Anne Cathrine Staff
Faglige interesser
- Translasjonsforskning, biomarkører, kombinasjon basalforskning og klinisk forskning innen:
- Svangerskapskomplikasjoner (preeklampsi, placentadysfunksjon og diabetes)
- Gynekologisk cancer (ovarialcancer, endometriecancer)
- Epidemiologiske og translasjonsstudier:
- Svangerskapskomplikasjoner (preeklampsi, diabetes) som risiko for kardiovaskulær sykdom (og kreft) hos mor og barn
- Kliniske studier:
- Urogynekologi: urin- og analinkontinens (operativ metode og obstetrisk risiko)
- Forskningsetikk
Undervisning
UiO, Medisin, 9. semester: http://www.uio.no/studier/emner/medisin/med/MEDSEM9/
Bakgrunn
Annetine Staff er leder for Forskningssenteret for Fødselshjelp og Kvinnesykdommer (formelt etablert i mai 2006), ved Oslo universitetssykehus (Kvinne- og barneklinikken, lokalisasjon Ullevål). Hun leder en egen forskningsgruppe på 13 personer http://www.oslo-universitetssykehus.no/omoss/avdelinger/forskningssenter-for-fodselshjelp-og-kvinnesykdommer/Sider/enhet.aspx
Hun var utdannet cand. med. ved Universitetet i Oslo (UiO) i 1987, og ble i 1996 spesialist i fødselshjelp og kvinnesykdommer i Norge.
Hun disputerte for den medisinske doktorgrad ved UiO i 2000, avhandlingen "Preeclampsia and uteroplacental tissues: lipids, oxidative stress, and trophoblast invasion".
Hun kombinerer nå arbeid som klinisk overlege og forskningsrådgiver ved Kvinne- og barneklinikken, OUS med arbeid som professor ved UiO.
Tidligere har Staff vært nestleder og fungerende leder i REK Sør-Norge samt medlem av NEM. Hun har også arbeidet som Forsknings- og innovasjonsdirektør, Helse Sør-Øst.
Hun er redaktør av Forskningshåndboken http://www.oslo-universitetssykehus.no/OMOSS/AVDELINGER/KVINNE-OG-BARNEKLINIKKEN/FORSKNING/FORSKNINGSHANDBOKEN/Sider/side.aspx
Priser
1998-99: 4 priser for beste foredrag/abstract på internasjonale (2) og nasjonale (2) forskningsmøter
2003-08: Direktørens belønning for fremragende forskning, Ullevål universitetssykehus
2006: Kunnskapsprisen Ullevål universitetssykehus, for arbeid med Forskningshåndboken.
Verv
Medlem av redaksjonskomiteen: Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, det offisielle tidsskriftet til den verdensomfattende organisasjonen ISSHP (International Society for the Study of Pregnancy Hypertension).
Medlem av Redaksjonskomiteen for Tidsskriftet den norske legeforening
Medlem av forskningsutvalget ved Oslo universitetssykehus (OUS) samt ved Kvinne- og barneklinikken OUS
Medlem av IFPA (International Federation of Placenta Associations) Executive Committee
Samarbeid
Nasjonalt samarbeid, Norge:
Kjetil Tasken, Bioteknologisenteret, UiO
Ben Davidson, OUS, lokalisasjon Radiumhospitalet, Avdeling for patologi.
Drude Fugelseth, OUS, Kvinne- og barneklinikken
Borghild Roald, OUS, Patologi
Øyvind Melien, Helsedirektoratet (tidligere OUS, klinisk farmakologi, lokalisasjon Rikshospitalet)
Asim Duttaroy, Avdeling for ernæring, Basalmedisin, UiO
Hilde Nebb, Avdeling for ernæring, Basalmedisin, UiO
Lene Frost Andersen, Avdeling for ernæring, Basalmedisin, UiO
NTNU/HUNT: Oddgeir/Jostein Holmen
Folkehelseinstituttet/ MoBa: Per Magnus
Internasjonalt samarbeid:
Global Pregnancy CoLaboratory
Ralf Dechend, Franz-Volhard-Clinic, Max Delbruck Center for Molecular Medicine, Department of Cardiology, Berlin, Tyskland
Rebecca Troisi, National Cancer Institute, Darthmouth Medical School, Hanover, USA
Harvey Kliman, Yale, USA
Ananth Karumanchi, Departments of Medicine, Obstetrics and Gynecology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
Christopher Redman, Ian Sargent, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, UK
Daniele Evain-Brion, INSERM, Paris, Frankrike
Publikasjoner
Publications in press
Stathmin Overexpression Identifies High-Risk Patients and Lymph Node Metastasis in Endometrial Cancer
Clin Cancer Res (in press)
PubMed 21242118 SFX (Details)
Adipose Tissue-Derived Soluble Fms-Like Tyrosine Kinase 1 Is an Obesity-Relevant Endogenous Paracrine Adipokine
Hypertension (in press)
PubMed 21555675 SFX (Details)
Myocardial function in offspring 5-8years after pregnancy complicated by preeclampsia
Early Hum Dev (in press)
PubMed 21550734 SFX (Details)
Endoglin (CD105) expression in ovarian serous carcinoma effusions is related to chemotherapy status
Tumour Biol (in press)
PubMed 21350924 SFX (Details)
Publications 2011
[No title available]
Tidsskr Nor Laegeforen, 131 (8), 806-807
PubMed 21556080 SFX (Details)
Prevalence and risk factors for anal incontinence after obstetric anal sphincter rupture
Acta Obstet Gynecol Scand, 90 (4), 319-24
PubMed 21306321 SFX ISI 000289515500005 (Details)
[Neural tube defects can be prevented]
Tidsskr Nor Laegeforen, 131 (4), 332
PubMed 21339770 SFX (Details)
Publications 2010
Learning from the placenta: acute atherosis and vascular remodeling in preeclampsia-novel aspects for atherosclerosis and future cardiovascular health
Hypertension, 56 (6), 1026-34
PubMed 20956732 SFX ISI 000284309800014 (Details)
CD105 (Endoglin) expression in breast carcinoma effusions is a marker of poor survival
Breast, 19 (6), 493-8
PubMed 21078485 SFX ISI 000285227000012 (Details)
Expression and clinical role of growth differentiation factor-15 in ovarian carcinoma effusions
Int J Gynecol Cancer, 20 (9), 1448-55
PubMed 21336029 SFX ISI 000284822900004 (Details)
POLD2 and KSP37 (FGFBP2) correlate strongly with histology, stage and outcome in ovarian carcinomas
PLoS One, 5 (11), e13837
PubMed 21079801 SFX ISI 000283838600012 (Details)
Dietary intake and physical activity in women and offspring after pregnancies complicated by preeclampsia or diabetes mellitus
Acta Obstet Gynecol Scand, 89 (11), 1486-90
PubMed 20955103 SFX ISI 000283130700017 (Details)
Anthropometry and cardiovascular risk factors in women and offspring after pregnancies complicated by preeclampsia or diabetes mellitus
Acta Obstet Gynecol Scand, 89 (11), 1478-85
PubMed 20955102 SFX ISI 000283130700016 (Details)
Growth differentiation factor-15 as a prognostic biomarker in ovarian cancer
Gynecol Oncol, 118 (3), 237-43
PubMed 20576287 SFX ISI 000281124000006 (Details)
Expression of liver X receptors in pregnancies complicated by preeclampsia
Placenta, 31 (9), 818-24
PubMed 20655109 SFX ISI 000282147100011 (Details)
Effects of circulating and local uteroplacental angiotensin II in rat pregnancy
Hypertension, 56 (2), 311-8
PubMed 20530295 SFX ISI 000279880200024 (Details)
Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells
J Lipid Res, 51 (7), 1886-96
PubMed 20219900 SFX ISI 000278628700025 (Details)
[Publication ethics--responsibility of all]
Tidsskr Nor Laegeforen, 130 (3), 259
PubMed 20160762 SFX (Details)
Surgical strategies for women with pelvic organ prolapse and urinary stress incontinence
Int Urogynecol J Pelvic Floor Dysfunct, 21 (2), 179-86
PubMed 19940978 SFX ISI 000273787500008 (Details)
Publications 2009
Long-chain polyunsaturated fatty acids stimulate cellular fatty acid uptake in human placental choriocarcinoma (BeWo) cells
Placenta, 30 (12), 1037-44
PubMed 19880178 SFX ISI 000272991400005 (Details)
Asymmetric dimethylarginine in the maternal and fetal circulation in preeclampsia
Pediatr Res, 66 (4), 411-5
PubMed 19581842 SFX ISI 000270285400011 (Details)
Plasma calprotectin concentrations in women with endometrial carcinoma
Gynecol Oncol, 114 (3), 491-5
PubMed 19577278 SFX ISI 000269139800022 (Details)
Circulating and placental growth-differentiation factor 15 in preeclampsia and in pregnancy complicated by diabetes mellitus
Hypertension, 54 (1), 106-12
PubMed 19470878 SFX ISI 000267103000019 (Details)
[Cesarean section--for benefit or damage?]
Tidsskr Nor Laegeforen, 129 (13), 1321
PubMed 19561654 SFX (Details)
Circulating and uteroplacental adipocytokine concentrations in preeclampsia
Reprod Sci, 16 (6), 584-90
PubMed 19276406 SFX ISI 000266017100007 (Details)
Hypoxia induces dilated cardiomyopathy in the chick embryo: mechanism, intervention, and long-term consequences
PLoS One, 4 (4), e5155
PubMed 19357774 SFX ISI 000265505900015 (Details)
Maternal, gestational and neonatal characteristics and maternal angiogenic factors in normotensive pregnancies
Eur J Obstet Gynecol Reprod Biol, 143 (1), 29-33
PubMed 19135290 SFX ISI 000264796000007 (Details)
[What does the Tidsskriftet's editorial committee do?]
Tidsskr Nor Laegeforen, 129 (3), 175
PubMed 19180158 SFX (Details)
Forskningshåndboken: fra idé til publikasjon
Oslo universitetssykehus, Ullevål i samarbeid med Haukeland universitetssykehus, Oslo (4. utg.), 184 s.
BIBSYS 093919913 ISBN 978-82-473-0022-0 (Details)
Long-chain polyunsaturated fatty acid transport across human placental choriocarcinoma (BeWo) cells
Placenta, 30 (1), 41-7
PubMed 19010540 SFX ISI 000262574700007 (Details)
Publications 2008
Blood pressure augmentation and maternal circulating concentrations of angiogenic factors at delivery in preeclamptic and uncomplicated pregnancies
Am J Obstet Gynecol, 199 (6), 653.e1-10
PubMed 18722574 SFX ISI 000261687000024 (Details)
Advanced glycation end products in pregnancies complicated with diabetes mellitus or preeclampsia
Hypertens Pregnancy, 27 (4), 374-86
PubMed 19003638 SFX ISI 000260834400006 (Details)
Assessment of endoglin and calprotectin as potential biomarkers in ovarian carcinoma and borderline tumors of the ovary
Am J Obstet Gynecol, 199 (5), 533.e1-8
PubMed 18533117 SFX ISI 000260585800033 (Details)
Levels of angiogenic factors in pregnancy and post-partum bleeding
Acta Obstet Gynecol Scand, 87 (10), 1081-3
PubMed 18792843 SFX ISI 000261016500016 (Details)
Iron supplements and oxidative stress in very low birth weight infants - Reply
J. Pediatr., 152 (6), 891
ISI 000256373800038 (Details)
AT1-receptor autoantibodies and uteroplacental RAS in pregnancy and pre-eclampsia
J Mol Med, 86 (6), 697-703
PubMed 18398593 SFX ISI 000255746900016 (Details)
Circulating calprotectin in ovarian carcinomas and borderline tumors of the ovary
Am J Obstet Gynecol, 198 (4), 418.e1-7
PubMed 18241816 SFX ISI 000254980200025 (Details)
Trophoblasts reduce the vascular smooth muscle cell proatherogenic response
Hypertension, 51 (2), 554-9
PubMed 18195163 SFX ISI 000252602200060 (Details)
Iron, oxidant injury, and practice choices in preterm infants - Reply
J. Pediatr., 152 (2), 296
ISI 000252819500035 (Details)
Publications 2007
[Reporting systems--an unused resource]
Tidsskr Nor Laegeforen, 127 (20), 2650
PubMed 17952143 SFX (Details)
Homocysteine, cysteine, and related metabolites in maternal and fetal plasma in preeclampsia
Pediatr Res, 62 (3), 319-24
PubMed 17622947 SFX ISI 000248973200017 (Details)
[Itching in pregnancy is mostly--but not always--harmless]
Tidsskr Nor Laegeforen, 127 (16), 2098
PubMed 17918308 SFX (Details)
Circulating concentrations of soluble endoglin (CD105) in fetal and maternal serum and in amniotic fluid in preeclampsia
Am J Obstet Gynecol, 197 (2), 176.e1-6
PubMed 17689641 SFX ISI 000248718900021 (Details)
[Who is a co-author?]
Tidsskr Nor Laegeforen, 127 (15), 1959
PubMed 17700741 SFX (Details)
Acute atherosis in decidual tissue: not associated with systemic oxidative stress in preeclampsia
Placenta, 28 (8-9), 958-64
PubMed 17218009 SFX ISI 000248720500026 (Details)
Oxidative stress markers and antioxidant status after oral iron supplementation to very low birth weight infants
J Pediatr, 151 (1), 23-8
PubMed 17586185 SFX ISI 000247851900008 (Details)
Surgery of borderline tumors of the ovary: retrospective comparison of short-term outcome after laparoscopy or laparotomy
Acta Obstet Gynecol Scand, 86 (5), 620-6
PubMed 17464594 SFX ISI 000247237400019 (Details)
Changes in circulating level of angiogenic factors from the first to second trimester as predictors of preeclampsia
Am J Obstet Gynecol, 196 (3), 239.e1-6
PubMed 17346536 SFX ISI 000244767700018 (Details)
Dysregulation of the circulating and tissue-based renin-angiotensin system in preeclampsia
Hypertension, 49 (3), 604-11
PubMed 17261642 SFX ISI 000244245200031 (Details)
The activated nerve growth factor receptor p-TrkA is selectively expressed in advanced-stage ovarian carcinoma
Hum Pathol, 38 (1), 140-6
PubMed 16996570 SFX ISI 000243267000017 (Details)
Forskningshåndboken: fra idé til publikasjon
Ullevål universitetssykehus i samarbeid med Haukeland universitetssykehus, Oslo (3. utg.), 151 s.
BIBSYS 071048723 ISBN 978-82-473-0019-0 (Details)
Publications 2006
Oxidative stress and antioxidant status in fetal circulation in preeclampsia
Pediatr Res, 60 (5), 560-4
PubMed 16988193 SFX ISI 000241570300010 (Details)
Augmented oxidative stress as well as antioxidant capacity in maternal circulation in preeclampsia
Eur J Obstet Gynecol Reprod Biol, 128 (1-2), 209-15
PubMed 16337725 SFX ISI 000240909100038 (Details)
Are d-ROM and FRAP tests suitable assays for detecting the oxidative status?
Eur. J. Obstet. Gynecol. Reprod. Biol., 127 (2), 272
ISI 000240483600025 (Details)
Regulation of ADRP expression by long-chain polyunsaturated fatty acids in BeWo cells, a human placental choriocarcinoma cell line
J Lipid Res, 47 (4), 815-23
PubMed 16391323 SFX ISI 000236223700015 (Details)
The AP-2gamma transcription factor is upregulated in advanced-stage ovarian carcinoma
Gynecol Oncol, 100 (3), 462-8
PubMed 16216317 SFX ISI 000235738800004 (Details)
Increased plasma levels of adipokines in preeclampsia: relationship to placenta and adipose tissue gene expression
Am J Physiol Endocrinol Metab, 290 (2), E326-33
PubMed 16144822 SFX ISI 000234530300016 (Details)
Publications 2005
Circulating concentrations of sFlt1 (soluble fms-like tyrosine kinase 1) in fetal and maternal serum during pre-eclampsia
Eur J Obstet Gynecol Reprod Biol, 122 (1), 33-9
PubMed 15935542 SFX ISI 000232419400004 (Details)
Calprotectin, a marker of inflammation, is elevated in the maternal but not in the fetal circulation in preeclampsia
Am J Obstet Gynecol, 193 (1), 227-33
PubMed 16021084 SFX ISI 000230691500036 (Details)
Leukocyte-platelet interaction in pregnancies complicated with preeclampsia
Platelets, 16 (2), 91-7
PubMed 15823865 SFX ISI 000228185100005 (Details)
Reduction in hospitalized women with pelvic inflammatory disease in Oslo over the past decade
Acta Obstet Gynecol Scand, 84 (3), 290-6
PubMed 15715539 SFX ISI 000227062100013 (Details)
[Does folic acid have effects on other health problems than neural tube defects?]
Tidsskr Nor Laegeforen, 125 (4), 438-41
PubMed 15742017 SFX (Details)
[Effects of public initiatives aimed at reducing neural tube defects with folic acid supplementation]
Tidsskr Nor Laegeforen, 125 (4), 435-7
PubMed 15742016 SFX (Details)
Calprotectin plasma level is elevated in preeclampsia
Acta Obstet Gynecol Scand, 84 (2), 151-4
PubMed 15683375 SFX ISI 000226704600009 (Details)
Forskningshåndbok: fra idé til publikasjon
I samarbeid med Kompetansesenter for klinisk forskning, Haukeland universitetssykehus, Oslo (2. utg.), 123 s.
BIBSYS 060317140 ISBN 82-473-0017-6 (Details)
Publications 2004
Dietary supplementation with L-arginine in women with preeclampsia - Reply
Acta Obstet. Gynecol. Scand., 83 (9), 872
ISI 000223378400018 (Details)
The decidual suction method: a new way of collecting decidual tissue for functional and morphological studies
Acta Obstet Gynecol Scand, 83 (8), 724-30
PubMed 15255844 SFX ISI 000223228400006 (Details)
Leukocyte adhesion molecules and reactive oxygen species in preeclampsia
Obstet Gynecol, 103 (5 Pt 1), 913-22
PubMed 15121565 SFX ISI 000225414200014 (Details)
Mary Burgan retires as AAUP general secretary
Academe-Bull. AAUP, 90 (3), 21
ISI 000222260400014 (Details)
Adiponectin is reduced in gestational diabetes mellitus in normal weight women
Acta Obstet Gynecol Scand, 83 (4), 341-7
PubMed 15005780 SFX ISI 000220099400005 (Details)
Different levels of platelet activation in preeclamptic, normotensive pregnant, and nonpregnant women
Am J Obstet Gynecol, 190 (4), 1128-34
PubMed 15118653 SFX ISI 000221209600062 (Details)
Dietary supplementation with L-arginine or placebo in women with pre-eclampsia
Acta Obstet Gynecol Scand, 83 (1), 103-7
PubMed 14678093 SFX ISI 000187243500016 (Details)
Publications 2003
Augmented PLA2 activity in pre-eclamptic decidual tissue--a key player in the pathophysiology of 'acute atherosis' in pre-eclampsia?
Placenta, 24 (10), 965-73
PubMed 14580379 SFX ISI 000186322100008 (Details)
[Inter-collegial guidance after completed specialty training]
Tidsskr Nor Laegeforen, 123 (20), 2899-900
PubMed 14600721 SFX (Details)
Periconceptional use of folic acid supplements in Oslo
Acta Obstet Gynecol Scand, 82 (7), 620-7
PubMed 12790843 SFX ISI 000183374400006 (Details)
[Isoprostanes--new markers of oxidative stress]
Tidsskr Nor Laegeforen, 123 (3), 315-8
PubMed 12640897 SFX (Details)
Forskningshåndbok: fra idé til publikasjon
Vitenskapsrådet Ullevål universitetssykehus HF, Oslo, 89 s.
BIBSYS 040620689 ISBN 82-473-0017-6 (Details)
Publications 2001
An introduction to cell migration and invasion
Scand J Clin Lab Invest, 61 (4), 257-68
PubMed 11465338 SFX ISI 000169789700001 (Details)
An introduction to gene therapy and its potential prenatal use
Acta Obstet Gynecol Scand, 80 (6), 485-91
PubMed 11380282 SFX ISI 000169176700001 (Details)
Publications 2000
Lithocholic acid and sulphated lithocholic acid differ in the ability to promote matrix metalloproteinase secretion in the human colon cancer cell line CaCo-2
Biochem J, 349 (Pt 1), 189-93
PubMed 10861227 SFX ISI 000088147100024 (Details)
8-Iso-prostaglandin f(2alpha) reduces trophoblast invasion and matrix metalloproteinase activity
Hypertension, 35 (6), 1307-13
PubMed 10856282 SFX ISI 000087806700025 (Details)
Preeclampsia and uteroplacental tissues: lipids, oxidative stress, and trophoblast invasion
Institute for Nutrition Research, Department of Obstetrics and Gynecology, Aker Hospital, University of Oslo, Oslo, 1 b. (flere pag.)
BIBSYS 00074090x ISBN 82-91061-21-1 (Details)
Publications 1999
Elevated level of free 8-iso-prostaglandin F2alpha in the decidua basalis of women with preeclampsia
Am J Obstet Gynecol, 181 (5 Pt 1), 1211-5
PubMed 10561647 SFX ISI 000083739000033 (Details)
Increased contents of phospholipids, cholesterol, and lipid peroxides in decidua basalis in women with preeclampsia
Am J Obstet Gynecol, 180 (3 Pt 1), 587-92
PubMed 10076133 SFX ISI 000079175300015 (Details)
Publications 1995
CLINICAL WEEK AT THE GYNECOLOGY-OBSTETRICS DEPARTMENT OF THE UNIVERSITATSSPITAL, ZURICH
Gynakol. Geburtshilfliche Rundsch., 35 (3), 179
ISI A1995TD39600016 (Details)
Publications 1988
An estimation of the prevalence of diabetes mellitus in Norway. A prescription registration study
Scand J Prim Health Care, 6 (4), 233-7
PubMed 3068761 SFX (Details)
Publications 1986
[Hypertension and type II diabetes. Therapeutic attitudes among Norwegian physicians. A questionnaire study]
Tidsskr Nor Laegeforen, 106 (25), 2018-22
PubMed 3775722 SFX (Details)