Sigrid Skånland

Image of Sigrid Skånland
Norwegian version of this page
Phone +47-22859128
Room 52115
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Visiting address Forskningsparken Gaustadalléen 21 0349 Oslo
Postal address Postboks 1137 Blindern 0318 OSLO

Academic interests

  • Cell signaling aberrations in Chronic lymphocytic leukemia
  • Cell signaling and protein-protein interactions in T cells

Positions held

  • 2015-present: Researcher, Taskén Group, funded by a Career Development Research Fellowship from the Norwegian Cancer Society.

Background

Research:

  • 2011-2015: Postdoctoral research fellow, Taskén Group, NCMM
  • 2009 - 2011:  Postdoctoral research fellow in Prof. Ivan Dikic's Group, Institute of Biochemistry II, Johan Wolfgang Goethe University, Frankfurt, Germany.
  • 2006:  Visiting student (3 months) in Prof. Tom Rapoport's Group, Department of Cell Biology, Harvard Medical School, Boston, MA, USA.

Education:

  • 2008:  PhD, Prof. Kirsten Sandvig's Group, Norwegian Radium Hospital, University of Oslo.
    PhD thesis:  "Mechanisms in intracellular transport of toxins." 
  • 2005:  MSc in Molecular Biology, Prof. Kirsten Sandvig's Group, Norwegian Radium Hospital, University of Oslo.
    MSc thesis:  "The phosphatidylinositol 3-kinase hVps34 modulates endosome to Golgi transport of ricin."
  • 2002:  BSc in Biology, Faculty of Mathematics and Natural Sciences, University of Oslo.

Awards and Grants

  • 2014 Career Development Research Fellowship, the Norwegian Cancer Society
  • 2009 - 2011:  EMBO Long term fellowship.
Tags: T cells, Cell signalling, Regulatory T cells, Cancer research, Cancer, Immunology, B cells, Chronic lymphocytic leukaemia

Publications

  • Skånland, Sigrid Strand; Moltu, Kristine; Berge, Torunn; Aandahl, Einar Martin & Tasken, Kjetil (2014). T-cell co-stimulation through the CD2 and CD28 co-receptors induces distinct signalling responses. Biochemical Journal.  ISSN 0264-6021.  460(3), s 399- 410 . doi: 10.1042/BJ20140040
  • Gregers, Tone Fredsvik; Skånland, Sigrid Strand; Waelchli, Sebastien; Bakke, Oddmund & Sandvig, Kirsten (2013). BiP Negatively Affects Ricin Transport. Toxins.  ISSN 2072-6651.  5(5), s 969- 982 . doi: 10.3390/toxins5050969
  • Pollheimer, Jürgen; Bodin, Johanna; Sundnes, Olav; Bekkeheien, Reidunn C; Skånland, Sigrid Strand; Sponheim, Jon; Brox, Mari Johanna; Sundlisæter, Eirik; Loos, Tamara; Vatn, Morten H; Kasprzycka, Monika; Wang, Junbai; Kuchler, Axel Matthias; Tasken, Kjetil; Haraldsen, Guttorm & Hol, Johanna (2013). Interleukin-33 drives a proinflammatory endothelial activation that selectively targets nonquiescent cells. Arteriosclerosis, Thrombosis and Vascular Biology.  ISSN 1079-5642.  33(2), s e47- e55 . doi: 10.1161/ATVBAHA.112.253427
  • Kalland, Maria Elisabeth; Solheim, Silje Anette; Skånland, Sigrid Strand; Tasken, Kjetil & Berge, Torunn (2012). Modulation of proximal signaling in normal and transformed B cells by transmembrane adapter Cbp/PAG. Experimental Cell Research.  ISSN 0014-4827.  318(14), s 1611- 1619 . doi: 10.1016/j.yexcr.2012.05.014
  • Tcatchoff, Lionel; Andersson, Sofia; Utskarpen, Audrun; Klokk, Tove Irene; Skånland, Sigrid Strand; Pust, Sascha; Gerke, Volker & Sandvig, Kirsten (2012). Annexin A1 and A2: Roles in Retrograde Trafficking of Shiga Toxin. PLoS ONE.  ISSN 1932-6203.  7(7) . doi: 10.1371/journal.pone.0040429
  • Skånland, Sigrid Strand; Walchli, S & Sandvig, Kirsten (2009). beta-arrestins attenuate p38-mediated endosome to Golgi transport. Cellular Microbiology.  ISSN 1462-5814.  11(5), s 796- 807 . doi: 10.1111/j.1462-5822.2009.01292.x
  • Skånland, Sigrid Strand; Wälchli, Sebastien; Brech, Andreas & Sandvig, Kirsten (2009). SNX4 in complex with clathrin and dynein: Implications for endosome movement. PLoS ONE.  ISSN 1932-6203.  s e5935 . doi: 10.1371/journal.pone.0005935
  • Wälchli, Sebastien; Aasheim, Hans-Christian; Skånland, Sigrid Strand; Spilsberg, Bjørn; Torgersen, M.L.; Rosendal, Ken & Sandvig, Kirsten (2009). Characterization of clathrin and Syk interaction upon Shiga toxin binding. Cellular Signalling.  ISSN 0898-6568.  21(7), s 1161- 1168 . doi: 10.1016/j.cellsig.2009.03.005
  • Walchli, S; Skånland, Sigrid Strand; Gregers, Tone Fredsvik; Lauvrak, Silje Anett Ugland; Torgersen, Maria Lyngaas; Ying, M; Kuroda, S; Maturana, A & Sandvig, Kirsten (2008). The mitogen-activated protein kinase p38 links Shiga toxin-dependent signaling and trafficking. Molecular Biology of the Cell.  ISSN 1059-1524.  19(1), s 95- 104 . doi: 10.1091/mbc.E07-06-0565
  • Skånland, Sigrid Strand; Waelchli, Sebastien; Utskarpen, Audrun; Wandinger-Ness, A & Sandvig, Kirsten (2007). Phosphoinositide-regulated retrograde transport of ricin: Crosstalk between hVps34 and sorting nexins. Traffic : the International Journal of Intracellular Transport.  ISSN 1398-9219.  8, s 297- 309 . doi: 10.1111/j.1600-0854.2006.00527.x
  • Torgersen, M.L.; Walchli, S; Grimmer, Stine J Staavi; Skånland, Sigrid Strand & Sandvig, Kirsten (2007). PKC is activated by Shiga toxin and regulates its transport. Journal of Biological Chemistry.  ISSN 0021-9258.  282, s 16317- 16328 . doi: 10.1074/jbc.M610886200
  • Utskarpen, Audrun; Slagsvold, Hege Holte; dyve, ab; Skånland, Sigrid Strand & Sandvig, Kirsten (2007). SNX1 and SNX2 mediate retrograde transport of Shiga toxin. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  358, s 566- 570 . doi: 10.1016/j.bbrc.2007.04.159

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  • Ribes, Anna Maria Parente; Skånland, Sigrid Strand; Bürgler, Simone; Os, Audun; Wang, Dong; Bogen, Bjarne; Tjønnfjord, Geir Erland; Tasken, Kjetil & Munthe, Ludvig Andre (2016). Spleen tyrosine kinase inhibitors reduce CD40l-induced proliferation of chronic lymphocytic leukemia cells but not normal B cells. Haematologica.  ISSN 0390-6078.  101(2), s e59- e62 . doi: 10.3324/haematol.2015.135590
  • Moltu, Kristine; Skånland, Sigrid Strand; Berge, Torunn & Tasken, Kjetil (2012). Distinct signalling patterns and functional responses to CD2 and CD28 co-stimulation of human primary T cells. Immunology.  ISSN 0019-2805.  137, s 374- 374
  • Skånland, Sigrid Strand & Sandvig, Kirsten (2009). Mechanisms in intracellular transport of toxins.

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Published Dec. 17, 2015 10:21 AM - Last modified Feb. 6, 2017 12:34 PM

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