og ved avvik i pasientens høyde, vekt
eller muskelmasse kan estimatet bli unøyaktig. Hvis det er
avgjørende å ha et nøyaktig mål på nyrefunksjonen, kan man
måle glomerulær filtrasjonshastighet ved hjelp av en
eksogen substans.
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Jenssen, Trond Geir & Hartmann, Anders
(2019).
Post-transplant diabetes mellitus in patients with solid organ transplants.
Nature Reviews Endocrinology.
ISSN 1759-5029.
15(3),
s. 172–188.
doi:
10.1038/s41574-018-0137-7.
Fulltekst i vitenarkiv
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Ussif, Mohammed Al-Amin; Åsberg, Anders; Strøm Halden, Thea Anine; Nordheim, Espen; Hartmann, Anders & Jenssen, Trond Geir
(2019).
Validation of diagnostic utility of fasting plasma glucose and HbA1c in stable renal transplant recipients one year after transplantation.
BMC Nephrology.
ISSN 1471-2369.
20:12,
s. 1–6.
doi:
10.1186/s12882-018-1171-3.
Fulltekst i vitenarkiv
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Egeland, Erlend Johannessen; Reisæter, Anna Varberg; Robertsen, Ida; Midtvedt, Karsten; Strøm, Erik Heyerdahl & Holdaas, Hallvard
[Vis alle 8 forfattere av denne artikkelen]
(2018).
High tacrolimus clearance ? a risk factor for development of interstitial fibrosis and tubular atrophy in the transplanted kidney: a retrospective single-center cohort study.
Transplant International.
ISSN 0934-0874.
32(3),
s. 257–269.
doi:
10.1111/tri.13356.
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Nordheim, Espen; Birkeland, Kåre I.; Åsberg, Anders; Hartmann, Anders; Horneland, Rune & Jenssen, Trond Geir
(2018).
Preserved insulin secretion and kidney function in recipients with functional pancreas grafts 1 year after transplantation: a single-center prospective observational study.
European Journal of Endocrinology (EJE).
ISSN 0804-4643.
179(4),
s. 251–259.
doi:
10.1530/EJE-18-0360.
Vis sammendrag
Objective: Successful simultaneous pancreas and kidney transplantation (SPK) or pancreas transplantation alone (PTA)
restores glycemic control. Diabetes and impaired kidney function are common side effects of immunosuppressive
therapy. This study addresses glucometabolic parameters and kidney function during the first year.
Methods: We examined 67 patients with functioning grafts (SPK n = 30, PTA n = 37) transplanted between September
2011 and November 2016 who underwent repeated oral glucose tolerance tests (OGTTs) 8 and 52 weeks after
transplantation. Another 19 patients lost their graft the first year post-transplant and 28 patients did not undergo
repeated OGTTs and could not be studied. All patients received ATG induction therapy plus tacrolimus, mycophenolate
and prednisolone. Glomerular filtration rate was measured before and 8 and 52 weeks after transplantation by serum
clearance methods.
Results: From week 8 to 52 after transplantation, mean fasting glucose decreased (SPK: 5.4 ± 0.7 to 5.1 ± 0.8 mmol/L,
PTA: 5.4 ± 0.6 to 5.2 ± 0.7 mmol/L; both P < 0.05), and also 120-min post-OGTT glucose (SPK: 6.9 ± 2.9 to 5.7 ± 2.2 mmol/L;
P = 0.07, PTA: 6.5 ± 1.7 to 5.7 ± 1.2 mmol/L; P < 0.05). Fasting C-peptide levels also decreased (SPK: 1500 ± 573 to
1078 ± 357 pmol/L, PTA: 1210 ± 487 to 1021 ± 434 pmol/L, both P < 0.005). Measured GFR decreased from enlistment
to 8 weeks post transplant in PTA patients (94 ± 22 to 78 ± 19 mL/min/1.73 m2; P < 0.005), but did not deteriorate from
week 8 to week 52 (SPK: 55.0 ± 15.1 vs 59.7 ± 11.3 ml/min/1.73 m²; P = 0.19, PTA: 76 ± 19 vs 77 ± 19 mL/min/1.73 m²;
P = 0.74).
Conclusion: Glycemic control and kidney function remain preserved in recipients with functioning SPK and PTA grafts
1 year after transplantation.
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Von Düring, Marit Elizabeth; Jenssen, Trond Geir; Bollerslev, Jens; Godang, Kristin; Hartmann, Anders & Åsberg, Anders
(2018).
Arterial stiffness is associated with visceral fat mass in kidney transplanted patients—A nationwide cohort study.
Clinical Transplantation.
ISSN 0902-0063.
32(8).
doi:
10.1111/ctr.13341.
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Eide, Ivar Anders; Dörje, Christina; Svensson, My Hanna Sofia; Jenssen, Trond Geir; Hammarström, Clara Louise & Scott, Helge
[Vis alle 13 forfattere av denne artikkelen]
(2018).
Development of Kidney Transplant Fibrosis Is Inversely Associated With Plasma Marine Fatty Acid Level.
Journal of renal nutrition.
ISSN 1051-2276.
28(2),
s. 118–124.
doi:
10.1053/j.jrn.2017.09.001.
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Salvador, Cathrin Lytomt; Hartmann, Anders; Åsberg, Anders; Bergan, Stein; Rowe, Alexander D. & Mørkrid, Lars
(2017).
Estimating Glomerular Filtration Rate in Kidney Transplant Recipients: Comparing a Novel Equation With Commonly Used Equations in this Population.
Transplantation direct.
ISSN 2373-8731.
3(12).
doi:
10.1097/TXD.0000000000000742.
Fulltekst i vitenarkiv
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Jenssen, Trond Geir; Hartmann, Anders & Birkeland, Kåre I.
(2017).
Long-term diabetes complications after pancreas transplantation.
Current Opinion in Organ Transplantation.
ISSN 1087-2418.
22(4),
s. 382–388.
doi:
10.1097/MOT.0000000000000436.
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Meyer, Käthe Birgitte; Hartmann, Anders; Mjøen, Geir & Andersen, Marit Helen
(2017).
Relationships between clinical, self-reported, and donation specific outcomes: a prospective follow-up study 10 years after kidney donation.
Annals of Transplantation.
ISSN 1425-9524.
22,
s. 148–155.
doi:
10.12659/AOT.902330.
Fulltekst i vitenarkiv
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Eide, Ivar Anders; Strøm Halden, Thea Anine; Hartmann, Anders; Dahle, Dag Olav; Åsberg, Anders & Jenssen, Trond Geir
(2017).
Associations Between Posttransplantation Diabetes Mellitus and Renal Graft Survival.
Transplantation.
ISSN 0041-1337.
101(6),
s. 1282–1289.
doi:
10.1097/TP.0000000000001259.
Vis sammendrag
BACKGROUND:
Previous reports indicate that posttransplantation diabetes mellitus (PTDM) is associated with overall renal graft loss, but not death-censored graft loss.
METHODS:
In this single-center retrospective cohort study of 2749 adult Norwegian renal transplant recipients, transplanted between 1999 and 2011, we estimated overall and death-censored renal graft loss hazard ratios in patients diagnosed with PTDM, impaired glucose tolerance and diabetes before transplantation, using multivariable Cox proportional hazard regression analysis.
RESULTS:
A total of 893 renal grafts were lost during the study period, either due to recipient death (n = 540) or death-censored graft loss (n = 353). When the observational time started at time of transplantation, diabetes before transplantation was associated with both overall and death-censored graft loss. Pretransplantation diabetes was also associated with a steeper decline in renal graft function, a higher risk of acute rejections and more renal grafts lost due to acute rejection. In patients with a functional renal graft 1 year after transplantation, PTDM was associated with overall graft loss (hazard ratio, 1.46; 95% confidence interval, 1.13-1.88; P < 0.001), but not death-censored graft loss (hazard ratio, 1.25; 95% confidence interval, 0.80-1.96; P = 0.33). We found no significant associations between PTDM and change in renal function during the first 5 years or acute rejection risk during the first year after renal transplantation. Impaired glucose tolerance was not associated with either overall or death-censored graft loss.
CONCLUSIONS:
The present study confirms previous findings of an increased risk of overall but not death-censored renal graft loss in renal transplant recipients with PTDM. Longstanding diabetes might increase the risk of acute rejections.
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Lindahl, Jørn Petter Hanto; Massey, Richard; Hartmann, Anders; Aakhus, Svend; Endresen, Knut & Günther, Anne
[Vis alle 12 forfattere av denne artikkelen]
(2017).
Cardiac Assessment of Patients With Type 1
Diabetes Median 10 Years After Successful Simultaneous Pancreas and Kidney Transplantation Compared With Living Donor Kidney Transplantation.
Transplantation.
ISSN 0041-1337.
101(6),
s. 1261–1267.
doi:
10.1097/TP.0000000000001274.
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Von Düring, Marit Elizabeth; Jenssen, Trond Geir; Bollerslev, Jens; Åsberg, Anders; Godang, Kristin & Hartmann, Anders
(2017).
Visceral fat is strongly associated with post-transplant diabetes mellitus and glucose metabolism 1 year after kidney transplantation.
Clinical Transplantation.
ISSN 0902-0063.
31:e12869(1),
s. 1–9.
doi:
10.1111/ctr.12869.
Fulltekst i vitenarkiv
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Eide, Ivar Anders; Åsberg, Anders; Svensson, My Hanna Sofia; Ueland, Thor; Mollnes, Tom Eirik & Hartmann, Anders
[Vis alle 12 forfattere av denne artikkelen]
(2017).
Plasma Levels of Marine n-3 Fatty Acids Are Inversely Correlated With Proinflammatory Markers sTNFR1 and IL-6 in Renal Transplant Recipients.
Journal of renal nutrition.
ISSN 1051-2276.
27(3),
s. 161–168.
doi:
10.1053/j.jrn.2016.09.008.
Vis sammendrag
OBJECTIVE:
Marine n-3 polyunsaturated fatty acids (PUFAs) exert potential anti-inflammatory effects and might improve long-term outcomes after renal transplantation. We assessed associations between plasma phospholipid levels of marine n-3 PUFAs and plasma inflammatory biomarkers 10 weeks after renal transplantation.
DESIGN:
Cross-sectional single-center study.
SUBJECTS:
A study population of 861 renal transplant recipients transplanted at Oslo University Hospital between 2007 and 2011.
METHODS AND MAIN OUTCOME MEASURE:
Plasma phospholipid fatty acids were determined by gas chromatography. Marine n-3 PUFA levels were defined as the sum of eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid levels in weight percentage of total plasma phospholipid fatty acids. Plasma inflammatory biomarkers were measured by enzyme immunoassays. We used multivariable linear regression analysis to assess associations between levels of marine n-3 PUFAs and inflammatory biomarkers in plasma.
RESULTS:
Plasma marine n-3 PUFA levels were inversely associated with plasma levels of proinflammatory biomarkers soluble tumor necrosis factor receptor 1 (standardized regression coefficient -0.11, P < .001) and interleukin-6 (standardized regression coefficient -0.09, P = .01). In contrast, there was no association between plasma levels of marine n-3 PUFAs and the anti-inflammatory mediator interleukin-10.
CONCLUSIONS:
In this renal transplant cohort, inverse associations between plasma levels of marine n-3 PUFAs and markers of inflammation were demonstrated.
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Nordheim, Espen; Dahle, Dag Olav; Syse, Ingrid Marie; Åsberg, Anders; Reisæter, Anna Varberg & Hartmann, Anders
(2016).
Resolution of Calciphylaxis After Urgent Kidney Transplantation in 3 Patients With End-Stage Kidney Failure.
Transplantation direct.
ISSN 2373-8731.
2(11).
doi:
10.1097/TXD.0000000000000627.
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SMEDBRÅTEN, Julia; Mjøen, Geir; Hartmann, Anders; Åsberg, Anders; Rollag, Halvor & Mollnes, Tom Eirik
[Vis alle 10 forfattere av denne artikkelen]
(2016).
Low level of MAp44, an inhibitor of the
lectin complement pathway, and long-term
graft and patient survival; a cohort study of
382 kidney recipients.
BMC Nephrology.
ISSN 1471-2369.
17(1).
doi:
10.1186/s12882-016-0373-9.
Fulltekst i vitenarkiv
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Background
Higher incidence of malignancy and infectious diseases in kidney transplant recipients is related to immunosuppressive treatment after transplantation and the recipient’s native immune system. The complement system is an essential component of the innate immunity. The aim of the present study was to investigate the association of effector molecules of the lectin complement pathway with graft and patient survival after kidney transplantation.
Methods
Two mannan-binding lectin (MBL) associated proteases, MASP-2 and MASP-3 (activators of the lectin pathway) and two MBL-associated proteins, MAp44 and MAp19 (inhibitors of the lectin pathway) were measured at the time of transplantation in 382 patients (≥17 years old) transplanted in 2000–2001. The cohort was followed until December 31, 2014. Data on patient and graft survival were obtained from the Norwegian Renal Registry. Cox proportional hazard regression models were performed for survival analyses.
Results
Low MAp44 level (1st versus 2–4 quartile) was significantly associated with overall mortality; HR 1.52, 95 % CI 1.08–2.14, p = 0.017. In the sub analyses in groups below and above median age (51.7 years), low MAp44 as a predictor of overall mortality was statistically significant only in recipients of ≤51.7 years; HR 2.57, 95 % CI 1.42–4.66, p = 0.002. Furthermore, low MAp44 was associated with mortality due to infectious diseases; HR 2.22, 95 % CI 1.11–4.41, p = 0.023. There was no association between MASP-2, MASP-3 or MAp19 levels and patient mortality. No association between any measured biomarkers and death censored graft loss was found.
Conclusions
Low MAp44 level at the time of transplantation was associated with increased overall mortality in kidney recipients of median age of 51.7 years or below and with mortality due to infectious diseases in the whole patient cohort after nearly 14-years of follow up after transplantation. No associations between other effector molecules; MASP-2, MASP-3 or MAp19 and recipient mortality were found, as well as no association of any biomarker with death censored graft loss.
Keywords
Kidney transplantation – Complement – Recipient survival
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Lønning, Kjersti; Midtvedt, Karsten; Leivestad, Torbjørn; Reisæter, Anna Varberg; Line, Pål Dag & Hartmann, Anders
[Vis alle 7 forfattere av denne artikkelen]
(2016).
Are Octogenarians with End-Stage Renal Disease Candidates for Renal Transplantation?
Transplantation.
ISSN 0041-1337.
100(12),
s. 2705–2709.
doi:
10.1097/TP.0000000000001363.
Vis sammendrag
BACKGROUND:
Elderly patients are the fastest growing group in need of renal transplantation. This study puts focus on renal transplant recipients in their eightieth year or older at time of engraftment. Is there evidence to support an absolute upper age limit for renal transplantation?
METHODS:
Recipients in their eightieth year or older, transplanted between 1983 and 2015, were included. Data were retrieved from the Norwegian Renal Registry in the end of October 2015. Graft and patient survival were compared to recipients aged 70-79 years at transplantation.
RESULTS:
47 patients older than 79 years were transplanted in the defined period. Median age 80.1 years, 81 % were male. Median time on dialysis prior to transplantation was 18.5 months. All patients received an allograft from a deceased donor (median donor age 61.8 years). In the death censored graft survival model, there was no statistical difference between the groups. We found improved patient and graft survival after introduction of mycophenolate mofetil and induction with basiliximab. Patients transplanted before 2000 had increased risk of death compared to those transplanted after 2000; HR 3.2 (95% CI 1.2-8.7). Median uncensored graft survival for patients transplanted after the year 2000 was 5.0 year (95% CI 2.4-7.6). Median patient survival was 5.0 years (3.1-6.9) and five year patient survival was 55 %.
CONCLUSION:
Age by itself should not be an absolute contraindication against renal transplantation. An estimated five years survival rate of 55 % post-engraftment for an 80 years old patient is in our opinion more than acceptable.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
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Eide, Ivar Anders; Dahle, Dag Olav; Svensson, My Hanna Sofia; Hartmann, Anders; Åsberg, Anders & Bjerve, Kristian S
[Vis alle 11 forfattere av denne artikkelen]
(2016).
Plasma levels of marine n-3 fatty acids and cardiovascular risk markers in renal transplant recipients.
European Journal of Clinical Nutrition.
ISSN 0954-3007.
70(7),
s. 824–830.
doi:
10.1038/ejcn.2016.14.
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Strøm Halden, Thea Anine; Egeland, Erlend Johannessen; Åsberg, Anders; Hartmann, Anders; Midtvedt, Karsten & Khiabani, Hassan Zare
[Vis alle 11 forfattere av denne artikkelen]
(2016).
GLP-1 restores altered insulin and glucagon secretion in posttransplantation diabetes.
Diabetes Care.
ISSN 0149-5992.
39(4),
s. 617–624.
doi:
10.2337/dc15-2383.
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Åsberg, Anders; Humar, Atul; Rollag, Halvor; Jardine, Alan G.; Kumar, Deepali & Aukrust, Pål
[Vis alle 9 forfattere av denne artikkelen]
(2016).
Lessons Learned from a Randomized Study of Oral Valganciclovir Versus Parenteral Ganciclovir Treatment of Cytomegalovirus Disease in Solid Organ Transplant Recipients: The VICTOR Trial.
Clinical Infectious Diseases.
ISSN 1058-4838.
62(9),
s. 1154–1160.
doi:
10.1093/cid/ciw084.
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Meyer, Käthe Birgitte; Wahl, Astrid Klopstad; Bjørk, Ida Torunn; Wisløff, Torbjørn; Hartmann, Anders & Andersen, Marit Helen
(2016).
Long-term, self-reported health outcomes in kidney donors.
BMC Nephrology.
ISSN 1471-2369.
17(8).
doi:
10.1186/s12882-016-0221-y.
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Jørgensen, Hanne Skou; Eide, Ivar Anders; Hartmann, Anders; Åsberg, Anders; Christensen, Jeppe H. & Schmidt, Erik B.
[Vis alle 9 forfattere av denne artikkelen]
(2016).
Plasma n-3 Polyunsaturated Fatty Acids and Bone Mineral Density in Renal Transplant Recipients.
Journal of renal nutrition.
ISSN 1051-2276.
26(3),
s. 196–203.
doi:
10.1053/j.jrn.2015.11.007.
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Eide, Ivar Anders; Jenssen, Trond Geir; Hartmann, Anders; Diep, Lien My; Dahle, Dag Olav & Reisæter, Anna Varberg
[Vis alle 10 forfattere av denne artikkelen]
(2016).
Plasma levels of marine n-3 polyunsaturated fatty acids and renal allograft survival.
Nephrology, Dialysis and Transplantation.
ISSN 0931-0509.
31(1),
s. 160–167.
doi:
10.1093/ndt/gfv339.
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Lindahl, Jørn Petter Hanto; Hartmann, Anders; Aakhus, Svend; Endresen, Knut; Midtvedt, Karsten & Holdaas, Hallvard
[Vis alle 10 forfattere av denne artikkelen]
(2016).
Long-term cardiovascular outcomes in type 1 diabetic patients
after simultaneous pancreas and kidney transplantation
compared with living donor kidney transplantation.
Diabetologia.
ISSN 0012-186X.
59(4),
s. 844–852.
doi:
10.1007/s00125-015-3853-8.
Vis sammendrag
Aims/hypothesis
Mortality due to cardiovascular disease
(CVD), particularly coronary artery disease (CAD), is high
in type 1 diabetic patients with end-stage renal disease
(ESRD). We aimed to determine whether normoglycaemia,
as achieved by successful simultaneous pancreas and kidney
(SPK) transplantation, could improve long-term outcomes
compared with living donor kidney-alone (LDK)
transplantation.
Methods
We studied 486 type 1 diabetic patients with ESRD
who underwent a first SPK (
n
=256)orLDK(
n
=230)trans-
plant between 1983 and 2012 and were followed to the end of
2014. Data were retrieved from the Norwegian Renal Registry
and hospital records. Kaplan
–
Meier plots and multivariate
Cox regression, with correction for recipient, donor and trans-
plant factors, were used to examine potential associations
between transplant type and all-cause and CVD- and CAD-
related mortality.
Results
Median follow-up time was 7.9 years (interquartile
range 4.3, 12.9). The adjusted HR for CVD-related deaths in
SPK recipients compared with LDK recipients was 0.63 (95%
CI 0.40, 0.99;
p
=0.047), while the HRs for all-cause and
CAD-related mortality were 0.81 (95% CI 0.57, 1.16;
p
=0.25) and 0.63 (95% CI 0.36, 1.12;
p
=0.12),respectively.
Compared with the LDK group, SPK recipients were younger
and received grafts from younger donors. Cardiovascular mor-
tality was higher in patients transplanted between 1983 and
1999 compared with those who received their grafts in subse-
quent years.
Conclusions/interpretation
In patients with type 1 diabetes
and ESRD, SPK transplantation was associated with reduced
long-term cardiovascular mortality compared with LDK
transplantation.
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Aulie, Hanne Aaserud; Selvaag, Anne Marit G; Günther, Anne; Lilleby, Vibke; Molberg, Øyvind & Hartmann, Anders
[Vis alle 8 forfattere av denne artikkelen]
(2015).
Arterial haemodynamics and coronary artery calcification in adult patients with juvenile idiopathic arthritis.
Annals of the Rheumatic Diseases.
ISSN 0003-4967.
74(8),
s. 1515–1521.
doi:
10.1136/annrheumdis-2013-204804.
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Jenssen, Trond A & Hartmann, Anders
(2015).
Emerging treatments for post-transplantation diabetes mellitus.
Nature Reviews Nephrology.
ISSN 1759-5061.
11(8),
s. 465–477.
doi:
10.1038/nrneph.2015.59.
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Eide, Ivar Anders; Jenssen, Trond Geir; Hartmann, Anders; Diep, Lien My; Dahle, Dag Olav & Reisæter, Anna Varberg
[Vis alle 10 forfattere av denne artikkelen]
(2015).
The association between marine n-3 polyunsaturated fatty acid levels and survival after renal transplantation.
American Society of Nephrology. Clinical Journal.
ISSN 1555-9041.
10(7),
s. 1246–1256.
doi:
10.2215/CJN.11931214.
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Smedbråten, Yuliya V.; Sagedal, Solbjørg; Mjøen, Geir; Hartmann, Anders; Fagerland, Morten & Rollag, Halvor
[Vis alle 8 forfattere av denne artikkelen]
(2015).
High Ficolin-3 level at the time of transplantation is an independent risk factor for graft loss in kidney transplant recipients.
Transplantation.
ISSN 0041-1337.
99(4),
s. 791–796.
doi:
10.1097/TP.0000000000000422.
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Ueland, Thor; Rollag, Halvor; Hartmann, Anders; Jardine, Alan G.; Humar, Atul & Bignamini, Angelo A
[Vis alle 8 forfattere av denne artikkelen]
(2015).
Increased osteoprotegerin predicts poor virological outcome during anticytomegalovirus theapy in solid organ transplant recipients.
Transplantation.
ISSN 0041-1337.
99(1),
s. 100–105.
doi:
10.1097/TP.0000000000000227.
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Chen, Zhigang; Bouamar, Rachida; Van schaik, Ron H.N.; de Fijter, Johan W.; Hartmann, Anders & Zeier, Martin
[Vis alle 11 forfattere av denne artikkelen]
(2014).
Genetic polymorphisms in IL-2, IL-10, TGF-β1, and IL-2RB and acute rejection in renal transplant patients.
Clinical Transplantation.
ISSN 0902-0063.
28(6),
s. 649–655.
doi:
10.1111/ctr.12346.
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Lindahl, Jørn Petter Hanto; Reinholt, Finn P.; Eide, Ivar Anders; Hartmann, Anders; Midtvedt, Karsten & Holdaas, Hallvard
[Vis alle 13 forfattere av denne artikkelen]
(2014).
In patients with type 1 diabetes simultaneous pancreas and kidney transplantation preserves long-term kidney graft ultrastructure and function better than transplantation of kidney alone.
Diabetologia.
ISSN 0012-186X.
doi:
10.1007/s00125-014-3353-2.
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Bleskestad, Inger Hjørdis; Bergrem, Harald; Leivestad, Torbjørn; Hartmann, Anders & Gøransson, Lasse G
(2014).
Parathyroid hormone and clinical outcome in kidney transplant patients with optimal transplant function.
Clinical Transplantation.
ISSN 0902-0063.
28(4),
s. 479–486.
doi:
10.1111/ctr.12341.
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Strøm Halden, Thea Anine; Åsberg, Anders; Vik, Karen; Hartmann, Anders & Jenssen, Trond Geir
(2014).
Short-term efficacy and safety of sitagliptin treatment in long-term stable renal recipients with new-onset diabetes after transplantation.
Nephrology, Dialysis and Transplantation.
ISSN 0931-0509.
29(4),
s. 926–933.
doi:
10.1093/ndt/gft536.
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Flechner, Stuart M.; Gurkan, Alihan; Hartmann, Anders; Legendre, Christophe M.; Russ, Graeme R. & Campistol, Josep M.
[Vis alle 12 forfattere av denne artikkelen]
(2013).
A randomized, open-label study of sirolimus versus cyclosporine in primary de novo renal allograft recipients.
Transplantation.
ISSN 0041-1337.
95(10),
s. 1233–1241.
doi:
10.1097/TP.0b013e318291a269.
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Mjøen, Geir; Reisæter, Anna Varberg; Hartmann, Anders; Dahle, Dag Olav & Holdaas, Hallvard
(2019).
Regarding age-calibrated glomerular filtration rate.
Kidney International.
ISSN 0085-2538.
95(1),
s. 234–235.
doi:
10.1016/j.kint.2018.10.003.
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Egeland, Erlend Johannessen; Robertsen, Ida; Hermann, Monica; Midtvedt, Karsten; Størset, Elisabet & Gustavsen, Marte Theie
[Vis alle 12 forfattere av denne artikkelen]
(2017).
High tacrolimus clearance may predict rejection and chronic damage to the transplanted kidney.
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Egeland, Erlend Johannessen; Robertsen, Ida; Hermann, Monica; Midtvedt, Karsten; Størset, Elisabet & Gustavsen, Marte Theie
[Vis alle 12 forfattere av denne artikkelen]
(2017).
High tacrolimus clearance – a risk factor for acute rejection and fibrosis in the transplanted kidney.
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Egeland, Erlend Johannessen; Robertsen, Ida; Hermann, Monica; Midtvedt, Karsten; Størset, Elisabet & Gustavsen, Marte Theie
[Vis alle 12 forfattere av denne artikkelen]
(2017).
High tacrolimus clearance and acute rejection risk after renal transplantation.
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Egeland, Erlend Johannessen; Hermann, Monica; Robertsen, Ida; Midtvedt, Karsten; Hartmann, Anders & Reisæter, Anna Varberg
[Vis alle 12 forfattere av denne artikkelen]
(2016).
High tacrolimus clearance is a risk factor for acute rejection early after renal transplantation.
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Lindahl, Jørn Petter Hanto; Endresen, Knut; Gunther, Anne; Hartmann, Anders & Jenssen, Trond Geir
(2013).
Coronary artery disease in diabetic patients long-term after simultaneous pancreas and kidney transplantation compared with kidney transplantation alone.
Diabetologia.
ISSN 0012-186X.
56,
s. S233–S233.
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Halden, Thea Anine Strøm; Åsberg, Anders; Hartmann, Anders & Jenssen, Trond Geir
(2013).
THE EFFECT OF SITAGLIPTIN TREATMENT ON HYPERGLYCEMIA AND INSULIN SECRETION AFTER RENAL TRANSPLANTATION.
Transplant International.
ISSN 0934-0874.
26,
s. 175–176.
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Mjøen, Geir; Hallan, Stein; Midtvedt, Karsten; Hartmann, Anders & Holdaas, Hallvard
(2013).
END STAGE RENAL DISEASE IN KIDNEY DONORS.
Transplant International.
ISSN 0934-0874.
26,
s. 119–119.
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Aulie, Hanne Aaserud; Selvaag, Anne Marit G; Lilleby, Vibke; Molberg, Øyvind; Hartmann, Anders & Holdaas, Hallvard
[Vis alle 7 forfattere av denne artikkelen]
(2013).
Increased Pulse Wave Velocity In Juvenile Idiopathic Arthritis Patients Compared To Controls From The General Population.
Arthritis and Rheumatism.
ISSN 0004-3591.
65,
s. S1142–S1142.
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Publisert
13. apr. 2011 11:39
- Sist endret
27. apr. 2018 15:03