Karl-Johan Malmberg

Bilde av Karl-Johan Malmberg
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Mobiltelefon +47-45390926
Brukernavn
Besøksadresse Ullernchausseen 70 None 0372 OSLO
Postadresse Postboks 4950 Nydalen 0424 OSLO


 

Publikasjoner

Béziat, V., Liu L. L., Malmberg, J-A., Ivarsson, A.M., Sohlberg, E., Björklund, A.T., Retière, C., Sverremark-Ekström, E., Traherne, J., Ljungman, P., Schaffer, M., Price, D., Trowsdale, J., Michaëlsson, J., Ljunggren, HG., Malmberg, KJ. NK Cell Responses to Cytomegalovirus Infection Lead to Stable Imprints in the Human KIR Repertoire and Involve Activating KIRs. Blood 2013, In press. Online First, Jan 16, 2013.

Malmberg KJ. Towards a prime-boost regime for NK cells. Blood. 2012. Dec 6;120(24):4663-4.

Björkström, N.K., Béziat, V., Cichocki, F., Liu, L. L., Levine, J., Larsson, S., Koup, RA, Anderson, SK., Ljunggren, HG., and Malmberg. KJ. CD8 T Cells Express Randomly Selected KIRs with Distinct Specificities Compared to NK Cells. Blood. 2012. Oct 25;120(17):3455-65. [0 citations]

Bjorkstrom NK, Lindgren T, Stoltz M, Fauriat C, Braun M, Evander M, Michaelsson J, Malmberg KJ, Klingstrom J, Ahlm C, Ljunggren HG. Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus. J Exp Med. 2011;208(1):13-21. [33 citations]

Malmberg KJ, Michaelsson J, Parham P, Ljunggren HG. Killer cell immunoglobulin-like receptor workshop: insights into evolution, genetics, function, and translation. Immunity. 2011;35(5):653-7.

Fauriat C, Ivarsson MA, Ljunggren HG, Malmberg KJ, Michaelsson J. Education of human natural killer cells by activating killer cell immunoglobulin-like receptors. Blood. 2010;115(6):1166-74. [39 citations]

Carlsten M, Baumann BC, Simonsson M, Jadersten M, Forsblom AM, Hammarstedt C, Bryceson YT, Ljunggren HG, Hellstrom-Lindberg E, Malmberg KJ. Reduced DNAM-1 expression on bone marrow NK cells associated with impaired killing of CD34+ blasts in myelodysplastic syndrome. Leukemia. 2010;24(9):1607-16. [10 citations]

Bjorkstrom NK, Riese P, Heuts F, Andersson S, Fauriat C, Ivarsson MA, Bjorklund AT, Flodstrom-Tullberg M, Michaelsson J, Rottenberg ME, Guzman CA, Ljunggren HG, Malmberg KJ. Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education. Blood. 2010;116(19):3853-64. [50 citations]

Bjorklund AT, Schaffer M, Fauriat C, Ringden O, Remberger M, Hammarstedt C, Barrett AJ, Ljungman P, Ljunggren HG, Malmberg KJ. NK cells expressing inhibitory KIR for non-self-ligands remain tolerant in HLA-matched sibling stem cell transplantation. Blood. 2010;115(13):2686-94. [16 citations]

Carlsten M, Norell H, Bryceson YT, Poschke I, Schedvins K, Ljunggren HG, Kiessling R, Malmberg KJ. Primary human tumor cells expressing CD155 impair tumor targeting by down-regulating DNAM-1 on NK cells. J Immunol. 2009;183(8):4921-30. [24 citations]

Andersson S, Fauriat C, Malmberg JA, Ljunggren HG, Malmberg KJ. KIR acquisition probabilities are independent of self-HLA class I ligands and increase with cellular KIR expression. Blood. 2009;114(1):95-104. [31 citations]

Malmberg KJ, Ljunggren HG. Spotlight on IL-22-producing NK cell receptor-expressing mucosal lymphocytes. Nat Immunol. 2009;10(1):11-2. [13 citations]

Fauriat C, Andersson S, Bjorklund AT, Carlsten M, Schaffer M, Bjorkstrom NK, Baumann BC, Michaelsson J, Ljunggren HG, Malmberg KJ. Estimation of the size of the alloreactive NK cell repertoire: studies in individuals homozygous for the group A KIR haplotype. J Immunol. 2008;181(9):6010-9. [29 citations]

Carlsten M, Bjorkstrom NK, Norell H, Bryceson Y, van Hall T, Baumann BC, Hanson M, Schedvins K, Kiessling R, Ljunggren HG, Malmberg KJ. DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells. Cancer Res. 2007;67(3):1317-25. [55 citations]

Ljunggren HG, Malmberg KJ. Prospects for the use of NK cells in immunotherapy of human cancer. Nat Rev Immunol. 2007;7(5):329-39. [144 citations]

 

  • Clancy, Trevor; dannenfelser, ruth; Troyanskaya, Olga G.; Malmberg, Karl-Johan; Hovig, Eivind & Kristensen, Vessela N. (2017). Bioinformatics approaches to profile the tumor microenvironment for immunotherapeutic discovery. Current pharmaceutical design.  ISSN 1381-6128.  23(32), s 4716- 4725 . doi: 10.2174/1381612823666170710154936 Vis sammendrag
  • Liu, Lisa L.; Béziat, Vivien; Oei, Vincent Yi Sheng; Pfefferle, Aline; Schaffer, Marie; Lehmann, Sören; Hellström-Lindberg, Eva; Söderhäll, Stefan; Heyman, Mats; Grandér, Dan & Malmberg, Karl-Johan (2017). Ex vivo expanded adaptive NK cells effectively kill primary acute lymphoblastic leukemia cells. Cancer immunology research.  ISSN 2326-6066.  5(8), s 654- 665 . doi: 10.1158/2326-6066.CIR-16-0296
  • Malmberg, Karl-Johan; Carlsten, Mattias; Björklund, Andreas; Sohlberg, Ebba; Bryceson, Yenan & Ljunggren, Hans-Gustaf (2017). Natural killer cell-mediated immunosurveillance of human cancer. Seminars in Immunology.  ISSN 1044-5323.  31, s 20- 29 . doi: 10.1016/j.smim.2017.08.002
  • Malmberg, Karl-Johan; Sohlberg, Ebba; Goodridge, Jodie & Ljunggren, Hans-Gustaf (2017). Immune selection during tumor checkpoint inhibition therapy paves way for NK-cell "missing self" recognition. Immunogenetics.  ISSN 0093-7711.  69(8-9), s 547- 556 . doi: 10.1007/s00251-017-1011-9
  • Wagner, Julia A.; Rosario, Maximillian; Romee, Rizwan; Berrien-Elliott, Melissa M.; Schneider, Stephanie E.; Leong, Jeffrey W.; Sullivan, Ryan P.; Jewell, Brea A.; Becker-Hapak, Michelle; Schappe, Timothy; Abdel-Latif, Sara; Ireland, Aaron R.; Jaishankar, Devika; King, Justin A.; Vij, Ravi; Clement, Dennis; Goodridge, Jodie; Malmberg, Karl-Johan; Wong, Hing C. & Fehniger, Todd A. (2017). CD56bright NK cells exhibit potent antitumor responses following IL-15 priming. Journal of Clinical Investigation.  ISSN 0021-9738.  127(11), s 4042- 4058 . doi: 10.1172/JCI90387
  • Björklund, Andreas T.; Clancy, Trevor; Goodridge, Jodie; Béziat, Vivien; Schaffer, Marie; Hovig, Johannes Eivind; Ljunggren, Hans-Gustaf; Ljungman, Per T. & Malmberg, Karl-Johan (2016). Naive donor NK cell repertoires associated with less leukemia relapse after allogeneic hematopoietic stem cell transplantation. Journal of Immunology.  ISSN 0022-1767.  196(3), s 1400- 1411 . doi: 10.4049/jimmunol.1501434
  • Landtwing, Vanessa; Raykova, Ana; Pezzino, Gaetana; Béziat, Vivien; Marcenaro, Emanuela; Graf, Claudine; Moretta, Alessandro; Capaul, Riccarda; Zbinden, Andrea; Ferlazzo, Guido; Malmberg, Karl-Johan; Chijioke, Obinna & Munz, Christian (2016). Cognate HLA absence in trans diminishes human NK cell education. Journal of Clinical Investigation.  ISSN 0021-9738.  126(10), s 3772- 3782 . doi: 10.1172/JCI86923
  • Liu, Lisa L.; Landskron, Johannes; Ask, Eivind Heggernes; Enqvist, Monika; Sohlberg, Ebba; Traherne, James A.; Hammer, Quirin; Goodridge, Jodie; Larsson, Stella; Jayaraman, Jyothi; Oei, Vincent Yi Sheng; Schaffer, Marie; Tasken, Kjetil; Ljunggren, Hans-Gustaf; Romagnani, Chiara; Trowsdale, John; Malmberg, Karl-Johan & Béziat, Vivien (2016). Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans. Cell reports.  ISSN 2211-1247.  15(3), s 1088- 1099 . doi: 10.1016/j.celrep.2016.04.005
  • Mensali, Nadia; Fan, Ying; Oei, Vincent Yi Sheng; Yang, Weiwen; Walseng, Even; Kumari, Shraddha; Fallang, Lars-Egil; Kolstad, Arne; Uckert, Wolfgang; Malmberg, Karl-Johan; Waelchli, Sebastien & Olweus, Johanna (2016). Targeting B-cell neoplasia with T-cell receptors recognizing a CD20-derived peptide on patient-specific HLA. Oncoimmunology.  ISSN 2162-402X.  5:e1138100(5) . doi: 10.1080/2162402X.2016.1138199
  • Béziat, Vivien; Sleiman, Marwan; Goodridge, Jodie; Kaarbø, Mari; Liu, Lisa L.; Rollag, Halvor; Ljunggren, Hans-Gustaf; Zimmer, Jacques & Malmberg, Karl-Johan (2015). Polyclonal expansion of NKG2C+ NK cells in TAP-deficient patients. Frontiers in Immunology.  ISSN 1664-3224.  6 . doi: 10.3389/fimmu.2015.00507
  • Enqvist, Monika; Ask, Eivind Heggernes; Forslund, Elin; Carlsten, Mattias; Abrahamsen, Greger; Béziat, Vivien; Andersson, Sandra; Schaffer, Marie; Spurkland, Anne; Bryceson, Yenan; Önfelt, Björn & Malmberg, Karl-Johan (2015). Coordinated expression of DNAM-1 and LFA-1 in educated NK cells. Journal of Immunology.  ISSN 0022-1767.  194(9), s 4518- 4527 . doi: 10.4049/jimmunol.1401972
  • Forslund, Elin; Sohlberg, Ebba; Enqvist, Monika; Olofsson, Per E.; Malmberg, Karl-Johan & Önfelt, Björn (2015). Microchip-Based Single-Cell Imaging Reveals That CD56dimCD57-KIR-NKG2A+ NK Cells Have More Dynamic Migration Associated with Increased Target Cell Conjugation and Probability of Killing Compared to CD56dimCD57-KIR-NKG2A- NK Cells. Journal of Immunology.  ISSN 0022-1767.  195(7), s 3374- 3381 . doi: 10.4049/jimmunol.1500171
  • Goodridge, Jodie; Önfelt, Björn & Malmberg, Karl-Johan (2015). Newtonian cell interactions shape natural killer cell education. Immunological Reviews.  ISSN 0105-2896.  267(1), s 197- 213 . doi: 10.1111/imr.12325
  • Liu, Lisa L.; Pfefferle, Aline; Oei, Vincent Yi Sheng; Björklund, Andreas T.; Béziat, Vivien; Goodridge, Jodie & Malmberg, Karl-Johan (2015). Harnessing adaptive natural killer cells in cancer immunotherapy. Molecular Oncology.  ISSN 1574-7891.  9(10), s 1904- 1917 . doi: 10.1016/j.molonc.2015.10.001
  • Lunemann, Sebastian; Malone, David F. G.; Grabowski, Jan; Port, Kerstin; Béziat, Vivien; Bremer, Birgit; Malmberg, Karl-Johan; Manns, Michael P.; Sandberg, Johan K.; Cornberg, Markus; Ljunggren, Hans-Gustaf; Wedemeyer, Heiner & Björkström, Niklas K (2015). Effects of HDV infection and pegylated interferon α treatment on the natural killer cell compartment in chronically infected individuals. Gut.  ISSN 0017-5749.  64(3), s 469- 482 . doi: 10.1136/gutjnl-2014-306767
  • Schlums, Heinrich; Cichocki, Frank; Tesi, Bianca; Theorell, Jakob; Béziat, Vivien; Holmes, Tim D.; Han, Hongya; Chiang, Samuel C.C.; Foley, Bree; Mattsson, Kristin; Larsson, Stella; Schaffer, Marie; Malmberg, Karl-Johan; Ljunggren, Hans-Gustaf; Miller, Jeffrey S. & Bryceson, Yenan (2015). Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function. Immunity.  ISSN 1074-7613.  42(3), s 443- 456 . doi: 10.1016/j.immuni.2015.02.008
  • Sobecks, Ronald M.; Wang, Tao; Askar, Medhat; Gallagher, Meighan M.; Haagenson, Michael; Spellman, Stephen; Fernandez-Vina, Marcelo; Malmberg, Karl-Johan; Müller, Carlheinz; Battiwalla, Minoo; Gajewski, James; Verneris, Michael R.; Ringden, Olle; Marino, Susana; Davies, Stella; Dehn, Jason; Bornhäuser, Martin; Inamoto, Yoshihiro; Woolfrey, Ann; Shaw, Peter; Pollack, Marilyn; Weisdorf, Daniel; Milller, Jeffrey; Hurley, Carolyn; Lee, Stephanie J. & Hsu, Katharine (2015). Impact of KIR and HLA Genotypes on Outcomes after Reduced-Intensity Conditioning Hematopoietic Cell Transplantation. Biology of blood and marrow transplantation.  ISSN 1083-8791.  21(9), s 1589- 1596 . doi: 10.1016/j.bbmt.2015.05.002
  • Sohlberg, Ebba; Pfefferle, Aline; Andersson, Sandra; Baumann, Bettina C.; Hellström-Lindberg, Eva & Malmberg, Karl-Johan (2015). Imprint of 5-azacytidine on the natural killer cell repertoire during systemic treatment for high-risk myelodysplastic syndrome. OncoTarget.  ISSN 1949-2553.  6(33), s 34178- 34190 . doi: 10.18632/oncotarget.6213
  • Von Bahr, Lena; Blennow, Ola; Alm, Jessica J.; Björklund, Andreas; Malmberg, Karl-Johan; Mougiakakos, Dimitrios; Le Blanc, A.; Oefner, Peter J.; Labopin, Myriam; Ljungman, Per T. & Le Blanc, Katarina (2015). Increased incidence of chronic GvHD and CMV disease in patients with Vitamin D deficiency before allogeneic stem cell transplantation. Bone Marrow Transplantation.  ISSN 0268-3369.  50(9), s 1217- 1223 . doi: 10.1038/bmt.2015.123
  • Azzi, Tarik; Lunemann, Anna; Murer, Anita; Ueda, Seigo; Béziat, Vivien; Malmberg, Karl-Johan; Staubli, Georg; Gysin, Claudine; Berger, Christoph; Munz, Christian; Chijioke, Obinna & Nadal, David (2014). Role for early-differentiated natural killer cells in infectious mononucleosis. Blood.  ISSN 0006-4971.  124(16), s 2533- 2543 . doi: 10.1182/blood-2014-01-553024
  • Bengner, Malin; Béziat, Vivien; Ernerudh, Jan; Nilsson, Bengt-Olof; Löfgren, Sture; Wikby, Anders; Malmberg, Karl-Johan & Strindhall, Jan (2014). Independent skewing of the T cell and NK cell compartments associated with cytomegalovirus infection suggests division of labor between innate and adaptive immunity. Age.  ISSN 0161-9152.  36(2), s 571- 582 . doi: 10.1007/s11357-013-9587-y
  • Béziat, Vivien; Traherne, James; Malmberg, Jenny-Ann; Ivarsson, Martin A.; Björkström, Niklas K; Retière, Christelle; Ljunggren, Hans-Gustaf; Michaëlsson, Jakob; Trowsdale, John & Malmberg, Karl-Johan (2014). Tracing dynamic expansion of human NK-cell subsets by high-resolution analysis of KIR repertoires and cellular differentiation. European Journal of Immunology.  ISSN 0014-2980.  44(7), s 2192- 2196 . doi: 10.1002/eji.201444464
  • Munneke, J. Marius; Björklund, Andreas T.; Mjösberg, Jenny M.; Garming-Legert, Karin; Bernink, Jochem H.; Blom, Bianca; Huisman, Cynthia; van Oers, Marinus H.J.; Spits, Hergen; Malmberg, Karl-Johan & Hazenberg, Mette D. (2014). Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease. Blood.  ISSN 0006-4971.  124(5), s 812- 821 . doi: 10.1182/blood-2013-11-536888
  • Béziat, Vivien; Liu, Lisa L.; Malmberg, Jenny-Ann; Ivarsson, Martin A.; Sohlberg, Ebba; Björklund, Andreas T.; Retière, Christelle; Sverremark-Ekström, Eva; Traherne, James; Ljungman, Per; Schaffer, Marie; Price, David A.; Trowsdale, John; Michaëlsson, Jacob; Ljunggren, Hans-Gustaf & Malmberg, Karl-Johan (2013). NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs. Blood.  ISSN 0006-4971.  121(14), s 2678- 2688 . doi: 10.1182/blood-2012-10-459545
  • Béziat, Vivien; Traherne, James A.; Liu, Lisa L; Jayaraman, Jyothi; Enqvist, Monika; Larsson, Stella; Trowsdale, John & Malmberg, Karl-Johan (2013). Influence of KIR gene copy number on natural killer cell education. Blood.  ISSN 0006-4971.  121(23), s 4703- 4707 . doi: 10.1182/blood-2012-10-461442
  • Vanherberghen, Bruno; Olofsson, Per E.; Forslund, Elin; Sternberg-Simon, Michal; Khorshidi, Mohammad Ali; Pacouret, Simon; Guldevall, Karolin; Enqvist, Monika; Malmberg, Karl-Johan; Mehr, Ramit & Önfelt, Björn (2013). Classification of human natural killer cells based on migration behavior and cytotoxic response. Blood.  ISSN 0006-4971.  121(8), s 1326- 1334 . doi: 10.1182/blood-2012-06-439851
  • Béziat, Vivien; Dalgard, Olav; Asselah, Tarik; Halfon, Philippe; Bedossa, Pierre; Boudifa, Ali; Hervier, Baptiste; Theodorou, Ioannis; Martinot, Michelle; Debre, Patrice; Björkström, Niklas K; Malmberg, Karl-Johan; Marcellin, Patrick & Vieillard, Vincent (2012). CMV drives clonal expansion of NKG2C(+) NK cells expressing self-specific KIRs in chronic hepatitis patients. European Journal of Immunology.  ISSN 0014-2980.  42(2), s 447- 457 . doi: 10.1002/eji.201141826
  • Björkström, Niklas K; Béziat, Vivien; Cichocki, Frank; Liu, Lisa L; Levine, Jeffrey; Larsson, Stella; Koup, Richard A; Anderson, Stephen K; Ljunggren, Hans-Gustaf & Malmberg, Karl-Johan (2012). CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells. Blood.  ISSN 0006-4971.  120(17), s 3455- 3465 . doi: 10.1182/blood-2012-03-416867

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  • Johnsen, Guro Mørk; Sheng, Vincent O.Y.; Tasken, Kjetil; Staff, Anne Cathrine & Malmberg, Karl-Johan (2015). Killer immunoglobulin-like receptors (KIRS) on 3rd trimester decidual natural killer cells. Journal of Reproductive Immunology.  ISSN 0165-0378.  111, s 11 . doi: 10.1016/j.jri.2015.06.073
  • Beziat, V.; Liu, L.; Sohlberg, Ebba; Retiere, C.; Traherne, James A.; Sverremark-Ekström, Eva; Trowsdale, John; Michaëlsson, Jacob; Ljunggren, Hans-Gustaf & Malmberg, Karl-Johan (2012). Mapping the diversity of human KIR repertoires and their adaptation to infection. Immunology.  ISSN 0019-2805.  137, s 128- 129
  • Malmberg, Karl-Johan (2012). Toward a prime-boost regime for NK cells?. Blood.  ISSN 0006-4971.  120(24), s 4663- 4664 . doi: 10.1182/blood-2012-09-457184
  • Malmberg, Karl-Johan; Béziat, Vivien & Ljunggren, Hans-Gustaf (2012). Spotlight on NKG2C and the human NK-cell response to CMV infection. European Journal of Immunology.  ISSN 0014-2980.  42(12), s 3141- 3145 . doi: 10.1002/eji.201243050

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Publisert 14. feb. 2012 13:40 - Sist endret 4. nov. 2014 10:58