Our research team is generally interested in understanding molecular processes during normal and malignant hematopoiesis.
Photo: Artur Cieslar-Pobuda
Hematopoiesis describes the formation of all blood cells throughout life. This is ensured by long-term repopulating hematopoietic stem cells (HSC) that give rise to HSC and progenitors with limited renewing capacity. These progenitors produce lineage specific daughter cells that in turn form terminally differentiated erythroid/myeloid and lymphoid cell types.
HSC division and blood cell differentiation is tightly regulated by genetics and epigenetic events as well as activation of specific signaling pathways. The dysregulation of one or more of these biological processes can lead to various blood disorders such as leukemia.
We use embryonic stem cells, primary samples and patient-derived induced pluripotent stem cells (iPSC) to unravel molecular and epigenetic processes underlying normal and malignant hematopoietic development.
The broad aims of our research are to:
- Identify key epigenetic events during human hematopoietic development.
- Identify underlying mechanisms of impaired blood cell differentiation.
- Understand how the nuclear lamina influences normal and malignant hematopoietic development.