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Lars Nilsson

English
Telefon +47-22840221
Faks +47-22840202
Brukernavn
Besøksadresse Rikshospitalet Sognsvannsveien 20 0372 OSLO
Postadresse Postboks 1057 Blindern 0316 OSLO

Faglige interesser

  • Alzheimers sykdom
  • Amyloidose
  • Neurodegeneration

Undervisning

  • Farmakologi og PBL-undervisning for medisinstudenter

Bakgrunn

  • Apotekarexamen, Uppsala Universitet, 1988
  • PhD Neurobiologi, Karolinska Institutet, 1996
  • Professor I Farmakologi, Universitetet i Oslo, 2012-
     
Emneord: Hjerne og nervesystem, Nevrodegenerative sykdommer

Publikasjoner

Utvalgte publikasjoner

  • Philipson O, Lord A, Lalowski M, Soliyman R, Thyberg R, Baumann M, Thyberg J, Bogdanovic N, Olofsson T, Tjernberg L, Ingelsson I, Lannfelt L, Kalimo H and Nilsson LNG. (2011) The Arctic mutation results in distinct plaques and accumulation of N- and C-truncated Aβ. Neurobiology of Aging, PMID: 22118948.
  • Yang J., Olson L., Nuntagij P., Oguchi T., Camassa LMA, Nilsson LNG, Lannfelt L., Xu Y., Amiry-Moghaddam M., Ottersen OP., Torp R. (2011) Loss of astrocyte polarization in the tg-ArcSwe mouse model of Alzheimer’s disease. Journal Alzheimer’s disease 27(4):711-22.
  • Ramberg V, Tracy L, Samuelsson M, Nilsson LNG and Iverfeldt K. (2011) CCAAT/enhancer binding protein (C/EBP) δ is differently regulated by fibrillar and oligomeric forms of the Alzheimer amyloid-β peptide. Journal of Neuroinflammation, 14;8:34
  • Lord A, Philipson P, Klingstedt T, Westermark G, Hammarström P, Nilsson KP and Nilsson LNG. (2011) Observations in APP bitransgenic mice suggest that diffuse and compact plaques form by independent processes in Alzheimer’s disease. American Journal of Pathology, 178(5): 2286-2298.
  • Codita, A, Gumucio A, Lannfelt L, Gellerfors P, Winblad B, Mohammed A.K, Nilsson LNG. (2010) Impaired behavior of female tg-ArcSwe APP mice in the IntelliCage: a longitudinal study. Behav. Brain Research, 215:83-94.
  • Philipson O., Lannfelt L. and Nilsson LNG. (2009) Genetic and pharmacological evidence of intraneuronal Aβ accumulation in APP transgenic mice. FEBS Lett., 583: 3021-6.
  • Lord A., Gumucio-Gatica A., Englund H., Sehlin D., Sundquist V., Söderberg L., Möller C., Gellerfors P., Lannfelt L., Ekholm Pettersson F. and Nilsson LNG. (2009) An amyloid-β protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer’s disease. Neurobiol. Dis., 36: 425-34.
  • Lord A., Englund H., Söderberg L., Tucker S., Clausen F., Hillered L., Gordon MN., Morgan D., Lannfelt L., Ekholm-Pettersson F., Nilsson LNG. (2009) Amyloid-β protofibrils correlate with spatial learning in Arctic Alzheimer’s disease transgenic mice. FEBS.J., 276, 995-1006.
  • Philipsson O., Hammarström P., Nilsson PKR., Portelius E., Blennow K., Olofsson T., Ingelson M., Hyman BT., Blennow K., Lannfelt L., Kalimo H., Nilsson LNG. (2009) A highly insoluble state of Aβ is found in both Alzheimer´s disease brain and in transgenic mice with the Arctic mutation. Neurobiol. Aging 30:1393-1405.
  • Lord A., Kalimo H., Eckman C., Zhang X-Q., Lannfelt L. and Nilsson LNG. (2006) The Arctic Alzheimer mutation facilitates early intraneuronal Aβ aggregation and senile plaque formation in transgenic mice. Neurobiol. Aging, 27: 67-77.
  • Stenh C., Englund H., Lord A., Johansson A-S., Almeida CG, Gellerfors P., Greengard P., Gouras GK., Lannfelt L., Nilsson LNG. (2005) Oligomers of amyloid- are inefficiently measured by ELISA. Ann Neurol., 58: 147-150.
  • Nilsson LNG., Arendash GW., Low MA., Leighty RE., Costa DA., Rojiani A., Wu X., Bales KR., Paul SM. and Potter H. (2004) Cognitive impairment in PDAPP mice depends on Apolipoprotein E and ACT-catalyzed amyloid formation. Neurobiol. Aging, 25(9): 1153-67.
  • Nilsson LNG., Bales KR., DiCarlo G., Gordon MN., Morgan D., Paul SM. and Potter H. (2001) Alpha-1-antichymotrypsin promotes -sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer’s disease. J. Neurosci., 21(5): 1444-1451.
  • Rogers J., Leiter L., McPhee J., Zhan SS., Potter H. and Nilsson LNG. (1999) Translation of the Alzheimer’s amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5’ untranslated region sequences. J. Biol. Chem., 274(10): 6421-6431.
     
  • Lillehaug, Sveinung; Syverstad, Gry-Helen Enger; Nilsson, Lars; Bjaalie, Jan G.; Leergaard, Trygve Brauns & Torp, Reidun (2014). Brainwide distribution and variance of amyloid-beta deposits in tg-ArcSwe mice. Neurobiology of Aging.  ISSN 0197-4580.  35, s 556- 564
  • Gumucio, Astrid; Lannfelt, Lars & Nilsson, Lars (2013). Lack of exon 10 in the murine tau gene results in mild sensorimotor defects with aging. BMC Neuroscience.  ISSN 1471-2202.  14:148 . doi: 10.1186/1471-2202-14-148
  • Lillenes, Meryl Sønderby; Støen, Mari; Gómez-Muñoz, Marta; Torp, Reidun; Günther, Clara-Cecilie; Nilsson, Lars & Tønjum, Tone (2013). Transient OGG1, APE1, PARP1 and Polβ expression in an Alzheimer's disease mouse model. Mechanisms of Ageing and Development.  ISSN 0047-6374.  134(10), s 467- 477 . doi: 10.1016/j.mad.2013.09.002
  • Magnusson, Kristina; Sehlin, Dag; Syvänen, Stina; Svedberg, Marie M.; Philipson, Ola; Söderberg, Linda; Tegerstedt, Karin; Holmquist, Mats; Gellerfors, Pär; Tolmachev, Vladimir; Antoni, Gunnar; Lannfelt, Lars; Hall, Håkan & Nilsson, Lars (2013). Specific Uptake of an Amyloid-beta Protofibril-Binding Antibody-Tracer in A beta PP Transgenic Mouse Brain. Journal of Alzheimer's Disease.  ISSN 1387-2877.  37(1), s 29- 40 . doi: 10.3233/JAD-130029
  • Philipson, O; Lord, A; Lalowski, M; Soliymani, R; Baumann, M; Thyberg, J; Bogdanovic, N; Olofsson, T; Tjernberg, LO; Ingelsson, M; Lannfelt, L; Kalimo, H & Nilsson, Lars (2012). The Arctic amyloid-beta precursor protein (A beta PP) mutation results in distinct plaques and accumulation of N- and C-truncated A beta. Neurobiology of Aging.  ISSN 0197-4580.  33(5) . doi: 10.1016/j.neurobiolaging.2011.10.022
Publisert 26. jan. 2012 10:00 - Sist endret 26. jan. 2012 10:55