Kjetil Tasken

Image of Kjetil Tasken
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Phone +47-22840505
Mobile phone +47-90860759
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Visiting address Gaustadalléen 21 Forskningsparken 0349 OSLO
Postal address Postboks 1137 Blindern 0318 OSLO

Academic Interests

  • Specificity in cAMP-signalling by targeting of protein kinase A via A kinase anchoring proteins (AKAPs).
  • Anchoring, docking and scaffolding as principles for cell signalling and integration of cellular signals.
  • Hormonally- and cAMP-regulated cellular processes (gene activity, metabolism, cell proliferation, immune function, steroidogenesis, cardiac function).
  • Modulation of immune function in normal and HIV-infected lymphocytes by regulatory signaling pathways (novel cAMP-PKA type I-Csk inhibitory pathway anchored in lipid rafts that regulates Src kinase signaling).
  • Development of immune stimulation as a therapeutic strategy for treatment of immunodeficiencies and cancer.
  • Cell signalling molecules as drug targets and corresponding drug development.

Positions held

  • 2003 - present:  Director, Biotechnology Centre of Oslo.
  • 2010 - present:  Director, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (Interim Director, 2008 - 2010).
  • 1997 - present:  Group leader, Research Group on Signaling Networks in Health and Disease
  • 2011 - present:  Adjunct senior scientist, Oslo University Hospital, Department of Infectious Disease.
  • 2002 - present:  Professor of Medicine, University of Oslo.

Background

Research:

  • 2010 - 2012:  Vice-coordinator EU ESFRI project EU-Openscreen.
  • 2008 - present:  Norwegian partner, EU FP7 ESFRI preparatory phase project EATRIS.
  • 2007 - 2009:  Partner of EU FP6 STREP project.
  • 2002 - 2006: Coordintator of EU FP5 RTD and CRAFT projects
  • 2001 - 2005:  Leader "Medicine and Health Group" on Signal Transduction in Health and Disease, Excellence programme, Research Council of Norway.
  • 2001 - 2005:  Chairman, Research area Signal Transduction, Faculty of Medicine, University of Oslo.
  • 2001 - 2002:  Associate Professor, Department of Medical Biochemistry, University of Oslo.
  • 1998 - 2001:  Senior Scientist and Group Leader, The Norwegian Cancer Society.
  • 1995 - 1997:  Postdoctoral research fellow, The Norwegian Cancer Society.
  • 1994:  Residency in Internal Medicine and Surgery, Østfold Sentralsykehus.

Teaching:

  • 2003-: PhD level training courses in Molecular BioLogy, Molecular Medicine and Signal Transduction (by BiO, NCMM and Faculty of Medicine)
  • 2000 - 2003:  Medical students, 5th year, University of Oslo, Subject: Reproductive biology and endocrinology (main lectures, problem based learning groups).
  • 1995 - 2001: Medical students, subject: Endocrinology and Medical Biochemistry (main lectures and group lectures).
  • 1992 - 1995:  Medical students, subject: Medical Biochemistry (molecular & cell biology).
  • 1987 - 1988:  Medical students, subject: Medical Genetics.
Education:
  • 2010 - 2011:  University of Oslo Scientific Leadership training.
  • 2004 & 2009:  University of Oslo Department Head Leadership training programme.
  • 1994:  PhD in Molecular Cell Biology, University of Oslo.
  • 1991:  MD, Medical Faculty, University of Oslo.

Academic and professional committees

  • 2011 - 2014:  Scientific Advisory Board, Institute of Medical Technology, Tampere Finland
  • 2008 - present:  Board member, PCI Biotech ASA.
  • 2007 - 2011:  Co-founder & Board Member, ChemLex AS.
  • 2004 - 2011:  Board member, Biomedical Innovation AS.
  • 2004 - 2011:  Board member, siRNAsense AS.
  • 1998 - 2011:  Co-founder, Board member and Vice President of R&D (2001 - 2010) in Lauras AS.
  • 2012:  Chair, Gordon Research Conference on Cyclic Nucleotide Phosphodiesterases.
  • 2009 - 2011:  Partner in Nordic Network of National CoEs by Nordforsk.
  • 2010:  Organizer, FEBS Workshop on Spatiotemporal Dynamics of Cell Signaling, co-sponsored by ESF, the European Association of Cancer Research and the University of Oslo.
  • 2010:  Vice-Chair, Gordon Research Conference on Cyclic Nucleotide Phosphodiesterases.
  • 2008 - 2010:  Partner in Nordic Network of Excellence grant by Nordforsk.
  • 2006 - 2010:  Program Steering Committee member, ESF “Frontiers of Functional Genomics”.
  • 2006 - 2009:  Scientific Advisory Board, Ullevål University Hospital.
  • 2008 - Organizer, FEBS Workshop on Dynamics of Cell Signal Systems, co-sponsored by ESF, the European Association of Cancer Research and the University of Oslo.
  • 2008 - Elected member, ScanBalt Academy.
  • 2005 - 2008:  Member of the Scientific Advisory Panel, Novartis Foundation, London.
  • 2006:  Board Member, Connect East.
  • 2006:  Co-organizer, Nobel Symposium on the Adipocyte, Gotheburg, Sweden.
  • 2006:  Organizer, FEBS Workshop on Spatial and Temporal Regulation of Signaling, co-sponsored by ESF, the European Association of Cancer Research and the University of Oslo.
  • 2003 - 2006:  Board member in Birkeland Innovation, Technology Transfer Office at the University of Oslo.
  • 2005:  Organizer for the 2nd Meeting on Functional Genomics and Disease, European Science Foundation (ESF), Oslo.
  • 2002 - 2006:  Coordinator EU FP5 RTD project on anchored cAMP signaling.
  • 2005:  Elected member, Norwegian Academy of Science and Letters.
  • 2002 - 2005:  Coordinator for CRAFT (industry) project on the development of cAMP antagonists as immunomodulating compounds.
  • 2004:  Organizing committee, ASBMB/IUBMB meeting, Boston, USA.
  • 2003:  Board member, interim board for the University of Oslo Technology Transfer Office.

Awards

  • 2003 - 2004:  University of Oslo excellence funding to “Unit For Cell Signalling”.
  • 2001 - 2007:  Young Excellent Investigator Programme, Research Council of Norway.
  • 2002:  Recipient of the Anders Jahre Medical Award for Younger Scientists (Nordic Prize).
  • 2000:  Odd Fellow Medical Award (also received award 1996 and 1998).

Communication of Science

Taskén has published more than 220 articles in peer-reviewed journals, which have been cited some 6000 times in the literature. He has given more than 190 lectures and seminars, both nationally and internationally, and his group's research has been described and featured in countless magazine and newspaper articles. Taskén has also published several popular press articles, as well as participated in numerous newspaper and radio interviews.

 

Tags: Cell signalling, Cancer, Cancer biology, Cancer research, Health, Immunology, Life sciences, Regulatory T cells, T cells

Publications

  • Chu, Dinh Toi; Tao, Yang & Tasken, Kjetil (2017). OPA1 in Lipid Metabolism: Function of OPA1 in Lipolysis and Thermogenesis of Adipocytes. Hormone and Metabolic Research.  ISSN 0018-5043.  49(4), s 276- 285 . doi: 10.1055/s-0043-100384
  • Dukic, Aleksandra; Haugen, Linda Hofstad; Pidoux, Guillaume; Leithe, Edward; Bakke, Oddmund & Tasken, Kjetil (2017). A protein kinase A-ezrin complex regulates connexin 43 gap junction communication in liver epithelial cells. Cellular Signalling.  ISSN 0898-6568.  32, s 1- 11 . doi: 10.1016/j.cellsig.2017.01.008
  • Dukic, Aleksandra; McClymont, David & Tasken, Kjetil (2017). A Cell-Based High-Throughput Assay for Gap Junction Communication Suitable for Assessing Connexin 43-Ezrin Interaction Disruptors Using IncuCyte ZOOM. Journal of Biomolecular Screening.  ISSN 1087-0571.  22(1), s 77- 85 . doi: 10.1177/1087057116669120
  • Gunasekaran, Stalin Chellappa; Hugenschmidt, Harald; Hagness, Morten; Subramani, Saranya; Melum, Espen; Line, Pål Dag; Labori, Knut Jørgen; Wiedswang, Gro; Tasken, Kjetil & Aandahl, Einar Martin (2017). CD8+ T cells that coexpress ROR?t and T-bet are functionally impaired and expand in patients with distal bile duct cancer. Journal of Immunology.  ISSN 0022-1767.  198(4), s 1729- 1739 . doi: 10.4049/jimmunol.1600061
  • Landskron, Johannes; Kraggerud, Sigrid M.; Wik, Elisabeth; Dørum, Anne; Bjørnslett, Merete Pauline; Melum, Espen; Helland, Øystein; Bjørge, Line; Lothe, Ragnhild A; Salvesen, Helga & Tasken, Kjetil (2017). C77G in PTPRC (CD45) is no risk allele for ovarian cancer, but associated with less aggressive disease. PLoS ONE.  ISSN 1932-6203.  12:e0182030(7), s 1- 12 . doi: 10.1371/journal.pone.0182030
  • Moltu, Kristine; Henjum, Karen; Oberprieler, Nikolaus; Bjørnbeth, Bjørn Atle & Tasken, Kjetil (2017). Proximal signaling responses in peripheral T cells from colorectal cancer patients are affected by high concentrations of circulating prostaglandin E2. Human Immunology.  ISSN 0198-8859.  78(2), s 129- 137 . doi: 10.1016/j.humimm.2016.10.007
  • Prebensen, Christian; Trøseid, Marius; Ueland, Thor; Dahm, Anders Erik A; Sandset, Per Morten; Aaberge, Ingeborg Sundsvalen; Waalen, Kristian; Dyrhol-Riise, Anne Ma; Tasken, Kjetil & Kvale, Dag (2017). Immune activation and HIV-specific T cell responses are modulated by a cyclooxygenase-2 inhibitor in untreated HIV-infected individuals: An exploratory clinical trial. PLoS ONE.  ISSN 1932-6203.  12:e0176527(5), s 1- 20 . doi: 10.1371/journal.pone.0176527 Full text in Research Archive.
  • Taraldsrud, Eli; Fevang, Børre; Jørgensen, Silje Fjellgård; Moltu, Kristine; Hilden, Vera Irene; Tasken, Kjetil; Aukrust, Pål; Myklebust, June & Olweus, Johanna (2017). Defective IL-4 signaling in T cells defines severe common variable immunodeficiency. Journal of Autoimmunity.  ISSN 0896-8411.  81, s 110- 119 . doi: 10.1016/j.jaut.2017.04.004
  • Bains, Simer Jit; Mahic, Milada; Myklebust, Tor Åge; Småstuen, Milada C; Yaqub, Sheraz; Dørum, Liv Marit; Bjørnbeth, Bjørn Atle; Møller, Bjørn; Brudvik, Kristoffer Watten & Tasken, Kjetil (2016). Aspirin as secondary prevention in patients with colorectal cancer: An unselected population-based study. Journal of Clinical Oncology.  ISSN 0732-183X.  34(21), s 2501- 2508 . doi: 10.1200/JCO.2015.65.3519
  • Bjerregaard-Andersen, Kaare; Østensen, Ellen; Scott, John D.; Tasken, Kjetil & Morth, Jens Preben (2016). Malonate in the nucleotide-binding site traps human AKAP18γ/δ in a novel conformational state. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications.  ISSN 1744-3091.  72, s 591- 597 . doi: 10.1107/S2053230X16010189 Show summary
  • Gunasekaran, Stalin Chellappa; Hugenschmidt, Harald; Hagness, Morten; Line, Pål Dag; Labori, Knut Jørgen; Wiedswang, Gro; Tasken, Kjetil & Aandahl, Einar Martin (2016). Regulatory T cells that co-express RORγt and FOXP3 are pro-inflammatory and immunosuppressive and expand in human pancreatic cancer. Oncoimmunology.  ISSN 2162-402X.  5(4) . doi: 10.1080/2162402X.2015.1102828
  • Gunasekaran, Stalin Chellappa; Lieske, Nora Valeska; Hagness, Morten; Line, Pål Dag; Tasken, Kjetil & Aandahl, Einar Martin (2016). Human regulatory T cells control TCR signaling and susceptibility to suppression in CD4+ T cells. Journal of Leukocyte Biology.  ISSN 0741-5400.  100(1), s 5- 16 . doi: 10.1189/jlb.2HI0815-334R
  • Liu, Lisa L.; Landskron, Johannes; Ask, Eivind Heggernes; Enqvist, Monika; Sohlberg, Ebba; Traherne, James A.; Hammer, Quirin; Goodridge, Jodie; Larsson, Stella; Jayaraman, Jyothi; Oei, Vincent Yi Sheng; Schaffer, Marie; Tasken, Kjetil; Ljunggren, Hans-Gustaf; Romagnani, Chiara; Trowsdale, John; Malmberg, Karl-Johan & Béziat, Vivien (2016). Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans. Cell reports.  ISSN 2211-1247.  15(3), s 1088- 1099 . doi: 10.1016/j.celrep.2016.04.005
  • Stiksrud, Birgitte; Lorvik, Kristina Berg; Kvale, Dag; Mollnes, Tom Eirik; Ueland, Per Magne; Trøseid, Marius; Tasken, Kjetil & Dyrhol-Riise, Anne Ma (2016). Plasma IP-10 is increased in immunological nonresponders and associated with activated regulatory T cells and persisting low CD4 counts. Journal of Acquired Immune Deficiency Syndromes.  ISSN 1525-4135.  73(2), s 138- 148 . doi: 10.1097/QAI.0000000000001080
  • Tonby, Kristian; Wergeland, Ida; Lieske, Nora Valeska; Kvale, Dag; Tasken, Kjetil & Dyrhol-Riise, Anne Ma (2016). The COX- inhibitor indomethacin reduces Th1 effector and T regulatory cells in vitro in Mycobacterium tuberculosis infection. BMC Infectious Diseases.  ISSN 1471-2334.  16:599, s 1- 12 . doi: 10.1186/s12879-016-1938-8 Full text in Research Archive.
  • Wehbi, Vanessa Leila & Tasken, Kjetil (2016). Molecular mechanisms for cAMP-mediated immunoregulation in T cells - role of anchored protein kinase a signaling units. Frontiers in Immunology.  ISSN 1664-3224.  7:222 . doi: 10.3389/fimmu.2016.00222
  • Costa Calejo, Ana Isabel & Tasken, Kjetil (2015). Targeting protein-protein interactions in complexes organized by A kinase anchoring proteins. Frontiers in Pharmacology.  ISSN 1663-9812.  6:192 . doi: 10.3389/fphar.2015.00192
  • Gerbaud, Pascal; Tasken, Kjetil & Pidoux, Guillaume (2015). Spatiotemporal regulation of cAMP signaling controls the human trophoblast fusion. Frontiers in Pharmacology.  ISSN 1663-9812.  6:202 . doi: 10.3389/fphar.2015.00202 Full text in Research Archive.
  • Landskron, Johannes; Helland, Øystein; Torgersen, Knut Martin; Aandahl, Einar Martin; Gjertsen, Bjørn Tore; Bjørge, Line & Tasken, Kjetil (2015). Activated regulatory and memory T-cells accumulate in malignant ascites from ovarian carcinoma patients. Cancer Immunology and Immunotherapy.  ISSN 0340-7004.  64(3), s 337- 347 . doi: 10.1007/s00262-014-1636-6
  • Landskron, Johannes; Helland, Øystein; Torgersen, Knut Martin; Aandahl, Einar Martin; Gjertsen, Bjørn Tore; Bjørge, Line & Tasken, Kjetil (2015). Activated regulatory and memory T-cells accumulate in malignant ascites from ovarian carcinoma patients. Cancer Immunology and Immunotherapy.  ISSN 0340-7004.  64(3), s 337- 347 . doi: doi: 10.1007/s00262-014-1636-6
  • Lieske, Nora Valeska; Tonby, Kristian; Kvale, Dag; Dyrhol-Riise, Anne Ma & Tasken, Kjetil (2015). Targeting tuberculosis and HIV infection-specific regulatory T cells with MEK/ERK signaling pathway inhibitors. PLoS ONE.  ISSN 1932-6203.  10:e0141903(11) . doi: 10.1371/journal.pone.0141903 Full text in Research Archive. Show summary
  • Pidoux, Guillaume & Tasken, Kjetil (2015). Anchored PKA as a gatekeeper for gap junctions. Communicative & Integrative Biology.  ISSN 1942-0889.  8(4), s 1- 4 . doi: 10.1080/19420889.2015.1057361
  • Raslan, Z; Magwenzi, S; Aburima, A; Tasken, Kjetil & Naseem, KM (2015). Targeting of type I protein kinase A to lipid rafts is required for platelet inhibition by the 3′,5′-cyclic adenosine monophosphate-signaling pathway. Journal of Thrombosis and Haemostasis.  ISSN 1538-7933.  13(9), s 1721- 1734 . doi: 10.1111/jth.13042
  • Santegoets, Saskia J.A.M.; Dijkgraaf, Eveline M.; Battaglia, Alessandra; Beckhove, Philipp; Britten, Cedrik M.; Gallimore, Awen; Godkin, Andrew; Gouttefangeas, Cecile; de Gruijl, Tanja D.; Koenen, Hans J.P.M.; Scheffold, Alexander; Shevach, Ethan M.; Staats, Janet; Tasken, Kjetil; Whiteside, Theresa L.; Kroep, Judith R.; Welters, Marij J.P. & van der Burg, Sjoerd H. (2015). Monitoring regulatory T cells in clinical samples: consensus on an essential marker set and gating strategy for regulatory T cell analysis by flow cytometry. Cancer Immunology and Immunotherapy.  ISSN 0340-7004.  64(10), s 1271- 1286 . doi: 10.1007/s00262-015-1729-x
  • Ellinger, Bernhard; Silber, Johanna; Prashar, Anjali; Landskron, Johannes; Weber, Jonas; Rehermann, Sarah; Müller, Franz-Josef; Smith, Stephen; Wrigley, Stephen; Tasken, Kjetil; Gribbon, Philip; Labes, Antje & Imhoff, Johannes F (2014). A phenotypic screening approach to identify anticancer compounds derived from marine fungi. Assay and drug development technologies.  ISSN 1540-658X.  12(3), s 162- 175 . doi: 10.1089/adt.2013.564
  • Halvorsen, Bente; Smedbakken, Linda Merete; Michelsen, Annika; Skjelland, Mona; Bjerkeli, Vigdis; Sagen, Ellen Lund; Tasken, Kjetil; Bendz, Bjørn; Holm, Sverre; Gullestad, Lars; Biessen, Erik A & Aukrust, Pål (2014). Activated platelets promote increased monocyte expression of CXCR5 through prostaglandin E2-related mechanisms and enhance the anti-inflammatory effects of CXCL13. Atherosclerosis.  ISSN 0021-9150.  234(2), s 352- 359 . doi: 10.1016/j.atherosclerosis.2014.03.021
  • Pidoux, Guillaume; Gerbaud, Pascal; Dompierre, Jim; Lygren, Birgitte; Saunders, Threrese Solstad; Evain-Brion, Daniéle & Tasken, Kjetil (2014). A PKA-ezrin-Cx43 signaling complex controls gap junction communication and thereby trophoblast cell fusion. Journal of Cell Science.  ISSN 0021-9533.  127(19), s 4172- 4185 . doi: 10.1242/jcs.149609 Show summary
  • Rogne, Marie & Tasken, Kjetil (2014). Compartmentalization of cAMP signaling in adipogenesis, lipogenesis and lipolysis. Hormone and Metabolic Research.  ISSN 0018-5043.  46(12), s 833- 840 . doi: 10.1055/s-0034-1389955
  • Singh, Maneesh; Singh, Partibha; Vaira, Dolores; Torheim, Eirik A.; Rahmoni, S.; Tasken, Kjetil & Moutchen, M. (2014). The RIAD peptidomimetic inhibits HIV-1 replication in humanized NSG mice. European Journal of Clinical Investigation.  ISSN 0014-2972.  44(2), s 146- 152 . doi: 10.1111/eci.12200
  • Skånland, Sigrid Strand; Moltu, Kristine; Berge, Torunn; Aandahl, Einar Martin & Tasken, Kjetil (2014). T-cell co-stimulation through the CD2 and CD28 co-receptors induces distinct signalling responses. Biochemical Journal.  ISSN 0264-6021.  460(3), s 399- 410 . doi: 10.1042/BJ20140040
  • Spurgeon, Benjamin E.J.; Aburima, Ahmed; Oberprieler, Nikolaus; Tasken, Kjetil & Naseem, Khalid M. (2014). Multiplexed phosphospecific flow cytometry enables large-scale signaling profiling and drug screening in blood platelets. Journal of Thrombosis and Haemostasis.  ISSN 1538-7933.  12(10), s 1733- 1743 . doi: 10.1111/jth.12670
  • Brudvik, Kristoffer Watten; Bains, Simer Jit; Seeberg, Lars Thomas; Labori, Knut Jørgen; Waage, Anne; Tasken, Kjetil; Aandahl, Einar Martin & Bjørnbeth, Bjørn Atle (2013). Aggressive Treatment of Patients with Metastatic Colorectal Cancer Increases Survival: A Scandinavian Single-Center Experience. HPB Surgery.  ISSN 0894-8569. . doi: 10.1155/2013/727095
  • Cornez, Isabelle Ann; Joel, Mrinal; Tasken, Kjetil; Langmoen, Iver Arne; Glover, Joel & Berge, Torunn (2013). EGF signalling and rapamycin-mediated mTOR inhibition in glioblastoma multiforme evaluated by phospho-specific flow cytometry. Journal of Neuro-Oncology.  ISSN 0167-594X.  112(1), s 49- 57 . doi: 10.1007/s11060-012-1035-9
  • Landskron, Johannes & Tasken, Kjetil (2013). CD147 in regulatory T cells. Cellular Immunology.  ISSN 0008-8749.  282(1), s 17- 20 . doi: 10.1016/j.cellimm.2013.04.008
  • Lone, Anna Mari & Tasken, Kjetil (2013). Proinflammatory and immunoregulatory roles of eicosanoids in T cells. Frontiers in Immunology.  ISSN 1664-3224.  4(130) . doi: doi: 10.3389/fimmu.2013.00130 Full text in Research Archive.
  • Moltu, Kristine; Bjørgo, Elisa; Berge, Torunn; Thiede, Bernd & Tasken, Kjetil (2013). A Proteomic Approach to Screening of Dynamic Changes in Detergent-Resistant Membranes from Activated Human Primary T Cells. Journal of Proteomics & Bioinformatics.  ISSN 0974-276X.  6, s 72- 80 . doi: 10.4172/jpb.1000264
  • Pollheimer, Jürgen; Bodin, Johanna; Sundnes, Olav; Bekkeheien, Reidunn C; Skånland, Sigrid Strand; Sponheim, Jon; Brox, Mari Johanna; Sundlisæter, Eirik; Loos, Tamara; Vatn, Morten H; Kasprzycka, Monika; Wang, Junbai; Kuchler, Axel Matthias; Tasken, Kjetil; Haraldsen, Guttorm & Hol, Johanna (2013). Interleukin-33 drives a proinflammatory endothelial activation that selectively targets nonquiescent cells. Arteriosclerosis, Thrombosis and Vascular Biology.  ISSN 1079-5642.  33(2), s e47- e55 . doi: 10.1161/ATVBAHA.112.253427
  • Rogne, Marie & Tasken, Kjetil (2013). Cell signalling analyses in the functional genomics era. New Biotechnology.  ISSN 1871-6784.  30(3), s 333- 338 . doi: 10.1016/j.nbt.2013.01.003
  • Scott, John D.; Dessauer, Carmen W. & Tasken, Kjetil (2013). Creating order from chaos: cellular regulation by kinase anchoring. Annual Review of Pharmacology and Toxicology.  ISSN 0362-1642.  53, s 187- 210 . doi: 10.1146/annurev-pharmtox-011112-140204
  • Størvold, Gro Leite; Landskron, Johannes; Strozynski, Margarita Anna; Arntzen, Magnus; Koehler, Christian; Kalland, Maria Elisabeth; Tasken, Kjetil & Thiede, Bernd (2013). Quantitative profiling of tyrosine phosphorylation revealed changes in the activity of the T cell receptor signaling pathway upon cisplatin-induced apoptosis. Journal of Proteomics.  ISSN 1874-3919.  91, s 344- 357 . doi: 10.1016/j.jprot.2013.07.019
  • Vang, Torkel; Landskron, Johannes; Viken, Marte K; Oberprieler, Nikolaus; Torgersen, Knut Martin; Mustelin, Tomas; Tasken, Kjetil; Tautz, Lutz; Rickert, Robert C. & Lie, Benedicte Alexandra (2013). The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses. Human Immunology.  ISSN 0198-8859.  74(5), s 574- 585 . doi: 10.1016/j.humimm.2012.12.017
  • Brudvik, Kristoffer Watten; Henjum, Karen; Aandahl, Einar Martin; Bjørnbeth, Bjørn Atle & Tasken, Kjetil (2012). Regulatory T-cell-mediated inhibition of antitumor immune responses is associated with clinical outcome in patients with liver metastasis from colorectal cancer. Cancer Immunology and Immunotherapy.  ISSN 0340-7004.  61(7), s 1045- 1053 . doi: 10.1007/s00262-011-1174-4
  • Brudvik, Kristoffer Watten & Tasken, Kjetil (2012). Modulation of T cell immune functions by the prostaglandin E2-cAMP pathway in chronic inflammatory states. British Journal of Pharmacology.  ISSN 0007-1188.  166(2), s 411- 419 . doi: 10.1111/j.1476-5381.2011.01800.x
  • Hagness, Morten; Henjum, Karen; Landskron, Johannes; Brudvik, Kristoffer Watten; Bjørnbeth, Bjørn Atle; Foss, Aksel; Tasken, Kjetil & Aandahl, Einar Martin (2012). Kinetics and Activation Requirements of Contact-Dependent Immune Suppression by Human Regulatory T Cells. Journal of Immunology.  ISSN 0022-1767.  188(11), s 5459- 5466 . doi: 10.4049/jimmunol.1101367
  • Kalland, Maria Elisabeth; Solheim, Silje Anette; Skånland, Sigrid Strand; Tasken, Kjetil & Berge, Torunn (2012). Modulation of proximal signaling in normal and transformed B cells by transmembrane adapter Cbp/PAG. Experimental Cell Research.  ISSN 0014-4827.  318(14), s 1611- 1619 . doi: 10.1016/j.yexcr.2012.05.014
  • Vang, Torkel; Liu, Wallace H.; Delacroix, Laurence; Wu, Shuangding; Vasile, Stefan; Dahl, Russell; Yang, Li; Musumeci, Lucia; Francis, Dana; Landskron, Johannes; Tasken, Kjetil; Tremblay, Michel L.; Lie, Benedicte Alexandra; Page, Rebecca; Mustelin, Tomas; Rahmouni, Souad; Rickert, Robert C. & Tautz, Lutz (2012). LYP inhibits T-cell activation when dissociated from CSK. Nature Chemical Biology.  ISSN 1552-4450.  8(5), s 437- 446 . doi: 10.1038/NCHEMBIO.916
  • Weedon-Fekjær, Mina Susanne & Tasken, Kjetil (2012). Review: Spatiotemporal dynamics of hCG/cAMP signaling and regulation of placental function. Placenta.  ISSN 0143-4004.  33, s S87- S91 . doi: 10.1016/j.placenta.2011.11.003
  • Ånensen, Nina; Hjelle, Sigrun Margrethe; Van, Belle Werner; Haaland, Ingvild; Silden, Elisabeth; Bourdon, Jean-Christophe; Hovland, Randi; Tasken, Kjetil; Knappskog, Stian; Lønning, Per Eystein; Bruserud, Øystein & Gjertsen, Bjørn Tore (2012). Correlation analysis of p53 protein isoforms with NPM1/FLT3 mutations and therapy response in acute myeloid leukemia. Oncogene.  ISSN 0950-9232.  31(12), s 1533- 1545 . doi: 10.1038/onc.2011.348
  • Andrei, Mioara; Bakkebø, Tina; Klaveness, Jo; Tasken, Kjetil & Undheim, Kjell (2011). Stereoselective synthesis of (R-P)-8-substituted-N-6-acylated and N-6-alkylated adenosine-3 ',5 '-cyclic phosphorothioic acids as cAMP antagonists. European Journal of Medicinal Chemistry.  ISSN 0223-5234.  46(12), s 5935- 5940 . doi: 10.1016/j.ejmech.2011.10.003
  • Bjørgo, Elisa; Moltu, Kristine & Tasken, Kjetil (2011). Phosphodiesterases as targets for modulating T-cell responses. Handbook of Experimental Pharmacology.  ISSN 0171-2004.  204, s 345- 363
  • Brudvik, Kristoffer Watten; Paulsen, Jan Erik; Aandahl, Einar Martin; Roald, Borghild & Tasken, Kjetil (2011). Protein kinase A antagonist inhibits beta-catenin nuclear translocation, c-Myc and COX-2 expression and tumor promotion in ApcMin/+ mice. Molecular Cancer.  ISSN 1476-4598.  10(1) . doi: 10.1186/1476-4598-10-149
  • Kalland, Maria Elisabeth; Oberprieler, Nikolaus; Vang, Torkel; Tasken, Kjetil & Torgersen, Knut Martin (2011). T Cell-Signaling Network Analysis Reveals Distinct Differences between CD28 and CD2 Costimulation Responses in Various Subsets and in the MAPK Pathway between Resting and Activated Regulatory T Cells. Journal of Immunology.  ISSN 0022-1767.  187(10), s 5233- 5245 . doi: 10.4049/jimmunol.1101804
  • Means, Christopher K.; Lygren, Birgitte; Langeberg, Loraine K; Jain, A.; Dixon, R.E.; Vega, A.L.; Gold, M.G.; Petrosyan, S.; Taylor, Susan; Murphy, A.N.; Ha, T.; Santana, L.F.; Tasken, Kjetil & Scott, John D. (2011). An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  108(48), s E1227- E1235 . doi: 10.1073/pnas.1107182108
  • Mosenden, Randi; Moltu, Kristine; Ruppelt, Anja; Berge, Torunn & Tasken, Kjetil (2011). Effects of Type I Protein Kinase A Modulation on the T Cell Distal Pole Complex. Scandinavian Journal of Immunology.  ISSN 0300-9475.  74(6), s 568- 573 . doi: 10.1111/j.1365-3083.2011.02611.x
  • Mosenden, Randi; Singh, P; Cornez, Isabelle Ann; Heglind, M; Ruppelt, Anja; Moutschen, M; Enerback, S; Rahmouni, S & Tasken, Kjetil (2011). Mice with Disrupted Type I Protein Kinase A Anchoring in T Cells Resist Retrovirus-Induced Immunodeficiency. Journal of Immunology.  ISSN 0022-1767.  186(9), s 5119- 5130 . doi: 10.4049/jimmunol.1100003
  • Mosenden, Randi & Tasken, Kjetil (2011). Cyclic AMP-mediated immune regulation - Overview of mechanisms of action in T cells. Cellular Signalling.  ISSN 0898-6568.  23(6), s 1009- 1016 . doi: 10.1016/j.cellsig.2010.11.018
  • Oberprieler, Nikolaus & Tasken, Kjetil (2011). Analysing phosphorylation-based signalling networks by phospho flow cytometry. Cellular Signalling.  ISSN 0898-6568.  23(1), s 14- 18 . doi: 10.1016/j.cellsig.2010.07.009
  • Pettersen, Frank Olav; Torheim, Eirik A.; Dahm, Anders Erik A; Aaberge, Ingeborg Sundsvalen; Lind, Andreas; Holm, Malin; Aandahl, Einar Martin; Sandset, Per Morten; Tasken, Kjetil & Kvale, Dag (2011). An exploratory trial of cyclooxygenase type 2 inhibitor in HIV-1 infection: Downregulated immune activation and improved T Cell-dependent vaccine responses. Journal of Virology.  ISSN 0022-538X.  85(13), s 6557- 6566 . doi: 10.1128/JVI.00073-11
  • Pidoux, Guillaume; Witczak, Oliwia; Jarnæss, Elisabeth; Myrvold, Linda; Urlaub, Henning; Stokka, Anne Jorunn; Küntziger, Thomas Michel & Tasken, Kjetil (2011). Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis. EMBO Journal.  ISSN 0261-4189.  30(21), s 4371- 4386 . doi: 10.1038/emboj.2011.365 Full text in Research Archive.
  • Saunders, Threrese Solstad; Bains, Simer Jit; Landskron, Johannes; Aandahl, Einar Martin; Thiede, Bernd; Tasken, Kjetil & Torgersen, Knut Martin (2011). CD147 (Basigin/Emmprin) identifies FoxP3(+)CD45RO(+)CTLA4(+)-activated human regulatory T cells. Blood.  ISSN 0006-4971.  118(19), s 5141- 5151 . doi: 10.1182/blood-2011-02-339242 Show summary

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  • Bains, Simer Jit; Mahic, Milada; Myklebust, Tor Åge; Småstuen, Milada C; Yaqub, Sheraz; Dørum, Liv Marit; Bjørnbeth, Bjørn Atle; Møller, Bjørn; Brudvik, Kristoffer Watten & Tasken, Kjetil (2017). Reply to M. Løberg et al. Journal of Clinical Oncology.  ISSN 0732-183X.  35(5), s 569- 570 . doi: 10.1200/JCO.2016.70.8263
  • Aronsen, Jan Magnus; Skogestad, Jonas; Hougen, Karina; Lunde, Marianne; Lothe, Gustav B; Albert, Ingrid; Marshall, Serena; Børstad, Mira Halvorsen; Lunde, Per Kristian; Morth, Jens Preben; Tasken, Kjetil; Carlson, Cathrine Rein & Sjaastad, Ivar (2016). Physical coupling of PDE3A regulates SERCA2 activity in cardiomyocytes.
  • Ribes, Anna Maria Parente; Skånland, Sigrid Strand; Bürgler, Simone; Os, Audun; Wang, Dong; Bogen, Bjarne; Tjønnfjord, Geir Erland; Tasken, Kjetil & Munthe, Ludvig Andre (2016). Spleen tyrosine kinase inhibitors reduce CD40l-induced proliferation of chronic lymphocytic leukemia cells but not normal B cells. Haematologica.  ISSN 0390-6078.  101(2), s e59- e62 . doi: 10.3324/haematol.2015.135590
  • Albert, Ingrid; Børstad, Mira Halvorsen; Carlson, Cathrine Rein; Calejo, Anna; Skogestad, Jonas; Lunde, Marianne; Lunde, Per Kristian; Tasken, Kjetil; Sjaastad, Ivar & Aronsen, Jan Magnus (2015). Development of SERCA2 activating agents.
  • Aronsen, Jan Magnus; Skogestad, Jonas; Hougen, Karina; Lunde, Marianne; Lothe, Gustav B; Albert, Ingrid; Marshall, Serena; Lunde, Per Kristian; Morth, Jens Preben; Tasken, Kjetil; Carlson, Cathrine Rein & Sjaastad, Ivar (2015). Physical coupling between SERCA2 and PDE3A regulates SERCA2 activity in cardiomyocytes.
  • Johnsen, Guro Mørk; Sheng, Vincent O.Y.; Tasken, Kjetil; Staff, Anne Cathrine & Malmberg, Karl-Johan (2015). Killer immunoglobulin-like receptors (KIRS) on 3rd trimester decidual natural killer cells. Journal of Reproductive Immunology.  ISSN 0165-0378.  111, s 11 . doi: http://dx.doi.org/10.1016/j.jri.2015.06.073
  • Stiksrud, Birgitte; Lorvik, Kristina Berg; Kvale, Dag; Mollnes, Tom Eirik; Ueland, Per Magne; Berge, Rolf Kristian; Trøseid, Marius; Tasken, Kjetil & Dyrhol-Riise, Anne Ma (2015). Plasma Interferon-inducible Protein 10 Levels, T-cell Activation and Regulation are Increased in HIV Immunological Non-Responders.
  • Aronsen, Jan Magnus; Skogestad, Jonas; Hougen, Karina; Lunde, Marianne; Lothe, Gustav B; Lunde, Per Kristian; Morth, Jens Preben; Tasken, Kjetil; Carlson, Cathrine Rein & Sjaastad, Ivar (2014). Hypokalemia induce CA2+ waves by lowering NKA alpha 2 activity in rat ventricular cardiomyocytes.
  • Aronsen, Jan Magnus; Skogestad, Jonas; Hougen, Karina; Lunde, Marianne; Lothe, Gustav B; Lunde, Per Kristian; Morth, Jens Preben; Tasken, Kjetil; Carlson, Cathrine Rein & Sjaastad, Ivar (2014). Physical coupling of PDE3A to SERCA2 regulates SERCA2 activity in cardiomyoyctes.
  • Tasken, Kjetil; Aronsen, J.M.; Sjaastad, I.; Skogestad, J. & Carlsson, Cathrine R. (2014). Serca2-PDE3a interaction peptides and uses thereof.
  • Aronsen, Jan Magnus; Hougen, Karina; Skogestad, Jonas; Lunde, Marianne; Enger, Ulla Helene; Moltzau, Lise Roman; Qvigstad, Eirik; Skomedal, Tor; Tasken, Kjetil; Carlson, Cathrine Rein & Sjaastad, Ivar (2013). PDE3A is part of the SERCA2-AKAP18 macromolecular complex in cardiomyocytes.
  • Johnsen, Guro Mørk; Tasken, Kjetil & Staff, Anne Cathrine (2013). CYTOKINE PROFILE OF CD4+T-CELLS IN DECIDUA AND CIRCULATION IN 3RD TRIMESTER PREGNANCY. Placenta.  ISSN 0143-4004.  34(9), s A75- A75 . doi: 10.1016/j.placenta.2013.06.222
  • Aronsen, Jan Magnus; Aronsen, Jan Magnus; Hougen, Karina; Skogestad, Jonas; Enger, Ulla Helene; Moltzau, Lise Roman; Qvigstad, Erik; Skomedal, Tor; Tasken, Kjetil; Carlson, Cathrine Rein & Sjaastad, Ivar (2012). PDE3A is part of the SERCA2-AKAP18 macromolecular complex in cardiomyocytes.
  • Hougen, Karina; Aronsen, Jan Magnus; Skogestad, Jonas; Enger, Ulla Helene; Moltzau, Lise Roman; Qvigstad, Eirik; Skomedal, Tor; Tasken, Kjetil; Carlson, Cathrine Rein & Sjaastad, Ivar (2012). PDE3A is part of the SERCA2-AKAP18delta macromolecular complex in cardiomyocytes.
  • Johnsen, Guro Mørk; Tasken, Kjetil & Staff, AC (2012). CD107A+CYTOTOXIC NK-CELLS IN DECIDUA AND CIRCULATION IN 3rd TRIMESTER PREGNANCY. Placenta.  ISSN 0143-4004.  33(9), s A5- A5
  • Moltu, Kristine; Skånland, Sigrid Strand; Berge, Torunn & Tasken, Kjetil (2012). Distinct signalling patterns and functional responses to CD2 and CD28 co-stimulation of human primary T cells. Immunology.  ISSN 0019-2805.  137, s 374- 374
  • Tasken, Kjetil (2012). A Kinase Anchoring Proteins organize signaling complexes that control lipolysis and gap junction communication.
  • Tasken, Kjetil (2012). A Protein Kinase A - A Kinase Anchoring Complex Controls Gap Junction Communication.
  • Tasken, Kjetil (2012). Activating and immunoregulatory signal networks in T cells.
  • Tasken, Kjetil (2012). Activating and immunoregulatory signal networks in T cells.
  • Tasken, Kjetil (2012). Activating and immunoregulatory signal networks in T cells.
  • Tasken, Kjetil (2012). Mice with disrupted type I protein kinase A anchoring in T cells resist murine AIDS and local immunosupression in cancer.
  • Tasken, Kjetil (2012). Optic Atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis.
  • Tasken, Kjetil (2012). Regulation of anti-tumor immune responses in colorectal cancer.
  • Tasken, Kjetil (2012). Signal complexes organized by A kinase Anchoring Proteins and regulation of protein functions via AKAPs in distinct cellular compartments.
  • Tasken, Kjetil (2012). Signal complexes organized by A kinase anchoring proteins.
  • Tasken, Kjetil (2012). Signal networks in cancer and immune cells.
  • Tasken, Kjetil (2012). Spatiotemporal dynamics of cAMP signaling.
  • Tautz, Lutz; Vang, Torkel; Liu, Wallace; Delacroix, Laurence; Wu, Shuangding; Vasile, Stefan; Dahl, Russell; Yang, Li; Musumeci, Lucia; Francis, Dana; Landskron, Johannes; Tasken, Kjetil; Tremblay, Michel L.; Lie, Benedicte Alexandra; Page, Rebecca; Mustelin, Tomas; Rahmouni, Souad & Rickert, Robert C. (2012). Dynamic interaction between lymphoid tyrosine phosphatase and C-terminal Src kinase controls T cell activation. The FASEB Journal.  ISSN 0892-6638.  26
  • Johnsen, Guro Mørk; Cornez, Isabelle Ann; Staff, Anne Cathrine & Tasken, Kjetil (2011). Is disruption of Type 1 Protein Kinase A Anchoring in Mice T-cells linked to infertility in females?.
  • Johnsen, Guro Mørk; Landskron, Johannes; Tasken, Kjetil & Staff, Anne Cathrine (2011). CHARACTERIZATION OF PLACENTAL AND CIRCULATING REGULATORY T-CELLS. Placenta.  ISSN 0143-4004.  32(9), s A122- A122
  • Johnsen, Guro Mørk; Landskron, Johannes; Tasken, Kjetil & Staff, Anne Cathrine (2011). Characterization of Placental and Circulating Regulatory T-Cells.
  • Johnsen, Guro Mørk; Landskron, Johannes; Tasken, Kjetil & Staff, Anne Cathrine (2011). Characterization of Subsets of T cells and NK cells in Pregnancy and Preeclampsia.
  • Pidoux, Guillaume; Gerbaud, P; Dompierre, J; Lygren, Birgitte; Saunders, Threrese Solstad; Evain-Brion, Daniéle & Tasken, Kjetil (2011). EZRIN ORGANIZES A SUPRAMOLECULAR COMPLEX CONTROLLING COMMUNICATION THROUGH GAP JUNCTIONS DURING TROPHOBLAST CELL FUSION. Placenta.  ISSN 0143-4004.  32(9), s A132- A132
  • Tasken, K & Tasken, Kjetil (2011). SPATIOTEMPORAL DYNAMICS OF HCG/CAMP SIGNALLING AND REGULATION OF PLACENTAL FUNCTION. Placenta.  ISSN 0143-4004.  32(9), s A2- A2
  • Tasken, Kjetil (2011). Chemical biology targeting of cAMP signal pathways.
  • Tasken, Kjetil (2011). Forward looking statement: Personalized and Stratified Medicine.
  • Tasken, Kjetil (2011). Individual patient anti-tumor immune responses in metastatic colorectal cancer and relation to prognosis.
  • Tasken, Kjetil (2011). Infrastructure for marine bioprospecting.
  • Tasken, Kjetil (2011). Spatiotemporal control of cyclic AMP signaling processes.

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Published Dec. 17, 2015 10:21 AM - Last modified Feb. 6, 2017 12:50 PM