Alfonso Urbanucci

Image of Alfonso Urbanucci
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Phone +47-22845618
Username
Visiting address Gaustadalléen 21 Forskningsparken 0349 OSLO
Postal address Postboks 1137 Blindern 0318 OSLO

Academic Interests

Dr Urbanucci's personal research interest is on the transcriptional and chromatin drivers underpinning prostate cancer progression, with the androgen receptor as a focal point.

Techniques and key words

  • Bioinformatics
  • Formaldehyde Assisted Isolation of Regulatory Elements (FAIRE)-seq 
  • Chromatin immunoprecipitation (ChIP)-seq
  • Transcriptomic (RNA-seq)
  • Bromodomain containing proteins (BRDs)
  • Gene signature
  • Chromatin biology
Tags: Cancer research, Bioinformatics, Cancer, Cancer biology, Chromatin, Transcriptomics, Prostate cancer, DNA sequencing, Biotech

Publications

  • Barfeld, Stefan Jörg; Urbanucci, Alfonso; Itkonen, Harri; Fazli, Ladan; Hicks, Jessica L.; Thiede, Bernd; Rennie, Paul S.; Yegnasubramanian, Srinivasan; DeMarzo, Angelo M. & Mills, Ian Geoffrey (2017). c-Myc antagonises the transcriptional activity of the androgen receptor in prostate cancer affecting key gene networks. EBioMedicine.  ISSN 2352-3964.  18, s 83- 93 . doi: 10.1016/j.ebiom.2017.04.006
  • Itkonen, Harri; Brown, Michael; Urbanucci, Alfonso; Tredwell, Gregory; Lau, Chung Ho; Barfeld, Stefan Jörg; Hart, Claire; Guldvik, Ingrid Jenny; Takhar, Mandeep; Heemers, Hannelore V.; Erho, Nicholas; Bloch, Katarzyna; Davicioni, Elai; Derua, Rita; Waelkens, Etienne; Mohler, James L.; Clarke, Noel; Swinnen, Johan V.; Keun, Hector C.; Rekvig, Ole Petter & Mills, Ian Geoffrey (2017). Lipid degradation promotes prostate cancer cell survival. OncoTarget.  ISSN 1949-2553.  8(24), s 38264- 38275 . doi: 10.18632/oncotarget.16123
  • Urbanucci, Alfonso; Barfeld, Stefan Jörg; Kytölä, Ville; Itkonen, Harri; Coleman, Ilsa M.; Vodák, Daniel; Sjöblom, Liisa; Sheng, Xia; Minner, Sarah; Burdelski, Christoph; Kivinummi, Kati K.; Kohvakka, Annika; Kregel, Steven; Takhar, Mandeep; Alshalalfa, Mohammed; Davicioni, Elai; Erho, Nicholas; Lloyd, Paul; Karnes, R. Jeffrey; Ross, Ashley E.; Schaeffer, Edward M.; Vander Griend, Donald J; Knapp, Stefan; Corey, Eva; Feng, Felix Y.; Nelson, Peter S.; Saatcioglu, Fahri; Knudsen, Karen E.; Tammela, Teuvo L.J.; Sauter, Guido; Schlomm, Thorsten; Nykter, Matti; Visakorpi, Tapio & Mills, Ian Geoffrey (2017). Androgen receptor deregulation drives bromodomain-mediated chromatin alterations in prostate cancer. Cell reports.  ISSN 2211-1247.  19(10), s 2045- 2059 . doi: 10.1016/j.celrep.2017.05.049
  • Zuber, Verena; Bettella, Francesco; Witoelar, Aree; Andreassen, Ole Andreas; Mills, Ian Geoffrey & Urbanucci, Alfonso (2017). Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer. BMC Genomics.  ISSN 1471-2164.  18:270, s 1- 11 . doi: 10.1186/s12864-017-3620-y
  • Fiorito, Elisa; Sharma, Yogita; Gilfillan, Siv; Wang, Shixiong; Singh, Sachin Kumar; Somisetty, Venkata Satheesh; Madhumohan, Katika; Urbanucci, Alfonso; Thiede, Bernd; Mills, Ian Geoffrey & Rodriguez, Antoni Hurtado (2016). CTCF modulates Estrogen Receptor function through specific chromatin and nuclear matrix interactions. Nucleic Acids Research.  ISSN 0305-1048.  44, s 10588- 10602 . doi: 10.1093/nar/gkw785
  • McNair, C; Urbanucci, Alfonso; Comstock, CES; Augello, MA; Goodwin, JF; Launchbury, R; Zhao, SG; Schiewer, MJ; Ertel, A; Karnes, J; Davicioni, E; Wang, L; Wang, Q; Mills, Ian Geoffrey; Feng, FY; Li, W; Carroll, JS & Knudsen, KE (2016). Cell cycle-coupled expansion of AR activity promotes cancer progression. Oncogene.  ISSN 0950-9232. . doi: 10.1038/onc.2016.334
  • Tekpli, Xavier; Urbanucci, Alfonso; Hashim, Adnan; Vågbø, Cathrine Broberg; Lyle, Robert; Kringen, Marianne K.; Staff, Anne Cathrine; Dybedal, Ingunn; Mills, Ian Geoffrey; Klungland, Arne & Staerk, Judith (2016). Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells. Epigenetics & Chromatin.  ISSN 1756-8935.  9 . doi: 10.1186/s13072-016-0070-8
  • Barfeld, Stefan; Fazli, Ladan; Persson, Margareta; Marjavaara, Lisette; Urbanucci, Alfonso; Kaukoniemi, Kirsi M.; Rennie, Paul S.; Ceder, Yvonne; Chabes, Andrei; Visakorpi, Tapio & Mills, Ian Geoffrey (2015). Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer. OncoTarget.  ISSN 1949-2553.  6(14), s 12587- 12602
  • Khanna, Anchit; Rane, Jayant K.; Kivinummi, Kati K.; Urbanucci, Alfonso; Helenius, Merja A.; Tolonen, Teemu T.; Saramäki, Outi R.; Latonen, Leena; Manni, Visa; Pimanda, John E.; Maitland, Norman J.; Westermarck, Jukka & Visakorpi, Tapio (2015). CIP2A is a candidate therapeutic target in clinically challenging prostate cancer cell populations. OncoTarget.  ISSN 1949-2553.  6(23), s 19661- 19670 . doi: 10.18632/oncotarget.3875 Full text in Research Archive.
  • Lund, Kaja; Dembinski, Jennifer Lynn; Solberg, Nina; Urbanucci, Alfonso; Mills, Ian Geoffrey & Krauss, Stefan (2015). Slug-dependent upregulation of L1CAM is responsible for the increased invasion potential of pancreatic cancer cells following long-term 5-FU treatment. PLoS ONE.  ISSN 1932-6203.  10(4) . doi: 10.1371/journal.pone.0123684 Full text in Research Archive.
  • Barfeld, Stefan; Itkonen, Harri; Urbanucci, Alfonso & Mills, Ian Geoffrey (2014). Androgen-regulated metabolism and biosynthesis in prostate cancer. Endocrine-Related Cancer.  ISSN 1351-0088.  21(4), s T57- T66 . doi: 10.1530/ERC-13-0515
  • Lehmusvaara, Saara; Erkkilä, Timo; Urbanucci, Alfonso; Jalava, Sanni; Seppälä, Janne; Kaipia, Antti; Kujala, Paula; Lähdesmäki, Harri; Tammela, Teuvo L.J. & Visakorpi, Tapio (2013). Goserelin and bicalutamide treatments alter the expression of microRNAs in the prostate. The Prostate.  ISSN 0270-4137.  73(1), s 101- 112 . doi: 10.1002/pros.22545

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Published Dec. 8, 2016 3:47 PM - Last modified Mar. 28, 2017 1:17 PM