Lars Eide

Bilde av Lars Eide
English version of this page
Telefon +47-23071062
Mobiltelefon 93241242
Rom B1.3054
Brukernavn
Besøksadresse Rikshospitalet; sognsvannsveien 20 0372 Oslo
Postadresse Postboks 4950 Nydalen 0424 OSLO
Andre tilknytninger Avdeling for medisinsk biokjemi

Faglige interesser

Mitokondrielt DNA (mtDNA); modifiseringer ("skader"), reparasjon og mutasjoner.

Mitokondriell funksjon knyttet til mtDNA dynamikk

 

Undervisning

PhD kurs MF9135 - "Biomarkers for Clinical Research". Kursansvarlig

 

Bakgrunn

  • Konstitutert forskningsleder KDI UiO, KRN OUS, KLM OUS, siden 1. oktober 2015
  • Enhetsleder MBK, OUS, konst.seksjonsleder FUI, 2014.
  • Professor ved Medisinsk Fakultet, UiO siden 2011
  • Førsteamanuensis ved Medisinsk Fakultet, UiO, 2006 - 2011
  • Dr. Scient, Matematisk-Naturvitenskapelige Fakultet, UiO, 1997
  • Sivilingeniør Kjemi, Trondheim 1992

 

Emneord: mitokondrier, mtDNA, mitochondrial DNA repair

Publikasjoner

  • Jackson, Catherine; Reppe, Sjur; Eidet, Jon Roger; Eide, Lars; Tønseth, Kim Alexander; Bergersen, Linda Hildegard; Dartt, Darlene A.; Griffith, May & Utheim, Tor Paaske (2017). Optimization of Storage Temperature for Retention of Undifferentiated Cell Character of Cultured Human Epidermal Cell Sheets. Scientific Reports.  ISSN 2045-2322.  7 . doi: 10.1038/s41598-017-08586-7
  • Li, Xiaoran; Lu, J; kan, q; Li, x; fan, q; Li, y; Huang, Ruixia; Slipicevic, Ana; Dong, HP; Eide, Lars; Wang, Junbai; zhang, h; berge, v; Goscinski, MA; Kvalheim, Gunnar; Nesland, Jahn M & Suo, Zhenhe (2017). Metabolic reprogramming is associated with flavopiridol resistance in prostate cancer DU145 cells.. Scientific Reports.  ISSN 2045-2322.  7(1) . doi: 10.1038/s41598-017-05086-6
  • Distante, Sonia; Eikeland, Joakim; Pawar, Tina; Skinnes, Ragnhild; Høie, Kari; You, Panpan; Mørkrid, Lars & Eide, Lars (2016). Blood removal therapy in hereditary hemochromatosis induces a stress response resulting in improved genome integrity. Transfusion.  ISSN 0041-1132.  56(6), s 1435- 1441 . doi: 10.1111/trf.13588
  • Khuu, Cuong; Sehic, Amer; Eide, Lars & Osmundsen, Harald (2016). Anti-proliferative properties of miR-20b and miR-363 from the miR-106a-363 cluster on human carcinoma cells. MicroRNA.  ISSN 2211-5366. . doi: 10.2174/2211536605666160322151813
  • Li, Xiaoran; Zhong, Yali; Lu, Jie; Axcrona, Karol; Eide, Lars; Syljuåsen, Randi G.; Qian, Peng; Wang, Junbai; Zhang, Hongquan; Goscinski, Mariusz Adam; Kvalheim, Gunnar; Nesland, Jahn M & Suo, Zhenhe (2016). MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features. OncoTarget.  ISSN 1949-2553.  7(26), s 40297- 40313 . doi: 10.18632/oncotarget.9610 Fulltekst i vitenarkiv
  • Pawar, Tina & Eide, Lars (2016). Pitfalls in mitochondrial epigenetics. Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis.  ISSN 2470-1394.  s 1- 10 . doi: 10.1080/24701394.2016.1180514
  • Skarpengland, Tonje; Dahl, Tuva Børresdatter; Skjelland, Mona; Scheffler, Katja; Sousa, Mirta; Gregersen, Ida; Kusnierczyk, Anna; Sharma, Animesh; Slupphaug, Geir; Eide, Lars; Segers, Filip; Skagen, Karolina Ryeng; Dahl, Christen Peder; Russell, David; Folkersen, Lasse; Krohg-Sørensen, Kirsten; Holm, Sverre; Bjørås, Magnar; Aukrust, Pål & Halvorsen, Bente (2016). Enhanced base excision repair capacity in carotid atherosclerosis may protect nuclear DNA but not mitochondrial DNA. Free Radical Biology & Medicine.  ISSN 0891-5849.  97, s 386- 397 . doi: 10.1016/j.freeradbiomed.2016.07.001
  • Skarpengland, Tonje; Holm, Sverre; Scheffler, Katja; Gregersen, Ida; Dahl, Tuva Børresdatter; Suganthan, Rajikala; Segers, Filip; Østlie, Ingunn; Otten, Jeroen J.T.; Gomez, Luisa Fernanda Luna; Ketelhuth, Daniel F.J.; Lundberg, Anna M.; Neurauter, Christine Gran; Hildrestrand, Gunn Annette; Skjelland, Mona; Bjørndal, Bodil; Svardal, Asbjørn M.; Iversen, Per Ole; Hedin, Ulf; Nygård, Ståle; Olstad, Ole Kristoffer; Krohg-Sørensen, Kirsten; Slupphaug, Geir; Eide, Lars; Kusnierczyk, Anna; Folkersen, Lasse; Ueland, Thor; Berge, Rolf Kristian; Hansson, Göran K.; Biessen, Erik A.L.; Halvorsen, Bente; Bjørås, Magnar & Aukrust, Pål (2016). Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice. Scientific Reports.  ISSN 2045-2322.  6:28337 . doi: 10.1038/srep28337
  • Skjellegrind, Håvard Kjesbu; Fayzullin, Artem; Johnsen, Erik Otter; Eide, Lars; Langmoen, Iver Arne; Moe, Morten Carsten & Vik-Mo, Einar O. (2016). Short-Term Differentiation of Glioblastoma Stem Cells Induces Hypoxia Tolerance. Neurochemical Research.  ISSN 0364-3190.  41(7), s 1545- 1558 . doi: 10.1007/s11064-016-1868-2
  • Sokolova, Marina; Vinge, Leif Erik; Alfsnes, Katrine; Olsen, Maria Belland; Eide, Lars; Kaasbøll, Ole Jørgen; Attramadal, Håvard; Torp, May-Kristin; Fosshaug, Linn Elisabeth Lillerud; Rashidi, Azita; Lien, Egil; Finsen, Alexandra; Sandanger, Øystein; Aukrust, Pål; Ranheim, Trine & Yndestad, Arne (2016). Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.  ISSN 1388-1981.  1862(2), s 234- 245 . doi: 10.1016/j.bbalip.2016.11.003
  • Bjørge, Monica Dahl; Hildrestrand, Gunn Annette; Scheffler, Katja; Suganthan, Rajikala; Rolseth, Veslemøy; Kusnierczyk, Anna; Rowe, Alexander D.; Vågbø, Cathrine Broberg; Vetlesen, Susanne; Eide, Lars; Slupphaug, Geir; Yusaku, Nakabeppu; Timothy, Bredy; Klungland, Arne & Bjørås, Magnar (2015). Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice. Cell reports.  ISSN 2211-1247.  13(12), s 2671- 2678 . doi: 10.1016/j.celrep.2015.12.001 Fulltekst i vitenarkiv
  • Bliksøen, Marte; Baysa, Anton; Eide, Lars; Bjørås, Magnar; Suganthan, Rajikala; Vaage, Ingvar Jarle; Stensløkken, Kåre-Olav & Valen, Guro (2015). Mitochondrial DNA damage and repair during ischemia-reperfusion injury of the heart. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  78, s 9- 22 . doi: 10.1016/j.yjmcc.2014.11.010
  • Lauritzen, Knut Husø; Kleppa, Liv; Aronsen, Jan Magnus; Eide, Lars; Carlsen, Harald; Haugen, Øyvind Pernell; Sjaastad, Ivar; Klungland, Arne; Rasmussen, Lene Juel; Attramadal, Håvard; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2015). Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure. American Journal of Physiology. Heart and Circulatory Physiology.  ISSN 0363-6135.  309(3), s H434- H449 . doi: 10.1152/ajpheart.00253.2014
  • Yang, Mingyi; Lin, Xiaolin; Rowe, Alexander D.; Rognes, Torbjørn; Eide, Lars & Bjørås, Magnar (2015). Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway. Scientific Reports.  ISSN 2045-2322.  5 . doi: 10.1038/srep17409
  • Hereng, Tuva Holt; Elgstøen, Katja B. Prestø; Eide, Lars; Rosendal, Ken Roger & Skålhegg, Bjørn Steen (2014). Serum albumin and HCO<sub>3</sub><sup>-</sup> regulate separate pools of ATP in human spermatozoa. Human Reproduction.  ISSN 0268-1161.  29(5), s 918- 930 . doi: 10.1093/humrep/deu028
  • Hystad, Eva Marit; Amdam, Gro Vang & Eide, Lars (2014). Mitochondrial DNA integrity changes with age but does not correlate with learning performance in honey bees. Experimental Gerontology.  ISSN 0531-5565.  49, s 12- 18 . doi: 10.1016/j.exger.2013.10.013
  • Jalland, Clara; Benestad, Sylvie Lafond; Ersdal, Cecilie; Scheffler, Katja; Suganthan, Rajikala; Nakabeppu, Yusaku; Eide, Lars; Bjørås, Magnar & Tranulis, Michael A. (2014). Accelerated clinical course of prion disease in mice compromised in repair of oxidative DNA damage. Free Radical Biology & Medicine.  ISSN 0891-5849.  68, s 1- 7 . doi: 10.1016/j.freeradbiomed.2013.11.013
  • Strand, Janne Maren; Scheffler, Katja; Bjørås, Magnar & Eide, Lars (2014). The distribution of DNA damage is defined by region-specific susceptibility to DNA damage formation rather than repair differences. DNA Repair.  ISSN 1568-7864.  18(1), s 44- 51 . doi: 10.1016/j.dnarep.2014.03.003
  • Strand, Janne Maren; Skinnes, Ragnhild; Scheffler, Katja; Rootwelt, Terje; Woldseth, Berit; Bjørås, Magnar & Eide, Lars (2014). Genome instability in Maple Syrup Urine Disease correlates with impaired mitochondrial biogenesis. Metabolism: Clinical and Experimental.  ISSN 0026-0495.  63(8), s 1063- 1070 . doi: 10.1016/j.metabol.2014.05.003
  • Wang, Wei; Scheffler, Katja; Esbensen, Qin Ying; Strand, Janne Maren; Stewart, James B.; Bjørås, Magnar & Eide, Lars (2014). Addressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age. PLoS ONE.  ISSN 1932-6203.  9(5) . doi: 10.1371/journal.pone.0096940
  • Yang, Mingyi; Luna, Linda; Sørbø, Jan Gunnar; Alseth, Ingrun; Johansen, Rune Forstrøm; Backe, Paul Hoff; Danbolt, Niels Christian; Eide, Lars & Bjørås, Magnar (2014). Human OXR1 maintains mitochondrial DNA integrity and counteracts hydrogen peroxide-induced oxidative stress by regulating antioxidant pathways involving p21. Free Radical Biology & Medicine.  ISSN 0891-5849.  77, s 41- 48 . doi: 10.1016/j.freeradbiomed.2014.09.003
  • Yuzefovych, Larysa V.; Schuler, A. Michele; Chen, Jemimah; Alvarez, Diego F.; Eide, Lars; Ledoux, Susan P.; Wilson, Glenn L. & Rachek, Lyudmila I. (2013). Alteration of Mitochondrial Function and Insulin Sensitivity in Primary Mouse Skeletal Muscle Cells Isolated From Transgenic and Knockout Mice: Role of OGG1. Endocrinology.  ISSN 0013-7227.  154(8), s 2640- 2649 . doi: 10.1210/en.2013-1076
  • Halsne, Ruth; Esbensen, Qin Ying; Wang, Wei; Scheffler, Katja; Suganthan, Rajikala; Bjørås, Magnar & Eide, Lars (2012). Lack of the DNA glycosylases MYH and OGG1 in the cancer prone double mutant mouse does not increase mitochondrial DNA mutagenesis. DNA Repair.  ISSN 1568-7864.  11(3), s 278- 285 . doi: 10.1016/j.dnarep.2011.12.001
  • Hereng, Tuva Holt; Elgstøen, Katja B. Prestø; Cederkvist, Fritjof Henning; Eide, Lars; Jahnsen, Tore; Skålhegg, Bjørn Steen & Rosendal, K.R (2011). Exogenous pyruvate accelerates glycolysis and promotes capacitation in human spermatozoa. Human Reproduction.  ISSN 0268-1161.  26(12), s 3249- 3263 . doi: 10.1093/humrep/der317
  • Kaarbø, Mari; Ager-Wick, Eirill; Osenbroch, Pia Madeleine Øistad; Kilander, Anette; Skinnes, Ragnhild; Müller, Fredrik & Eide, Lars (2011). Human cytomegalovirus infection increases mitochondrial biogenesis. Mitochondrion (Amsterdam. Print).  ISSN 1567-7249.  11(6), s 935- 945 . doi: 10.1016/j.mito.2011.08.008
  • Wang, Wei; Esbensen, Ying; Kunke, David; Suganthan, Rajikala; Rachek, Lyudmila; Bjørås, Magnar & Eide, Lars (2011). Mitochondrial DNA Damage Level Determines Neural Stem Cell Differentiation Fate. Journal of Neuroscience.  ISSN 0270-6474.  31(26), s 9746- 9751 . doi: 10.1523/JNEUROSCI.0852-11.2011
  • Brodtkorb, Else; Strand, Janne Maren; Backe, Paul Hoff; Lund, Anne Marie; Bjørås, Magnar; Rootwelt, Terje; Rootwelt, Helge; Woldseth, Berit & Eide, Lars (2010). Four novel mutations identified in Norwegian patients result in intermittent maple syrup urine disease when combined with the R301C mutation. Molecular Genetics and Metabolism.  ISSN 1096-7192.  100(4), s 324- 332 . doi: 10.1016/j.ymgme.2010.04.017
  • Lauritzen, Knut Husø; Moldestad, Olve; Eide, Lars; Carlsen, Harald; Nesse, Gaute; Storm, Johan Frederik; Mansuy, Isabelle M.; Bergersen, Linda Hildegard & Klungland, Arne (2010). Mitochondrial DNA Toxicity in Forebrain Neurons Causes Apoptosis, Neurodegeneration, and Impaired Behavior. Molecular and Cellular Biology.  ISSN 0270-7306.  30(6), s 1357- 1367 . doi: 10.1128/MCB.01149-09
  • Wang, Wei; Osenbroch, Pia Madeleine Øistad; Skinnes, Ragnhild; Esbensen, Qin Ying; Bjørås, Magnar & Eide, Lars (2010). Mitochondrial DNA Integrity Is Essential for Mitochondrial Maturation During Differentiation of Neural Stem Cells. Stem Cells.  ISSN 1066-5099.  28(12), s 2195- 2204 . doi: 10.1002/stem.542
  • Osenbroch, Pia Madeleine Øistad; Auk, Pia Nenseth; Halsne, Ruth; Strand, Janne Maren; Johansen, Rune Forstrøm; van der Pluijm, I & Eide, Lars (2009). Accumulation of mitochondrial DNA damage and bioenergetic dysfunction in CSB defective cells. The FEBS Journal.  ISSN 1742-464X.  276(10), s 2811- 2821 . doi: 10.1111/j.1742-4658.2009.07004.x
  • Sejersted, Yngve; Aasland, Anne Leikny; Bjørås, Magnar; Eide, Lars & Saugstad, Ola Didrik (2009). Accumulation of 8-Oxoguanine in Liver DNA During Hyperoxic Resuscitation of Newborn Mice. Pediatric Research.  ISSN 0031-3998.  66(5), s 533- 538 . doi: 10.1203/PDR.0b013e3181ba1a42
  • Yndestad, Arne; Neurauter, Christine Gran; Øie, Erik; Johansen, Rune Forstrøm; Vinge, Leif Erik; Eide, Lars; Luna, Gomez Luisa; Aukrust, Pål & Bjørås, Magnar (2009). Up-regulation of myocardial DNA base excision repair activities in experimental heart failure. Mutation research.  ISSN 0027-5107.  666(1-2), s 32- 38 . doi: 10.1016/j.mrfmmm.2009.03.008
  • Ringvoll, Jeanette; Uldal, Lene; Røed, Marie Aslaksen; Stenersen, Karen Oppland; Baynton, K; Klungland, Arne & Eide, Lars (2007). Mutations in the RAD27 and SGS1 genes differentially affect the chronological and replicative lifespan of yeast cells growing on glucose and glycerol. FEMS yeast research (Print).  ISSN 1567-1356.  7, s 848- 859 . doi: 10.1111/j.1567-1364.2007.00248.x
  • Eide, Lars & McMurray, Cynthia T. (2005). Culture of adult mouse neurons. BioTechniques.  ISSN 0736-6205.  38(1), s 99- 104
  • Trushina, E; Dyer, RB; Badger, JD; Ure, D; Eide, Lars; Tran, DD; Vrieze, BT; Legendre-Guillemin, V; McPherson, PS; Mandavilli, BS; Van Houten, B; Zeitlin, S; McNiven, M; Aebersold, R; Hayden, M; Parisi, JE; Seeberg, Erling Christen; Dragatsis, I; Doyle, K; Bender, A; Chacko, C & McMurray, CT (2004). Muntant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro. Molecular and Cellular Biology.  ISSN 0270-7306.  24, s 8195- 8209
  • Ulbert, S; Eide, Lars; Seeberg, Erling Christen & Borst, P. (2004). Base J, found in nuclear DNA of Trypanosoma brucei, is not a target for DNA glycosylases. DNA Repair.  ISSN 1568-7864.  3(2), s 145- 154

Se alle arbeider i Cristin

  • Bousquet, Paula; Meltzer, Sebastian; Sønstevold, Linda; Esbensen, Qin Ying; Lyckander, Lars Gustav; Dueland, Svein; Flatmark, Kjersti; Redalen, Kathrine Røe; Eide, Lars & Ree, Anne Hansen (2017). Reactive oxygen species (ROS) and mitochondrial DNA (mtDNA) damage in tumor hypoxia, poor radiotherapy response, and metastatic progression of rectal cancer. Cancer Research.  ISSN 0008-5472.  77, s 1782- 1782 . doi: 10.1158/1538-7445.AM2017-1782
  • Eide, Lars (2016). Hvordan kvaliteten på mitokondrielt DNA påvirker brystkreft. BestPractice onkologi hematologi i Norge.  (27), s 28- 29
  • Wang, Wei; Scheffler, Katja; Esbensen, Qin Ying & Eide, Lars (2016). Quantification of DNA Damage by Real-Time qPCR, In John M Walker (ed.),  Mitochondrial DNA Methods and Protocols.  Springer.  ISBN 978-1-4939-3039-5.  3.  s 27 - 32
  • Yuzefovych, Larysa V.; Kahn, Andrea G.; Schuler, Michele A.; Eide, Lars; Arora, Ritu; Wilson, Glenn L.; Tan, Ming & Rachek, Lyudmila I. (2016). Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis. Cancer Research.  ISSN 0008-5472.  76(1), s 30- 34 . doi: 10.1158/0008-5472.CAN-15-0692
  • Jackson, Catherine; Eidet, Jon Roger; Reppe, Sjur; Eide, Lars; Tønseth, Kim Aleksander; Bergersen, Linda Hildegard; Dartt, Darlene A.; Griffith, May & Utheim, Tor Paaske (2015). Storage of cultured skin cell sheets for treatment of limbal stem cell deficiency.
  • Jackson, Catherine; Eidet, Jon Roger; Tønseth, Kim Aleksander; Eide, Lars; Messelt, Edward B. & Utheim, Tor Paaske (2015). 12oC is the Optimal Storage Temperature for Retention of Viability and Undifferentiated Cell Character of Cultured Epidermal Cells.
  • Wang, Wei; Esbensen, Qin Ying; Scheffler, Katja & Eide, Lars (2015). Analysis of Mitochondrial DNA and RNA Integrity by a Real-Time qPCR-Based Method, In John M Walker (ed.),  Mitochondrial Medicine.  Springer.  ISBN 978-1-4939-2256-7.  10.  s 97 - 106
  • Distante, Sonia; Høie, Kari; Mørkrid, Lars & Eide, Lars (2013). ASSESSING THE MITOCHONDRIAL IRON METABOLISM IN HEREDITARY HEMOCHROMATOSIS. American Journal of Hematology.  ISSN 0361-8609.  88(5), s E207- E207
  • Halsne, Ruth & Eide, Lars (2011). Mitochondrial and cellular effects of mitochondrial DNA damage.
  • Osenbroch, Pia Madeleine Øistad & Eide, Lars (2011). Characterization of mitochondrial function in Cockayne syndrome, human cytomegalovirus infection and neural stem cell differentiation.
  • Bugge, Markus; Eide, Lars; Grünfeld, Leo A. & Thune, Taran Mari (2010). Brukerstyrte innovasjonsprosjekter og samfunnsøkonomisk avkastning.

Se alle arbeider i Cristin

Publisert 13. apr. 2011 11:37 - Sist endret 16. des. 2016 11:27

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